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Q04CQ7 (RTPR_LACDB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:LBUL_0079
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [Complete proteome] [HAMAP]
Taxonomic identifier321956 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326540

Regions

Region147 – 15812Effector region-1 By similarity
Region168 – 313146Effector region-2 By similarity
Region565 – 62662Adenosylcobalamin-binding-1 By similarity
Region685 – 72440Adenosylcobalamin-binding-2 By similarity

Sites

Active site4081 By similarity
Active site4101 By similarity

Amino acid modifications

Disulfide bond119 ↔ 419Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04CQ7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: AA7CF94DD05214CF

FASTA73981,896
        10         20         30         40         50         60 
MSEGISLSAE FIDRVKASVK PHWGKLGWVT YKRTYARWLP EKGRSENWDE TVKRVVEGNI 

        70         80         90        100        110        120 
NLDPRLQDSP SLELKQSLTE EAERLYKLIY GLGATPSGRN LWISGTDYQR RTGDSLNNCW 

       130        140        150        160        170        180 
FVAIRPQKYG DSKIVPSYLG KQEKAVSMPF SFLFDELMKG GGVGFSVARS NISQIPRVDF 

       190        200        210        220        230        240 
AIDLQVVVDE SSESYDASVK VGAVGKNEVV QDADSIYYRL PDTREGWVLA NALLIDLHFA 

       250        260        270        280        290        300 
QTNPDRKQKL ILDLSDIRPY GAEIHGFGGT ASGPMPLISM LLDINEVLNN KAGGRLTSVD 

       310        320        330        340        350        360 
AADICNLIGK AVVAGNVRRS AELALGSNDD QDFISMKQDQ EKLMHHRWAS NNSVAVDSAF 

       370        380        390        400        410        420 
SGYQPIAAGI RENGEPGIVN LDLSKNYGRI VDGYQAGIDG DVEGTNPCGE ISLANGEPCN 

       430        440        450        460        470        480 
LFEVFPLIAE EQGWDLQEVF ALAARYAKRV TFSPYDWEIS REIIQKNRRI GISMSGIQDW 

       490        500        510        520        530        540 
LLTRLGNRVV TGFKDDFDPE THEAIKVPVY DKRAIKMVDQ LYKAVVKADQ DYSKTLGCNE 

       550        560        570        580        590        600 
SIKHTTVKPS GTVAKLAGAS EGMHFHYGAY LIQRIRFQNS DPLLPALKAC GYRTEADIYT 

       610        620        630        640        650        660 
ENTTCVEFPV KAVGADNPNF ASAGTVSIAE QFATQAFLQT YWSDNAVSCT ITFQDSEGDQ 

       670        680        690        700        710        720 
VESLLRQYRF IIKSTSLLPY FGGSLQQAPK EPIDKETYEK RSQEITGNVE EVFSQLNSDV 

       730 
KDLELVDQTD CEGGACPIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000412 Genomic DNA. Translation: ABJ57765.1.
RefSeqYP_812203.1. NC_008529.1.

3D structure databases

ProteinModelPortalQ04CQ7.
SMRQ04CQ7. Positions 5-724.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321956.LBUL_0079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ57765; ABJ57765; LBUL_0079.
GeneID4436385.
KEGGlbu:LBUL_0079.
PATRIC22219969. VBILacDel70259_0076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00525.
OMADSLNNCW.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLDEL321956:GI15-78-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACDB
AccessionPrimary (citable) accession number: Q04CQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families