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Q04C46 (ACPS_LACDB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene names
Name:acpS
Ordered Locus Names:LBUL_0314
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [Complete proteome] [HAMAP]
Taxonomic identifier321956 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101

Cofactor

Magnesium By similarity. HAMAP MF_00101

Subcellular location

Cytoplasm By similarity HAMAP MF_00101.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

macromolecule biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionholo-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Holo-[acyl-carrier-protein] synthase HAMAP MF_00101
PRO_1000008439

Sites

Metal binding81Magnesium By similarity
Metal binding581Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04C46 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: B19CCBB3C653DC2C

FASTA13715,283
        10         20         30         40         50         60 
MIKNIGVDQI EVDRIAKVVD RGDGFARKVL TDREFAQYQD LTHKRKIEYL GGRFAIKEAF 

        70         80         90        100        110        120 
SKAWGTGIGQ AVSFEDVETL RTESGAPVTT SRIFTGRIFS SIAHDDHEIV AVVVLEEPAG 

       130 
WRRAIGKLSH LLSGRKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000412 Genomic DNA. Translation: ABJ57976.1.
RefSeqYP_812414.1. NC_008529.1.

3D structure databases

ProteinModelPortalQ04C46.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ04C46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4436255.
GenomeReviewsGene locus LBUL_0314 in contig CP000412_GR.
KEGGlbu:LBUL_0314.
PATRIC22220451. VBILacDel70259_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0736.
HOGENOMHBG734479.
OMAIFPSITH.
ProtClustDBPRK00070.

Enzyme and pathway databases

BioCycLDEL321956:LBUL_0314-MONOMER.

Family and domain databases

HAMAPMF_00101. AcpS.
[Tree]
InterProIPR008278. 4-PPantetheinyl_Trfase.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase.
[Graphical view]
Gene3DG3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KOK00997.
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56214. 4-PPT_transf. 1 hit.
TIGRFAMsTIGR00516. AcpS. 1 hit.
TIGR00556. Pantethn_trn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACPS_LACDB
AccessionPrimary (citable) accession number: Q04C46
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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