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Q04983

- TYRC_ZYMMO

UniProt

Q04983 - TYRC_ZYMMO

Protein

Protein TyrC

Gene

tyrC

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (15 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Is competent to function as either prephenate dehydrogenase or as arogenate dehydrogenase.

    Catalytic activityi

    L-arogenate + NAD+ = L-tyrosine + NADH + CO2.
    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Enzyme regulationi

    Insensitive to feedback inhibition by L-tyrosine.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3025NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. cyclohexadienyl dehydrogenase activity Source: UniProtKB-EC
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3890-MONOMER.
    UniPathwayiUPA00122; UER00959.
    UPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein TyrC
    Alternative name(s):
    Arogenate dehydrogenase (EC:1.3.1.43)
    Short name:
    ADH
    Cyclohexadienyl dehydrogenase
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrC
    Ordered Locus Names:ZMO0420
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Protein TyrCPRO_0000119209Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi264203.ZMO0420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 293289Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    HOGENOMiHOG000043493.
    KOiK00220.
    OMAiLQITFKN.
    OrthoDBiEOG6B8XMB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF02153. PDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04983-1 [UniParc]FASTAAdd to Basket

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    MTVFKHIAII GLGLIGSSAA RATKAYCPDV TVSLYDKSEF VRDRARALNL    50
    GDNVTDDIQD AVREADLVLL CVPVRAMGIV AAAMAPALKK DVIICDTGSV 100
    KVSVIKTLQD NLPNHIIVPS HPLAGTENNG PDAGFAELFQ DHPVILTPDA 150
    HTPAQAIAYI ADYWEEIGGR INLMSAEHHD HVLALTSHLP HVIAYQLIGM 200
    VSGYEKKSRT PIMRYSAGSF RDATRVAASE PRLWQDIMLE NAPALLPVLD 250
    HFIADLKKLR TAIASQDGDY LLEHFKESQK ARLALKTDHD IRP 293
    Length:293
    Mass (Da):32,051
    Last modified:February 15, 2005 - v2
    Checksum:i027683380D81146C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421R → C in AAA27684. (PubMed:7916685)Curated
    Sequence conflicti42 – 421R → C in CAA47647. (PubMed:7916685)Curated
    Sequence conflicti268 – 2681G → E in AAA27684. (PubMed:7916685)Curated
    Sequence conflicti268 – 2681G → E in CAA47647. (PubMed:7916685)Curated
    Sequence conflicti292 – 2921R → H in AAA27684. (PubMed:7916685)Curated
    Sequence conflicti292 – 2921R → H in CAA47647. (PubMed:7916685)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75891 Genomic DNA. Translation: AAA27684.1.
    X67208 Genomic DNA. Translation: CAA47647.1.
    AE008692 Genomic DNA. Translation: AAV89044.1.
    PIRiS29384.
    RefSeqiWP_011240335.1. NC_006526.2.
    YP_162155.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV89044; AAV89044; ZMO0420.
    GeneIDi3188887.
    KEGGizmo:ZMO0420.
    PATRICi32566170. VBIZymMob102260_0397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75891 Genomic DNA. Translation: AAA27684.1 .
    X67208 Genomic DNA. Translation: CAA47647.1 .
    AE008692 Genomic DNA. Translation: AAV89044.1 .
    PIRi S29384.
    RefSeqi WP_011240335.1. NC_006526.2.
    YP_162155.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q04983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO0420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV89044 ; AAV89044 ; ZMO0420 .
    GeneIDi 3188887.
    KEGGi zmo:ZMO0420.
    PATRICi 32566170. VBIZymMob102260_0397.

    Phylogenomic databases

    eggNOGi COG0287.
    HOGENOMi HOG000043493.
    KOi K00220.
    OMAi LQITFKN.
    OrthoDBi EOG6B8XMB.

    Enzyme and pathway databases

    UniPathwayi UPA00122 ; UER00959 .
    UPA00122 ; UER00961 .
    BioCyci RETL1328306-WGS:GSTH-3890-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF02153. PDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An allosterically insensitive class of cyclohexadienyl dehydrogenase from Zymomonas mobilis."
      Zhao G., Xia T., Ingram L.O., Jensen R.A.
      Eur. J. Biochem. 212:157-165(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-11.
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiTYRC_ZYMMO
    AccessioniPrimary (citable) accession number: Q04983
    Secondary accession number(s): Q5NQG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3