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Q04CQ7

- RTPR_LACDB

UniProt

Q04CQ7 - RTPR_LACDB

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene
rtpR, LBUL_0079
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Enzyme regulationi

Allosterically regulated by ATP and dNTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei408 – 4081 By similarity
Active sitei410 – 4101 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLDEL321956:GI15-78-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LBUL_0079
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000665: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 419Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi321956.LBUL_0079.

Structurei

3D structure databases

ProteinModelPortaliQ04CQ7.
SMRiQ04CQ7. Positions 5-724.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni147 – 15812Effector region-1 By similarityAdd
BLAST
Regioni168 – 313146Effector region-2 By similarityAdd
BLAST
Regioni565 – 62662Adenosylcobalamin-binding-1 By similarityAdd
BLAST
Regioni685 – 72440Adenosylcobalamin-binding-2 By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00525.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04CQ7-1 [UniParc]FASTAAdd to Basket

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MSEGISLSAE FIDRVKASVK PHWGKLGWVT YKRTYARWLP EKGRSENWDE    50
TVKRVVEGNI NLDPRLQDSP SLELKQSLTE EAERLYKLIY GLGATPSGRN 100
LWISGTDYQR RTGDSLNNCW FVAIRPQKYG DSKIVPSYLG KQEKAVSMPF 150
SFLFDELMKG GGVGFSVARS NISQIPRVDF AIDLQVVVDE SSESYDASVK 200
VGAVGKNEVV QDADSIYYRL PDTREGWVLA NALLIDLHFA QTNPDRKQKL 250
ILDLSDIRPY GAEIHGFGGT ASGPMPLISM LLDINEVLNN KAGGRLTSVD 300
AADICNLIGK AVVAGNVRRS AELALGSNDD QDFISMKQDQ EKLMHHRWAS 350
NNSVAVDSAF SGYQPIAAGI RENGEPGIVN LDLSKNYGRI VDGYQAGIDG 400
DVEGTNPCGE ISLANGEPCN LFEVFPLIAE EQGWDLQEVF ALAARYAKRV 450
TFSPYDWEIS REIIQKNRRI GISMSGIQDW LLTRLGNRVV TGFKDDFDPE 500
THEAIKVPVY DKRAIKMVDQ LYKAVVKADQ DYSKTLGCNE SIKHTTVKPS 550
GTVAKLAGAS EGMHFHYGAY LIQRIRFQNS DPLLPALKAC GYRTEADIYT 600
ENTTCVEFPV KAVGADNPNF ASAGTVSIAE QFATQAFLQT YWSDNAVSCT 650
ITFQDSEGDQ VESLLRQYRF IIKSTSLLPY FGGSLQQAPK EPIDKETYEK 700
RSQEITGNVE EVFSQLNSDV KDLELVDQTD CEGGACPIK 739
Length:739
Mass (Da):81,896
Last modified:November 14, 2006 - v1
Checksum:iAA7CF94DD05214CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ57765.1.
RefSeqiYP_812203.1. NC_008529.1.

Genome annotation databases

EnsemblBacteriaiABJ57765; ABJ57765; LBUL_0079.
GeneIDi4436385.
KEGGilbu:LBUL_0079.
PATRICi22219969. VBILacDel70259_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ57765.1 .
RefSeqi YP_812203.1. NC_008529.1.

3D structure databases

ProteinModelPortali Q04CQ7.
SMRi Q04CQ7. Positions 5-724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321956.LBUL_0079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ57765 ; ABJ57765 ; LBUL_0079 .
GeneIDi 4436385.
KEGGi lbu:LBUL_0079.
PATRICi 22219969. VBILacDel70259_0076.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00525.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LDEL321956:GI15-78-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-365.

Entry informationi

Entry nameiRTPR_LACDB
AccessioniPrimary (citable) accession number: Q04CQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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