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Protein

Reticulon-like protein 1

Gene

RTN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • endoplasmic reticulum inheritance Source: SGD
  • endoplasmic reticulum organization Source: UniProtKB
  • endoplasmic reticulum tubular network maintenance Source: SGD
  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • ER-dependent peroxisome organization Source: SGD
  • nuclear pore complex assembly Source: SGD
  • response to endoplasmic reticulum stress Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29810-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-like protein 1
Gene namesi
Name:RTN1
Ordered Locus Names:YDR233C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR233C.
SGDiS000002641. RTN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 73HelicalSequence analysisAdd BLAST23
Topological domaini74 – 142LumenalSequence analysisAdd BLAST69
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 295CytoplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: SGD
  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum tubular network Source: UniProtKB
  • Golgi apparatus Source: SGD
  • integral component of cytoplasmic side of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681681 – 295Reticulon-like protein 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphothreonineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04947.
PRIDEiQ04947.
TopDownProteomicsiQ04947.

PTM databases

iPTMnetiQ04947.

Interactioni

Subunit structurei

Interacts with POM33.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEY1Q992872EBI-38020,EBI-37523

Protein-protein interaction databases

BioGridi32284. 119 interactors.
DIPiDIP-4090N.
IntActiQ04947. 15 interactors.
MINTiMINT-510849.

Structurei

3D structure databases

ProteinModelPortaliQ04947.
SMRiQ04947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 220ReticulonPROSITE-ProRule annotationAdd BLAST201

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili265 – 295Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 16Poly-Gln8

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000066264.
HOGENOMiHOG000248018.
InParanoidiQ04947.
OMAiGASKFPD.
OrthoDBiEOG092C4TX2.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASAQHSQA QQQQQQKSCN CDLLLWRNPV QTGKYFGGSL LALLILKKVN
60 70 80 90 100
LITFFLKVAY TILFTTGSIE FVSKLFLGQG LITKYGPKEC PNIAGFIKPH
110 120 130 140 150
IDEALKQLPV FQAHIRKTVF AQVPKHTFKT AVALFLLHKF FSWFSIWTIV
160 170 180 190 200
FVADIFTFTL PVIYHSYKHE IDATVAQGVE ISKQKTQEFS QMACEKTKPY
210 220 230 240 250
LDKVESKLGP ISNLVKSKTA PVSSTAGPQT ASTSKLAADV PLEPESKAYT
260 270 280 290
SSAQVMPEVP QHEPSTTQEF NVDELSNELK KSTKNLQNEL EKNNA
Length:295
Mass (Da):32,916
Last modified:November 1, 1996 - v1
Checksum:i245575E65D3C2193
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164798 mRNA. Translation: AAP47373.1.
Z48612 Genomic DNA. Translation: CAA88512.1.
AY558579 Genomic DNA. Translation: AAS56905.1.
BK006938 Genomic DNA. Translation: DAA12074.1.
PIRiS59439.
RefSeqiNP_010519.3. NM_001180541.3.

Genome annotation databases

EnsemblFungiiYDR233C; YDR233C; YDR233C.
GeneIDi851819.
KEGGisce:YDR233C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164798 mRNA. Translation: AAP47373.1.
Z48612 Genomic DNA. Translation: CAA88512.1.
AY558579 Genomic DNA. Translation: AAS56905.1.
BK006938 Genomic DNA. Translation: DAA12074.1.
PIRiS59439.
RefSeqiNP_010519.3. NM_001180541.3.

3D structure databases

ProteinModelPortaliQ04947.
SMRiQ04947.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32284. 119 interactors.
DIPiDIP-4090N.
IntActiQ04947. 15 interactors.
MINTiMINT-510849.

PTM databases

iPTMnetiQ04947.

Proteomic databases

MaxQBiQ04947.
PRIDEiQ04947.
TopDownProteomicsiQ04947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR233C; YDR233C; YDR233C.
GeneIDi851819.
KEGGisce:YDR233C.

Organism-specific databases

EuPathDBiFungiDB:YDR233C.
SGDiS000002641. RTN1.

Phylogenomic databases

GeneTreeiENSGT00530000066264.
HOGENOMiHOG000248018.
InParanoidiQ04947.
OMAiGASKFPD.
OrthoDBiEOG092C4TX2.

Enzyme and pathway databases

BioCyciYEAST:G3O-29810-MONOMER.

Miscellaneous databases

PROiQ04947.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN1_YEAST
AccessioniPrimary (citable) accession number: Q04947
Secondary accession number(s): D6VSL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 37105 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.