Reviewed, UniProtKB/Swiss-Prot Q04FK3 (UPPP1_OENOB)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	OEOE_0848

Organism

Oenococcus oeni (strain BAA-331 / PSU-1) [Complete proteome] [HAMAP]

Taxonomic identifier

203123 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Oenococcus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000290739
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	43 – 63	21	Potential
	Transmembrane	83 – 103	21	Potential
	Transmembrane	112 – 132	21	Potential
	Transmembrane	192 – 212	21	Potential
	Transmembrane	224 – 244	21	Potential
	Transmembrane	257 – 277	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q04FK3-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 5661E2C62C6892F4	FASTA	278	30,998
	10 20 30 40 50 60 MFFGILKAII LGIVEGITEF LPISSTGHLI IVDQFVKISS NKAFTTTFEY VIQLGAIIAV 70 80 90 100 110 120 VLLYWKRLWP FGGGKTEKQR FNIWATWVKV VVGVIPSVII GFLLNDWMDK HLMNWLVVSI 130 140 150 160 170 180 ALIVYGIAFI FIENYQKNRR PRVRTINHLT LADVLKIGFF QVLSIVPGTS RSGATILGGI 190 200 210 220 230 240 SIGVSREAAA EFSFFLSIPT MLGVSVLKIG SYLHSHGMFS GEQIVILLVG MFVSFVVAYV 250 260 270 VIKWLLRFIQ THDFKAFGWY RIILGVLVIA LGAIGIID

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000411 Genomic DNA. Translation: ABJ56769.1.
RefSeq	YP_810434.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4416107.
GenomeReviews	Gene locus OEOE_0848 in contig CP000411_GR.
KEGG	ooe:OEOE_0848.
NMPDR	fig|203123.1.peg.8.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q04FK3. IYGIAFI.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_OENOB

Accession

Primary (citable) accession number: Q04FK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)