Q04956 (ATX1_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable cation-transporting ATPase 1 EC=3.6.3.-
Organism	Plasmodium falciparum
Taxonomic identifier	5833 [NCBI]
Taxonomic lineage	Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	1956 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1956	1956	Probable cation-transporting ATPase 1		PRO_0000046354
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 58	23	Helical; Potential
	Topological domain	59 – 61	3	Extracellular Potential
	Transmembrane	62 – 80	19	Helical; Potential
	Topological domain	81 – 407	327	Cytoplasmic Potential
	Transmembrane	408 – 427	20	Helical; Potential
	Topological domain	428 – 440	13	Extracellular Potential
	Transmembrane	441 – 462	22	Helical; Potential
	Topological domain	463 – 1818	1356	Cytoplasmic Potential
	Transmembrane	1819 – 1837	19	Helical; Potential
	Topological domain	1838 – 1845	8	Extracellular Potential
	Transmembrane	1846 – 1863	18	Helical; Potential
	Topological domain	1864 – 1881	18	Cytoplasmic Potential
	Transmembrane	1882 – 1905	24	Helical; Potential
	Topological domain	1906 – 1928	23	Extracellular Potential
	Transmembrane	1929 – 1952	24	Helical; Potential
	Topological domain	1953 – 1956	4	Cytoplasmic Potential
	Compositional bias	246 – 251	6	Poly-Asn
	Compositional bias	252 – 256	5	Poly-Lys
	Compositional bias	937 – 941	5	Poly-Asn
	Compositional bias	1344 – 1347	4	Poly-Lys
	Compositional bias	1363 – 1372	10	Poly-Asn
	Compositional bias	1680 – 1684	5	Poly-Asn
Sites
	Active site	496	1	4-aspartylphosphate intermediate By similarity
	Metal binding	1760	1	Magnesium By similarity
	Metal binding	1764	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04956 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AE708AAE99009335	FASTA	1,956	230,286
	10 20 30 40 50 60 MHLMCTGLRN EKLINDRKIL YGECNLNIKS DSFIILLFKE IMNPFFIFQI FAMIVWSLDN 70 80 90 100 110 120 YIEYTISILF ITSISIILEL KNTIKNQKKI KNMLNYTCPI NVYRYNTSYI ISSSELVPGD 130 140 150 160 170 180 IYEIKNNMTI PCDTIILSGS VTMSEHMLTG ESVPIHKERL PFEGNAIINK NNKYDSNDEK 190 200 210 220 230 240 DDYLRIYNNH ASINMIKRNH LIEETLGKKD REYKSNTHDL CSMNKLCYIN NTYDDVHMKN 250 260 270 280 290 300 NKMDYNNNNN NKKKKKINNL NFVKGTYINS NDLLYDDKIG VNIFEDDVNN MKHKFNQRNI 310 320 330 340 350 360 NYYNKDTNNL EYNNKHRYIY DCLLKKVEAI SQKNKIIYSN EDINKYMLYG GTYVLSLYNI 370 380 390 400 410 420 NKIKYNNKEE NRILGLVIKT GFITTKGKIV NNILYHKKKE LNLINDSYKF LIILIIYALF 430 440 450 460 470 480 SVFILLYITL SNNEYTNHII IKCLDIITDA IPPALPTTLT VGISIAISRL KKKFSISCLC 490 500 510 520 530 540 PHKINIAGQI NTMVFDKTGT LTENNLQFIG IITQNKKNKN MLSDFIHIKE MNTESYIHSK 550 560 570 580 590 600 DDNMIHNKNS IISEYYIKDN MKNLHTSSKK KSITKERSNF LVQTIKSCLL KDHYIKEKKK 610 620 630 640 650 660 EYYTNNTYCN DLHINDSTCS SYLLNSETKD AYCEYYNIDH LCDINKKNMD INSKNELMGK 670 680 690 700 710 720 YSKNELMGKT