Q04906 (BMP6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 6
Short name=BMP-6

Alternative name(s):
VG-1-related protein
Short name=VGR-1

Gene names

Name:	Bmp6
Synonyms:	Bmp-6, Vgr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces cartilage and bone formation By similarity.
Subunit structure	Interacts with SOSTDC1 By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara SMAD protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB cartilage development Inferred from electronic annotation. Source: UniProtKB-KW endochondral ossification Inferred from electronic annotation. Source: Compara eye development Inferred from electronic annotation. Source: Compara growth Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara male genitalia development Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from expression pattern PubMed 11995934. Source: RGD positive regulation of aldosterone biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from mutant phenotype PubMed 9202223. Source: RGD positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB response to glucocorticoid stimulus Inferred from expression pattern PubMed 9202223. Source: RGD response to retinoic acid Inferred from expression pattern PubMed 8385738. Source: RGD type B pancreatic cell development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay PubMed 15589212. Source: RGD extracellular space Inferred from direct assay PubMed 11245809PubMed 18758911. Source: RGD membrane-bounded vesicle Inferred from direct assay PubMed 18758911. Source: RGD
Molecular_function	growth factor activity Inferred from direct assay PubMed 9168801. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 367	347	Potential		PRO_0000033874
	Chain	368 – 506	139	Bone morphogenetic protein 6		PRO_0000033875
Amino acid modifications
	Glycosylation	234	1	N-linked (GlcNAc...) Potential
	Glycosylation	262	1	N-linked (GlcNAc...) Potential
	Glycosylation	379	1	N-linked (GlcNAc...) Potential
	Glycosylation	397	1	N-linked (GlcNAc...) Potential
	Glycosylation	447	1	N-linked (GlcNAc...) Potential
	Disulfide bond	405 ↔ 471		By similarity
	Disulfide bond	434 ↔ 503		By similarity
	Disulfide bond	438 ↔ 505		By similarity
	Disulfide bond	470		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04906 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 703D077D7E94416C	FASTA	506	56,223
	10 20 30 40 50 60 MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR AEQPPPQSSS 70 80 90 100 110 120 SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ SPVLPQQQQS QQTAREEPPP 130 140 150 160 170 180 GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE GLEPESHGRA SSSQLKQPSP GAAHSLNRKS 190 200 210 220 230 240 LLAPGPGGSA SPLTSAQDSA FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE 250 260 270 280 290 300 GEAVTAAEFR VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE 310 320 330 340 350 360 FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP FMVAFFKVSE 370 380 390 400 410 420 VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE LKTACKKHEL YVSFQDLGWQ 430 440 450 460 470 480 DWIIAPKGYA ANYCDGECSF PLNAHMNATN HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS 490 500 VLYFDDNSNV ILKKYRNMVV RACGCH

References

[1]	"An immunological study of BMP6 adenoviral gene therapy." Li H., Li J., Pittman D.D., Amalfitano A., Hankins G.R., Helm G.A. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	"Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines." Sauermann U., Meyermann R., Schluesener H.J. J. Neurosci. Res. 33:142-147(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-506. Strain: Lewis. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY184240 mRNA. Translation: AAO25744.1. X58830 mRNA. Translation: CAA41634.1.
IPI	IPI00324269.
PIR	S37618.
RefSeq	NP_037239.1. NM_013107.1.
UniGene	Rn.40476.
3D structure databases
ProteinModelPortal	Q04906.
SMR	Q04906. Positions 402-506.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000018359.
PTM databases
PhosphoSite	Q04906.
Proteomic databases
PRIDE	Q04906.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
GeneID	25644.
KEGG	rno:25644.
UCSC	RGD:2214. rat.
Organism-specific databases
CTD	654.
RGD	2214. Bmp6.
Phylogenomic databases
eggNOG	NOG272883.
GeneTree	ENSGT00620000087601.
HOVERGEN	HBG004860.
KO	K16620.
Gene expression databases
Genevestigator	Q04906.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607495.

Entry information

Entry name

BMP6_RAT

Accession

Primary (citable) accession number: Q04906
Secondary accession number(s): Q811S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	December 20, 2005
Last modified:	April 3, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program