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Q04F24

- BGAL_OENOB

UniProt

Q04F24 - BGAL_OENOB

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Protein

Beta-galactosidase

Gene

lacZ

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer.UniRule annotation
Binds 1 sodium ion per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981SubstrateUniRule annotation
Metal bindingi197 – 1971SodiumUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Sitei353 – 3531Transition state stabilizerUniRule annotation
Sitei387 – 3871Transition state stabilizerUniRule annotation
Metal bindingi412 – 4121Magnesium 1UniRule annotation
Metal bindingi414 – 4141Magnesium 1UniRule annotation
Active sitei457 – 4571Proton donorUniRule annotation
Metal bindingi457 – 4571Magnesium 1UniRule annotation
Binding sitei457 – 4571SubstrateUniRule annotation
Active sitei533 – 5331NucleophileUniRule annotation
Metal bindingi593 – 5931Magnesium 2UniRule annotation
Metal bindingi597 – 5971Sodium; via carbonyl oxygenUniRule annotation
Metal bindingi600 – 6001SodiumUniRule annotation
Binding sitei600 – 6001SubstrateUniRule annotation
Binding sitei1005 – 10051SubstrateUniRule annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciOOEN203123:GHNL-1044-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZUniRule annotation
Ordered Locus Names:OEOE_1044
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
ProteomesiUP000000774: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Beta-galactosidasePRO_0000367004Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi203123.OEOE_1044.

Structurei

3D structure databases

ProteinModelPortaliQ04F24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni533 – 5364Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiCHGFESI.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04F24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNKISFRDI INRKDWENPV ITNWHRLPIH TEMNYSKSLN EDKQKTIQSL
60 70 80 90 100
NGNWCFSYFS KVTDVPENWA DRDLTKSNIM PVPSNWQLHG YDQPIYSNVA
110 120 130 140 150
YPFPANPPYL PEENPTACYS RIFQLNDDWL QSGQNHVIFN GVGSAFHLWL
160 170 180 190 200
NGQWIGYSED SRLPAEFDLT KYLKSGKNRI SVMVLRWSKG SYFEDQDMWR
210 220 230 240 250
MSGIFRDVEV KHLPATYLQD YQLQTDLDDD LDQAKITIKA QVAGKNFSQN
260 270 280 290 300
KLRTRLYFAN EKVADQSSRL STRAVDERGP LDNQFIAELN LKDPYLWSAE
310 320 330 340 350
LPYLYQLVIE LLTDDGDILQ VEKVNIGVRK VEIKNGLLKL NGKPLLIRGT
360 370 380 390 400
NKHEFDSKKG YAVDEETMIQ DIKAMKRNNF NAVRCSHYPN NRRWYELCDQ
410 420 430 440 450
YGLYVVDEAN IETHGMVPMN RLTNDPVYLP LMSDRVTRMV TRDRNHPSII
460 470 480 490 500
IWSLGNESGY GRNHAALYNW IKQSDLSRPV QYEGGGANTA VTDIIVPMYA
510 520 530 540 550
RVEQDQIESV NSKWSLKKWI GLPGETRPLI LCEYAHDMGN SLGGFGKYWQ
560 570 580 590 600
AFHKYPRLQG GFIWDWVDQG LLKKDVNGND FYAYGGDFKD QPNDRQFCLD
610 620 630 640 650
GLLFPDRTPK PAMHEVKYWQ QYYLFNLQRN PLGQAESFTV TNDYSFKKSS
660 670 680 690 700
NERLHYQIKS ENEIVIDKYI DLVLNPGESL LIKLPKGRSS TSSLLDIDIS
710 720 730 740 750
LIKGNSWAPS GFKIASEQYV LAKKFGPTNA VTAATNKISL IENKDTNTFE
760 770 780 790 800
IKLDDQKWQF AKNSGLLVSW SKSGNENLLD ALRDQFTRAP LDNDIGVSKV
810 820 830 840 850
DHIDPNAWYE RWKSAGMYNL KTNLVSIDAE QLERAVLIRT EHSYSNHFQI
860 870 880 890 900
LFKSSKIYRI DANGTMTVTV DVSLAQGIPF PARIGLTCHL ADQITDVSYT
910 920 930 940 950
GLGPFENYPD RQSAAQYGHW QMELDDLYTP YIFPSENGSR GQVSQLEFGK
960 970 980 990 1000
QKISAYHEQN FSFNLSRFSK QQLARISHRN LLQAENGVWL SIDGYRMGVG
1010 1020 1030
GDDSWSPSVA PEYLLSNNYY HYAFQWCRKD I
Length:1,031
Mass (Da):118,758
Last modified:November 14, 2006 - v1
Checksum:iABBC52BF9A20F31B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56948.1.
RefSeqiYP_810613.1. NC_008528.1.

Genome annotation databases

EnsemblBacteriaiABJ56948; ABJ56948; OEOE_1044.
GeneIDi4415716.
KEGGiooe:OEOE_1044.
PATRICi22800265. VBIOenOen113004_1059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56948.1 .
RefSeqi YP_810613.1. NC_008528.1.

3D structure databases

ProteinModelPortali Q04F24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203123.OEOE_1044.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ56948 ; ABJ56948 ; OEOE_1044 .
GeneIDi 4415716.
KEGGi ooe:OEOE_1044.
PATRICi 22800265. VBIOenOen113004_1059.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi CHGFESI.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci OOEN203123:GHNL-1044-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-331 / PSU-1.

Entry informationi

Entry nameiBGAL_OENOB
AccessioniPrimary (citable) accession number: Q04F24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3