ID RON_HUMAN STANDARD; PRT; 1400 AA. AC Q04912; DT 01-OCT-1994 (Rel. 30, Created) DT 01-OCT-1994 (Rel. 30, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (EC 2.7.1.112) DE (MSP RECEPTOR) (P185-RON) (CDW136) (CD136 ANTIGEN). GN MST1R OR RON. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=KERATINOCYTES; RX MEDLINE; 93241719. RA Ronsin C., Muscatelli F., Mattei M.-G., Breathnach R.; RT "A novel putative receptor protein tyrosine kinase of the met RT family."; RL Oncogene 8:1195-1202(1993). RN [2] RP SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING. RX MEDLINE; 96413302. RA Collesi C., Santoro M.M., Gaudino G., Comoglio P.M.; RT "A splicing variant of the RON transcript induces constitutive RT tyrosine kinase activity and an invasive phenotype."; RL Mol. Cell. Biol. 16:5518-5526(1996). RN [3] RP FUNCTION. RX MEDLINE; 95025877. RA Wang M.-H., Ronsin C., Gesnel M.-C., Coupey L., Skeel A., RA Leonard E.J., Breatnach R.; RT "Identification of the ron gene product as the receptor for the human RT macrophage stimulating protein."; RL Science 266:117-119(1994). CC -!- FUNCTION: RECEPTOR FOR MACROPHAGE STIMULATING PROTEIN (MSP). HAS A CC TYROSINE-PROTEIN KINASE ACTIVITY. CC -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP + CC PROTEIN TYROSINE PHOSPHATE. CC -!- SUBUNIT: HETERODIMER FORMED OF AN ALPHA CHAIN AND A BETA CC CHAIN WHICH ARE DISULFIDE LINKED. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- ALTERNATIVE PRODUCTS: 2 ISOFORMS; ISOFORM RON (SHOWN HERE) AND CC ISOFORM DELTA-RON; ARE PRODUCED BY ALTERNATIVE SPLICING. DELTA-RON CC LACKS PART OF THE EXTRACELLULAR DOMAIN, OLIGOMERIZES AND IS CC CONSTITUTIVELY ACTIVATED. CC -!- TISSUE SPECIFICITY: KERATINOCYTES, AND LUNG. CC -!- PTM: THE TWO SUBUNITS ARE PROTEOLYTICALLY DERIVED. CC -!- PTM: PHOSPHORYLATED IN RESPONSE TO LIGAND BINDING (PROBABLE). CC -!- SIMILARITY: BELONGS TO THE MET TYROSINE KINASE FAMILY OF CC RECEPTORS. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CDw136 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cdw136.htm". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X70040; CAA49634.1; -. DR PIR; S31736; S31736. DR HSSP; P11362; 1FGI. DR MIM; 600168; -. DR INTERPRO; IPR000719; -. DR INTERPRO; IPR001245; -. DR INTERPRO; IPR001627; -. DR INTERPRO; IPR002165; -. DR INTERPRO; IPR002909; -. DR PFAM; PF01437; Plexin_repeat; 1. DR PFAM; PF01403; Sema; 1. DR PFAM; PF01833; TIG; 3. DR PFAM; PF00069; pkinase; 1. DR PRINTS; PR00109; TYRKINASE. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. KW Transferase; Tyrosine-protein kinase; Receptor; Transmembrane; KW Glycoprotein; Signal; Phosphorylation; ATP-binding; Polymorphism; KW Alternative splicing. FT SIGNAL 1 24 POTENTIAL. FT CHAIN 25 1400 MACROPHAGE-STIMULATING PROTEIN RECEPTOR. FT CHAIN 25 304 MSP RECEPTOR ALPHA CHAIN (POTENTIAL). FT CHAIN 310 1400 MSP RECEPTOR BETA CHAIN (POTENTIAL). FT DOMAIN 25 957 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 958 982 POTENTIAL. FT DOMAIN 983 1400 CYTOPLASMIC (POTENTIAL). FT DOMAIN 1082 1345 PROTEIN KINASE. FT NP_BIND 1088 1096 ATP (BY SIMILARITY). FT BINDING 1114 1114 ATP (BY SIMILARITY). FT ACT_SITE 1208 1208 BY SIMILARITY. FT MOD_RES 1353 1353 PHOSPHORYLATION (AUTO-) (BY SIMILARITY). FT MOD_RES 1360 1360 PHOSPHORYLATION (AUTO-) (BY SIMILARITY). FT CARBOHYD 66 66 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 419 419 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 458 458 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 488 488 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 654 654 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 720 720 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 841 841 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 897 897 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 884 932 MISSING (IN ISOFORM DELTA-RON). FT VARIANT 322 322 Q -> R. FT /FTId=VAR_006350. SQ SEQUENCE 1400 AA; 152227 MW; EE782D07E4D2568A CRC64; MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS PLGTRVTVVE QGQASYFYVA SSLDAAVAGS FSPRSVSIRR LKADASGFAP GFVALSVLPK HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC RFAPKRRRRG APEGGQPYPV LQVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCRHF LTCGRCLRAW HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG LALPAIDGLD STTCVHGASF SDSEDESCVP LLRKESIQLR DLDSALLAEV KDVLIPHERV VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH PNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM QQCWEADPAV RPTFRVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF SPMPGNVRRP RPLSEPPRPT //