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Q04AM0

- FTHS_LACDB

UniProt

Q04AM0 - FTHS_LACDB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLDEL321956:GI15-926-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LBUL_0928
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
    Taxonomic identifieri321956 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000665: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293040Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321956.LBUL_0928.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04AM0.
    SMRiQ04AM0. Positions 5-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04AM0-1 [UniParc]FASTAAdd to Basket

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    MVKSDIEIAQ AAEELPITDV AAKLGLTSQD LEPYGYDKAK VNWQAIKRSE    50
    ENGHLGKMIL VTSISPTPAG EGKSTMTIGI GDAINNQLGK KTVIALREPS 100
    MGPVFGMKGG AAGGGYAQVI PMEDINLHFT GDMHALTSAI DNLSALVDNY 150
    IYQGNELGLD PEKIVIKRGL DVNDRTLRKV TIGQGSKFNG VERPASFQLT 200
    VGHELMAILC LSKDIADLKE RIGKVLVGYT YEDEPVFVKD LGFQGAIAAL 250
    LSTALKPNLV QTLEHTPAFV HGGPFANIAH GNNSILSTNL ALHLSDYVLS 300
    EAGFGSDLGG QKFLDFVSTK LEKKPDAAVV VATVRALKYQ AEKSTDHLKE 350
    ENLDSLKEGF ANLDRHMNNV RSYNIPVLVV INKFPTDTEA ELDLLKSLIE 400
    EQGFPCEIVT AHDEGSKGAK AAAEKIVELA DKSDYEIKRS YDLDDDLETK 450
    IEKVAKRIYH AADVEYTDKA KDQLVKLKKM GKDKLPVIIA KTQYSFTDNV 500
    KELGAPTGFT LHVKGLSLRN GAGFVVVSTG HILDMPGLPK HPAALDIDVD 550
    ETGKISGLF 559
    Length:559
    Mass (Da):60,521
    Last modified:November 14, 2006 - v1
    Checksum:i350ABAED922A042D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ58502.1.
    RefSeqiYP_812940.1. NC_008529.1.

    Genome annotation databases

    EnsemblBacteriaiABJ58502; ABJ58502; LBUL_0928.
    GeneIDi4436078.
    KEGGilbu:LBUL_0928.
    PATRICi22221709. VBILacDel70259_0905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ58502.1 .
    RefSeqi YP_812940.1. NC_008529.1.

    3D structure databases

    ProteinModelPortali Q04AM0.
    SMRi Q04AM0. Positions 5-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321956.LBUL_0928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ58502 ; ABJ58502 ; LBUL_0928 .
    GeneIDi 4436078.
    KEGGi lbu:LBUL_0928.
    PATRICi 22221709. VBILacDel70259_0905.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LDEL321956:GI15-926-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-365.

    Entry informationi

    Entry nameiFTHS_LACDB
    AccessioniPrimary (citable) accession number: Q04AM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3