IKNELMGKYS KNELMGKYSK NELMGKYSKN ELMGKYSKNE LMGKYSKNEL 730 740 750 760 770 780 MGKTIKNQVG VDTNIYHMNC DNDYNYDYPC DYNCNNCNDT YHRLEYHNIN KDNSFNIPPE 790 800 810 820 830 840 KNKSYNNISE HIKINYPLLF EALACCHTLS KVNNKIMGDV LEILMFNFTN CDMLINNNSF 850 860 870 880 890 900 IIKEKKKNCS YDFQKIDGDK NIGANDERCH LNNNLVSYNI LKRFEFQSRL QRMSVIVKST 910 920 930 940 950 960 YGNNNDDNND DDNNNDDDNN DDNNNDDNNN DDNNDDNNNN NYYYNIFCKG SPEKIKELCL 970 980 990 1000 1010 1020 KSKIPNNYDE ILNKYTKQGM RILSISYKRV KSKNINLLNV KRSFVESNLH FLGFLIFTNN 1030 1040 1050 1060 1070 1080 MKKNAPDIIH NLQTSGCQCI MSTGDNVLTS IHVAKKCGII NSNVESIIIG DVIPVVGKNN 1090 1100 1110 1120 1130 1140 KQKKKLVWYN HKNDTYLKGH DKTCIDNEFT SIQSQMNSDN ICGDNICGDN IYGDNICGDN 1150 1160 1170 1180 1190 1200 IYGDNINGDN INGDNIYGDN INGDNINGDN INTYDNIYGD NYNLDYCPTE YHKCTYNNSI 1210 1220 1230 1240 1250 1260 LYRNNFLYKK ENKKDKNYKN ISTLYEHRTN DIQFDKLCDI LINKDPRNVN IVLTGKAFIF 1270 1280 1290 1300 1310 1320 LKKKFYSFHL PYYEECKNIV HYIMKKKHKK IKNIINNHNS NLYYHYNIID TFVKRMNKEY 1330 1340 1350 1360 1370 1380 MCFNKLLYKI QQKLLYNLIH NLYKKKKYMN NYYDIDEVHL IGNNNNNNNK NNSKEKKLPL 1390 1400 1410 1420 1430 1440 KNKMKHIRKN ESNDNITFNT YTSNNIHLSK YKYVHHKNYY YPDSCTNLRK KKNSLFYNLK 1450 1460 1470 1480 1490 1500 KYIYYEKKKY LQHCLLKHDN YKKVELPRIK DINYSYQMES IKTRNFIHSL SEQFAFSNLI 1510 1520 1530 1540 1550 1560 LSFYIIKNDD NNVYNKNYIY NKNYIYNKNS ICNKNYICNK NYIYNKNNIY NKNNIYNKKN 1570 1580 1590 1600 1610 1620 ILTHAKSVLL SGSSKKFLKF FSNIIRRHKL KEKKNKKNIK RYKMNHVNNT SKGHIILNMC 1630 1640 1650 1660 1670 1680 THGFKKDYSS LKNKYRIVNN KRYMLKNDNV YDRHMYNLTD MYRGTQYGCS KKKNKNIYMN 1690 1700 1710 1720 1730 1740 NNNNILKNKI NRFLEHLLVD KCKRNICHKY TDIKNIKLSI YEYILRTCTV YARMKPKDKS 1750 1760 1770 1780 1790 1800 DLILSLKKLP NNSYVGMCGD GANDCLALSC ADIGISLCNN NESSICSSFT SNKLCLHSIV 1810 1820 1830 1840 1850 1860 HILIEGRASL VNSFQLFKFI SLYSIMQCSQ VLILYSISNK LTDNQYIFID IVTILPLSIF 1870 1880 1890 1900 1910 1920 MCWTSASEKL SKNIPIGKLF SFPILISIYG QIIIQLFFVM ISLVVLMNLS FYKYDKNKVM 1930 1940 1950 KEKSDDTYLY KAQKYTLIYS LLFSKFVYVY IFKYKE

References

[1]	"A family of cation ATPase-like molecules from Plasmodium falciparum." Krishna S., Cowan G., Meade J.C., Wells R.A., Stringer J.R., Robson K.J. J. Cell Biol. 120:385-398(1993) [PubMed: 8421054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T9/96.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65738 Genomic DNA. Translation: CAA46646.1.
3D structure databases
ProteinModelPortal	Q04956.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	KOG0208.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 3 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
Pfam	PF00122. E1-E2_ATPase. 2 hits. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATX1_PLAFA

Accession

Primary (citable) accession number: Q04956

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)