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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei408By similarity1
Active sitei410By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
Biological processDNA replication
LigandCobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LBUL_0079
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003265401 – 739Adenosylcobalamin-dependent ribonucleoside-triphosphate reductaseAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 419Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ04CQ7

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ04CQ7
SMRiQ04CQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 158Effector region-1By similarityAdd BLAST12
Regioni168 – 313Effector region-2By similarityAdd BLAST146
Regioni565 – 626Adenosylcobalamin-binding-1By similarityAdd BLAST62
Regioni685 – 724Adenosylcobalamin-binding-2By similarityAdd BLAST40

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000068540
KOiK00527
OMAiSDKCLLP

Family and domain databases

InterProiView protein in InterPro
IPR000788 RNR_lg_C
IPR013345 RTP_Rdtase_AdoCbl-dep
PfamiView protein in Pfam
PF02867 Ribonuc_red_lgC, 1 hit
TIGRFAMsiTIGR02505 RTPR, 1 hit

Sequencei

Sequence statusi: Complete.

Q04CQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGISLSAE FIDRVKASVK PHWGKLGWVT YKRTYARWLP EKGRSENWDE
60 70 80 90 100
TVKRVVEGNI NLDPRLQDSP SLELKQSLTE EAERLYKLIY GLGATPSGRN
110 120 130 140 150
LWISGTDYQR RTGDSLNNCW FVAIRPQKYG DSKIVPSYLG KQEKAVSMPF
160 170 180 190 200
SFLFDELMKG GGVGFSVARS NISQIPRVDF AIDLQVVVDE SSESYDASVK
210 220 230 240 250
VGAVGKNEVV QDADSIYYRL PDTREGWVLA NALLIDLHFA QTNPDRKQKL
260 270 280 290 300
ILDLSDIRPY GAEIHGFGGT ASGPMPLISM LLDINEVLNN KAGGRLTSVD
310 320 330 340 350
AADICNLIGK AVVAGNVRRS AELALGSNDD QDFISMKQDQ EKLMHHRWAS
360 370 380 390 400
NNSVAVDSAF SGYQPIAAGI RENGEPGIVN LDLSKNYGRI VDGYQAGIDG
410 420 430 440 450
DVEGTNPCGE ISLANGEPCN LFEVFPLIAE EQGWDLQEVF ALAARYAKRV
460 470 480 490 500
TFSPYDWEIS REIIQKNRRI GISMSGIQDW LLTRLGNRVV TGFKDDFDPE
510 520 530 540 550
THEAIKVPVY DKRAIKMVDQ LYKAVVKADQ DYSKTLGCNE SIKHTTVKPS
560 570 580 590 600
GTVAKLAGAS EGMHFHYGAY LIQRIRFQNS DPLLPALKAC GYRTEADIYT
610 620 630 640 650
ENTTCVEFPV KAVGADNPNF ASAGTVSIAE QFATQAFLQT YWSDNAVSCT
660 670 680 690 700
ITFQDSEGDQ VESLLRQYRF IIKSTSLLPY FGGSLQQAPK EPIDKETYEK
710 720 730
RSQEITGNVE EVFSQLNSDV KDLELVDQTD CEGGACPIK
Length:739
Mass (Da):81,896
Last modified:November 14, 2006 - v1
Checksum:iAA7CF94DD05214CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000412 Genomic DNA Translation: ABJ57765.1
RefSeqiWP_003620293.1, NC_008529.1

Genome annotation databases

EnsemblBacteriaiABJ57765; ABJ57765; LBUL_0079
KEGGilbu:LBUL_0079

Similar proteinsi

Entry informationi

Entry nameiRTPR_LACDB
AccessioniPrimary (citable) accession number: Q04CQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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