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Protein

14-3-3 protein eta

Gene

YWHAH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glucocorticoid receptor binding Source: UniProtKB
  • insulin-like growth factor receptor binding Source: UniProtKB
  • ion channel binding Source: BHF-UCL
  • protein domain specific binding Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128245-MONOMER.
ReactomeiR-HSA-111447. Activation of BAD and translocation to mitochondria.
R-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkiQ04917.
SIGNORiQ04917.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein eta
Alternative name(s):
Protein AS1
Gene namesi
Name:YWHAH
Synonyms:YWHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:12853. YWHAH.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle membrane Source: Reactome
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • intercalated disc Source: BHF-UCL
  • mitochondrion Source: GOC
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7533.
OpenTargetsiENSG00000128245.
PharmGKBiPA37442.

Polymorphism and mutation databases

BioMutaiYWHAH.
DMDMi1345593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000586232 – 24614-3-3 protein etaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei25PhosphoserineCombined sources1
Modified residuei59PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ04917.
MaxQBiQ04917.
PaxDbiQ04917.
PeptideAtlasiQ04917.
PRIDEiQ04917.
TopDownProteomicsiQ04917.

PTM databases

iPTMnetiQ04917.
PhosphoSitePlusiQ04917.
SwissPalmiQ04917.

Expressioni

Tissue specificityi

Expressed mainly in the brain and present in other tissues albeit at lower levels.

Gene expression databases

BgeeiENSG00000128245.
CleanExiHS_YWHAH.
ExpressionAtlasiQ04917. baseline and differential.
GenevisibleiQ04917. HS.

Organism-specific databases

HPAiCAB025918.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).By similarity8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction with phosphoserine on interacting protein1
Sitei132Interaction with phosphoserine on interacting protein1

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1S1Q96B363EBI-306940,EBI-720593
CAMKK1Q8N5S95EBI-306940,EBI-6424030
CDC25BP303054EBI-306940,EBI-1051746
CDK14O949213EBI-306940,EBI-1043945
CSNK1A1P678288EBI-306940,EBI-7540603From a different organism.
GREM1O605655EBI-306940,EBI-944395
HDAC4P565244EBI-306940,EBI-308629
KANK1Q14678-23EBI-306940,EBI-6173812
LRRK2Q5S0073EBI-306940,EBI-5323863
MARK2Q7KZI78EBI-306940,EBI-516560
MARK3P274484EBI-306940,EBI-707595
MARK4Q96L346EBI-306940,EBI-302319
PARD3Q8TEW06EBI-306940,EBI-81968
PARD6AQ9NPB62EBI-306940,EBI-81876
PARD6BQ9BYG53EBI-306940,EBI-295391
PARD6GQ9BYG42EBI-306940,EBI-295417
PRKCIP417433EBI-306940,EBI-286199
RAF1P040496EBI-306940,EBI-365996
Rnd3P615882EBI-306940,EBI-6930266From a different organism.
SNCAP37840-19EBI-306940,EBI-9684465

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • glucocorticoid receptor binding Source: UniProtKB
  • insulin-like growth factor receptor binding Source: UniProtKB
  • ion channel binding Source: BHF-UCL
  • protein domain specific binding Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi113365. 195 interactors.
DIPiDIP-27566N.
IntActiQ04917. 209 interactors.
MINTiMINT-124456.
STRINGi9606.ENSP00000248975.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi20 – 31Combined sources12
Helixi39 – 73Combined sources35
Helixi76 – 106Combined sources31
Turni107 – 111Combined sources5
Helixi117 – 137Combined sources21
Helixi140 – 164Combined sources25
Helixi170 – 185Combined sources16
Helixi190 – 206Combined sources17
Helixi207 – 210Combined sources4
Turni213 – 215Combined sources3
Helixi216 – 234Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C63X-ray2.15A/B/C/D2-246[»]
2C74X-ray2.70A/B2-246[»]
ProteinModelPortaliQ04917.
SMRiQ04917.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04917.

