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Protein

Inhibin beta B chain

Gene

Inhbb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

GO - Biological processi

  • activin receptor signaling pathway Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to leptin stimulus Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • eye development Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
  • negative regulation of hepatocyte growth factor biosynthetic process Source: UniProtKB
  • negative regulation of insulin secretion Source: MGI
  • oocyte development Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
  • positive regulation of ovulation Source: UniProtKB
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • response to mechanical stimulus Source: MGI
  • response to wounding Source: UniProtKB
  • SMAD protein signal transduction Source: GO_Central

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-1502540 Signaling by Activin
R-MMU-209822 Glycoprotein hormones
R-MMU-2473224 Antagonism of Activin by Follistatin

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta B chain
Alternative name(s):
Activin beta-B chain
Gene namesi
Name:Inhbb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96571 Inhbb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000003372429 – 296Sequence analysisAdd BLAST268
ChainiPRO_0000033725297 – 411Inhibin beta B chainAdd BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 308By similarity
Disulfide bondi307 ↔ 376By similarity
Disulfide bondi336 ↔ 408By similarity
Disulfide bondi340 ↔ 410By similarity
Disulfide bondi375InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ04999
PeptideAtlasiQ04999
PRIDEiQ04999

PTM databases

PhosphoSitePlusiQ04999

Expressioni

Tissue specificityi

Uterus, testis, ovary, lung, kidney, brain, CJ7 embryonic stem cells, and possibly in liver.

Gene expression databases

BgeeiENSMUSG00000037035
CleanExiMM_INHBB
GenevisibleiQ04999 MM

Interactioni

Subunit structurei

Homo- or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200763, 1 interactor
STRINGi10090.ENSMUSP00000044918

Structurei

3D structure databases

ProteinModelPortaliQ04999
SMRiQ04999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiQ04999
KOiK04667
OMAiQGHGDRW
OrthoDBiEOG091G09LW
PhylomeDBiQ04999
TreeFamiTF351791

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000381 Inhibin_betaB
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF29 PTHR11848:SF29, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00671 INHIBINBB
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGLPGRALG AACLLLLVAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG
60 70 80 90 100
SQDTCTSCGG GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH
110 120 130 140 150
AVPKAAMVTA LRKLHAGKVR EDGRVEIPHL DGHASPGADG QERVSEIISF
160 170 180 190 200
AETDGLASSR VRLYFFVSNE GNQNLFVVQA SLWLYLKLLP YVLEKGSRRK
210 220 230 240 250
VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ ALFERGERRL
260 270 280 290 300
NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC
310 320 330 340 350
DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS
360 370 380 390 400
ASSFHTAVVN QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV
410
PNMIVEECGC A
Length:411
Mass (Da):45,211
Last modified:January 9, 2007 - v4
Checksum:i345F6919F583BC49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291H → D in CAA49326 (PubMed:8330535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132352 mRNA Translation: BAE21120.1
BC048845 mRNA Translation: AAH48845.1
X83376 mRNA Translation: CAA58290.1
X69620 mRNA Translation: CAA49326.1
CCDSiCCDS15224.1
PIRiI48235
RefSeqiNP_032407.1, NM_008381.4
UniGeneiMm.3092

Genome annotation databases

EnsembliENSMUST00000038765; ENSMUSP00000044918; ENSMUSG00000037035
GeneIDi16324
KEGGimmu:16324
UCSCiuc007cir.1 mouse

Similar proteinsi

Entry informationi

Entry nameiINHBB_MOUSE
AccessioniPrimary (citable) accession number: Q04999
Secondary accession number(s): Q3V1N0, Q61277, Q80VC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 145 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health