Reticulon-like protein 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q04947 (RTN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Reticulon-like protein 1

Gene names

Name:	RTN1
Ordered Locus Names:	YDR233C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with POM33. Ref.11
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6.
Miscellaneous	Present with 37105 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 reticulon domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	endoplasmic reticulum tubular network maintenance Inferred from genetic interaction PubMed 21502358. Source: SGD nuclear pore complex assembly Inferred from genetic interaction PubMed 19273614. Source: SGD
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 16002643. Source: SGD cortical endoplasmic reticulum Inferred from direct assay PubMed 16624861. Source: SGD integral to cytosolic side of endoplasmic reticulum membrane Inferred from direct assay PubMed 16624861. Source: UniProtKB mitochondrion Inferred from direct assay PubMed 14576278 PubMed 16823961. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SEY1	Q99287	2	EBI-38020,EBI-37523

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 295

295

Reticulon-like protein 1

PRO_0000168168

Regions

Topological domain

1 – 50

Cytoplasmic Potential

Transmembrane

51 – 73

Helical; Potential

Topological domain

74 – 142

Lumenal Potential

Transmembrane

143 – 163

Helical; Potential

Topological domain

164 – 295

132

Cytoplasmic Potential

Domain

20 – 220

201

Reticulon

Coiled coil

265 – 295

Potential

Compositional bias

9 – 16

Poly-Gln

Amino acid modifications

Modified residue

186

Phosphothreonine Ref.9 Ref.10

Modified residue

219

Phosphothreonine Ref.9

Modified residue

230

Phosphothreonine Ref.10

Modified residue

232

Phosphoserine Ref.10

Modified residue

234

Phosphoserine Ref.10

Modified residue

265

Phosphoserine Ref.10

Modified residue

267

Phosphothreonine Ref.10

Modified residue

276

Phosphoserine Ref.10

Sequences

Sequence

Length

Mass (Da)

Tools

Q04947 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 245575E65D3C2193
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FASTA

295

32,916

        10         20         30         40         50         60 
MSASAQHSQA QQQQQQKSCN CDLLLWRNPV QTGKYFGGSL LALLILKKVN LITFFLKVAY 

        70         80         90        100        110        120 
TILFTTGSIE FVSKLFLGQG LITKYGPKEC PNIAGFIKPH IDEALKQLPV FQAHIRKTVF 

       130        140        150        160        170        180 
AQVPKHTFKT AVALFLLHKF FSWFSIWTIV FVADIFTFTL PVIYHSYKHE IDATVAQGVE 

       190        200        210        220        230        240 
ISKQKTQEFS QMACEKTKPY LDKVESKLGP ISNLVKSKTA PVSSTAGPQT ASTSKLAADV 

       250        260        270        280        290 
PLEPESKAYT SSAQVMPEVP QHEPSTTQEF NVDELSNELK KSTKNLQNEL EKNNA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family." Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E. FASEB J. 17:1238-1247(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P. Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	Bienvenut W.V., Peters C. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 18-27; 219-247 AND 285-295, MASS SPECTROMETRY.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
[9]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186 AND THR-219, MASS SPECTROMETRY.
[10]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186; THR-230; SER-232; SER-234; SER-265; THR-267 AND SER-276, MASS SPECTROMETRY.
[11]	"Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution." Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V. J. Cell Biol. 189:795-811(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH POM33.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY164798 mRNA. Translation: AAP47373.1. Z48612 Genomic DNA. Translation: CAA88512.1. AY558579 Genomic DNA. Translation: AAS56905.1. BK006938 Genomic DNA. Translation: DAA12074.1.
PIR	S59439.
RefSeq	NP_010519.3. NM_001180541.3.
3D structure databases
ProteinModelPortal	Q04947.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4090N.
IntAct	Q04947. 15 interactions.
MINT	MINT-510849.
STRING	4932.YDR233C.
Proteomic databases
PaxDb	Q04947.
PeptideAtlas	Q04947.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR233C; YDR233C; YDR233C.
GeneID	851819.
KEGG	sce:YDR233C. sce:YDR237W.
Organism-specific databases
CYGD	YDR233c.
SGD	S000002641. RTN1.
Phylogenomic databases
eggNOG	NOG116114.
GeneTree	ENSGT00530000066264.
HOGENOM	HOG000248018.
KO	K02931.
OMA	AFIFAAR.
OrthoDB	EOG44BFB7.
Gene expression databases
Genevestigator	Q04947.
GermOnline	YDR233C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003388. Reticulon. [Graphical view]
PANTHER	PTHR10994. PTHR10994. 1 hit.
Pfam	PF02453. Reticulon. 1 hit. [Graphical view]
PROSITE	PS50845. RETICULON. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	969686.

Entry information

Entry name

RTN1_YEAST

Accession

Primary (citable) accession number: Q04947
Secondary accession number(s): D6VSL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents