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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87SubstrateUniRule annotation1
Binding sitei119NAD or substrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Active sitei174Proton acceptor1
Binding sitei224SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 39NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:LBUL_0100
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000604391 – 307L-lactate dehydrogenaseAdd BLAST307

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ04CN9.
SMRiQ04CN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793.
KOiK00016.
OMAiVDELVIC.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04CN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKVLLVGD GAVGSNFAND LLQTTQVDEL VICDLNKDRA AGDCLDLEDM
60 70 80 90 100
TYFTGQTKLR AGDYSDAADA DVVVITAGVP RKPGESRLDL IKKNEAILRS
110 120 130 140 150
IVDPVVASGF SGIFVVSANP VDILTTLTQK LSGFPKKRVI GTGTSLDSAR
160 170 180 190 200
LRVELAKRLQ VPIESVNAWV LGEHGDSSFE NFSSAVVNGK PLLDYPGMTE
210 220 230 240 250
AALDEIEAHV REKGSEIIVK KGATYYGVAM MLAKIVTAIL ENNDLALPLS
260 270 280 290 300
APLHGEYGIK DEIYLGTLAI INGQGISHVL ELPLNDSELA KMRASAATIK

ATLDSLG
Length:307
Mass (Da):32,725
Last modified:November 14, 2006 - v1
Checksum:i250F00A0D0BDDAA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000412 Genomic DNA. Translation: ABJ57783.1.
RefSeqiWP_011677908.1. NC_008529.1.

Genome annotation databases

EnsemblBacteriaiABJ57783; ABJ57783; LBUL_0100.
KEGGilbu:LBUL_0100.

Similar proteinsi

Entry informationi

Entry nameiLDH_LACDB
AccessioniPrimary (citable) accession number: Q04CN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families