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Q04FR4

- TYSY_OENOB

UniProt

Q04FR4 - TYSY_OENOB

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Protein
Thymidylate synthase
Gene
thyA, OEOE_0782
Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciOOEN203123:GHNL-782-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:OEOE_0782
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
ProteomesiUP000000774: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Thymidylate synthaseUniRule annotation
PRO_1000000645Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi203123.OEOE_0782.

Structurei

3D structure databases

ProteinModelPortaliQ04FR4.
SMRiQ04FR4. Positions 5-319.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiAQWRHWE.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04FR4-1 [UniParc]FASTAAdd to Basket

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MSRNEEQYLN LARRILETGA SKMDRTKTGT HSIFGAQMRF DLSEGFPLLT    50
SKKVAFGRIK SELLWFLRGD NNIRFLLQHH NHIWDEWPFK KWVESNEYKG 100
PDMTDFGLRT QKDPIFAEQY KEQKKIFVDR ILNDDEFSKK FGTIGDVYGK 150
LWRHWPDAND DGSVDQITRL INEIKVNPNS RRLILTAWDP ETTPFATLPS 200
CHVMSQFYVV DGKISLQMYQ RSADYFLGVP FNIASYSLLL SMVAAQTGLE 250
VGEFIHTIGD AHIYNNHVDQ IKEQLSKPTH KLPTLKLNPD VKSIFDYEMS 300
DIKLENYIHE DVIKAPIAV 319
Length:319
Mass (Da):36,992
Last modified:November 14, 2006 - v1
Checksum:i39B048FABA5F019A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56708.1.
RefSeqiYP_810373.1. NC_008528.1.

Genome annotation databases

EnsemblBacteriaiABJ56708; ABJ56708; OEOE_0782.
GeneIDi4416836.
KEGGiooe:OEOE_0782.
PATRICi22799723. VBIOenOen113004_0795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56708.1 .
RefSeqi YP_810373.1. NC_008528.1.

3D structure databases

ProteinModelPortali Q04FR4.
SMRi Q04FR4. Positions 5-319.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203123.OEOE_0782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ56708 ; ABJ56708 ; OEOE_0782 .
GeneIDi 4416836.
KEGGi ooe:OEOE_0782.
PATRICi 22799723. VBIOenOen113004_0795.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi AQWRHWE.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci OOEN203123:GHNL-782-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-331 / PSU-1.

Entry informationi

Entry nameiTYSY_OENOB
AccessioniPrimary (citable) accession number: Q04FR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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