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Protein

Transcriptional regulatory protein AfsQ1

Gene

afsQ1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi124 – 223OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein AfsQ1
Gene namesi
Name:afsQ1
Ordered Locus Names:SCO4907
ORF Names:2SCK8.33c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52D → E: Loss of protein's ability to stimulate antibiotic production and pigmentation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809931 – 225Transcriptional regulatory protein AfsQ1Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei524-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by AfsQ2.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ04942

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4907

Structurei

3D structure databases

ProteinModelPortaliQ04942
SMRiQ04942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST114

Phylogenomic databases

eggNOGiENOG4108KXV Bacteria
ENOG4111MTR LUCA
HOGENOMiHOG000034819
InParanoidiQ04942
OMAiVDWQADG
OrthoDBiPOG091H02GJ
PhylomeDBiQ04942

Family and domain databases

CDDicd00156 REC, 1 hit
cd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001867 OmpR/PhoB-type_DNA-bd
IPR001789 Sig_transdc_resp-reg_receiver
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q04942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLLIEDD DAIRTALELS LTRQGHRVAT AASGEDGLKL LREQRPDLIV
60 70 80 90 100
LDVMLPGIDG FEVCRRIRRT DQLPIILLTA RNDDIDVVVG LESGADDYVV
110 120 130 140 150
KPVQGRVLDA RIRAVLRRGE RESTDSASFG SLVIDRSAMT VTKNGEDLQL
160 170 180 190 200
TPTELRLLLE LSRRPGQALS RQQLLRLVWE HDYLGDSRLV DACVQRLRAK
210 220
VEDVPSSPTL IRTVRGVGYR LDPPQ
Length:225
Mass (Da):25,107
Last modified:October 18, 2001 - v2
Checksum:i2834669A9F3F1E3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → E in BAA01502 (PubMed:1339426).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10654 Genomic DNA Translation: BAA01502.1
AL939121 Genomic DNA Translation: CAC33072.1
PIRiA45270
RefSeqiNP_629060.1, NC_003888.3
WP_003974066.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAC33072; CAC33072; CAC33072
GeneIDi1100348
29660760
KEGGisco:SCO4907
PATRICifig|100226.15.peg.4986

Similar proteinsi

Entry informationi

Entry nameiAFSQ1_STRCO
AccessioniPrimary (citable) accession number: Q04942
Secondary accession number(s): Q9AK20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 18, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome