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Protein

Probable cation-transporting ATPase 1

Gene
N/A
Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei496 – 49614-aspartylphosphate intermediateBy similarity
Metal bindingi1760 – 17601MagnesiumBy similarity
Metal bindingi1764 – 17641MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 1 (EC:3.6.3.-)
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5823HelicalSequence analysisAdd
BLAST
Topological domaini59 – 613ExtracellularSequence analysis
Transmembranei62 – 8019HelicalSequence analysisAdd
BLAST
Topological domaini81 – 407327CytoplasmicSequence analysisAdd
BLAST
Transmembranei408 – 42720HelicalSequence analysisAdd
BLAST
Topological domaini428 – 44013ExtracellularSequence analysisAdd
BLAST
Transmembranei441 – 46222HelicalSequence analysisAdd
BLAST
Topological domaini463 – 18181356CytoplasmicSequence analysisAdd
BLAST
Transmembranei1819 – 183719HelicalSequence analysisAdd
BLAST
Topological domaini1838 – 18458ExtracellularSequence analysis
Transmembranei1846 – 186318HelicalSequence analysisAdd
BLAST
Topological domaini1864 – 188118CytoplasmicSequence analysisAdd
BLAST
Transmembranei1882 – 190524HelicalSequence analysisAdd
BLAST
Topological domaini1906 – 192823ExtracellularSequence analysisAdd
BLAST
Transmembranei1929 – 195224HelicalSequence analysisAdd
BLAST
Topological domaini1953 – 19564CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19561956Probable cation-transporting ATPase 1PRO_0000046354Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04956.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFE0805w.

Structurei

3D structure databases

ProteinModelPortaliQ04956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2516Poly-Asn
Compositional biasi252 – 2565Poly-Lys
Compositional biasi937 – 9415Poly-Asn
Compositional biasi1344 – 13474Poly-Lys
Compositional biasi1363 – 137210Poly-Asn
Compositional biasi1680 – 16845Poly-Asn

