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Q04998

- INHBA_MOUSE

UniProt

Q04998 - INHBA_MOUSE

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Protein

Inhibin beta A chain

Gene

Inhba

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB
  2. peptide hormone binding Source: Ensembl
  3. receptor binding Source: MGI

GO - Biological processi

  1. activin receptor signaling pathway Source: BHF-UCL
  2. cell cycle arrest Source: UniProtKB
  3. cellular response to cholesterol Source: Ensembl
  4. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
  5. endodermal cell differentiation Source: Ensembl
  6. extrinsic apoptotic signaling pathway Source: Ensembl
  7. eyelid development in camera-type eye Source: UniProtKB
  8. G1/S transition of mitotic cell cycle Source: UniProtKB
  9. growth Source: InterPro
  10. hair follicle development Source: UniProtKB
  11. hematopoietic progenitor cell differentiation Source: MGI
  12. hemoglobin biosynthetic process Source: UniProtKB
  13. male gonad development Source: UniProtKB
  14. mesodermal cell differentiation Source: MGI
  15. mesoderm formation Source: MGI
  16. negative regulation of cell cycle Source: UniProtKB
  17. negative regulation of cell growth Source: UniProtKB
  18. negative regulation of cell proliferation Source: UniProtKB
  19. negative regulation of hair follicle development Source: MGI
  20. odontogenesis Source: UniProtKB
  21. ovarian follicle development Source: UniProtKB
  22. palate development Source: UniProtKB
  23. positive regulation of erythrocyte differentiation Source: UniProtKB
  24. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
  25. positive regulation of ovulation Source: UniProtKB
  26. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  27. positive regulation of transcription, DNA-templated Source: UniProtKB
  28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  29. progesterone secretion Source: UniProtKB
  30. regulation of follicle-stimulating hormone secretion Source: UniProtKB
  31. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  32. response to drug Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_196633. Antagonism of Activin by Follistatin.
REACT_216258. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Gene namesi
Name:Inhba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:96570. Inhba.

Subcellular locationi

GO - Cellular componenti

  1. activin A complex Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. inhibin A complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Propeptidei21 – 3082881 PublicationPRO_0000033710Add
BLAST
Chaini309 – 424116Inhibin beta A chainPRO_0000033711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 320By similarity
Disulfide bondi319 ↔ 389By similarity
Disulfide bondi348 ↔ 421By similarity
Disulfide bondi352 ↔ 423By similarity
Disulfide bondi388 – 388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04998.

PTM databases

PhosphoSiteiQ04998.

Expressioni

Tissue specificityi

Uterus, ovary and liver.

Gene expression databases

BgeeiQ04998.
CleanExiMM_INHBA.
ExpressionAtlasiQ04998. baseline and differential.
GenevestigatoriQ04998.

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200762. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ04998.
SMRiQ04998. Positions 287-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG312557.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiQ04998.
KOiK04667.
OMAiRKSTWHI.
OrthoDBiEOG7NSB2Q.
PhylomeDBiQ04998.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000491. Inhibin_betaA.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00670. INHIBINBA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04998-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGD EAEEMGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED
310 320 330 340 350
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG
360 370 380 390 400
ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML
410 420
YYDDGQNIIK KDIQNMIVEE CGCS
Length:424
Mass (Da):47,392
Last modified:February 1, 1994 - v1
Checksum:i80C251B8754A7213
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69619 mRNA. Translation: CAA49325.1.
BC053527 mRNA. Translation: AAH53527.1.
CCDSiCCDS26251.1.
PIRiA60087. S31440.
RefSeqiNP_032406.1. NM_008380.1.
XP_006516621.1. XM_006516558.1.
XP_006516622.1. XM_006516559.1.
UniGeneiMm.8042.

Genome annotation databases

EnsembliENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324.
ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
GeneIDi16323.
KEGGimmu:16323.
UCSCiuc007pnw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69619 mRNA. Translation: CAA49325.1 .
BC053527 mRNA. Translation: AAH53527.1 .
CCDSi CCDS26251.1.
PIRi A60087. S31440.
RefSeqi NP_032406.1. NM_008380.1.
XP_006516621.1. XM_006516558.1.
XP_006516622.1. XM_006516559.1.
UniGenei Mm.8042.

3D structure databases

ProteinModelPortali Q04998.
SMRi Q04998. Positions 287-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200762. 5 interactions.

PTM databases

PhosphoSitei Q04998.

Proteomic databases

PRIDEi Q04998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042603 ; ENSMUSP00000047894 ; ENSMUSG00000041324 .
ENSMUST00000164993 ; ENSMUSP00000132085 ; ENSMUSG00000041324 .
GeneIDi 16323.
KEGGi mmu:16323.
UCSCi uc007pnw.1. mouse.

Organism-specific databases

CTDi 3624.
MGIi MGI:96570. Inhba.

Phylogenomic databases

eggNOGi NOG312557.
HOGENOMi HOG000220890.
HOVERGENi HBG105613.
InParanoidi Q04998.
KOi K04667.
OMAi RKSTWHI.
OrthoDBi EOG7NSB2Q.
PhylomeDBi Q04998.
TreeFami TF351791.

Enzyme and pathway databases

Reactomei REACT_196633. Antagonism of Activin by Follistatin.
REACT_216258. Signaling by Activin.

Miscellaneous databases

NextBioi 289390.
PROi Q04998.
SOURCEi Search...

Gene expression databases

Bgeei Q04998.
CleanExi MM_INHBA.
ExpressionAtlasi Q04998. baseline and differential.
Genevestigatori Q04998.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR000491. Inhibin_betaA.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00670. INHIBINBA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation."
    Albano P.M., Groome N., Smith J.C.
    Development 117:711-723(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. "A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A."
    Albano R.M., Godsave S.F., Huylebroeck D., Van Nimmen K., Isaacs H.V., Slack J.M., Smith J.C.
    Development 110:435-443(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 309-325.

Entry informationi

Entry nameiINHBA_MOUSE
AccessioniPrimary (citable) accession number: Q04998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3