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Protein

Protein TyrC

Gene

tyrC

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is competent to function as either prephenate dehydrogenase or as arogenate dehydrogenase.

Catalytic activityi

L-arogenate + NAD+ = L-tyrosine + NADH + CO2.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Enzyme regulationi

Insensitive to feedback inhibition by L-tyrosine.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3025NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. cyclohexadienyl dehydrogenase activity Source: UniProtKB-EC
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3890-MONOMER.
UniPathwayiUPA00122; UER00959.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TyrC
Alternative name(s):
Arogenate dehydrogenase (EC:1.3.1.43)
Short name:
ADH
Cyclohexadienyl dehydrogenase
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrC
Ordered Locus Names:ZMO0420
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Protein TyrCPRO_0000119209Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi264203.ZMO0420.

Structurei

3D structure databases

ProteinModelPortaliQ04983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 293289Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043493.
KOiK00220.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFKHIAII GLGLIGSSAA RATKAYCPDV TVSLYDKSEF VRDRARALNL
60 70 80 90 100
GDNVTDDIQD AVREADLVLL CVPVRAMGIV AAAMAPALKK DVIICDTGSV
110 120 130 140 150
KVSVIKTLQD NLPNHIIVPS HPLAGTENNG PDAGFAELFQ DHPVILTPDA
160 170 180 190 200
HTPAQAIAYI ADYWEEIGGR INLMSAEHHD HVLALTSHLP HVIAYQLIGM
210 220 230 240 250
VSGYEKKSRT PIMRYSAGSF RDATRVAASE PRLWQDIMLE NAPALLPVLD
260 270 280 290
HFIADLKKLR TAIASQDGDY LLEHFKESQK ARLALKTDHD IRP
Length:293
Mass (Da):32,051
Last modified:February 15, 2005 - v2
Checksum:i027683380D81146C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421R → C in AAA27684 (PubMed:7916685).Curated
Sequence conflicti42 – 421R → C in CAA47647 (PubMed:7916685).Curated
Sequence conflicti268 – 2681G → E in AAA27684 (PubMed:7916685).Curated
Sequence conflicti268 – 2681G → E in CAA47647 (PubMed:7916685).Curated
Sequence conflicti292 – 2921R → H in AAA27684 (PubMed:7916685).Curated
Sequence conflicti292 – 2921R → H in CAA47647 (PubMed:7916685).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75891 Genomic DNA. Translation: AAA27684.1.
X67208 Genomic DNA. Translation: CAA47647.1.
AE008692 Genomic DNA. Translation: AAV89044.1.
PIRiS29384.
RefSeqiWP_011240335.1. NC_006526.2.
YP_162155.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89044; AAV89044; ZMO0420.
GeneIDi3188887.
KEGGizmo:ZMO0420.
PATRICi32566170. VBIZymMob102260_0397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75891 Genomic DNA. Translation: AAA27684.1.
X67208 Genomic DNA. Translation: CAA47647.1.
AE008692 Genomic DNA. Translation: AAV89044.1.
PIRiS29384.
RefSeqiWP_011240335.1. NC_006526.2.
YP_162155.1. NC_006526.2.

3D structure databases

ProteinModelPortaliQ04983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264203.ZMO0420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89044; AAV89044; ZMO0420.
GeneIDi3188887.
KEGGizmo:ZMO0420.
PATRICi32566170. VBIZymMob102260_0397.

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043493.
KOiK00220.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.

Enzyme and pathway databases

UniPathwayiUPA00122; UER00959.
UPA00122; UER00961.
BioCyciRETL1328306-WGS:GSTH-3890-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An allosterically insensitive class of cyclohexadienyl dehydrogenase from Zymomonas mobilis."
    Zhao G., Xia T., Ingram L.O., Jensen R.A.
    Eur. J. Biochem. 212:157-165(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-11.
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiTYRC_ZYMMO
AccessioniPrimary (citable) accession number: Q04983
Secondary accession number(s): Q5NQG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.