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Q04998 (INHBA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Gene names
Name:Inhba
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.

Subcellular location

Secreted.

Tissue specificity

Uterus, ovary and liver.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
Hormone
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG1/S transition of mitotic cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

activin receptor signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

cell cycle arrest

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to cholesterol

Inferred from electronic annotation. Source: Ensembl

cellular response to follicle-stimulating hormone stimulus

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

eyelid development in camera-type eye

Inferred from genetic interaction PubMed 14551263. Source: UniProtKB

growth

Inferred from electronic annotation. Source: InterPro

hair follicle development

Inferred from sequence or structural similarity. Source: UniProtKB

hematopoietic progenitor cell differentiation

Inferred from direct assay PubMed 7799920. Source: MGI

hemoglobin biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

male gonad development

Inferred from sequence or structural similarity. Source: UniProtKB

mesoderm formation

Inferred from direct assay PubMed 7799920. Source: MGI

mesodermal cell differentiation

Inferred from direct assay PubMed 7799920. Source: MGI

negative regulation of cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of hair follicle development

Inferred from sequence alignment PubMed 12514121. Source: MGI

odontogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

ovarian follicle development

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of erythrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ovulation

Inferred from mutant phenotype PubMed 17609433. Source: UniProtKB

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10391928. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from genetic interaction PubMed 14551263. Source: UniProtKB

progesterone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of follicle-stimulating hormone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

response to drug

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentactivin A complex

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from sequence or structural similarity. Source: UniProtKB

inhibin A complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncytokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

receptor binding

Inferred from physical interaction PubMed 1646080PubMed 7577669. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Propeptide21 – 308288
PRO_0000033710
Chain309 – 424116Inhibin beta A chain
PRO_0000033711

Amino acid modifications

Glycosylation1651N-linked (GlcNAc...) Potential
Disulfide bond312 ↔ 320 By similarity
Disulfide bond319 ↔ 389 By similarity
Disulfide bond348 ↔ 421 By similarity
Disulfide bond352 ↔ 423 By similarity
Disulfide bond388Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04998 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 80C251B8754A7213

FASTA42447,392
        10         20         30         40         50         60 
MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS QPEMVEAVKK 

        70         80         90        100        110        120 
HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 

       130        140        150        160        170        180 
SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK 

       190        200        210        220        230        240 
HPQGSLDTGD EAEEMGLKGE RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV 

       250        260        270        280        290        300 
RIACEQCQES GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED 

       310        320        330        340        350        360 
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS 

       370        380        390        400        410        420 
GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE 


CGCS 

« Hide

References

« Hide 'large scale' references
[1]"Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation."
Albano P.M., Groome N., Smith J.C.
Development 117:711-723(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
[3]"A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A."
Albano R.M., Godsave S.F., Huylebroeck D., Van Nimmen K., Isaacs H.V., Slack J.M., Smith J.C.
Development 110:435-443(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 309-325.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69619 mRNA. Translation: CAA49325.1.
BC053527 mRNA. Translation: AAH53527.1.
CCDSCCDS26251.1.
PIRS31440. A60087.
RefSeqNP_032406.1. NM_008380.1.
XP_006516621.1. XM_006516558.1.
XP_006516622.1. XM_006516559.1.
UniGeneMm.8042.

3D structure databases

ProteinModelPortalQ04998.
SMRQ04998. Positions 287-424.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200762. 5 interactions.

PTM databases

PhosphoSiteQ04998.

Proteomic databases

PRIDEQ04998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324.
ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
GeneID16323.
KEGGmmu:16323.
UCSCuc007pnw.1. mouse.

Organism-specific databases

CTD3624.
MGIMGI:96570. Inhba.

Phylogenomic databases

eggNOGNOG312557.
HOGENOMHOG000220890.
HOVERGENHBG105613.
InParanoidQ04998.
KOK04667.
OMARKSTWHI.
OrthoDBEOG7NSB2Q.
PhylomeDBQ04998.
TreeFamTF351791.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressQ04998.
BgeeQ04998.
CleanExMM_INHBA.
GenevestigatorQ04998.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR000491. Inhibin_betaA.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00670. INHIBINBA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289390.
PROQ04998.
SOURCESearch...

Entry information

Entry nameINHBA_MOUSE
AccessionPrimary (citable) accession number: Q04998
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot