ID RON_HUMAN STANDARD; PRT; 1400 AA. AC Q04912; DT 01-OCT-1994 (Rel. 30, Created) DT 01-OCT-1994 (Rel. 30, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Macrophage-stimulating protein receptor precursor (EC 2.7.1.112) (MSP DE receptor) (p185-Ron) (CDW136) (CD136 antigen) [Contains: Macrophage- DE stimulating protein receptor alpha chain; Macrophage-stimulating DE protein receptor beta chain]. GN Name=MST1R; Synonyms=RON; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Keratinocyte; RX MEDLINE=93241719; PubMed=8386824; RA Ronsin C., Muscatelli F., Mattei M.-G., Breathnach R.; RT "A novel putative receptor protein tyrosine kinase of the met RT family."; RL Oncogene 8:1195-1202(1993). RN [2] RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING. RX MEDLINE=96413302; PubMed=8816464; RA Collesi C., Santoro M.M., Gaudino G., Comoglio P.M.; RT "A splicing variant of the RON transcript induces constitutive RT tyrosine kinase activity and an invasive phenotype."; RL Mol. Cell. Biol. 16:5518-5526(1996). RN [3] RP FUNCTION. RX MEDLINE=95025877; PubMed=7939629; RA Wang M.-H., Ronsin C., Gesnel M.-C., Coupey L., Skeel A., RA Leonard E.J., Breatnach R.; RT "Identification of the ron gene product as the receptor for the human RT macrophage stimulating protein."; RL Science 266:117-119(1994). RN [4] RP INTERACTION WITH PLXNB1. RX PubMed=15184888; DOI=10.1038/sj.onc.1207650; RA Conrotto P., Corso S., Gamberini S., Comoglio P.M., Giordano S.; RT "Interplay between scatter factor receptors and B plexins controls RT invasive growth."; RL Oncogene 23:5131-5137(2004). CC -!- FUNCTION: Receptor for macrophage stimulating protein (MSP). Has a CC tyrosine-protein kinase activity. CC -!- CATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + a protein CC tyrosine phosphate. CC -!- SUBUNIT: Heterodimer formed of an alpha chain and a beta chain CC which are disulfide linked. Binds PLXNB1. CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=RON; CC IsoId=Q04912-1; Sequence=Displayed; CC Name=Delta-RON; CC IsoId=Q04912-2; Sequence=VSP_005007; CC Note=Lacks part of the extracellular domain, oligomerizes and is CC constitutively activated; CC -!- TISSUE SPECIFICITY: Keratinocytes and lung. CC -!- PTM: Proteolytic processing yields the two subunits. CC -!- PTM: Phosphorylated in response to ligand binding (Probable). CC -!- SIMILARITY: Belongs to the Tyr protein kinase family. CC -!- SIMILARITY: Contains 3 IPT/TIG domains. CC -!- SIMILARITY: Contains 1 Sema domain. CC -!- DATABASE: NAME=Atlas Genet. Cytogenet. Oncol. Haematol.; CC WWW="http://www.infobiogen.fr/services/chromcancer/Genes/RONID287.html". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X70040; CAA49634.1; -; mRNA. DR PIR; I38185; I38185. DR HSSP; P11362; 1FGK. DR Ensembl; ENSG00000164078; Homo sapiens. DR HGNC; HGNC:7381; MST1R. DR MIM; 600168; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005011; F:macrophage colony stimulating factor recept...; TAS. DR GO; GO:0006928; P:cell motility; TAS. DR GO; GO:0006952; P:defense response; TAS. DR GO; GO:0007338; P:fertilization (sensu Metazoa); TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR002909; IPT/TIG_recept. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR001627; Sema. DR InterPro; IPR001245; Tyr_pkinase. DR InterPro; IPR008266; Tyr_pkinase_AS. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01403; Sema; 1. DR Pfam; PF01833; TIG; 3. DR PRINTS; PR00109; TYRKINASE. DR ProDom; PD000001; Prot_kinase; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS51004; SEMA; 1. KW Alternative splicing; ATP-binding; Glycoprotein; Kinase; KW Nucleotide-binding; Phosphorylation; Polymorphism; Receptor; Repeat; KW Signal; Transferase; Transmembrane; Tyrosine-protein kinase. FT SIGNAL 1 24 Potential. FT CHAIN 25 1400 Macrophage-stimulating protein receptor. FT CHAIN 25 304 Macrophage-stimulating protein receptor FT alpha chain (Potential). FT CHAIN 310 1400 Macrophage-stimulating protein receptor FT beta chain (Potential). FT TOPO_DOM 25 957 Extracellular (Potential). FT TRANSMEM 958 978 Potential. FT TOPO_DOM 979 1400 Cytoplasmic (Potential). FT DOMAIN 31 522 Sema. FT DOMAIN 569 671 IPT/TIG 1. FT DOMAIN 684 767 IPT/TIG 2. FT DOMAIN 770 860 IPT/TIG 3. FT DOMAIN 1082 1345 Protein kinase. FT NP_BIND 1088 1096 ATP (By similarity). FT ACT_SITE 1208 1208 Proton acceptor (By similarity). FT BINDING 1114 1114 ATP (By similarity). FT MOD_RES 1353 1353 Phosphotyrosine (by autocatalysis) (By FT similarity). FT MOD_RES 1360 1360 Phosphotyrosine (by autocatalysis) (By FT similarity). FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT CARBOHYD 419 419 N-linked (GlcNAc...) (Potential). FT CARBOHYD 458 458 N-linked (GlcNAc...) (Potential). FT CARBOHYD 488 488 N-linked (GlcNAc...) (Potential). FT CARBOHYD 654 654 N-linked (GlcNAc...) (Potential). FT CARBOHYD 720 720 N-linked (GlcNAc...) (Potential). FT CARBOHYD 841 841 N-linked (GlcNAc...) (Potential). FT CARBOHYD 897 897 N-linked (GlcNAc...) (Potential). FT VARSPLIC 884 932 Missing (in isoform Delta-RON). FT /FTId=VSP_005007. FT VARIANT 322 322 Q -> R. FT /FTId=VAR_006350. SQ SEQUENCE 1400 AA; 152227 MW; EE782D07E4D2568A CRC64; MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS PLGTRVTVVE QGQASYFYVA SSLDAAVAGS FSPRSVSIRR LKADASGFAP GFVALSVLPK HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC RFAPKRRRRG APEGGQPYPV LQVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCRHF LTCGRCLRAW HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG LALPAIDGLD STTCVHGASF SDSEDESCVP LLRKESIQLR DLDSALLAEV KDVLIPHERV VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH PNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM QQCWEADPAV RPTFRVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF SPMPGNVRRP RPLSEPPRPT //