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLMCTGLRN EKLINDRKIL YGECNLNIKS DSFIILLFKE IMNPFFIFQI
60 70 80 90 100
FAMIVWSLDN YIEYTISILF ITSISIILEL KNTIKNQKKI KNMLNYTCPI
110 120 130 140 150
NVYRYNTSYI ISSSELVPGD IYEIKNNMTI PCDTIILSGS VTMSEHMLTG
160 170 180 190 200
ESVPIHKERL PFEGNAIINK NNKYDSNDEK DDYLRIYNNH ASINMIKRNH
210 220 230 240 250
LIEETLGKKD REYKSNTHDL CSMNKLCYIN NTYDDVHMKN NKMDYNNNNN
260 270 280 290 300
NKKKKKINNL NFVKGTYINS NDLLYDDKIG VNIFEDDVNN MKHKFNQRNI
310 320 330 340 350
NYYNKDTNNL EYNNKHRYIY DCLLKKVEAI SQKNKIIYSN EDINKYMLYG
360 370 380 390 400
GTYVLSLYNI NKIKYNNKEE NRILGLVIKT GFITTKGKIV NNILYHKKKE
410 420 430 440 450
LNLINDSYKF LIILIIYALF SVFILLYITL SNNEYTNHII IKCLDIITDA
460 470 480 490 500
IPPALPTTLT VGISIAISRL KKKFSISCLC PHKINIAGQI NTMVFDKTGT
510 520 530 540 550
LTENNLQFIG IITQNKKNKN MLSDFIHIKE MNTESYIHSK DDNMIHNKNS
560 570 580 590 600
IISEYYIKDN MKNLHTSSKK KSITKERSNF LVQTIKSCLL KDHYIKEKKK
610 620 630 640 650
EYYTNNTYCN DLHINDSTCS SYLLNSETKD AYCEYYNIDH LCDINKKNMD
660 670 680 690 700
INSKNELMGK YSKNELMGKT IKNELMGKYS KNELMGKYSK NELMGKYSKN
710 720 730 740 750
ELMGKYSKNE LMGKYSKNEL MGKTIKNQVG VDTNIYHMNC DNDYNYDYPC
760 770 780 790 800
DYNCNNCNDT YHRLEYHNIN KDNSFNIPPE KNKSYNNISE HIKINYPLLF
810 820 830 840 850
EALACCHTLS KVNNKIMGDV LEILMFNFTN CDMLINNNSF IIKEKKKNCS
860 870 880 890 900
YDFQKIDGDK NIGANDERCH LNNNLVSYNI LKRFEFQSRL QRMSVIVKST
910 920 930 940 950
YGNNNDDNND DDNNNDDDNN DDNNNDDNNN DDNNDDNNNN NYYYNIFCKG
960 970 980 990 1000
SPEKIKELCL KSKIPNNYDE ILNKYTKQGM RILSISYKRV KSKNINLLNV
1010 1020 1030 1040 1050
KRSFVESNLH FLGFLIFTNN MKKNAPDIIH NLQTSGCQCI MSTGDNVLTS
1060 1070 1080 1090 1100
IHVAKKCGII NSNVESIIIG DVIPVVGKNN KQKKKLVWYN HKNDTYLKGH
1110 1120 1130 1140 1150
DKTCIDNEFT SIQSQMNSDN ICGDNICGDN IYGDNICGDN IYGDNINGDN
1160 1170 1180 1190 1200
INGDNIYGDN INGDNINGDN INTYDNIYGD NYNLDYCPTE YHKCTYNNSI
1210 1220 1230 1240 1250
LYRNNFLYKK ENKKDKNYKN ISTLYEHRTN DIQFDKLCDI LINKDPRNVN
1260 1270 1280 1290 1300
IVLTGKAFIF LKKKFYSFHL PYYEECKNIV HYIMKKKHKK IKNIINNHNS
1310 1320 1330 1340 1350
NLYYHYNIID TFVKRMNKEY MCFNKLLYKI QQKLLYNLIH NLYKKKKYMN
1360 1370 1380 1390 1400
NYYDIDEVHL IGNNNNNNNK NNSKEKKLPL KNKMKHIRKN ESNDNITFNT
1410 1420 1430 1440 1450
YTSNNIHLSK YKYVHHKNYY YPDSCTNLRK KKNSLFYNLK KYIYYEKKKY
1460 1470 1480 1490 1500
LQHCLLKHDN YKKVELPRIK DINYSYQMES IKTRNFIHSL SEQFAFSNLI
1510 1520 1530 1540 1550
LSFYIIKNDD NNVYNKNYIY NKNYIYNKNS ICNKNYICNK NYIYNKNNIY
1560 1570 1580 1590 1600
NKNNIYNKKN ILTHAKSVLL SGSSKKFLKF FSNIIRRHKL KEKKNKKNIK
1610 1620 1630 1640 1650
RYKMNHVNNT SKGHIILNMC THGFKKDYSS LKNKYRIVNN KRYMLKNDNV
1660 1670 1680 1690 1700
YDRHMYNLTD MYRGTQYGCS KKKNKNIYMN NNNNILKNKI NRFLEHLLVD
1710 1720 1730 1740 1750
KCKRNICHKY TDIKNIKLSI YEYILRTCTV YARMKPKDKS DLILSLKKLP
1760 1770 1780 1790 1800
NNSYVGMCGD GANDCLALSC ADIGISLCNN NESSICSSFT SNKLCLHSIV
1810 1820 1830 1840 1850
HILIEGRASL VNSFQLFKFI SLYSIMQCSQ VLILYSISNK LTDNQYIFID
1860 1870 1880 1890 1900
IVTILPLSIF MCWTSASEKL SKNIPIGKLF SFPILISIYG QIIIQLFFVM
1910 1920 1930 1940 1950
ISLVVLMNLS FYKYDKNKVM KEKSDDTYLY KAQKYTLIYS LLFSKFVYVY

IFKYKE
Length:1,956
Mass (Da):230,286
Last modified:November 1, 1996 - v1
Checksum:iAE708AAE99009335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65738 Genomic DNA. Translation: CAA46646.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65738 Genomic DNA. Translation: CAA46646.1.

3D structure databases

ProteinModelPortaliQ04956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PFE0805w.

Proteomic databases

PaxDbiQ04956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 2 hits.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A family of cation ATPase-like molecules from Plasmodium falciparum."
    Krishna S., Cowan G., Meade J.C., Wells R.A., Stringer J.R., Robson K.J.
    J. Cell Biol. 120:385-398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: T9/96.

Entry informationi

Entry nameiATX1_PLAFA
AccessioniPrimary (citable) accession number: Q04956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.