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Reviewed, UniProtKB/Swiss-Prot Q04943 (AFSQ2_STRCO)

Last modified February 9, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Signal transduction histidine-protein kinase afsQ2
    EC=2.7.13.3
Gene names
Name: afsQ2
Ordered Locus Names: SCO4906
ORF Names: 2SCK8.32c
OrganismStreptomyces coelicolor [Complete proteome] [HAMAP]
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

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Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Forms part of a two-component regulatory system afsQ1/afsQ2 involved in secondary metabolism. May activate afsQ1 by phosphorylation.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Contains 1 HAMP domain.

Contains 1 histidine kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Signal transduction histidine-protein kinase afsQ2
PRO_0000074683

Regions

Topological domain1 – 3030Cytoplasmic Potential
Transmembrane31 – 5222 Potential
Topological domain53 – 198146Extracellular Potential
Transmembrane199 – 21921 Potential
Topological domain220 – 535316Cytoplasmic Potential
Domain224 – 27653HAMP
Domain291 – 510220Histidine kinase

Amino acid modifications

Modified residue2941Phosphohistidine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q04943-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: D2D02CD5568AF73C

FASTA53557,425
        10         20         30         40         50         60 
MTREHQGGTR GLAAARKGFW SGLRFTSLRL RLVLVFGLVA LTAAVSASGI AYWLNREAVL 

        70         80         90        100        110        120 
TRTQDAVLRD FEQEMQNRAG ALPEHPTQDE VQHTAGQMAN SSQRFSVLLV AENADGTAVY 

       130        140        150        160        170        180 
GSSGGLGGVA LSDVPESLRT AVNKEQKLTS ANKHPYHLYW QRITDDGTPY LVAGTKVIGG 

       190        200        210        220        230        240 
GPTGYMLKSL EPEAKDLNSL AWSLGIATAL ALLGSALLAQ ALATTVLKPV HRLGVAARRL 

       250        260        270        280        290        300 
GEGKLDTRLR VSGTDELADL SRTFNSAAEN LEKRVADMAG REQASRRFVA DMSHELRTPL 

       310        320        330        340        350        360 
TALTAVTEVL EEELEYAGEG EGEGGSFDPM VEPAVRLVVS ETRRLNDLVE NLMEVTRFDA 

       370        380        390        400        410        420 
GTARLVLDDV DVADQITACI DARAWLDAVD LDAERGVHAR LDPRRLDVIL ANLIGNALKH 

       430        440        450        460        470        480 
GGSPVRVSVA RADHEIVIRV RDNGPGIPED VLPHVFDRFY KASASRPRSE GSGLGLSIAL 

       490        500        510        520        530 
ENAHIHGGEI TAENAPEGGA VFTLRLPQDP SPPADEDGGP DEETEDRGKD AKGQV

« Hide

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References

« Hide 'large scale' references
[1]"A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp."
Ishizuka H., Horinouchi S., Kieser H.M., Hopwood D.A., Beppu T.
J. Bacteriol. 174:7585-7594(1992) [PubMed: 1339426] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A3(2).
[2]"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)."
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. expand/collapse author list , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.
Nature 417:141-147(2002) [PubMed: 12000953] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-471 / A3(2) / M145.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10654 Genomic DNA. Translation: BAA01503.1.
AL939121 Genomic DNA. Translation: CAC33071.1.
PIRB45270.
RefSeqNP_629059.1.

3D structure databases

SMRQ04943. Positions 278-509.
ModBaseSearch...

Genome annotation databases

GeneID1100347.
KEGGsco:SCO4906.
NMPDRfig|100226.1.peg.4861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG695485.
OMALENAHIH.

Enzyme and pathway databases

BioCycSCOE100226:SCO4906-MONOMER.
BRENDA2.7.13.3. 1084.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR003660. HAMP_linker_domain.
IPR004358. Sig_transdc_His_kin-like_C.
IPR003661. Sig_transdc_His_kin_sub1_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PfamPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
PROSITEPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAFSQ2_STRCO
AccessionPrimary (citable) accession number: Q04943
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 9, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents