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Q049L9

- PUR5_LACDB

UniProt

Q049L9 - PUR5_LACDB

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, LBUL_1333
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLDEL321956:GI15-1328-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:LBUL_1333
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000665: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000046442Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321956.LBUL_1333.

Structurei

3D structure databases

ProteinModelPortaliQ049L9.
SMRiQ049L9. Positions 15-336.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q049L9-1 [UniParc]FASTAAdd to Basket

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MIVNRYKDAG VDVNAGYELV RRIKGAVAST KRPGYVGNIG GFGGLFDLDS    50
LGYDHPVLVS GTDGVGTKLI IAQKMDKNDT VGIDVVAMCV NDVLAQGAEP 100
LFFLDYIACG HNDPALLASV VQGVAEGCKQ AGASLIGGET AEMPDMYAPD 150
EYDLAGFTVG VAEKDRLLSV DTPQAGDVLL GLASSGVHSN GFSLVRKILF 200
KDHDVKLTDK PAELKGKSVG ESLLAPTRIY IKSVLPLIKQ GLVHGVAHIT 250
GGGLIENVPR MFNDGLRAEI AAGSWEVPDI FNYLKQVGNL SDDDCWQTFN 300
MGLGMILAVP ADKKEEAKQL LLASGEKVFE VGHLSERTDG EKIFIKLVE 349
Length:349
Mass (Da):37,160
Last modified:November 14, 2006 - v1
Checksum:iD95F4BC11C10151B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ58853.1.
RefSeqiYP_813291.1. NC_008529.1.

Genome annotation databases

EnsemblBacteriaiABJ58853; ABJ58853; LBUL_1333.
GeneIDi4435741.
KEGGilbu:LBUL_1333.
PATRICi22222523. VBILacDel70259_1311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000412 Genomic DNA. Translation: ABJ58853.1 .
RefSeqi YP_813291.1. NC_008529.1.

3D structure databases

ProteinModelPortali Q049L9.
SMRi Q049L9. Positions 15-336.
ModBasei Search...

Protein-protein interaction databases

STRINGi 321956.LBUL_1333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ58853 ; ABJ58853 ; LBUL_1333 .
GeneIDi 4435741.
KEGGi lbu:LBUL_1333.
PATRICi 22222523. VBILacDel70259_1311.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LDEL321956:GI15-1328-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-365.

Entry informationi

Entry nameiPUR5_LACDB
AccessioniPrimary (citable) accession number: Q049L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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