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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46S-adenosyl-L-methionineUniRule annotation1
Binding sitei71S-adenosyl-L-methionineUniRule annotation1
Binding sitei100S-adenosyl-L-methionineUniRule annotation1
Active sitei122By similarity1
Binding sitei122S-adenosyl-L-methionineUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei158SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciOOEN203123:G1G6W-1244-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:OEOE_1272
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
Proteomesi
  • UP000000774 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881931 – 219tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST219

Proteomic databases

PRIDEiQ04EH7

Interactioni

Protein-protein interaction databases

STRINGi203123.OEOE_1272

Structurei

3D structure databases

ProteinModelPortaliQ04EH7
SMRiQ04EH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 133Interaction with RNAUniRule annotation6
Regioni199 – 202Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000251689
KOiK03439
OMAiWITFPDP

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q04EH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRSKKWAV PFIDEHPDLI IKDQRAKQLK GSWSSVFGNN HPLYLEIGSG
60 70 80 90 100
KGQFILDNAI KYPENNFIGL ELQPTAVAIA GKKAFKQEPQ LANLKLILGD
110 120 130 140 150
GGDVSDYFAD NEISKIFLNH SDPWPKAKHE KRRLTAENFL KSYSKILLPN
160 170 180 190 200
GSLELKTDNL GLFEYSLSSF KKFGLSWPEE QISYDLHHEL KKNPVNIETE
210
YEKKFAEMNQ PEYWIRVNF
Length:219
Mass (Da):25,272
Last modified:November 14, 2006 - v1
Checksum:i2BBD8BD0D72C25AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000411 Genomic DNA Translation: ABJ57145.1
RefSeqiWP_002820317.1, NC_008528.1

Genome annotation databases

EnsemblBacteriaiABJ57145; ABJ57145; OEOE_1272
GeneIDi4415463
KEGGiooe:OEOE_1272
PATRICifig|203123.7.peg.1284

Similar proteinsi

Entry informationi

Entry nameiTRMB_OENOB
AccessioniPrimary (citable) accession number: Q04EH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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