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Q04CQ7

- RTPR_LACDB

UniProt

Q04CQ7 - RTPR_LACDB

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei408 – 4081By similarity
    Active sitei410 – 4101By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciLDEL321956:GI15-78-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:LBUL_0079
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
    Taxonomic identifieri321956 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000665: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi119 ↔ 419Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi321956.LBUL_0079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04CQ7.
    SMRiQ04CQ7. Positions 5-724.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni147 – 15812Effector region-1By similarityAdd
    BLAST
    Regioni168 – 313146Effector region-2By similarityAdd
    BLAST
    Regioni565 – 62662Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni685 – 72440Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000068540.
    KOiK00525.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04CQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEGISLSAE FIDRVKASVK PHWGKLGWVT YKRTYARWLP EKGRSENWDE    50
    TVKRVVEGNI NLDPRLQDSP SLELKQSLTE EAERLYKLIY GLGATPSGRN 100
    LWISGTDYQR RTGDSLNNCW FVAIRPQKYG DSKIVPSYLG KQEKAVSMPF 150
    SFLFDELMKG GGVGFSVARS NISQIPRVDF AIDLQVVVDE SSESYDASVK 200
    VGAVGKNEVV QDADSIYYRL PDTREGWVLA NALLIDLHFA QTNPDRKQKL 250
    ILDLSDIRPY GAEIHGFGGT ASGPMPLISM LLDINEVLNN KAGGRLTSVD 300
    AADICNLIGK AVVAGNVRRS AELALGSNDD QDFISMKQDQ EKLMHHRWAS 350
    NNSVAVDSAF SGYQPIAAGI RENGEPGIVN LDLSKNYGRI VDGYQAGIDG 400
    DVEGTNPCGE ISLANGEPCN LFEVFPLIAE EQGWDLQEVF ALAARYAKRV 450
    TFSPYDWEIS REIIQKNRRI GISMSGIQDW LLTRLGNRVV TGFKDDFDPE 500
    THEAIKVPVY DKRAIKMVDQ LYKAVVKADQ DYSKTLGCNE SIKHTTVKPS 550
    GTVAKLAGAS EGMHFHYGAY LIQRIRFQNS DPLLPALKAC GYRTEADIYT 600
    ENTTCVEFPV KAVGADNPNF ASAGTVSIAE QFATQAFLQT YWSDNAVSCT 650
    ITFQDSEGDQ VESLLRQYRF IIKSTSLLPY FGGSLQQAPK EPIDKETYEK 700
    RSQEITGNVE EVFSQLNSDV KDLELVDQTD CEGGACPIK 739
    Length:739
    Mass (Da):81,896
    Last modified:November 14, 2006 - v1
    Checksum:iAA7CF94DD05214CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ57765.1.
    RefSeqiYP_812203.1. NC_008529.1.

    Genome annotation databases

    EnsemblBacteriaiABJ57765; ABJ57765; LBUL_0079.
    GeneIDi4436385.
    KEGGilbu:LBUL_0079.
    PATRICi22219969. VBILacDel70259_0076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ57765.1 .
    RefSeqi YP_812203.1. NC_008529.1.

    3D structure databases

    ProteinModelPortali Q04CQ7.
    SMRi Q04CQ7. Positions 5-724.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321956.LBUL_0079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ57765 ; ABJ57765 ; LBUL_0079 .
    GeneIDi 4436385.
    KEGGi lbu:LBUL_0079.
    PATRICi 22219969. VBILacDel70259_0076.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000068540.
    KOi K00525.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci LDEL321956:GI15-78-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-365.

    Entry informationi

    Entry nameiRTPR_LACDB
    AccessioniPrimary (citable) accession number: Q04CQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3