Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

26S proteasome non-ATPase regulatory subunit 3

Gene

rpn-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 3
Alternative name(s):
26S proteasome regulatory subunit rpn-3
Gene namesi
Name:rpn-3
ORF Names:C30C11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC30C11.2; CE00101; WBGene00004460; rpn-3.

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738181 – 50426S proteasome non-ATPase regulatory subunit 3Add BLAST504

Proteomic databases

EPDiQ04908.
PaxDbiQ04908.
PeptideAtlasiQ04908.
PRIDEiQ04908.

Expressioni

Gene expression databases

BgeeiWBGene00004460.

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
dss-1Q95Y722EBI-312239,EBI-312245

Protein-protein interaction databases

BioGridi41400. 4 interactors.
DIPiDIP-25350N.
IntActiQ04908. 4 interactors.
MINTiMINT-211615.
STRINGi6239.C30C11.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ04908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 433PCIPROSITE-ProRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the proteasome subunit S3 family.Curated

Phylogenomic databases

eggNOGiKOG2581. Eukaryota.
ENOG410XS40. LUCA.
GeneTreeiENSGT00490000043406.
HOGENOMiHOG000193909.
InParanoidiQ04908.
KOiK03033.
OMAiAMRYPPK.
OrthoDBiEOG091G05QN.
PhylomeDBiQ04908.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013586. 26S_Psome_reg_C.
IPR000717. PCI_dom.
IPR035267. PSMD3.
IPR011990. TPR-like_helical_dom_sf.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PANTHERiPTHR10758:SF2. PTHR10758:SF2. 1 hit.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
PF08375. Rpn3_C. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50250. PCI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKTGETVV EKMEVDEAKQ DVPATEPAKD LNAIAVENIK EQLAALDKGE
60 70 80 90 100
EHLITRVLQV LPKTRKQIND NVLYKLVSSH LSSDAQFAEG MLKYLHYTPA
110 120 130 140 150
ADTEVQPMDT SNVKTKSPKK GVKPVFASPE SDCYLRLLVL LHLYAQKKNT
160 170 180 190 200
EALALGENQL TSIYNFDRRT LDGLAAKTLY FLCVIYEREG RLFDHQGFLN
210 220 230 240 250
SRLRTATLRN FSESQAVLIC WLLRCYLINR QYQSAAHLVS KVAFPDNASN
260 270 280 290 300
NDLARYMYYQ GRIKALQLDY NSAAGYFLQA QRKAPQEGAI GFKQAVQKWV
310 320 330 340 350
VVIGLLQGEI PDRSVFRQPI YRKCLAHYLD LSRGVRDGDV ARFNHNLEQF
360 370 380 390 400
KTQFEADDTL TLIVRLRQNV IKTAIKQISL AYSRIYIKDI AKKLYITNET
410 420 430 440 450
ETEYIVAKAI ADGAIDAVIT SDVRDGPRYM QSSETADIYR TSEPQAHFDT
460 470 480 490 500
RIRYCLELHN QAVKALRYPP KKKIAVETIE QAREREQQEL EFAKELADED

DDDF
Length:504
Mass (Da):57,507
Last modified:February 1, 1994 - v1
Checksum:i062E476685FCD0A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080722 Genomic DNA. Translation: CCD66158.1.
PIRiS44783.
RefSeqiNP_498869.1. NM_066468.4.
UniGeneiCel.5638.

Genome annotation databases

EnsemblMetazoaiC30C11.2; C30C11.2; WBGene00004460.
GeneIDi176196.
KEGGicel:CELE_C30C11.2.
UCSCiC30C11.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPSMD3_CAEEL
AccessioniPrimary (citable) accession number: Q04908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families