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Q04998

- INHBA_MOUSE

UniProt

Q04998 - INHBA_MOUSE

Protein

Inhibin beta A chain

Gene

Inhba

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB
    2. peptide hormone binding Source: Ensembl
    3. receptor binding Source: MGI

    GO - Biological processi

    1. activin receptor signaling pathway Source: BHF-UCL
    2. cell cycle arrest Source: UniProtKB
    3. cellular response to cholesterol Source: Ensembl
    4. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
    5. extrinsic apoptotic signaling pathway Source: Ensembl
    6. eyelid development in camera-type eye Source: UniProtKB
    7. G1/S transition of mitotic cell cycle Source: UniProtKB
    8. growth Source: InterPro
    9. hair follicle development Source: UniProtKB
    10. hematopoietic progenitor cell differentiation Source: MGI
    11. hemoglobin biosynthetic process Source: UniProtKB
    12. male gonad development Source: UniProtKB
    13. mesodermal cell differentiation Source: MGI
    14. mesoderm formation Source: MGI
    15. negative regulation of cell cycle Source: UniProtKB
    16. negative regulation of cell growth Source: UniProtKB
    17. negative regulation of cell proliferation Source: UniProtKB
    18. negative regulation of hair follicle development Source: MGI
    19. odontogenesis Source: UniProtKB
    20. ovarian follicle development Source: UniProtKB
    21. palate development Source: UniProtKB
    22. positive regulation of erythrocyte differentiation Source: UniProtKB
    23. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
    24. positive regulation of ovulation Source: UniProtKB
    25. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    26. positive regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    28. progesterone secretion Source: UniProtKB
    29. regulation of follicle-stimulating hormone secretion Source: UniProtKB
    30. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    31. response to drug Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor, Hormone

    Enzyme and pathway databases

    ReactomeiREACT_196633. Antagonism of Activin by Follistatin.
    REACT_216258. Signaling by Activin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibin beta A chain
    Alternative name(s):
    Activin beta-A chain
    Gene namesi
    Name:Inhba
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:96570. Inhba.

    Subcellular locationi

    GO - Cellular componenti

    1. activin A complex Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. inhibin A complex Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Propeptidei21 – 3082881 PublicationPRO_0000033710Add
    BLAST
    Chaini309 – 424116Inhibin beta A chainPRO_0000033711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi312 ↔ 320By similarity
    Disulfide bondi319 ↔ 389By similarity
    Disulfide bondi348 ↔ 421By similarity
    Disulfide bondi352 ↔ 423By similarity
    Disulfide bondi388 – 388InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ04998.

    PTM databases

    PhosphoSiteiQ04998.

    Expressioni

    Tissue specificityi

    Uterus, ovary and liver.

    Gene expression databases

    ArrayExpressiQ04998.
    BgeeiQ04998.
    CleanExiMM_INHBA.
    GenevestigatoriQ04998.

    Interactioni

    Subunit structurei

    Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200762. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04998.
    SMRiQ04998. Positions 287-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG312557.
    HOGENOMiHOG000220890.
    HOVERGENiHBG105613.
    InParanoidiQ04998.
    KOiK04667.
    OMAiRKSTWHI.
    OrthoDBiEOG7NSB2Q.
    PhylomeDBiQ04998.
    TreeFamiTF351791.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR000491. Inhibin_betaA.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00670. INHIBINBA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04998-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS    50
    QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY 100
    VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV 150
    ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGD EAEEMGLKGE 200
    RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV RIACEQCQES 250
    GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED 300
    HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG 350
    ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML 400
    YYDDGQNIIK KDIQNMIVEE CGCS 424
    Length:424
    Mass (Da):47,392
    Last modified:February 1, 1994 - v1
    Checksum:i80C251B8754A7213
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69619 mRNA. Translation: CAA49325.1.
    BC053527 mRNA. Translation: AAH53527.1.
    CCDSiCCDS26251.1.
    PIRiA60087. S31440.
    RefSeqiNP_032406.1. NM_008380.1.
    XP_006516621.1. XM_006516558.1.
    XP_006516622.1. XM_006516559.1.
    UniGeneiMm.8042.

    Genome annotation databases

    EnsembliENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324.
    ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
    GeneIDi16323.
    KEGGimmu:16323.
    UCSCiuc007pnw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69619 mRNA. Translation: CAA49325.1 .
    BC053527 mRNA. Translation: AAH53527.1 .
    CCDSi CCDS26251.1.
    PIRi A60087. S31440.
    RefSeqi NP_032406.1. NM_008380.1.
    XP_006516621.1. XM_006516558.1.
    XP_006516622.1. XM_006516559.1.
    UniGenei Mm.8042.

    3D structure databases

    ProteinModelPortali Q04998.
    SMRi Q04998. Positions 287-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200762. 5 interactions.

    PTM databases

    PhosphoSitei Q04998.

    Proteomic databases

    PRIDEi Q04998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042603 ; ENSMUSP00000047894 ; ENSMUSG00000041324 .
    ENSMUST00000164993 ; ENSMUSP00000132085 ; ENSMUSG00000041324 .
    GeneIDi 16323.
    KEGGi mmu:16323.
    UCSCi uc007pnw.1. mouse.

    Organism-specific databases

    CTDi 3624.
    MGIi MGI:96570. Inhba.

    Phylogenomic databases

    eggNOGi NOG312557.
    HOGENOMi HOG000220890.
    HOVERGENi HBG105613.
    InParanoidi Q04998.
    KOi K04667.
    OMAi RKSTWHI.
    OrthoDBi EOG7NSB2Q.
    PhylomeDBi Q04998.
    TreeFami TF351791.

    Enzyme and pathway databases

    Reactomei REACT_196633. Antagonism of Activin by Follistatin.
    REACT_216258. Signaling by Activin.

    Miscellaneous databases

    NextBioi 289390.
    PROi Q04998.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04998.
    Bgeei Q04998.
    CleanExi MM_INHBA.
    Genevestigatori Q04998.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR000491. Inhibin_betaA.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00670. INHIBINBA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation."
      Albano P.M., Groome N., Smith J.C.
      Development 117:711-723(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    3. "A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A."
      Albano R.M., Godsave S.F., Huylebroeck D., Van Nimmen K., Isaacs H.V., Slack J.M., Smith J.C.
      Development 110:435-443(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 309-325.

    Entry informationi

    Entry nameiINHBA_MOUSE
    AccessioniPrimary (citable) accession number: Q04998
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3