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Q04917

- 1433F_HUMAN

UniProt

Q04917 - 1433F_HUMAN

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Protein
14-3-3 protein eta
Gene
YWHAH, YWHA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 571Interaction with phosphoserine on interacting protein
Sitei132 – 1321Interaction with phosphoserine on interacting protein

GO - Molecular functioni

  1. enzyme binding Source: BHF-UCL
  2. glucocorticoid receptor binding Source: UniProtKB
  3. insulin-like growth factor receptor binding Source: UniProtKB
  4. ion channel binding Source: BHF-UCL
  5. protein binding Source: UniProtKB
  6. protein domain specific binding Source: UniProtKB
  7. protein heterodimerization activity Source: BHF-UCL
  8. sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  1. apoptotic process Source: Reactome
  2. glucocorticoid catabolic process Source: UniProtKB
  3. glucocorticoid receptor signaling pathway Source: UniProtKB
  4. intracellular protein transport Source: UniProtKB
  5. intrinsic apoptotic signaling pathway Source: Reactome
  6. membrane depolarization during action potential Source: BHF-UCL
  7. membrane organization Source: Reactome
  8. negative regulation of dendrite morphogenesis Source: UniProtKB
  9. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
  10. positive regulation of transcription, DNA-templated Source: UniProtKB
  11. regulation of neuron differentiation Source: UniProtKB
  12. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  13. regulation of sodium ion transport Source: BHF-UCL
  14. regulation of synaptic plasticity Source: UniProtKB
  15. substantia nigra development Source: UniProt
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
SignaLinkiQ04917.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein eta
Alternative name(s):
Protein AS1
Gene namesi
Name:YWHAH
Synonyms:YWHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:12853. YWHAH.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle membrane Source: Reactome
  3. cytosol Source: Reactome
  4. extracellular vesicular exosome Source: UniProtKB
  5. intercalated disc Source: BHF-UCL
  6. plasma membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 24624514-3-3 protein eta
PRO_0000058623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei59 – 591Phosphoserine By similarity

Post-translational modificationi

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04917.
PaxDbiQ04917.
PeptideAtlasiQ04917.
PRIDEiQ04917.

PTM databases

PhosphoSiteiQ04917.

Expressioni

Tissue specificityi

Expressed mainly in the brain and present in other tissues albeit at lower levels.

Gene expression databases

ArrayExpressiQ04917.
BgeeiQ04917.
CleanExiHS_YWHAH.
GenevestigatoriQ04917.

Organism-specific databases

HPAiCAB025918.

Interactioni

Subunit structurei

Homodimer By similarity. Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 By similarity. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 By similarity. Interacts with the 'Ser-241' phosphorylated form of PDPK1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1S1Q96B363EBI-306940,EBI-720593
CAMKK1Q8N5S95EBI-306940,EBI-6424030
CDC25BP303053EBI-306940,EBI-1051746
CDK14O949213EBI-306940,EBI-1043945
CSNK1A1P678288EBI-306940,EBI-7540603From a different organism.
GREM1O605655EBI-306940,EBI-944395
HDAC4P565243EBI-306940,EBI-308629
KANK1Q14678-23EBI-306940,EBI-6173812
LRRK2Q5S0073EBI-306940,EBI-5323863
MARK2Q7KZI78EBI-306940,EBI-516560
MARK3P274484EBI-306940,EBI-707595
MARK4Q96L346EBI-306940,EBI-302319
PARD3Q8TEW06EBI-306940,EBI-81968
PARD6AQ9NPB62EBI-306940,EBI-81876
PARD6BQ9BYG52EBI-306940,EBI-295391
PARD6GQ9BYG42EBI-306940,EBI-295417
PRKCIP417433EBI-306940,EBI-286199
RAF1P040493EBI-306940,EBI-365996
Rnd3P615882EBI-306940,EBI-6930266From a different organism.

