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Q04AM0 (FTHS_LACDB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LBUL_0928
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [Complete proteome] [HAMAP]
Taxonomic identifier321956 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293040

Regions

Nucleotide binding67 – 748ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04AM0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 350ABAED922A042D

FASTA55960,521
        10         20         30         40         50         60 
MVKSDIEIAQ AAEELPITDV AAKLGLTSQD LEPYGYDKAK VNWQAIKRSE ENGHLGKMIL 

        70         80         90        100        110        120 
VTSISPTPAG EGKSTMTIGI GDAINNQLGK KTVIALREPS MGPVFGMKGG AAGGGYAQVI 

       130        140        150        160        170        180 
PMEDINLHFT GDMHALTSAI DNLSALVDNY IYQGNELGLD PEKIVIKRGL DVNDRTLRKV 

       190        200        210        220        230        240 
TIGQGSKFNG VERPASFQLT VGHELMAILC LSKDIADLKE RIGKVLVGYT YEDEPVFVKD 

       250        260        270        280        290        300 
LGFQGAIAAL LSTALKPNLV QTLEHTPAFV HGGPFANIAH GNNSILSTNL ALHLSDYVLS 

       310        320        330        340        350        360 
EAGFGSDLGG QKFLDFVSTK LEKKPDAAVV VATVRALKYQ AEKSTDHLKE ENLDSLKEGF 

       370        380        390        400        410        420 
ANLDRHMNNV RSYNIPVLVV INKFPTDTEA ELDLLKSLIE EQGFPCEIVT AHDEGSKGAK 

       430        440        450        460        470        480 
AAAEKIVELA DKSDYEIKRS YDLDDDLETK IEKVAKRIYH AADVEYTDKA KDQLVKLKKM 

       490        500        510        520        530        540 
GKDKLPVIIA KTQYSFTDNV KELGAPTGFT LHVKGLSLRN GAGFVVVSTG HILDMPGLPK 

       550 
HPAALDIDVD ETGKISGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000412 Genomic DNA. Translation: ABJ58502.1.
RefSeqYP_812940.1. NC_008529.1.

3D structure databases

ProteinModelPortalQ04AM0.
SMRQ04AM0. Positions 5-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321956.LBUL_0928.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ58502; ABJ58502; LBUL_0928.
GeneID4436078.
KEGGlbu:LBUL_0928.
PATRIC22221709. VBILacDel70259_0905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycLDEL321956:GI15-926-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACDB
AccessionPrimary (citable) accession number: Q04AM0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways