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Q04F24

- BGAL_OENOB

UniProt

Q04F24 - BGAL_OENOB

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Protein
Beta-galactosidase
Gene
lacZ, OEOE_1044
Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate By similarity
Metal bindingi197 – 1971Sodium By similarity
Binding sitei197 – 1971Substrate By similarity
Sitei353 – 3531Transition state stabilizer By similarity
Sitei387 – 3871Transition state stabilizer By similarity
Metal bindingi412 – 4121Magnesium 1 By similarity
Metal bindingi414 – 4141Magnesium 1 By similarity
Active sitei457 – 4571Proton donor By similarity
Metal bindingi457 – 4571Magnesium 1 By similarity
Binding sitei457 – 4571Substrate By similarity
Active sitei533 – 5331Nucleophile By similarity
Metal bindingi593 – 5931Magnesium 2 By similarity
Metal bindingi597 – 5971Sodium; via carbonyl oxygen By similarity
Metal bindingi600 – 6001Sodium By similarity
Binding sitei600 – 6001Substrate By similarity
Binding sitei1005 – 10051Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Enzyme and pathway databases

BioCyciOOEN203123:GHNL-1044-MONOMER.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:OEOE_1044
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
ProteomesiUP000000774: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Beta-galactosidaseUniRule annotation
PRO_0000367004Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi203123.OEOE_1044.

Structurei

3D structure databases

ProteinModelPortaliQ04F24.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni533 – 5364Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiCHGFESI.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04F24-1 [UniParc]FASTAAdd to Basket

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MTNKISFRDI INRKDWENPV ITNWHRLPIH TEMNYSKSLN EDKQKTIQSL     50
NGNWCFSYFS KVTDVPENWA DRDLTKSNIM PVPSNWQLHG YDQPIYSNVA 100
YPFPANPPYL PEENPTACYS RIFQLNDDWL QSGQNHVIFN GVGSAFHLWL 150
NGQWIGYSED SRLPAEFDLT KYLKSGKNRI SVMVLRWSKG SYFEDQDMWR 200
MSGIFRDVEV KHLPATYLQD YQLQTDLDDD LDQAKITIKA QVAGKNFSQN 250
KLRTRLYFAN EKVADQSSRL STRAVDERGP LDNQFIAELN LKDPYLWSAE 300
LPYLYQLVIE LLTDDGDILQ VEKVNIGVRK VEIKNGLLKL NGKPLLIRGT 350
NKHEFDSKKG YAVDEETMIQ DIKAMKRNNF NAVRCSHYPN NRRWYELCDQ 400
YGLYVVDEAN IETHGMVPMN RLTNDPVYLP LMSDRVTRMV TRDRNHPSII 450
IWSLGNESGY GRNHAALYNW IKQSDLSRPV QYEGGGANTA VTDIIVPMYA 500
RVEQDQIESV NSKWSLKKWI GLPGETRPLI LCEYAHDMGN SLGGFGKYWQ 550
AFHKYPRLQG GFIWDWVDQG LLKKDVNGND FYAYGGDFKD QPNDRQFCLD 600
GLLFPDRTPK PAMHEVKYWQ QYYLFNLQRN PLGQAESFTV TNDYSFKKSS 650
NERLHYQIKS ENEIVIDKYI DLVLNPGESL LIKLPKGRSS TSSLLDIDIS 700
LIKGNSWAPS GFKIASEQYV LAKKFGPTNA VTAATNKISL IENKDTNTFE 750
IKLDDQKWQF AKNSGLLVSW SKSGNENLLD ALRDQFTRAP LDNDIGVSKV 800
DHIDPNAWYE RWKSAGMYNL KTNLVSIDAE QLERAVLIRT EHSYSNHFQI 850
LFKSSKIYRI DANGTMTVTV DVSLAQGIPF PARIGLTCHL ADQITDVSYT 900
GLGPFENYPD RQSAAQYGHW QMELDDLYTP YIFPSENGSR GQVSQLEFGK 950
QKISAYHEQN FSFNLSRFSK QQLARISHRN LLQAENGVWL SIDGYRMGVG 1000
GDDSWSPSVA PEYLLSNNYY HYAFQWCRKD I 1031
Length:1,031
Mass (Da):118,758
Last modified:November 14, 2006 - v1
Checksum:iABBC52BF9A20F31B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56948.1.
RefSeqiYP_810613.1. NC_008528.1.

Genome annotation databases

EnsemblBacteriaiABJ56948; ABJ56948; OEOE_1044.
GeneIDi4415716.
KEGGiooe:OEOE_1044.
PATRICi22800265. VBIOenOen113004_1059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56948.1 .
RefSeqi YP_810613.1. NC_008528.1.

3D structure databases

ProteinModelPortali Q04F24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203123.OEOE_1044.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ56948 ; ABJ56948 ; OEOE_1044 .
GeneIDi 4415716.
KEGGi ooe:OEOE_1044.
PATRICi 22800265. VBIOenOen113004_1059.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi CHGFESI.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci OOEN203123:GHNL-1044-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-331 / PSU-1.

Entry informationi

Entry nameiBGAL_OENOB
AccessioniPrimary (citable) accession number: Q04F24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi