Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04947

- RTN1_YEAST

UniProt

Q04947 - RTN1_YEAST

Protein

Reticulon-like protein 1

Gene

RTN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. endoplasmic reticulum organization Source: UniProtKB
    2. endoplasmic reticulum tubular network maintenance Source: SGD
    3. endoplasmic reticulum tubular network organization Source: UniProtKB
    4. nuclear pore complex assembly Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29810-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-like protein 1
    Gene namesi
    Name:RTN1
    Ordered Locus Names:YDR233C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR233c.
    SGDiS000002641. RTN1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cortical endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum Source: SGD
    3. endoplasmic reticulum tubular network Source: UniProtKB
    4. Golgi apparatus Source: SGD
    5. integral component of cytoplasmic side of endoplasmic reticulum membrane Source: UniProtKB
    6. integral component of endoplasmic reticulum membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Reticulon-like protein 1PRO_0000168168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei186 – 1861Phosphothreonine2 Publications
    Modified residuei219 – 2191Phosphothreonine1 Publication
    Modified residuei232 – 2321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04947.
    PaxDbiQ04947.
    PeptideAtlasiQ04947.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04947.

    Interactioni

    Subunit structurei

    Interacts with POM33.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SEY1Q992872EBI-38020,EBI-37523

    Protein-protein interaction databases

    BioGridi32284. 114 interactions.
    DIPiDIP-4090N.
    IntActiQ04947. 15 interactions.
    MINTiMINT-510849.
    STRINGi4932.YDR233C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04947.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 14269LumenalSequence AnalysisAdd
    BLAST
    Topological domaini164 – 295132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 220201ReticulonPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili265 – 29531Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 168Poly-Gln

    Sequence similaritiesi

    Contains 1 reticulon domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG116114.
    GeneTreeiENSGT00530000066264.
    HOGENOMiHOG000248018.
    OMAiGASKFPD.
    OrthoDBiEOG7C8GVW.

    Family and domain databases

    InterProiIPR003388. Reticulon.
    [Graphical view]
    PANTHERiPTHR10994. PTHR10994. 1 hit.
    PfamiPF02453. Reticulon. 1 hit.
    [Graphical view]
    PROSITEiPS50845. RETICULON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04947-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASAQHSQA QQQQQQKSCN CDLLLWRNPV QTGKYFGGSL LALLILKKVN    50
    LITFFLKVAY TILFTTGSIE FVSKLFLGQG LITKYGPKEC PNIAGFIKPH 100
    IDEALKQLPV FQAHIRKTVF AQVPKHTFKT AVALFLLHKF FSWFSIWTIV 150
    FVADIFTFTL PVIYHSYKHE IDATVAQGVE ISKQKTQEFS QMACEKTKPY 200
    LDKVESKLGP ISNLVKSKTA PVSSTAGPQT ASTSKLAADV PLEPESKAYT 250
    SSAQVMPEVP QHEPSTTQEF NVDELSNELK KSTKNLQNEL EKNNA 295
    Length:295
    Mass (Da):32,916
    Last modified:November 1, 1996 - v1
    Checksum:i245575E65D3C2193
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY164798 mRNA. Translation: AAP47373.1.
    Z48612 Genomic DNA. Translation: CAA88512.1.
    AY558579 Genomic DNA. Translation: AAS56905.1.
    BK006938 Genomic DNA. Translation: DAA12074.1.
    PIRiS59439.
    RefSeqiNP_010519.3. NM_001180541.3.

    Genome annotation databases

    EnsemblFungiiYDR233C; YDR233C; YDR233C.
    GeneIDi851819.
    KEGGisce:YDR233C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY164798 mRNA. Translation: AAP47373.1 .
    Z48612 Genomic DNA. Translation: CAA88512.1 .
    AY558579 Genomic DNA. Translation: AAS56905.1 .
    BK006938 Genomic DNA. Translation: DAA12074.1 .
    PIRi S59439.
    RefSeqi NP_010519.3. NM_001180541.3.

    3D structure databases

    ProteinModelPortali Q04947.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32284. 114 interactions.
    DIPi DIP-4090N.
    IntActi Q04947. 15 interactions.
    MINTi MINT-510849.
    STRINGi 4932.YDR233C.

    Proteomic databases

    MaxQBi Q04947.
    PaxDbi Q04947.
    PeptideAtlasi Q04947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR233C ; YDR233C ; YDR233C .
    GeneIDi 851819.
    KEGGi sce:YDR233C.

    Organism-specific databases

    CYGDi YDR233c.
    SGDi S000002641. RTN1.

    Phylogenomic databases

    eggNOGi NOG116114.
    GeneTreei ENSGT00530000066264.
    HOGENOMi HOG000248018.
    OMAi GASKFPD.
    OrthoDBi EOG7C8GVW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29810-MONOMER.

    Miscellaneous databases

    NextBioi 969686.

    Gene expression databases

    Genevestigatori Q04947.

    Family and domain databases

    InterProi IPR003388. Reticulon.
    [Graphical view ]
    PANTHERi PTHR10994. PTHR10994. 1 hit.
    Pfami PF02453. Reticulon. 1 hit.
    [Graphical view ]
    PROSITEi PS50845. RETICULON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family."
      Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.
      FASEB J. 17:1238-1247(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Bienvenut W.V., Peters C.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 18-27; 219-247 AND 285-295, IDENTIFICATION BY MASS SPECTROMETRY.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186; THR-219 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution."
      Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V.
      J. Cell Biol. 189:795-811(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH POM33.

    Entry informationi

    Entry nameiRTN1_YEAST
    AccessioniPrimary (citable) accession number: Q04947
    Secondary accession number(s): D6VSL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 37105 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3