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ04917.
KOiK16198.
OMAiVCQDVLT.
OrthoDBiEOG091G0VKY.
PhylomeDBiQ04917.
TreeFamiTF102003.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV
110 120 130 140 150
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS
160 170 180 190 200
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
Length:246
Mass (Da):28,219
Last modified:January 23, 2007 - v4
Checksum:iD70FBC100C45D6E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144N → T in CAA40620 (PubMed:8515476).Curated1
Sequence conflicti157A → G in AAA35483 (PubMed:8218406).Curated1
Sequence conflicti237Q → L in AAA35483 (PubMed:8218406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20422 mRNA. Translation: AAA35483.1.
X80536 Genomic DNA. Translation: CAA56676.1.
X78138 mRNA. Translation: CAA55017.1.
X57345 mRNA. Translation: CAA40620.1.
D78577 Genomic DNA. Translation: BAA11418.1.
S80794 mRNA. Translation: AAB36036.1.
CR456612 mRNA. Translation: CAG30498.1.
Z82248 Genomic DNA. Translation: CAB05112.1.
BC003047 mRNA. Translation: AAH03047.1.
CCDSiCCDS13901.1.
PIRiS34756.
S38509.
S38532.
RefSeqiNP_003396.1. NM_003405.3.
UniGeneiHs.226755.

Genome annotation databases

EnsembliENST00000248975; ENSP00000248975; ENSG00000128245.
GeneIDi7533.
KEGGihsa:7533.
UCSCiuc003alz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20422 mRNA. Translation: AAA35483.1.
X80536 Genomic DNA. Translation: CAA56676.1.
X78138 mRNA. Translation: CAA55017.1.
X57345 mRNA. Translation: CAA40620.1.
D78577 Genomic DNA. Translation: BAA11418.1.
S80794 mRNA. Translation: AAB36036.1.
CR456612 mRNA. Translation: CAG30498.1.
Z82248 Genomic DNA. Translation: CAB05112.1.
BC003047 mRNA. Translation: AAH03047.1.
CCDSiCCDS13901.1.
PIRiS34756.
S38509.
S38532.
RefSeqiNP_003396.1. NM_003405.3.
UniGeneiHs.226755.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C63X-ray2.15A/B/C/D2-246[»]
2C74X-ray2.70A/B2-246[»]
ProteinModelPortaliQ04917.
SMRiQ04917.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113365. 195 interactors.
DIPiDIP-27566N.
IntActiQ04917. 209 interactors.
MINTiMINT-124456.
STRINGi9606.ENSP00000248975.

PTM databases

iPTMnetiQ04917.
PhosphoSitePlusiQ04917.
SwissPalmiQ04917.

Polymorphism and mutation databases

BioMutaiYWHAH.
DMDMi1345593.

Proteomic databases

EPDiQ04917.
MaxQBiQ04917.
PaxDbiQ04917.
PeptideAtlasiQ04917.
PRIDEiQ04917.
TopDownProteomicsiQ04917.

Protocols and materials databases

DNASUi7533.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248975; ENSP00000248975; ENSG00000128245.
GeneIDi7533.
KEGGihsa:7533.
UCSCiuc003alz.4. human.

Organism-specific databases

CTDi7533.
DisGeNETi7533.
GeneCardsiYWHAH.
HGNCiHGNC:12853. YWHAH.
HPAiCAB025918.
MIMi113508. gene.
neXtProtiNX_Q04917.
OpenTargetsiENSG00000128245.
PharmGKBiPA37442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ04917.
KOiK16198.
OMAiVCQDVLT.
OrthoDBiEOG091G0VKY.
PhylomeDBiQ04917.
TreeFamiTF102003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128245-MONOMER.
ReactomeiR-HSA-111447. Activation of BAD and translocation to mitochondria.
R-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkiQ04917.
SIGNORiQ04917.

Miscellaneous databases

ChiTaRSiYWHAH. human.
EvolutionaryTraceiQ04917.
GeneWikiiYWHAH.
GenomeRNAii7533.
PROiQ04917.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128245.
CleanExiHS_YWHAH.
ExpressionAtlasiQ04917. baseline and differential.
GenevisibleiQ04917. HS.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1433F_HUMAN
AccessioniPrimary (citable) accession number: Q04917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 187 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.