Protein-protein interaction databases

BioGridi113365. 119 interactions.
DIPiDIP-27566N.
IntActiQ04917. 145 interactions.
MINTiMINT-124456.
STRINGi9606.ENSP00000248975.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1613
Helixi20 – 3112
Helixi39 – 7335
Helixi76 – 10631
Turni107 – 1115
Helixi117 – 13721
Helixi140 – 16425
Helixi170 – 18516
Helixi190 – 20617
Helixi207 – 2104
Turni213 – 2153
Helixi216 – 23419

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C63X-ray2.15A/B/C/D2-246[»]
2C74X-ray2.70A/B2-246[»]
ProteinModelPortaliQ04917.
SMRiQ04917. Positions 3-235.

Miscellaneous databases

EvolutionaryTraceiQ04917.

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.

Phylogenomic databases

eggNOGiCOG5040.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ04917.
KOiK16198.
OMAiESSEAAY.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ04917.
TreeFamiTF102003.

Family and domain databases

Gene3Di1.20.190.20. 1 hit.
InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04917-1 [UniParc]FASTAAdd to Basket

« Hide

MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK    50
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV 100
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS 150
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA 200
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN 246
Length:246
Mass (Da):28,219
Last modified:January 23, 2007 - v4
Checksum:iD70FBC100C45D6E5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441N → T in CAA40620. 1 Publication
Sequence conflicti157 – 1571A → G in AAA35483. 1 Publication
Sequence conflicti237 – 2371Q → L in AAA35483. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20422 mRNA. Translation: AAA35483.1.
X80536 Genomic DNA. Translation: CAA56676.1.
X78138 mRNA. Translation: CAA55017.1.
X57345 mRNA. Translation: CAA40620.1.
D78577 Genomic DNA. Translation: BAA11418.1.
S80794 mRNA. Translation: AAB36036.1.
CR456612 mRNA. Translation: CAG30498.1.
Z82248 Genomic DNA. Translation: CAB05112.1.
BC003047 mRNA. Translation: AAH03047.1.
CCDSiCCDS13901.1.
PIRiS34756.
S38509.
S38532.
RefSeqiNP_003396.1. NM_003405.3.
UniGeneiHs.226755.

Genome annotation databases

EnsembliENST00000248975; ENSP00000248975; ENSG00000128245.
GeneIDi7533.
KEGGihsa:7533.
UCSCiuc003alz.3. human.

Polymorphism databases

DMDMi1345593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20422 mRNA. Translation: AAA35483.1 .
X80536 Genomic DNA. Translation: CAA56676.1 .
X78138 mRNA. Translation: CAA55017.1 .
X57345 mRNA. Translation: CAA40620.1 .
D78577 Genomic DNA. Translation: BAA11418.1 .
S80794 mRNA. Translation: AAB36036.1 .
CR456612 mRNA. Translation: CAG30498.1 .
Z82248 Genomic DNA. Translation: CAB05112.1 .
BC003047 mRNA. Translation: AAH03047.1 .
CCDSi CCDS13901.1.
PIRi S34756.
S38509.
S38532.
RefSeqi NP_003396.1. NM_003405.3.
UniGenei Hs.226755.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2C63 X-ray 2.15 A/B/C/D 2-246 [» ]
2C74 X-ray 2.70 A/B 2-246 [» ]
ProteinModelPortali Q04917.
SMRi Q04917. Positions 3-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113365. 119 interactions.
DIPi DIP-27566N.
IntActi Q04917. 145 interactions.
MINTi MINT-124456.
STRINGi 9606.ENSP00000248975.

PTM databases

PhosphoSitei Q04917.

Polymorphism databases

DMDMi 1345593.

Proteomic databases

MaxQBi Q04917.
PaxDbi Q04917.
PeptideAtlasi Q04917.
PRIDEi Q04917.

Protocols and materials databases

DNASUi 7533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248975 ; ENSP00000248975 ; ENSG00000128245 .
GeneIDi 7533.
KEGGi hsa:7533.
UCSCi uc003alz.3. human.

Organism-specific databases

CTDi 7533.
GeneCardsi GC22P032340.
HGNCi HGNC:12853. YWHAH.
HPAi CAB025918.
MIMi 113508. gene.
neXtProti NX_Q04917.
PharmGKBi PA37442.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5040.
HOGENOMi HOG000240379.
HOVERGENi HBG050423.
InParanoidi Q04917.
KOi K16198.
OMAi ESSEAAY.
OrthoDBi EOG7HHWT3.
PhylomeDBi Q04917.
TreeFami TF102003.

Enzyme and pathway databases

Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
SignaLinki Q04917.

Miscellaneous databases

ChiTaRSi YWHAH. human.
EvolutionaryTracei Q04917.
GeneWikii YWHAH.
GenomeRNAii 7533.
NextBioi 29471.
PROi Q04917.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q04917.
Bgeei Q04917.
CleanExi HS_YWHAH.
Genevestigatori Q04917.

Family and domain databases

Gene3Di 1.20.190.20. 1 hit.
InterProi IPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view ]
PANTHERi PTHR18860. PTHR18860. 1 hit.
Pfami PF00244. 14-3-3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000868. 14-3-3. 1 hit.
PRINTSi PR00305. 1433ZETA.
SMARTi SM00101. 14_3_3. 1 hit.
[Graphical view ]
SUPFAMi SSF48445. SSF48445. 1 hit.
PROSITEi PS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions."
    Swanson K.D., Dhar M.S., Joshi J.G.
    Biochim. Biophys. Acta 1216:145-148(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain."
    Ichimura-Ohshima Y., Morii K., Ichimura T., Araki K., Takahashi Y., Isobe T., Minoshima S., Fukuyama R., Shimizu N., Kuwano R.
    J. Neurosci. Res. 31:600-605(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  3. Leffers H., Tommerup N., Celis J.E.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells."
    Muratake T., Hayashi S., Ichimura Y., Morii K., Kuwano R., Ichikawa T., Kumanishi T., Isobe T., Watanabe M., Kondo H.
    Mol. Neurobiol. 11:223-230(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH)."
    Muratake T., Hayashi S., Ichikawa T., Kumanishi T., Ichimura Y., Kuwano R., Isobe T., Wang Y., Minoshima S., Shimizu N., Takahashi Y.
    Genomics 36:63-69(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  9. "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway."
    Leffers H., Madsen P., Rasmussen H.H., Honore B., Andersen A.H., Walbum E., Vandekerckhove J., Celis J.E.
    J. Mol. Biol. 231:982-998(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-225.
    Tissue: Keratinocyte.
  10. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10.
    Tissue: Platelet.
  11. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10; 29-50; 62-69; 126-132; 144-155; 163-172 AND 218-227, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  12. "Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140."
    Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J.-A.
    Mol. Endocrinol. 15:501-511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AR; ESR1; ESR2; MC2R; NRIP1; NR3C1; PPARBP AND THRA.
  13. "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3."
    Sato S., Fujita N., Tsuruo T.
    J. Biol. Chem. 277:39360-39367(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PDPK1.
  14. "Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization."
    Fujita N., Sato S., Tsuruo T.
    J. Biol. Chem. 278:49254-49260(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDKN1B.
  15. "JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage."
    Yoshida K., Yamaguchi T., Natsume T., Kufe D., Miki Y.
    Nat. Cell Biol. 7:278-285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ABL1, IDENTIFICATION BY MASS SPECTROMETRY.
  16. "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
    Brummer T., Larance M., Herrera Abreu M.T., Lyons R.J., Timpson P., Emmerich C.H., Fleuren E.D.G., Lehrbach G.M., Schramek D., Guilhaus M., James D.E., Daly R.J.
    EMBO J. 27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GAB2.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH PHOSPHOSERINE MOTIFS, SUBUNIT.

Entry informationi

Entry namei1433F_HUMAN
AccessioniPrimary (citable) accession number: Q04917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 162 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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