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Q04947 (RTN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-like protein 1
Gene names
Name:RTN1
Ordered Locus Names:YDR233C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with POM33. Ref.11

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6.

Miscellaneous

Present with 37105 molecules/cell in log phase SD medium. Ref.7

Sequence similarities

Contains 1 reticulon domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SEY1Q992873EBI-38020,EBI-37523

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Reticulon-like protein 1
PRO_0000168168

Regions

Topological domain1 – 5050Cytoplasmic Potential
Transmembrane51 – 7323Helical; Potential
Topological domain74 – 14269Lumenal Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 295132Cytoplasmic Potential
Domain20 – 220201Reticulon
Coiled coil265 – 29531 Potential
Compositional bias9 – 168Poly-Gln

Amino acid modifications

Modified residue1861Phosphothreonine Ref.9 Ref.10
Modified residue2191Phosphothreonine Ref.9
Modified residue2301Phosphothreonine Ref.10
Modified residue2321Phosphoserine Ref.10
Modified residue2341Phosphoserine Ref.10
Modified residue2651Phosphoserine Ref.10
Modified residue2671Phosphothreonine Ref.10
Modified residue2761Phosphoserine Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q04947 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 245575E65D3C2193

FASTA29532,916
        10         20         30         40         50         60 
MSASAQHSQA QQQQQQKSCN CDLLLWRNPV QTGKYFGGSL LALLILKKVN LITFFLKVAY 

        70         80         90        100        110        120 
TILFTTGSIE FVSKLFLGQG LITKYGPKEC PNIAGFIKPH IDEALKQLPV FQAHIRKTVF 

       130        140        150        160        170        180 
AQVPKHTFKT AVALFLLHKF FSWFSIWTIV FVADIFTFTL PVIYHSYKHE IDATVAQGVE 

       190        200        210        220        230        240 
ISKQKTQEFS QMACEKTKPY LDKVESKLGP ISNLVKSKTA PVSSTAGPQT ASTSKLAADV 

       250        260        270        280        290 
PLEPESKAYT SSAQVMPEVP QHEPSTTQEF NVDELSNELK KSTKNLQNEL EKNNA 

« Hide

References

« Hide 'large scale' references
[1]"A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family."
Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.
FASEB J. 17:1238-1247(2003) [PubMed: 12832288] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Bienvenut W.V., Peters C.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-27; 219-247 AND 285-295, MASS SPECTROMETRY.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186 AND THR-219, MASS SPECTROMETRY.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186; THR-230; SER-232; SER-234; SER-265; THR-267 AND SER-276, MASS SPECTROMETRY.
[11]"Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution."
Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V.
J. Cell Biol. 189:795-811(2010) [PubMed: 20498018] [Abstract]
Cited for: INTERACTION WITH POM33.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY164798 mRNA. Translation: AAP47373.1.
Z48612 Genomic DNA. Translation: CAA88512.1.
AY558579 Genomic DNA. Translation: AAS56905.1.
BK006938 Genomic DNA. Translation: DAA12074.1.
PIRS59439.
RefSeqNP_010519.1. NM_001180541.1.

3D structure databases

ProteinModelPortalQ04947.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4090N.
IntActQ04947. 98 interactions.
MINTMINT-510849.
STRINGQ04947.

Proteomic databases

PeptideAtlasQ04947.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR233C; YDR233C; YDR233C.
GeneID851819.
KEGGsce:YDR233C.
NMPDRfig|4932.3.peg.1276.

Organism-specific databases

CYGDYDR233c.
SGDS000002641. RTN1.

Phylogenomic databases

eggNOGfuNOG09841.
GeneTreeEFGT00050000006485.
HOGENOMHBG396976.
OMAAFIFAAR.
OrthoDBEOG44BFB7.

Gene expression databases

ArrayExpressQ04947.
GenevestigatorQ04947.
GermOnlineYDR233C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013326. ApoA/E_ApoLp.
IPR003388. Reticulon.
[Graphical view]
Gene3DG3DSA:1.20.120.20. ApoA/E_ApoLp. 2 hits.
PANTHERPTHR10994. Reticulon. 1 hit.
PfamPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969686.

Entry information

Entry nameRTN1_YEAST
AccessionPrimary (citable) accession number: Q04947
Secondary accession number(s): D6VSL4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families