Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transduction histidine-protein kinase AfsQ2

Gene

afsQ2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. May activate AfsQ1 by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase AfsQ2 (EC:2.7.13.3)
Gene namesi
Name:afsQ2
Ordered Locus Names:SCO4906
ORF Names:2SCK8.32c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 52HelicalSequence analysisAdd BLAST22
Topological domaini53 – 198ExtracellularSequence analysisAdd BLAST146
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 535CytoplasmicSequence analysisAdd BLAST316

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746831 – 535Signal transduction histidine-protein kinase AfsQ2Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294PhosphohistidineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4906.

Structurei

3D structure databases

ProteinModelPortaliQ04943.
SMRiQ04943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 276HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini291 – 510Histidine kinasePROSITE-ProRule annotationAdd BLAST220

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41065SU. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
InParanoidiQ04943.
KOiK07654.
OMAiMEVTRFD.
OrthoDBiPOG091H06SL.
PhylomeDBiQ04943.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTREHQGGTR GLAAARKGFW SGLRFTSLRL RLVLVFGLVA LTAAVSASGI
60 70 80 90 100
AYWLNREAVL TRTQDAVLRD FEQEMQNRAG ALPEHPTQDE VQHTAGQMAN
110 120 130 140 150
SSQRFSVLLV AENADGTAVY GSSGGLGGVA LSDVPESLRT AVNKEQKLTS
160 170 180 190 200
ANKHPYHLYW QRITDDGTPY LVAGTKVIGG GPTGYMLKSL EPEAKDLNSL
210 220 230 240 250
AWSLGIATAL ALLGSALLAQ ALATTVLKPV HRLGVAARRL GEGKLDTRLR
260 270 280 290 300
VSGTDELADL SRTFNSAAEN LEKRVADMAG REQASRRFVA DMSHELRTPL
310 320 330 340 350
TALTAVTEVL EEELEYAGEG EGEGGSFDPM VEPAVRLVVS ETRRLNDLVE
360 370 380 390 400
NLMEVTRFDA GTARLVLDDV DVADQITACI DARAWLDAVD LDAERGVHAR
410 420 430 440 450
LDPRRLDVIL ANLIGNALKH GGSPVRVSVA RADHEIVIRV RDNGPGIPED
460 470 480 490 500
VLPHVFDRFY KASASRPRSE GSGLGLSIAL ENAHIHGGEI TAENAPEGGA
510 520 530
VFTLRLPQDP SPPADEDGGP DEETEDRGKD AKGQV
Length:535
Mass (Da):57,425
Last modified:June 1, 1994 - v1
Checksum:iD2D02CD5568AF73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10654 Genomic DNA. Translation: BAA01503.1.
AL939121 Genomic DNA. Translation: CAC33071.1.
PIRiB45270.
RefSeqiNP_629059.1. NC_003888.3.
WP_003974067.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC33071; CAC33071; CAC33071.
GeneIDi1100347.
29660759.
KEGGisco:SCO4906.
PATRICifig|100226.15.peg.4985.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAFSQ2_STRCO
AccessioniPrimary (citable) accession number: Q04943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 7, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome