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Q04906

- BMP6_RAT

UniProt

Q04906 - BMP6_RAT

Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.By similarity

    GO - Molecular functioni

    1. growth factor activity Source: RGD

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. cartilage development Source: UniProtKB-KW
    3. cellular response to mechanical stimulus Source: RGD
    4. endochondral ossification Source: Ensembl
    5. eye development Source: Ensembl
    6. growth Source: InterPro
    7. immune response Source: Ensembl
    8. inflammatory response Source: Ensembl
    9. kidney development Source: Ensembl
    10. male genitalia development Source: Ensembl
    11. ossification Source: RGD
    12. osteoblast differentiation Source: RGD
    13. positive regulation of aldosterone biosynthetic process Source: Ensembl
    14. positive regulation of aldosterone secretion Source: RGD
    15. positive regulation of bone mineralization Source: Ensembl
    16. positive regulation of chondrocyte differentiation Source: RGD
    17. positive regulation of endothelial cell differentiation Source: Ensembl
    18. positive regulation of endothelial cell proliferation Source: Ensembl
    19. positive regulation of neuron differentiation Source: Ensembl
    20. positive regulation of osteoblast differentiation Source: RGD
    21. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    22. regulation of cell differentiation Source: RGD
    23. response to activity Source: RGD
    24. response to glucocorticoid Source: RGD
    25. response to iron ion Source: RGD
    26. response to magnesium ion Source: RGD
    27. response to retinoic acid Source: RGD
    28. SMAD protein signal transduction Source: UniProtKB
    29. type B pancreatic cell development Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 6
    Short name:
    BMP-6
    Alternative name(s):
    VG-1-related protein
    Short name:
    VGR-1
    Gene namesi
    Name:Bmp6
    Synonyms:Bmp-6, Vgr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi2214. Bmp6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. membrane-bounded vesicle Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 367347Sequence AnalysisPRO_0000033874Add
    BLAST
    Chaini368 – 506139Bone morphogenetic protein 6PRO_0000033875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi405 ↔ 471By similarity
    Disulfide bondi434 ↔ 503By similarity
    Disulfide bondi438 ↔ 505By similarity
    Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi470 – 470InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ04906.

    PTM databases

    PhosphoSiteiQ04906.

    Expressioni

    Gene expression databases

    ArrayExpressiQ04906.
    GenevestigatoriQ04906.

    Interactioni

    Subunit structurei

    Interacts with SOSTDC1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04906.
    SMRiQ04906. Positions 402-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG272883.
    GeneTreeiENSGT00730000110505.
    HOVERGENiHBG004860.
    KOiK16620.
    OMAiWWGLLCS.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiQ04906.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04906-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR    50
    AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ 100
    SPVLPQQQQS QQTAREEPPP GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE 150
    GLEPESHGRA SSSQLKQPSP GAAHSLNRKS LLAPGPGGSA SPLTSAQDSA 200
    FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE GEAVTAAEFR 250
    VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE 300
    FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP 350
    FMVAFFKVSE VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE 400
    LKTACKKHEL YVSFQDLGWQ DWIIAPKGYA ANYCDGECSF PLNAHMNATN 450
    HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS VLYFDDNSNV ILKKYRNMVV 500
    RACGCH 506
    Length:506
    Mass (Da):56,223
    Last modified:December 20, 2005 - v2
    Checksum:i703D077D7E94416C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184240 mRNA. Translation: AAO25744.1.
    X58830 mRNA. Translation: CAA41634.1.
    PIRiS37618.
    RefSeqiNP_037239.1. NM_013107.1.
    UniGeneiRn.40476.

    Genome annotation databases

    EnsembliENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
    GeneIDi25644.
    KEGGirno:25644.
    UCSCiRGD:2214. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184240 mRNA. Translation: AAO25744.1 .
    X58830 mRNA. Translation: CAA41634.1 .
    PIRi S37618.
    RefSeqi NP_037239.1. NM_013107.1.
    UniGenei Rn.40476.

    3D structure databases

    ProteinModelPortali Q04906.
    SMRi Q04906. Positions 402-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018359.

    PTM databases

    PhosphoSitei Q04906.

    Proteomic databases

    PRIDEi Q04906.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018359 ; ENSRNOP00000018359 ; ENSRNOG00000013717 .
    GeneIDi 25644.
    KEGGi rno:25644.
    UCSCi RGD:2214. rat.

    Organism-specific databases

    CTDi 654.
    RGDi 2214. Bmp6.

    Phylogenomic databases

    eggNOGi NOG272883.
    GeneTreei ENSGT00730000110505.
    HOVERGENi HBG004860.
    KOi K16620.
    OMAi WWGLLCS.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi Q04906.

    Miscellaneous databases

    NextBioi 607495.
    PROi Q04906.

    Gene expression databases

    ArrayExpressi Q04906.
    Genevestigatori Q04906.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An immunological study of BMP6 adenoviral gene therapy."
      Li H., Li J., Pittman D.D., Amalfitano A., Hankins G.R., Helm G.A.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines."
      Sauermann U., Meyermann R., Schluesener H.J.
      J. Neurosci. Res. 33:142-147(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-506.
      Strain: Lewis.
      Tissue: Brain.

    Entry informationi

    Entry nameiBMP6_RAT
    AccessioniPrimary (citable) accession number: Q04906
    Secondary accession number(s): Q811S4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3