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Q04983 (TYRC_ZYMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein TyrC
Alternative name(s):
Arogenate dehydrogenase
Short name=ADH
EC=1.3.1.43
Cyclohexadienyl dehydrogenase
Prephenate dehydrogenase
Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrC
Ordered Locus Names:ZMO0420
OrganismZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) [Complete proteome] [HAMAP]
Taxonomic identifier264203 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is competent to function as either prephenate dehydrogenase or as arogenate dehydrogenase.

Catalytic activity

L-arogenate + NAD+ = L-tyrosine + NADH + CO2.

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Enzyme regulation

Insensitive to feedback inhibition by L-tyrosine.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from L-arogenate (NAD(+) route): step 1/1.

Subunit structure

Homodimer.

Sequence similarities

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Protein TyrC
PRO_0000119209

Regions

Domain5 – 293289Prephenate/arogenate dehydrogenase
Nucleotide binding6 – 3025NAD Potential

Experimental info

Sequence conflict421R → C in AAA27684. Ref.1
Sequence conflict421R → C in CAA47647. Ref.1
Sequence conflict2681G → E in AAA27684. Ref.1
Sequence conflict2681G → E in CAA47647. Ref.1
Sequence conflict2921R → H in AAA27684. Ref.1
Sequence conflict2921R → H in CAA47647. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04983 [UniParc].

Last modified February 15, 2005. Version 2.
Checksum: 027683380D81146C

FASTA29332,051
        10         20         30         40         50         60 
MTVFKHIAII GLGLIGSSAA RATKAYCPDV TVSLYDKSEF VRDRARALNL GDNVTDDIQD 

        70         80         90        100        110        120 
AVREADLVLL CVPVRAMGIV AAAMAPALKK DVIICDTGSV KVSVIKTLQD NLPNHIIVPS 

       130        140        150        160        170        180 
HPLAGTENNG PDAGFAELFQ DHPVILTPDA HTPAQAIAYI ADYWEEIGGR INLMSAEHHD 

       190        200        210        220        230        240 
HVLALTSHLP HVIAYQLIGM VSGYEKKSRT PIMRYSAGSF RDATRVAASE PRLWQDIMLE 

       250        260        270        280        290 
NAPALLPVLD HFIADLKKLR TAIASQDGDY LLEHFKESQK ARLALKTDHD IRP 

« Hide

References

« Hide 'large scale' references
[1]"An allosterically insensitive class of cyclohexadienyl dehydrogenase from Zymomonas mobilis."
Zhao G., Xia T., Ingram L.O., Jensen R.A.
Eur. J. Biochem. 212:157-165(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-11.
Strain: ATCC 31821 / ZM4 / CP4.
[2]"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4."
Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. expand/collapse author list , Kang H.L., Lee S.Y., Lee K.J., Kang H.S.
Nat. Biotechnol. 23:63-68(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M75891 Genomic DNA. Translation: AAA27684.1.
X67208 Genomic DNA. Translation: CAA47647.1.
AE008692 Genomic DNA. Translation: AAV89044.1.
PIRS29384.
RefSeqYP_162155.1. NC_006526.2.

3D structure databases

ProteinModelPortalQ04983.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264203.ZMO0420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV89044; AAV89044; ZMO0420.
GeneID3188887.
KEGGzmo:ZMO0420.
PATRIC32566170. VBIZymMob102260_0397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043493.
KOK00220.
OMAQRAIRWG.
OrthoDBEOG6B8XMB.
ProtClustDBCLSK2524568.

Enzyme and pathway databases

UniPathwayUPA00122; UER00959.
UPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRC_ZYMMO
AccessionPrimary (citable) accession number: Q04983
Secondary accession number(s): Q5NQG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 15, 2005
Last modified: November 13, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways