Reviewed, UniProtKB/Swiss-Prot Q04983 (TYRC_ZYMMO)

Names and origin

Protein names

Recommended name:
    Protein tyrC
Alternative name(s):
    Cyclohexadienyl dehydrogenase
    Arogenate dehydrogenase
      Short name=ADH
    EC=1.3.1.43
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrC
Ordered Locus Names:	ZMO0420

Organism

Zymomonas mobilis [Complete proteome] [HAMAP]

Taxonomic identifier

542 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Zymomonas

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Is competent to function as either prephenate dehydrogenase or as arogenate dehydrogenase.
Catalytic activity	L-arogenate + NAD(+) = L-tyrosine + NADH + CO(2). Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH.
Enzyme regulation	Insensitive to feedback inhibition by L-tyrosine.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from L-arogenate: step 1/1. Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2.
Subunit structure	Homodimer.
Sequence similarities	Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro cyclohexadienyl dehydrogenase activity Inferred from electronic annotation. Source: EC prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Protein tyrC		PRO_0000119209
Regions
	Domain	5 – 293	289	Prephenate/arogenate dehydrogenase
	Nucleotide binding	6 – 30	25	NAD Potential
Experimental info
	Sequence conflict	42	1	R → C in AAA27684 and CAA47647. Ref.1
	Sequence conflict	268	1	G → E in AAA27684 and CAA47647. Ref.1
	Sequence conflict	292	1	R → H in AAA27684 and CAA47647. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q04983-1 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: 027683380D81146C	FASTA	293	32,051
	10 20 30 40 50 60 MTVFKHIAII GLGLIGSSAA RATKAYCPDV TVSLYDKSEF VRDRARALNL GDNVTDDIQD 70 80 90 100 110 120 AVREADLVLL CVPVRAMGIV AAAMAPALKK DVIICDTGSV KVSVIKTLQD NLPNHIIVPS 130 140 150 160 170 180 HPLAGTENNG PDAGFAELFQ DHPVILTPDA HTPAQAIAYI ADYWEEIGGR INLMSAEHHD 190 200 210 220 230 240 HVLALTSHLP HVIAYQLIGM VSGYEKKSRT PIMRYSAGSF RDATRVAASE PRLWQDIMLE 250 260 270 280 290 NAPALLPVLD HFIADLKKLR TAIASQDGDY LLEHFKESQK ARLALKTDHD IRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An allosterically insensitive class of cyclohexadienyl dehydrogenase from Zymomonas mobilis." Zhao G., Xia T., Ingram L.O., Jensen R.A. Eur. J. Biochem. 212:157-165(1993) [PubMed: 7916685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-11. Strain: ATCC 31821 / ZM4 / CP4.
[2]	"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4." Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. , Kang H.L., Lee S.Y., Lee K.J., Kang H.S. Nat. Biotechnol. 23:63-68(2005) [PubMed: 15592456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M75891 Genomic DNA. Translation: AAA27684.1. X67208 Genomic DNA. Translation: CAA47647.1. AE008692 Genomic DNA. Translation: AAV89044.1.
PIR	S29384.
RefSeq	YP_162155.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3188887.
GenomeReviews	Gene locus ZMO0420 in contig AE008692_GR.
KEGG	zmo:ZMO0420.
NMPDR	fig|264203.3.peg.916.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q04983.
Enzyme and pathway databases
BioCyc	ZMOB264203:ZMO0420-MON.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd. IPR003099. Prephen_DHase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRC_ZYMMO

Accession

Primary (citable) accession number: Q04983
Secondary accession number(s): Q5NQG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 15, 2005
Last modified:	November 25, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)