Q04998 (INHBA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inhibin beta A chain

Alternative name(s):
Activin beta-A chain

Gene names

Name:

Inhba

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subunit structure	Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 By similarity.
Subcellular location	Secreted.
Tissue specificity	Uterus, ovary and liver.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor Hormone
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB cell cycle arrest Inferred from sequence or structural similarity. Source: UniProtKB cellular response to cholesterol Inferred from electronic annotation. Source: Compara cellular response to follicle-stimulating hormone stimulus Inferred from electronic annotation. Source: Compara eyelid development in camera-type eye Inferred from genetic interaction PubMed 14551263. Source: UniProtKB growth Inferred from electronic annotation. Source: InterPro hair follicle development Inferred from sequence or structural similarity. Source: UniProtKB hematopoietic progenitor cell differentiation Inferred from direct assay PubMed 7799920. Source: MGI hemoglobin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB induction of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB male gonad development Inferred from sequence or structural similarity. Source: UniProtKB mesodermal cell differentiation Inferred from direct assay PubMed 7799920. Source: MGI negative regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of hair follicle development Inferred from sequence alignment PubMed 12514121. Source: MGI odontogenesis Inferred from sequence or structural similarity. Source: UniProtKB ovarian follicle development Inferred from sequence or structural similarity. Source: UniProtKB palate development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of erythrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of ovulation Inferred from mutant phenotype PubMed 17609433. Source: UniProtKB positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10391928. Source: MGI progesterone secretion Inferred from sequence or structural similarity. Source: UniProtKB regulation of activin receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of follicle-stimulating hormone secretion Inferred from sequence or structural similarity. Source: UniProtKB response to drug Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	activin A complex Inferred from sequence or structural similarity. Source: UniProtKB inhibin A complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cytokine activity Inferred from sequence or structural similarity. Source: UniProtKB peptide hormone binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Propeptide	21 – 308	288			PRO_0000033710
	Chain	309 – 424	116	Inhibin beta A chain		PRO_0000033711
Amino acid modifications
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Disulfide bond	312 ↔ 320		By similarity
	Disulfide bond	319 ↔ 389		By similarity
	Disulfide bond	348 ↔ 421		By similarity
	Disulfide bond	352 ↔ 423		By similarity
	Disulfide bond	388		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04998 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 80C251B8754A7213	FASTA	424	47,392
	10 20 30 40 50 60 MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS QPEMVEAVKK 70 80 90 100 110 120 HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 130 140 150 160 170 180 SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK 190 200 210 220 230 240 HPQGSLDTGD EAEEMGLKGE RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV 250 260 270 280 290 300 RIACEQCQES GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED 310 320 330 340 350 360 HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS 370 380 390 400 410 420 GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE CGCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation." Albano P.M., Groome N., Smith J.C. Development 117:711-723(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary tumor.
[3]	"A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A." Albano R.M., Godsave S.F., Huylebroeck D., Van Nimmen K., Isaacs H.V., Slack J.M., Smith J.C. Development 110:435-443(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 309-325.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69619 mRNA. Translation: CAA49325.1. BC053527 mRNA. Translation: AAH53527.1.
IPI	IPI00112347.
PIR	S31440. A60087.
RefSeq	NP_032406.1. NM_008380.1.
UniGene	Mm.8042.
3D structure databases
ProteinModelPortal	Q04998.
SMR	Q04998. Positions 287-424.
ModBase	Search...
PTM databases
PhosphoSite	Q04998.
Proteomic databases
PRIDE	Q04998.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324. ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324.
GeneID	16323.
KEGG	mmu:16323.
Organism-specific databases
CTD	3624.
MGI	MGI:96570. Inhba.
Phylogenomic databases
eggNOG	NOG312557.
HOGENOM	HOG000220890.
HOVERGEN	HBG105613.
InParanoid	Q04998.
KO	K04667.
OMA	RKSTWHI.
OrthoDB	EOG4C87T4.
Enzyme and pathway databases
Reactome	REACT_115202. Signal Transduction.
Gene expression databases
ArrayExpress	Q04998.
Bgee	Q04998.
CleanEx	MM_INHBA.
Genevestigator	Q04998.
GermOnline	ENSMUSG00000041324. Mus musculus.
Family and domain databases
InterPro	IPR000491. Inhibin_betaA. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00670. INHIBINBA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289390.
SOURCE	Search...

Entry information

Entry name

INHBA_MOUSE

Accession

Primary (citable) accession number: Q04998

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program