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Q04906

- BMP6_RAT

UniProt

Q04906 - BMP6_RAT

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Protein

Bone morphogenetic protein 6

Gene
Bmp6, Bmp-6, Vgr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation By similarity.

GO - Molecular functioni

  1. growth factor activity Source: RGD

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. cartilage development Source: UniProtKB-KW
  3. cellular response to mechanical stimulus Source: RGD
  4. endochondral ossification Source: Ensembl
  5. eye development Source: Ensembl
  6. growth Source: InterPro
  7. immune response Source: Ensembl
  8. inflammatory response Source: Ensembl
  9. kidney development Source: Ensembl
  10. male genitalia development Source: Ensembl
  11. ossification Source: RGD
  12. osteoblast differentiation Source: RGD
  13. positive regulation of aldosterone biosynthetic process Source: Ensembl
  14. positive regulation of aldosterone secretion Source: RGD
  15. positive regulation of bone mineralization Source: Ensembl
  16. positive regulation of chondrocyte differentiation Source: RGD
  17. positive regulation of endothelial cell differentiation Source: Ensembl
  18. positive regulation of endothelial cell proliferation Source: Ensembl
  19. positive regulation of neuron differentiation Source: Ensembl
  20. positive regulation of osteoblast differentiation Source: RGD
  21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  22. regulation of cell differentiation Source: RGD
  23. response to activity Source: RGD
  24. response to glucocorticoid Source: RGD
  25. response to iron ion Source: RGD
  26. response to magnesium ion Source: RGD
  27. response to retinoic acid Source: RGD
  28. SMAD protein signal transduction Source: UniProtKB
  29. type B pancreatic cell development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VGR-1
Gene namesi
Name:Bmp6
Synonyms:Bmp-6, Vgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2214. Bmp6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Propeptidei21 – 367347 Reviewed predictionPRO_0000033874Add
BLAST
Chaini368 – 506139Bone morphogenetic protein 6PRO_0000033875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi405 ↔ 471 By similarity
Disulfide bondi434 ↔ 503 By similarity
Disulfide bondi438 ↔ 505 By similarity
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi470 – 470Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04906.

PTM databases

PhosphoSiteiQ04906.

Expressioni

Gene expression databases

ArrayExpressiQ04906.
GenevestigatoriQ04906.

Interactioni

Subunit structurei

Interacts with SOSTDC1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018359.

Structurei

3D structure databases

ProteinModelPortaliQ04906.
SMRiQ04906. Positions 402-506.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG272883.
GeneTreeiENSGT00730000110505.
HOVERGENiHBG004860.
KOiK16620.
OMAiWWGLLCS.
OrthoDBiEOG7J9VPQ.
PhylomeDBiQ04906.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04906-1 [UniParc]FASTAAdd to Basket

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MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR    50
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ 100
SPVLPQQQQS QQTAREEPPP GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE 150
GLEPESHGRA SSSQLKQPSP GAAHSLNRKS LLAPGPGGSA SPLTSAQDSA 200
FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE GEAVTAAEFR 250
VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE 300
FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP 350
FMVAFFKVSE VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE 400
LKTACKKHEL YVSFQDLGWQ DWIIAPKGYA ANYCDGECSF PLNAHMNATN 450
HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS VLYFDDNSNV ILKKYRNMVV 500
RACGCH 506
Length:506
Mass (Da):56,223
Last modified:December 20, 2005 - v2
Checksum:i703D077D7E94416C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184240 mRNA. Translation: AAO25744.1.
X58830 mRNA. Translation: CAA41634.1.
PIRiS37618.
RefSeqiNP_037239.1. NM_013107.1.
UniGeneiRn.40476.

Genome annotation databases

EnsembliENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
GeneIDi25644.
KEGGirno:25644.
UCSCiRGD:2214. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184240 mRNA. Translation: AAO25744.1 .
X58830 mRNA. Translation: CAA41634.1 .
PIRi S37618.
RefSeqi NP_037239.1. NM_013107.1.
UniGenei Rn.40476.

3D structure databases

ProteinModelPortali Q04906.
SMRi Q04906. Positions 402-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018359.

PTM databases

PhosphoSitei Q04906.

Proteomic databases

PRIDEi Q04906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018359 ; ENSRNOP00000018359 ; ENSRNOG00000013717 .
GeneIDi 25644.
KEGGi rno:25644.
UCSCi RGD:2214. rat.

Organism-specific databases

CTDi 654.
RGDi 2214. Bmp6.

Phylogenomic databases

eggNOGi NOG272883.
GeneTreei ENSGT00730000110505.
HOVERGENi HBG004860.
KOi K16620.
OMAi WWGLLCS.
OrthoDBi EOG7J9VPQ.
PhylomeDBi Q04906.

Miscellaneous databases

NextBioi 607495.
PROi Q04906.

Gene expression databases

ArrayExpressi Q04906.
Genevestigatori Q04906.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An immunological study of BMP6 adenoviral gene therapy."
    Li H., Li J., Pittman D.D., Amalfitano A., Hankins G.R., Helm G.A.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines."
    Sauermann U., Meyermann R., Schluesener H.J.
    J. Neurosci. Res. 33:142-147(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-506.
    Strain: Lewis.
    Tissue: Brain.

Entry informationi

Entry nameiBMP6_RAT
AccessioniPrimary (citable) accession number: Q04906
Secondary accession number(s): Q811S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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