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Protein

Transcriptional regulatory protein AfsQ1

Gene

afsQ1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 223100OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein AfsQ1
Gene namesi
Name:afsQ1
Ordered Locus Names:SCO4907
ORF Names:2SCK8.33c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 521D → E: Loss of protein's ability to stimulate antibiotic production and pigmentation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Transcriptional regulatory protein AfsQ1PRO_0000080993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 5214-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by AfsQ2.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ04942.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4907.

Structurei

3D structure databases

ProteinModelPortaliQ04942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 116114Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108KXV. Bacteria.
ENOG4111MTR. LUCA.
HOGENOMiHOG000034819.
InParanoidiQ04942.
OMAiKTGLEIC.
OrthoDBiPOG091H02GJ.
PhylomeDBiQ04942.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLLIEDD DAIRTALELS LTRQGHRVAT AASGEDGLKL LREQRPDLIV
60 70 80 90 100
LDVMLPGIDG FEVCRRIRRT DQLPIILLTA RNDDIDVVVG LESGADDYVV
110 120 130 140 150
KPVQGRVLDA RIRAVLRRGE RESTDSASFG SLVIDRSAMT VTKNGEDLQL
160 170 180 190 200
TPTELRLLLE LSRRPGQALS RQQLLRLVWE HDYLGDSRLV DACVQRLRAK
210 220
VEDVPSSPTL IRTVRGVGYR LDPPQ
Length:225
Mass (Da):25,107
Last modified:October 18, 2001 - v2
Checksum:i2834669A9F3F1E3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111D → E in BAA01502 (PubMed:1339426).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10654 Genomic DNA. Translation: BAA01502.1.
AL939121 Genomic DNA. Translation: CAC33072.1.
PIRiA45270.
RefSeqiNP_629060.1. NC_003888.3.
WP_003974066.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC33072; CAC33072; CAC33072.
GeneIDi1100348.
KEGGisco:SCO4907.
PATRICi23739652. VBIStrCoe124346_4986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10654 Genomic DNA. Translation: BAA01502.1.
AL939121 Genomic DNA. Translation: CAC33072.1.
PIRiA45270.
RefSeqiNP_629060.1. NC_003888.3.
WP_003974066.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ04942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4907.

Proteomic databases

PRIDEiQ04942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC33072; CAC33072; CAC33072.
GeneIDi1100348.
KEGGisco:SCO4907.
PATRICi23739652. VBIStrCoe124346_4986.

Phylogenomic databases

eggNOGiENOG4108KXV. Bacteria.
ENOG4111MTR. LUCA.
HOGENOMiHOG000034819.
InParanoidiQ04942.
OMAiKTGLEIC.
OrthoDBiPOG091H02GJ.
PhylomeDBiQ04942.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAFSQ1_STRCO
AccessioniPrimary (citable) accession number: Q04942
Secondary accession number(s): Q9AK20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 18, 2001
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.