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Q04999

- INHBB_MOUSE

UniProt

Q04999 - INHBB_MOUSE

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Protein

Inhibin beta B chain

Gene
Inhbb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. activin receptor signaling pathway Source: UniProtKB
  2. cellular response to insulin stimulus Source: UniProtKB
  3. cellular response to leptin stimulus Source: UniProtKB
  4. cellular response to starvation Source: UniProtKB
  5. eye development Source: UniProtKB
  6. fat cell differentiation Source: UniProtKB
  7. growth Source: InterPro
  8. negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
  9. negative regulation of hepatocyte growth factor biosynthetic process Source: UniProtKB
  10. negative regulation of insulin secretion Source: MGI
  11. oocyte development Source: MGI
  12. positive regulation of apoptotic signaling pathway Source: MGI
  13. positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
  14. positive regulation of ovulation Source: UniProtKB
  15. response to mechanical stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_196633. Antagonism of Activin by Follistatin.
REACT_216258. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta B chain
Alternative name(s):
Activin beta-B chain
Gene namesi
Name:Inhbb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96571. Inhbb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Propeptidei29 – 296268 Reviewed predictionPRO_0000033724Add
BLAST
Chaini297 – 411115Inhibin beta B chainPRO_0000033725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi300 ↔ 308 By similarity
Disulfide bondi307 ↔ 376 By similarity
Disulfide bondi336 ↔ 408 By similarity
Disulfide bondi340 ↔ 410 By similarity
Disulfide bondi375 – 375Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04999.

PTM databases

PhosphoSiteiQ04999.

Expressioni

Tissue specificityi

Uterus, testis, ovary, lung, kidney, brain, CJ7 embryonic stem cells, and possibly in liver.

Gene expression databases

BgeeiQ04999.
CleanExiMM_INHBB.
GenevestigatoriQ04999.

Interactioni

Subunit structurei

Homo- or heterodimer; disulfide-linked. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.

Protein-protein interaction databases

BioGridi200763. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ04999.
SMRiQ04999. Positions 200-411.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278663.
GeneTreeiENSGT00620000087864.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ04999.
KOiK04667.
OMAiQGHGDRW.
OrthoDBiEOG74R1Q4.
PhylomeDBiQ04999.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000381. Inhibin_betaB.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF29. PTHR11848:SF29. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00671. INHIBINBB.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04999-1 [UniParc]FASTAAdd to Basket

« Hide

MDGLPGRALG AACLLLLVAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG    50
SQDTCTSCGG GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH 100
AVPKAAMVTA LRKLHAGKVR EDGRVEIPHL DGHASPGADG QERVSEIISF 150
AETDGLASSR VRLYFFVSNE GNQNLFVVQA SLWLYLKLLP YVLEKGSRRK 200
VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ ALFERGERRL 250
NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC 300
DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS 350
ASSFHTAVVN QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV 400
PNMIVEECGC A 411
Length:411
Mass (Da):45,211
Last modified:January 9, 2007 - v4
Checksum:i345F6919F583BC49
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911H → D in CAA49326. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK132352 mRNA. Translation: BAE21120.1.
BC048845 mRNA. Translation: AAH48845.1.
X83376 mRNA. Translation: CAA58290.1.
X69620 mRNA. Translation: CAA49326.1.
CCDSiCCDS15224.1.
PIRiI48235.
RefSeqiNP_032407.1. NM_008381.3.
UniGeneiMm.3092.

Genome annotation databases

EnsembliENSMUST00000038765; ENSMUSP00000044918; ENSMUSG00000037035.
GeneIDi16324.
KEGGimmu:16324.
UCSCiuc007cir.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK132352 mRNA. Translation: BAE21120.1 .
BC048845 mRNA. Translation: AAH48845.1 .
X83376 mRNA. Translation: CAA58290.1 .
X69620 mRNA. Translation: CAA49326.1 .
CCDSi CCDS15224.1.
PIRi I48235.
RefSeqi NP_032407.1. NM_008381.3.
UniGenei Mm.3092.

3D structure databases

ProteinModelPortali Q04999.
SMRi Q04999. Positions 200-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200763. 1 interaction.

PTM databases

PhosphoSitei Q04999.

Proteomic databases

PRIDEi Q04999.

Protocols and materials databases

DNASUi 16324.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038765 ; ENSMUSP00000044918 ; ENSMUSG00000037035 .
GeneIDi 16324.
KEGGi mmu:16324.
UCSCi uc007cir.1. mouse.

Organism-specific databases

CTDi 3625.
MGIi MGI:96571. Inhbb.

Phylogenomic databases

eggNOGi NOG278663.
GeneTreei ENSGT00620000087864.
HOGENOMi HOG000220890.
HOVERGENi HBG105613.
InParanoidi Q04999.
KOi K04667.
OMAi QGHGDRW.
OrthoDBi EOG74R1Q4.
PhylomeDBi Q04999.
TreeFami TF351791.

Enzyme and pathway databases

Reactomei REACT_196633. Antagonism of Activin by Follistatin.
REACT_216258. Signaling by Activin.

Miscellaneous databases

NextBioi 289394.
PROi Q04999.
SOURCEi Search...

Gene expression databases

Bgeei Q04999.
CleanExi MM_INHBB.
Genevestigatori Q04999.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR000381. Inhibin_betaB.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
PTHR11848:SF29. PTHR11848:SF29. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00671. INHIBINBB.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-411.
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse."
    Ritvos O., Tuuri T., Eramaa M., Sainio K., Hilden K., Saxen L., Gilbert S.
    Mech. Dev. 50:229-245(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 157-390.
    Strain: CBA X NMRI.
    Tissue: Testis.
  4. "Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation."
    Albano P.M., Groome N., Smith J.C.
    Development 117:711-723(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 290-411.

Entry informationi

Entry nameiINHBB_MOUSE
AccessioniPrimary (citable) accession number: Q04999
Secondary accession number(s): Q3V1N0, Q61277, Q80VC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi