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Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.By similarity

GO - Molecular functioni

  1. BMP receptor binding Source: GO_Central
  2. cytokine activity Source: GO_Central
  3. growth factor activity Source: RGD
  4. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. BMP signaling pathway Source: GO_Central
  2. cartilage development Source: UniProtKB-KW
  3. cell development Source: GO_Central
  4. cellular iron ion homeostasis Source: Ensembl
  5. cellular response to mechanical stimulus Source: RGD
  6. endochondral ossification Source: Ensembl
  7. eye development Source: Ensembl
  8. growth Source: InterPro
  9. immune response Source: Ensembl
  10. inflammatory response Source: Ensembl
  11. kidney development Source: Ensembl
  12. male genitalia development Source: Ensembl
  13. ossification Source: RGD
  14. osteoblast differentiation Source: RGD
  15. positive regulation of aldosterone biosynthetic process Source: Ensembl
  16. positive regulation of aldosterone secretion Source: RGD
  17. positive regulation of bone mineralization Source: Ensembl
  18. positive regulation of chondrocyte differentiation Source: RGD
  19. positive regulation of endothelial cell differentiation Source: Ensembl
  20. positive regulation of endothelial cell proliferation Source: Ensembl
  21. positive regulation of neuron differentiation Source: Ensembl
  22. positive regulation of osteoblast differentiation Source: RGD
  23. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  24. regulation of apoptotic process Source: GO_Central
  25. regulation of cell differentiation Source: RGD
  26. regulation of MAPK cascade Source: GO_Central
  27. response to activity Source: RGD
  28. response to glucocorticoid Source: RGD
  29. response to iron ion Source: RGD
  30. response to magnesium ion Source: RGD
  31. response to retinoic acid Source: RGD
  32. SMAD protein signal transduction Source: UniProtKB
  33. type B pancreatic cell development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VGR-1
Gene namesi
Name:Bmp6
Synonyms:Bmp-6, Vgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2214. Bmp6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 367347Sequence AnalysisPRO_0000033874Add
BLAST
Chaini368 – 506139Bone morphogenetic protein 6PRO_0000033875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi405 ↔ 471By similarity
Disulfide bondi434 ↔ 503By similarity
Disulfide bondi438 ↔ 505By similarity
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi470 – 470InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04906.

PTM databases

PhosphoSiteiQ04906.

Expressioni

Gene expression databases

GenevestigatoriQ04906.

Interactioni

Subunit structurei

Interacts with SOSTDC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018359.

Structurei

3D structure databases

ProteinModelPortaliQ04906.
SMRiQ04906. Positions 402-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG004860.
InParanoidiQ04906.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG7J9VPQ.
PhylomeDBiQ04906.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR
60 70 80 90 100
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ
110 120 130 140 150
SPVLPQQQQS QQTAREEPPP GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE
160 170 180 190 200
GLEPESHGRA SSSQLKQPSP GAAHSLNRKS LLAPGPGGSA SPLTSAQDSA
210 220 230 240 250
FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE GEAVTAAEFR
260 270 280 290 300
VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE
310 320 330 340 350
FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP
360 370 380 390 400
FMVAFFKVSE VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE
410 420 430 440 450
LKTACKKHEL YVSFQDLGWQ DWIIAPKGYA ANYCDGECSF PLNAHMNATN
460 470 480 490 500
HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS VLYFDDNSNV ILKKYRNMVV

RACGCH
Length:506
Mass (Da):56,223
Last modified:December 20, 2005 - v2
Checksum:i703D077D7E94416C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184240 mRNA. Translation: AAO25744.1.
X58830 mRNA. Translation: CAA41634.1.
PIRiS37618.
RefSeqiNP_037239.1. NM_013107.1.
UniGeneiRn.40476.

Genome annotation databases

EnsembliENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
GeneIDi25644.
KEGGirno:25644.
UCSCiRGD:2214. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184240 mRNA. Translation: AAO25744.1.
X58830 mRNA. Translation: CAA41634.1.
PIRiS37618.
RefSeqiNP_037239.1. NM_013107.1.
UniGeneiRn.40476.

3D structure databases

ProteinModelPortaliQ04906.
SMRiQ04906. Positions 402-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018359.

PTM databases

PhosphoSiteiQ04906.

Proteomic databases

PRIDEiQ04906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
GeneIDi25644.
KEGGirno:25644.
UCSCiRGD:2214. rat.

Organism-specific databases

CTDi654.
RGDi2214. Bmp6.

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00760000118883.
HOVERGENiHBG004860.
InParanoidiQ04906.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG7J9VPQ.
PhylomeDBiQ04906.

Miscellaneous databases

NextBioi607495.
PROiQ04906.

Gene expression databases

GenevestigatoriQ04906.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An immunological study of BMP6 adenoviral gene therapy."
    Li H., Li J., Pittman D.D., Amalfitano A., Hankins G.R., Helm G.A.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines."
    Sauermann U., Meyermann R., Schluesener H.J.
    J. Neurosci. Res. 33:142-147(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-506.
    Strain: Lewis.
    Tissue: Brain.

Entry informationi

Entry nameiBMP6_RAT
AccessioniPrimary (citable) accession number: Q04906
Secondary accession number(s): Q811S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: March 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.