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Q04AM0

- FTHS_LACDB

UniProt

Q04AM0 - FTHS_LACDB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLDEL321956:GI15-926-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LBUL_0928
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000665: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293040Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321956.LBUL_0928.

Structurei

3D structure databases

ProteinModelPortaliQ04AM0.
SMRiQ04AM0. Positions 5-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04AM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKSDIEIAQ AAEELPITDV AAKLGLTSQD LEPYGYDKAK VNWQAIKRSE
60 70 80 90 100
ENGHLGKMIL VTSISPTPAG EGKSTMTIGI GDAINNQLGK KTVIALREPS
110 120 130 140 150
MGPVFGMKGG AAGGGYAQVI PMEDINLHFT GDMHALTSAI DNLSALVDNY
160 170 180 190 200
IYQGNELGLD PEKIVIKRGL DVNDRTLRKV TIGQGSKFNG VERPASFQLT
210 220 230 240 250
VGHELMAILC LSKDIADLKE RIGKVLVGYT YEDEPVFVKD LGFQGAIAAL
260 270 280 290 300
LSTALKPNLV QTLEHTPAFV HGGPFANIAH GNNSILSTNL ALHLSDYVLS
310 320 330 340 350
EAGFGSDLGG QKFLDFVSTK LEKKPDAAVV VATVRALKYQ AEKSTDHLKE
360 370 380 390 400
ENLDSLKEGF ANLDRHMNNV RSYNIPVLVV INKFPTDTEA ELDLLKSLIE
410 420 430 440 450
EQGFPCEIVT AHDEGSKGAK AAAEKIVELA DKSDYEIKRS YDLDDDLETK
460 470 480 490 500
IEKVAKRIYH AADVEYTDKA KDQLVKLKKM GKDKLPVIIA KTQYSFTDNV
510 520 530 540 550
KELGAPTGFT LHVKGLSLRN GAGFVVVSTG HILDMPGLPK HPAALDIDVD

ETGKISGLF
Length:559
Mass (Da):60,521
Last modified:November 14, 2006 - v1
Checksum:i350ABAED922A042D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ58502.1.
RefSeqiYP_812940.1. NC_008529.1.

Genome annotation databases

EnsemblBacteriaiABJ58502; ABJ58502; LBUL_0928.
GeneIDi4436078.
KEGGilbu:LBUL_0928.
PATRICi22221709. VBILacDel70259_0905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ58502.1 .
RefSeqi YP_812940.1. NC_008529.1.

3D structure databases

ProteinModelPortali Q04AM0.
SMRi Q04AM0. Positions 5-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321956.LBUL_0928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ58502 ; ABJ58502 ; LBUL_0928 .
GeneIDi 4436078.
KEGGi lbu:LBUL_0928.
PATRICi 22221709. VBILacDel70259_0905.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LDEL321956:GI15-926-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-365.

Entry informationi

Entry nameiFTHS_LACDB
AccessioniPrimary (citable) accession number: Q04AM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3