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Reviewed, UniProtKB/Swiss-Prot Q04947 (RTN1_YEAST)

Last modified June 16, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Reticulon-like protein 1
Gene names
Name: RTN1
Ordered Locus Names: YDR233C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Ref.5

Miscellaneous

Present with 37105 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Contains 1 reticulon domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

P360761EBI-38020,EBI-26778
Q120661EBI-38020,EBI-35877
Q123051EBI-38020,EBI-32453
CBR1P386261EBI-38020,EBI-2048224
CHO1P084561EBI-38020,EBI-14055
CPT1P178981EBI-38020,EBI-2050738
DAL5P153651EBI-38020,EBI-5527
DAP1Q120911EBI-38020,EBI-5554
DNM1P548611EBI-38020,EBI-6002
EFR3Q036531EBI-38020,EBI-27465
EHT1P382951EBI-38020,EBI-20890
EPT1P221401EBI-38020,EBI-6494
ERG11P106141EBI-38020,EBI-5127
ERG25P530451EBI-38020,EBI-6506
ERG4P253401EBI-38020,EBI-6558
ERG5P547811EBI-38020,EBI-6563
ERP1Q053591EBI-38020,EBI-6581
ERP4Q124501EBI-38020,EBI-6598
ERV25P548371EBI-38020,EBI-6642
ERV29P533371EBI-38020,EBI-23662
FPS1P239001EBI-38020,EBI-7074
GAP1P191451EBI-38020,EBI-7314
GET3Q121541EBI-38020,EBI-2989
GOT1Q035541EBI-38020,EBI-2057821
GPA2P108231EBI-38020,EBI-7382
GPT2P361481EBI-38020,EBI-26471
HNM1P198071EBI-38020,EBI-8409
HSP30P256191EBI-38020,EBI-8563
HXT1P324651EBI-38020,EBI-8759
ILM1P471551EBI-38020,EBI-2051644
ITR1P306051EBI-38020,EBI-2050956
KEL1P388531EBI-38020,EBI-9619
KRE27P405401EBI-38020,EBI-24977
LCB1P250451EBI-38020,EBI-10059
LSP1Q122301EBI-38020,EBI-34978
MPG1P419401EBI-38020,EBI-11191
MUP1P502761EBI-38020,EBI-11624
NDC1P325001EBI-38020,EBI-11950
NUP100Q026291EBI-38020,EBI-11698
NUP133P361611EBI-38020,EBI-11722
NUP159P404771EBI-38020,EBI-11747
NUP82P403681EBI-38020,EBI-12331
NUP84P528911EBI-38020,EBI-12337
NUP85P466731EBI-38020,EBI-12345
OLE1P211471EBI-38020,EBI-2098
ORM2Q061441EBI-38020,EBI-34916
OSH7P387551EBI-38020,EBI-12641
PEM1P053741EBI-38020,EBI-2049142
PEX11Q124621EBI-38020,EBI-13198
PEX30Q061691EBI-38020,EBI-31008
PHO84P252971EBI-38020,EBI-13320
PHO86P469561EBI-38020,EBI-13337
PHO88P382641EBI-38020,EBI-13350
PIS1P061971EBI-38020,EBI-13458
PKR1Q038801EBI-38020,EBI-27252
PLM2Q043831EBI-38020,EBI-2079237
PPZ1P265701EBI-38020,EBI-13807
PST2Q123351EBI-38020,EBI-14064
RTN2Q124431EBI-38020,EBI-32591
SAC1P323681EBI-38020,EBI-16210
SCS7Q035291EBI-38020,EBI-16747
SEY1Q992871EBI-38020,EBI-37523
SHR3Q027741EBI-38020,EBI-17099
SIS2P360241EBI-38020,EBI-17250
SLA2P333381EBI-38020,EBI-17323
SLC1P333331EBI-38020,EBI-13494
SNA3P143591EBI-38020,EBI-26122
SNL1P405481EBI-38020,EBI-24950
SOP4P395431EBI-38020,EBI-26193
SPC1P469651EBI-38020,EBI-17823
SPC2Q049691EBI-38020,EBI-27827
SPF1P399861EBI-38020,EBI-3128
SSH1P383531EBI-38020,EBI-18175
STE24P471541EBI-38020,EBI-18298
SUR2P389921EBI-38020,EBI-18574
SWP1Q027951EBI-38020,EBI-12666
SYP1P256231EBI-38020,EBI-21900
TCB3Q036401EBI-38020,EBI-27872
TPO4Q122561EBI-38020,EBI-37213
TVP15Q038601EBI-38020,EBI-37537
URA7P282741EBI-38020,EBI-20128
VHS2P404631EBI-38020,EBI-25234
VHS3Q084381EBI-38020,EBI-30482
WBP1P337671EBI-38020,EBI-12658
YDC1Q028961EBI-38020,EBI-22203
YOP1Q124021EBI-38020,EBI-37092
YPC1P382981EBI-38020,EBI-2103141

