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Protein

Inhibin beta A chain

Gene

Inhba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB
  2. identical protein binding Source: MGI
  3. peptide hormone binding Source: MGI
  4. receptor binding Source: MGI
  5. transforming growth factor beta receptor binding Source: GO_Central
  6. type II activin receptor binding Source: MGI

GO - Biological processi

  1. activin receptor signaling pathway Source: BHF-UCL
  2. cell cycle arrest Source: UniProtKB
  3. cell development Source: GO_Central
  4. cellular response to cholesterol Source: Ensembl
  5. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
  6. endodermal cell differentiation Source: MGI
  7. extrinsic apoptotic signaling pathway Source: MGI
  8. eyelid development in camera-type eye Source: UniProtKB
  9. G1/S transition of mitotic cell cycle Source: UniProtKB
  10. growth Source: InterPro
  11. hair follicle development Source: UniProtKB
  12. hematopoietic progenitor cell differentiation Source: MGI
  13. hemoglobin biosynthetic process Source: UniProtKB
  14. male gonad development Source: UniProtKB
  15. mesodermal cell differentiation Source: MGI
  16. mesoderm formation Source: MGI
  17. negative regulation of cell cycle Source: UniProtKB
  18. negative regulation of cell growth Source: UniProtKB
  19. negative regulation of cell proliferation Source: UniProtKB
  20. negative regulation of hair follicle development Source: MGI
  21. odontogenesis Source: UniProtKB
  22. ovarian follicle development Source: UniProtKB
  23. palate development Source: UniProtKB
  24. positive regulation of cellular protein metabolic process Source: MGI
  25. positive regulation of erythrocyte differentiation Source: UniProtKB
  26. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
  27. positive regulation of ovulation Source: UniProtKB
  28. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  29. positive regulation of transcription, DNA-templated Source: UniProtKB
  30. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  31. progesterone secretion Source: UniProtKB
  32. regulation of apoptotic process Source: GO_Central
  33. regulation of follicle-stimulating hormone secretion Source: UniProtKB
  34. regulation of MAPK cascade Source: GO_Central
  35. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  36. response to drug Source: UniProtKB
  37. SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_287438. Glycoprotein hormones.
REACT_347120. Signaling by Activin.
REACT_348555. Antagonism of Activin by Follistatin.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Gene namesi
Name:Inhba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96570. Inhba.

Subcellular locationi

GO - Cellular componenti

  1. activin A complex Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: GO_Central
  4. inhibin A complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Propeptidei21 – 3082881 PublicationPRO_0000033710Add
BLAST
Chaini309 – 424116Inhibin beta A chainPRO_0000033711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 320By similarity
Disulfide bondi319 ↔ 389By similarity
Disulfide bondi348 ↔ 421By similarity
Disulfide bondi352 ↔ 423By similarity
Disulfide bondi388 – 388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04998.

PTM databases

PhosphoSiteiQ04998.

Expressioni

Tissue specificityi

Uterus, ovary and liver.

Gene expression databases

BgeeiQ04998.
CleanExiMM_INHBA.
ExpressionAtlasiQ04998. baseline and differential.
GenevestigatoriQ04998.

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200762. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ04998.
SMRiQ04998. Positions 287-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG312557.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ04998.
KOiK04667.
OMAiNITRPVP.
OrthoDBiEOG7NSB2Q.
PhylomeDBiQ04998.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000491. Inhibin_betaA.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00670. INHIBINBA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGD EAEEMGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED
310 320 330 340 350
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG
360 370 380 390 400
ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML
410 420
YYDDGQNIIK KDIQNMIVEE CGCS
Length:424
Mass (Da):47,392
Last modified:January 31, 1994 - v1
Checksum:i80C251B8754A7213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69619 mRNA. Translation: CAA49325.1.
BC053527 mRNA. Translation: AAH53527.1.
CCDSiCCDS26251.1.
PIRiA60087. S31440.
RefSeqiNP_032406.1. NM_008380.1.
XP_006516621.1. XM_006516558.2.
XP_006516622.1. XM_006516559.2.
UniGeneiMm.8042.

Genome annotation databases

EnsembliENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324.
ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
GeneIDi16323.
KEGGimmu:16323.
UCSCiuc007pnw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69619 mRNA. Translation: CAA49325.1.
BC053527 mRNA. Translation: AAH53527.1.
CCDSiCCDS26251.1.
PIRiA60087. S31440.
RefSeqiNP_032406.1. NM_008380.1.
XP_006516621.1. XM_006516558.2.
XP_006516622.1. XM_006516559.2.
UniGeneiMm.8042.

3D structure databases

ProteinModelPortaliQ04998.
SMRiQ04998. Positions 287-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200762. 5 interactions.

PTM databases

PhosphoSiteiQ04998.

Proteomic databases

PRIDEiQ04998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324.
ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
GeneIDi16323.
KEGGimmu:16323.
UCSCiuc007pnw.1. mouse.

Organism-specific databases

CTDi3624.
MGIiMGI:96570. Inhba.

Phylogenomic databases

eggNOGiNOG312557.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ04998.
KOiK04667.
OMAiNITRPVP.
OrthoDBiEOG7NSB2Q.
PhylomeDBiQ04998.
TreeFamiTF351791.

Enzyme and pathway databases

ReactomeiREACT_287438. Glycoprotein hormones.
REACT_347120. Signaling by Activin.
REACT_348555. Antagonism of Activin by Follistatin.

Miscellaneous databases

NextBioi289390.
PROiQ04998.
SOURCEiSearch...

Gene expression databases

BgeeiQ04998.
CleanExiMM_INHBA.
ExpressionAtlasiQ04998. baseline and differential.
GenevestigatoriQ04998.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000491. Inhibin_betaA.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00670. INHIBINBA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation."
    Albano P.M., Groome N., Smith J.C.
    Development 117:711-723(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. "A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A."
    Albano R.M., Godsave S.F., Huylebroeck D., Van Nimmen K., Isaacs H.V., Slack J.M., Smith J.C.
    Development 110:435-443(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 309-325.

Entry informationi

Entry nameiINHBA_MOUSE
AccessioniPrimary (citable) accession number: Q04998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 31, 1994
Last modified: March 31, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.