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Q04FL2

- SYL_OENOB

UniProt

Q04FL2 - SYL_OENOB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOOEN203123:GHNL-839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:OEOE_0839
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
ProteomesiUP000000774: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Leucine--tRNA ligasePRO_0000334785Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203123.OEOE_0839.

Structurei

3D structure databases

ProteinModelPortaliQ04FL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi582 – 5865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04FL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYDHKAIEK RWQTYWDEHK TFKTAPETSG KPKYYVMNMF PYPSGQGLHV
60 70 80 90 100
GHPESYTATD IMARFNRMRG FNVLQPMGWD AFGLPAEQYA IKTGHNPADF
110 120 130 140 150
TNENIKHFKK QVKSLGFSYD WDREINTTDP EYYKWTQWIF EQLYKKGLAY
160 170 180 190 200
EDEIMVNWAP DFPGGGIVVA NEEVIDGKTE RGSYPVYRVP MKQWVLRITK
210 220 230 240 250
YAERLLSDLD DLDWPEAIKE QQRNWIGKST GAAVFFKVDG KSDYQVEVYT
260 270 280 290 300
TRPDTLFGAS YMVLAPEHDL VDKITTSECR ADVDAYKAKI ASKSDLERTD
310 320 330 340 350
LNREKTGAFT GAYGINPVNG EKIPIWIADY VLSSYGTGAI MAVPAHDTRD
360 370 380 390 400
YEFAKKFDLP IRQVIKGGDI SKEAFTGDGT HINSAFLDVL DKKQAIEKII
410 420 430 440 450
DWLEEHDAGH KQVNYKLRDW IFSRQRYWGE PIPVIHWEDG KQTLVPESEL
460 470 480 490 500
PLRLPHLNQD QMKPSGTGES PLANAKSWLE VTRQDGVKGR RETNTMPQWA
510 520 530 540 550
GSSWYFLRYI DPHNDKVLAD PEKLKYWMNV DLYVGGAEHA VLHLLYARFW
560 570 580 590 600
HKFLYDLGIV PTKEPFQKLV NQGMILGTNH EKMSKSKGNV VNPDEIVDSY
610 620 630 640 650
GADALRVYEM FMGPLTQSKP WSTESLAGIR RYLDRVWRIF TSDGDGINPI
660 670 680 690 700
IVSENDHKLD KIFNQTVKKV TEDYAAMRFN TAISQMMVFI NETFKAEKLP
710 720 730 740 750
KKYMNAFLQL LNPVAPHITE ELWQRMGHQE TIAYATWPTY DESQIIEKQI
760 770 780 790 800
EMAVQINGKV RAKINTPVDI SRDELAKMAT DNPDVKKQVA DKNIVKIIAI
810
PGKIINIVVK
Length:810
Mass (Da):93,102
Last modified:May 20, 2008 - v2
Checksum:i69B5134C35CB569A
GO

Sequence cautioni

The sequence ABJ56760.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000411 Genomic DNA. Translation: ABJ56760.1. Different initiation.
RefSeqiYP_810425.1. NC_008528.1.

Genome annotation databases

EnsemblBacteriaiABJ56760; ABJ56760; OEOE_0839.
GeneIDi4416877.
KEGGiooe:OEOE_0839.
PATRICi22799851. VBIOenOen113004_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000411 Genomic DNA. Translation: ABJ56760.1 . Different initiation.
RefSeqi YP_810425.1. NC_008528.1.

3D structure databases

ProteinModelPortali Q04FL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203123.OEOE_0839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ56760 ; ABJ56760 ; OEOE_0839 .
GeneIDi 4416877.
KEGGi ooe:OEOE_0839.
PATRICi 22799851. VBIOenOen113004_0858.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci OOEN203123:GHNL-839-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-331 / PSU-1.

Entry informationi

Entry nameiSYL_OENOB
AccessioniPrimary (citable) accession number: Q04FL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3