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Reticulon-like protein 1
PRO_0000168168

Regions

Topological domain1 – 5050Cytoplasmic Potential
Transmembrane51 – 7323 Potential
Topological domain74 – 14269Lumenal Potential
Transmembrane143 – 16321 Potential
Topological domain164 – 295132Cytoplasmic Potential
Domain20 – 220201Reticulon
Coiled coil265 – 29531 Potential
Compositional bias9 – 168Poly-Gln

Amino acid modifications

Modified residue1861Phosphothreonine Ref.8 Ref.9
Modified residue2191Phosphothreonine Ref.8
Modified residue2301Phosphothreonine Ref.9
Modified residue2321Phosphoserine Ref.9
Modified residue2341Phosphoserine Ref.9
Modified residue2651Phosphoserine Ref.9
Modified residue2671Phosphothreonine Ref.9
Modified residue2761Phosphoserine Ref.9

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Sequences

Sequence LengthMass (Da)Tools
Q04947-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 245575E65D3C2193

FASTA29532,916
        10         20         30         40         50         60 
MSASAQHSQA QQQQQQKSCN CDLLLWRNPV QTGKYFGGSL LALLILKKVN LITFFLKVAY 

        70         80         90        100        110        120 
TILFTTGSIE FVSKLFLGQG LITKYGPKEC PNIAGFIKPH IDEALKQLPV FQAHIRKTVF 

       130        140        150        160        170        180 
AQVPKHTFKT AVALFLLHKF FSWFSIWTIV FVADIFTFTL PVIYHSYKHE IDATVAQGVE 

       190        200        210        220        230        240 
ISKQKTQEFS QMACEKTKPY LDKVESKLGP ISNLVKSKTA PVSSTAGPQT ASTSKLAADV 

       250        260        270        280        290 
PLEPESKAYT SSAQVMPEVP QHEPSTTQEF NVDELSNELK KSTKNLQNEL EKNNA

« Hide

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References

« Hide 'large scale' references
[1]"A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family."
Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.
FASEB J. 17:1238-1247(2003) [PubMed: 12832288] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Bienvenut W.V., Peters C.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-27; 219-247 AND 285-295, MASS SPECTROMETRY.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[8]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186 AND THR-219, MASS SPECTROMETRY.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-186; THR-230; SER-232; SER-234; SER-265; THR-267 AND SER-276, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AY164798 mRNA. Translation: AAP47373.1.
Z48612 Genomic DNA. Translation: CAA88512.1.
AY558579 Genomic DNA. Translation: AAS56905.1.
PIRS59439.
RefSeqNP_010519.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4090N.
IntActQ04947. 107 interactions.

Proteomic databases

PeptideAtlasQ04947.

Genome annotation databases

EnsemblYDR233C. Saccharomyces cerevisiae. [Contig view]
GeneID851819.
GenomeReviewsGene locus YDR233C in contig Z71256_GR.
KEGGsce:YDR233C.
NMPDRfig|4932.3.peg.1276.

Organism-specific databases

CYGDYDR233c.
SGDS000002641. RTN1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ04947.
OMAQ04947. CDLLLWR.

Gene expression databases

ArrayExpressQ04947.
GermOnlineYDR233C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003388. Reticulon.
[Graphical view]
PANTHERPTHR10994. Reticulon. 1 hit.
PfamPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio969686.

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Entry information

Entry nameRTN1_YEAST
AccessionPrimary (citable) accession number: Q04947
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents