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Q049W0

- LUXS2_LACDB

UniProt

Q049W0 - LUXS2_LACDB

Protein

S-ribosylhomocysteine lyase 2

Gene

luxS2

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

    Cofactori

    Binds 1 iron ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541IronUniRule annotation
    Metal bindingi58 – 581IronUniRule annotation
    Metal bindingi124 – 1241IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciLDEL321956:GI15-1228-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyase 2UniRule annotation (EC:4.4.1.21UniRule annotation)
    Alternative name(s):
    AI-2 synthesis protein 2UniRule annotation
    Autoinducer-2 production protein LuxS 2UniRule annotation
    Gene namesi
    Name:luxS2UniRule annotation
    Ordered Locus Names:LBUL_1233
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
    Taxonomic identifieri321956 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000665: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157S-ribosylhomocysteine lyase 2PRO_0000298008Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi321956.LBUL_1233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ049W0.
    SMRiQ049W0. Positions 3-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040372.
    KOiK07173.
    OMAiIANDIEW.
    OrthoDBiEOG68WRBM.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q049W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVESFTLD HTKVKAPYVR LITEETGKKG DVISNYDLRL VQPNTNAIPT    50
    AGLHTIEHLL AGLLRDRLDG VIDCSPFGCR TGFHLITWGE HSTTEVAKAL 100
    KGSLDAIAND IEWKDVQGTD KYSCGNYRDH SLFSAKEWSK EILSQGISDQ 150
    PFERHVI 157
    Length:157
    Mass (Da):17,511
    Last modified:November 14, 2006 - v1
    Checksum:iEA4BBDE91CA8AAC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ58762.1.
    RefSeqiYP_813200.1. NC_008529.1.

    Genome annotation databases

    EnsemblBacteriaiABJ58762; ABJ58762; LBUL_1233.
    GeneIDi4436307.
    KEGGilbu:LBUL_1233.
    PATRICi22222307. VBILacDel70259_1203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000412 Genomic DNA. Translation: ABJ58762.1 .
    RefSeqi YP_813200.1. NC_008529.1.

    3D structure databases

    ProteinModelPortali Q049W0.
    SMRi Q049W0. Positions 3-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321956.LBUL_1233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ58762 ; ABJ58762 ; LBUL_1233 .
    GeneIDi 4436307.
    KEGGi lbu:LBUL_1233.
    PATRICi 22222307. VBILacDel70259_1203.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040372.
    KOi K07173.
    OMAi IANDIEW.
    OrthoDBi EOG68WRBM.

    Enzyme and pathway databases

    BioCyci LDEL321956:GI15-1228-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-365.

    Entry informationi

    Entry nameiLUXS2_LACDB
    AccessioniPrimary (citable) accession number: Q049W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3