ID   TYRC_ZYMMO              Reviewed;         293 AA.
AC   Q04983; Q5NQG0;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   16-JUN-2009, entry version 65.
DE   RecName: Full=Protein tyrC;
DE   AltName: Full=Cyclohexadienyl dehydrogenase;
DE   AltName: Full=Arogenate dehydrogenase;
DE            Short=ADH;
DE            EC=1.3.1.43;
DE   AltName: Full=Prephenate dehydrogenase;
DE            Short=PDH;
DE            EC=1.3.1.12;
GN   Name=tyrC; OrderedLocusNames=ZMO0420;
OS   Zymomonas mobilis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Zymomonas.
OX   NCBI_TaxID=542;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-11.
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   MEDLINE=93185620; PubMed=7916685;
RX   DOI=10.1111/j.1432-1033.1993.tb17646.x;
RA   Zhao G., Xia T., Ingram L.O., Jensen R.A.;
RT   "An allosterically insensitive class of cyclohexadienyl dehydrogenase
RT   from Zymomonas mobilis.";
RL   Eur. J. Biochem. 212:157-165(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J.,
RA   Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M.,
RA   Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y.,
RA   Kang H.L., Lee S.Y., Lee K.J., Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- FUNCTION: Is competent to function as either prephenate
CC       dehydrogenase or as arogenate dehydrogenase.
CC   -!- CATALYTIC ACTIVITY: L-arogenate + NAD(+) = L-tyrosine + NADH +
CC       CO(2).
CC   -!- CATALYTIC ACTIVITY: Prephenate + NAD(+) = 4-hydroxyphenylpyruvate
CC       + CO(2) + NADH.
CC   -!- ENZYME REGULATION: Insensitive to feedback inhibition by L-
CC       tyrosine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from L-arogenate: step 1/1.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; L-
CC       tyrosine from prephenate: step 1/2.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Contains 1 prephenate/arogenate dehydrogenase domain.
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DR   EMBL; M75891; AAA27684.1; -; Genomic_DNA.
DR   EMBL; X67208; CAA47647.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV89044.1; -; Genomic_DNA.
DR   PIR; S29384; S29384.
DR   RefSeq; YP_162155.1; -.
DR   GeneID; 3188887; -.
DR   GenomeReviews; AE008692_GR; ZMO0420.
DR   KEGG; zmo:ZMO0420; -.
DR   NMPDR; fig|264203.3.peg.916; -.
DR   HOGENOM; Q04983; -.
DR   OMA; Q04983; QRAIRWG.
DR   BioCyc; ZMOB264203:ZMO0420-MON; -.
DR   BRENDA; 1.3.1.12; 1658.
DR   BRENDA; 1.3.1.43; 1658.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0047794; F:cyclohexadienyl dehydrogenase activity; IEA:EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR003099; Prephen_DH.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR21363; Prephen_DH; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Direct protein sequencing; NAD; Oxidoreductase;
KW   Tyrosine biosynthesis.
FT   CHAIN         1    293       Protein tyrC.
FT                                /FTId=PRO_0000119209.
FT   DOMAIN        5    293       Prephenate/arogenate dehydrogenase.
FT   NP_BIND       6     30       NAD (Potential).
FT   CONFLICT     42     42       R -> C (in Ref. 1; AAA27684/CAA47647).
FT   CONFLICT    268    268       G -> E (in Ref. 1; AAA27684/CAA47647).
FT   CONFLICT    292    292       R -> H (in Ref. 1; AAA27684/CAA47647).
SQ   SEQUENCE   293 AA;  32051 MW;  027683380D81146C CRC64;
     MTVFKHIAII GLGLIGSSAA RATKAYCPDV TVSLYDKSEF VRDRARALNL GDNVTDDIQD
     AVREADLVLL CVPVRAMGIV AAAMAPALKK DVIICDTGSV KVSVIKTLQD NLPNHIIVPS
     HPLAGTENNG PDAGFAELFQ DHPVILTPDA HTPAQAIAYI ADYWEEIGGR INLMSAEHHD
     HVLALTSHLP HVIAYQLIGM VSGYEKKSRT PIMRYSAGSF RDATRVAASE PRLWQDIMLE
     NAPALLPVLD HFIADLKKLR TAIASQDGDY LLEHFKESQK ARLALKTDHD IRP
//