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Q04BL0 (UPPP_LACDB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LBUL_0523
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [Complete proteome] [HAMAP]
Taxonomic identifier321956 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290717

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q04BL0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 1DA86A3C310A1584

FASTA27530,670
        10         20         30         40         50         60 
MLDIFKAIIL GIIEGVTEFL PISSTGHLYL ADYIIKLDQP TSFINMFMVV IQLGAILSVI 

        70         80         90        100        110        120 
VIYFNKLNPF APSKSKREKG QTWQIWFKVI AAVLPSIIIG LPLNDWLEEN MTSWQVISAT 

       130        140        150        160        170        180 
LIIYGILFIV LENYYAKRQP SLTDLNKMSN KTALLIGCFQ VLSMIPGTSR SGATILGAML 

       190        200        210        220        230        240 
IGSSRYVATE FSFFLAIPTM FGASLLKLVK FFKAGHVFVG NQLAILLVGM VVSFIVAYLS 

       250        260        270 
IKFLLKYVQT HDFKPFGWYR IVLGIIVTIC GLVFA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000412 Genomic DNA. Translation: ABJ58162.1.
RefSeqYP_812600.1. NC_008529.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321956.LBUL_0523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ58162; ABJ58162; LBUL_0523.
GeneID4436627.
KEGGlbu:LBUL_0523.
PATRIC22220881. VBILacDel70259_0521.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycLDEL321956:GI15-521-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACDB
AccessionPrimary (citable) accession number: Q04BL0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families