ID   RON_HUMAN      STANDARD;      PRT;  1400 AA.
AC   Q04912;
DT   01-OCT-1994 (REL. 30, CREATED)
DT   01-OCT-1994 (REL. 30, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (EC 2.7.1.112)
DE   (MSP RECEPTOR) (P185-RON) (CD136 ANTIGEN).
GN   MST1R OR RON.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=KERATINOCYTES;
RX   MEDLINE; 93241719.
RA   RONSIN C., MUSCATELLI F., MATTEI M.-G., BREATHNACH R.;
RL   ONCOGENE 8:1195-1202(1993).
RN   [2]
RP   SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING.
RX   MEDLINE; 96413302.
RA   COLLESI C., SANTORO M.M., GAUDINO G., COMOGLIO P.M.;
RL   MOL. CELL. BIOL. 16:5518-5526(1996).
RN   [3]
RP   FUNCTION.
RX   MEDLINE; 95025877.
RA   WANG M.-H., RONSIN C., GESNEL M.-C., COUPEY L., SKEEL A.,
RA   LEONARD E.J., BREATNACH R.;
RL   SCIENCE 266:117-119(1994).
CC   -!- FUNCTION: RECEPTOR FOR MACROPHAGE STIMULATING PROTEIN (MSP). HAS A
CC       TYROSINE-PROTEIN KINASE ACTIVITY.
CC   -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP +
CC       PROTEIN TYROSINE PHOSPHATE.
CC   -!- SUBUNIT: HETERODIMER FORMED OF AN ALPHA CHAIN AND A BETA
CC       CHAIN WHICH ARE DISULFIDE LINKED.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN.
CC   -!- TISSUE SPECIFICITY: KERATINOCYTES, AND LUNG.
CC   -!- PTM: THE TWO SUBUNITS ARE PROTEOLYTICALLY DERIVED.
CC   -!- PTM: PHOSPHORYLATED IN RESPONSE TO LIGAND BINDING (PROBABLE).
CC   -!- ALTERNATIVE PRODUCTS: AN ALTERNATIVELY SPLICED FORM FOUND IN A
CC       GASTRIC CANCER CELL LINE AND CALLED DELTA-RON, LACKS PART OF THE
CC       EXTRACELLULAR DOMAIN, OLIGOMERIZE AND IS CONSTITUTIVELY ACTIVATED.
CC   -!- SIMILARITY: BELONGS TO THE MET TYROSINE KINASE FAMILY OF RECEPTOR.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CDw136 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cdw136.htm".
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DR   EMBL; X70040; G36110; -.
DR   PIR; S31736; S31736.
DR   MIM; 600168; -.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW   TRANSFERASE; TYROSINE-PROTEIN KINASE; RECEPTOR; TRANSMEMBRANE;
KW   GLYCOPROTEIN; SIGNAL; PHOSPHORYLATION; ATP-BINDING; POLYMORPHISM;
KW   ALTERNATIVE SPLICING.
FT   SIGNAL        1     24       POTENTIAL.
FT   CHAIN        25   1400       MACROPHAGE-STIMULATING PROTEIN RECEPTOR.
FT   CHAIN        25    304       MSP RECEPTOR ALPHA CHAIN (POTENTIAL).
FT   CHAIN       310   1400       MSP RECEPTOR BETA CHAIN (POTENTIAL).
FT   DOMAIN       25    957       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    958    982       POTENTIAL.
FT   DOMAIN      983   1400       CYTOPLASMIC (POTENTIAL).
FT   DOMAIN     1082   1345       PROTEIN KINASE.
FT   NP_BIND    1088   1096       ATP (BY SIMILARITY).
FT   BINDING    1114   1114       ATP (BY SIMILARITY).
FT   ACT_SITE   1208   1208       BY SIMILARITY.
FT   MOD_RES    1353   1353       PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
FT   MOD_RES    1360   1360       PHOSPHORYLATION (AUTO-) (BY SIMILARITY).
FT   CARBOHYD     66     66       POTENTIAL.
FT   CARBOHYD    419    419       POTENTIAL.
FT   CARBOHYD    458    458       POTENTIAL.
FT   CARBOHYD    488    488       POTENTIAL.
FT   CARBOHYD    654    654       POTENTIAL.
FT   CARBOHYD    720    720       POTENTIAL.
FT   CARBOHYD    841    841       POTENTIAL.
FT   CARBOHYD    897    897       POTENTIAL.
FT   VARSPLIC      ?      ?       MISSING (IN DELTA-RON).
FT   VARIANT     322    322       Q -> R.
SQ   SEQUENCE   1400 AA;  152227 MW;  E122777A CRC32;
     MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT
     YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT
     KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS
     PLGTRVTVVE QGQASYFYVA SSLDAAVAGS FSPRSVSIRR LKADASGFAP GFVALSVLPK
     HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC
     RFAPKRRRRG APEGGQPYPV LQVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV
     GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT
     SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL
     NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCRHF LTCGRCLRAW
     HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG
     LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT
     NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN
     GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG
     YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG
     NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV
     GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG
     ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG
     LALPAIDGLD STTCVHGASF SDSEDESCVP LLRKESIQLR DLDSALLAEV KDVLIPHERV
     VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH
     PNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA
     EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ
     TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM
     QQCWEADPAV RPTFRVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF
     SPMPGNVRRP RPLSEPPRPT
//