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Protein

Inhibin alpha chain

Gene

Inha

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:Inha
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96569. Inha.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000003368821 – 63By similarityAdd BLAST43
PropeptideiPRO_000003368964 – 233Inhibin alpha N-terminal regionBy similarityAdd BLAST170
ChainiPRO_0000033690234 – 366Inhibin alpha chainAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 328By similarity
Glycosylationi269N-linked (GlcNAc...)By similarity1
Disulfide bondi292 ↔ 363By similarity
Disulfide bondi296 ↔ 365By similarity
Disulfide bondi327InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64CleavageBy similarity2
Sitei233 – 234CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ04997.
PaxDbiQ04997.
PRIDEiQ04997.

PTM databases

iPTMnetiQ04997.
PhosphoSitePlusiQ04997.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032968.
CleanExiMM_INHA.
GenevisibleiQ04997. MM.

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200761. 1 interactor.
STRINGi10090.ENSMUSP00000040310.

Structurei

3D structure databases

ProteinModelPortaliQ04997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiQ04997.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG091G0CTF.
TreeFamiTF331531.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQRSLLLL LLLTLRDVDS CQGPELVREL VLAKVKALFL DALGPPAMDG
60 70 80 90 100
EGGDPGIRRL PRRHAVGGFM HRTSEPEEED VSQAILFPAT GATCEDQPAA
110 120 130 140 150
RGLAQEAEEG LFTYVFRPSQ HIRSHQVTSA QLWFHTGLGR KSTAAANSSA
160 170 180 190 200
PLLDLLVLSS GGPMAVPVSL GQGPPRWAVL HLAASAFPLL THPILVLLLR
210 220 230 240 250
CPLCSCSGRP ETTPFLVAHT RARAPSAGER ARRSTPSVPW PWSPAALRLL
260 270 280 290 300
QRPPEEPAAH AFCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGSCGMPT
310 320 330 340 350
SDLPLPVPGV PPTPVQPLFL VPGAKPCCAA LPGSMRSLRV RTTSDGGYSF
360
KYEMVPNLIT QHCACI
Length:366
Mass (Da):39,550
Last modified:July 27, 2011 - v2
Checksum:i2CFD44AD9D41B66B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165A → R in AAA39314 (PubMed:1632772).Curated1
Sequence conflicti171G → V in CAA49324 (PubMed:8330535).Curated1
Sequence conflicti336R → T in CAA49324 (PubMed:8330535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69618 mRNA. Translation: CAA49324.1.
M95525, M95526 Genomic DNA. Translation: AAA39314.1.
CH466548 Genomic DNA. Translation: EDL00422.1.
BC056627 mRNA. Translation: AAH56627.1.
X55957 mRNA. Translation: CAA39424.1.
CCDSiCCDS15078.1.
PIRiJC1106.
RefSeqiNP_034694.3. NM_010564.5.
UniGeneiMm.1100.

Genome annotation databases

EnsembliENSMUST00000037330; ENSMUSP00000040310; ENSMUSG00000032968.
GeneIDi16322.
KEGGimmu:16322.
UCSCiuc007bps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69618 mRNA. Translation: CAA49324.1.
M95525, M95526 Genomic DNA. Translation: AAA39314.1.
CH466548 Genomic DNA. Translation: EDL00422.1.
BC056627 mRNA. Translation: AAH56627.1.
X55957 mRNA. Translation: CAA39424.1.
CCDSiCCDS15078.1.
PIRiJC1106.
RefSeqiNP_034694.3. NM_010564.5.
UniGeneiMm.1100.

3D structure databases

ProteinModelPortaliQ04997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200761. 1 interactor.
STRINGi10090.ENSMUSP00000040310.

PTM databases

iPTMnetiQ04997.
PhosphoSitePlusiQ04997.

Proteomic databases

MaxQBiQ04997.
PaxDbiQ04997.
PRIDEiQ04997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037330; ENSMUSP00000040310; ENSMUSG00000032968.
GeneIDi16322.
KEGGimmu:16322.
UCSCiuc007bps.1. mouse.

Organism-specific databases

CTDi3623.
MGIiMGI:96569. Inha.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiQ04997.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG091G0CTF.
TreeFamiTF331531.

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Miscellaneous databases

ChiTaRSiInha. mouse.
PROiQ04997.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032968.
CleanExiMM_INHA.
GenevisibleiQ04997. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINHA_MOUSE
AccessioniPrimary (citable) accession number: Q04997
Secondary accession number(s): Q6GTG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.