Q04967 (HSP76_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein 6

Alternative name(s):
Heat shock 70 kDa protein B'

Gene names

Name:	HSPA6
Synonyms:	HSP70B'

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	643 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage By similarity.
Induction	By heat shock.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 643	643	Heat shock 70 kDa protein 6		PRO_0000078265

Sequences

	Sequence		Length	Mass (Da)
	Q04967 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 70C7F3BF766B4C03	FASTA	643	71,109
	10 20 30 40 50 60 MSAAREVAIG IDLGTTYSCV GVFQHGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 70 80 90 100 110 120 AALNPQNTVF DAKRLIGRKF ADPTVQSDLK HWPFQVVSEG GKPKVRVSYR GEDKAFYPEE 130 140 150 160 170 180 ISSMVLSKMK ETAEAYLGQP VRHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA 190 200 210 220 230 240 AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLTIDAGVFE VKATAGDTHL GGEDFDNRLV 250 260 270 280 290 300 NHFMEEFRRK HRKDLSRNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT 310 320 330 340 350 360 RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDIVLVG GSTRIPKIQK LLQDFFNGRE 370 380 390 400 410 420 LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA 430 440 450 460 470 480 TIPTKQTQTF TTYSDNQPGV LIQVYEGERA MTRDNNLLGR FELSGIPPAP RGVPQIEVTF 490 500 510 520 530 540 DIDANGILSV TATDRSTGRA NKITITNDKG RLSKEEVERM VREADEYKVE DEAQRDRVAA 550 560 570 580 590 600 KNSLEAYVFH VKGSLHEESL RDKIPEEDRC KVQDKCQEVL TWLEHNQLAE KEEYEHQKRE 610 620 630 640 LEQICRPIFS RLYGAPGIPG GSSCGAQARQ GAPSTGPVIE EVD

References

[1]	"Characterization of a polymorphic heat shock protein 70 gene in swine outside the SLA major histocompatibility complex." Dezeure F., Vaiman M., Chardon P. Biochim. Biophys. Acta 1174:17-26(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X68213 mRNA. Translation: CAA48295.1.
PIR	S25585. S34625.
RefSeq	NP_001116599.1. NM_001123127.1.
UniGene	Ssc.114.
3D structure databases
ProteinModelPortal	Q04967.
SMR	Q04967. Positions 8-555.
ModBase	Search...
Proteomic databases
PRIDE	Q04967.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396906.
KEGG	ssc:396906.
Organism-specific databases
CTD	30671.
Phylogenomic databases
HOVERGEN	HBG051845.
KO	K03283.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP76_PIG

Accession

Primary (citable) accession number: Q04967

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program