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Q04EU6

- PUR9_OENOB

UniProt

Q04EU6 - PUR9_OENOB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciOOEN203123:GHNL-1129-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:OEOE_1129
    OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
    Taxonomic identifieri203123 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
    ProteomesiUP000000774: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Bifunctional purine biosynthesis protein PurHPRO_1000018921Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203123.OEOE_1129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04EU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiGIGQADN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04EU6-1 [UniParc]FASTAAdd to Basket

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    MKRALLSVSD KRGLIDFAKG LIKNNYEIIS TGGTLKFLTE AGVKAKAVEE    50
    ITGFPEILNG RVKTLHPKIH AALLAKRENS EHMKTLEEHQ ITPIDLLAVN 100
    LYPFKETIEK KDVSYDQAIE NIDIGGPSML RSAAKNARDV IVVVDPDDYD 150
    SILKAIANDD LSHDFRRHLQ AKTFRHTAAY DALIADYLSK EEYPEKLTVT 200
    YDKDFDLRYG ENPNQTAAVY ADAIPKAYSI LQAKILHGKK LSYNNIKDAD 250
    AALRTIADFQ DQPTVVTLKH MNPAGIGQAI TIEKAWDKAF YADDISIFGG 300
    IVVLNREVDL ATAQKMHTIF LEIIIAPGFS EEAYQILAKK KNLRLLTVAM 350
    TNTLPKELEL TSVLGGAVVQ EMDRLVENAA DFEVVSSAKP TDEQLEALVF 400
    AQKAVKHVKS NAILIAAQGQ TLGIGAGQPN RIDSVKIAFK HAEAKKNFDQ 450
    AVLASDAFFP MDDSVEFAAE HGIKAIVEPG GSIKDKDSIA MADKLGVVLV 500
    FSHNRHFRH 509
    Length:509
    Mass (Da):56,130
    Last modified:November 14, 2006 - v1
    Checksum:i2DB56A46B16940E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000411 Genomic DNA. Translation: ABJ57026.1.
    RefSeqiYP_810691.1. NC_008528.1.

    Genome annotation databases

    EnsemblBacteriaiABJ57026; ABJ57026; OEOE_1129.
    GeneIDi4415337.
    KEGGiooe:OEOE_1129.
    PATRICi22800454. VBIOenOen113004_1153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000411 Genomic DNA. Translation: ABJ57026.1 .
    RefSeqi YP_810691.1. NC_008528.1.

    3D structure databases

    ProteinModelPortali Q04EU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203123.OEOE_1129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ57026 ; ABJ57026 ; OEOE_1129 .
    GeneIDi 4415337.
    KEGGi ooe:OEOE_1129.
    PATRICi 22800454. VBIOenOen113004_1153.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi GIGQADN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci OOEN203123:GHNL-1129-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-331 / PSU-1.

    Entry informationi

    Entry nameiPUR9_OENOB
    AccessioniPrimary (citable) accession number: Q04EU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3