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Q04906 (BMP6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 6

Short name=BMP-6
Alternative name(s):
VG-1-related protein
Short name=VGR-1
Gene names
Name:Bmp6
Synonyms:Bmp-6, Vgr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation By similarity.

Subunit structure

Interacts with SOSTDC1 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

SMAD protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to mechanical stimulus

Inferred from expression pattern PubMed 23198877. Source: RGD

endochondral ossification

Inferred from electronic annotation. Source: Ensembl

eye development

Inferred from electronic annotation. Source: Ensembl

growth

Inferred from electronic annotation. Source: InterPro

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

ossification

Inferred from direct assay PubMed 16761078. Source: RGD

osteoblast differentiation

Inferred from expression pattern PubMed 11995934. Source: RGD

positive regulation of aldosterone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of aldosterone secretion

Inferred from direct assay PubMed 22538126. Source: RGD

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of chondrocyte differentiation

Inferred from direct assay PubMed 23077084. Source: RGD

positive regulation of endothelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 9202223. Source: RGD

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell differentiation

Traceable author statement PubMed 9168801. Source: RGD

response to activity

Inferred from expression pattern PubMed 23198877. Source: RGD

response to glucocorticoid

Inferred from expression pattern PubMed 9202223. Source: RGD

response to iron ion

Inferred from expression pattern PubMed 21859731. Source: RGD

response to magnesium ion

Inferred from expression pattern PubMed 21736832. Source: RGD

response to retinoic acid

Inferred from expression pattern PubMed 8385738. Source: RGD

type B pancreatic cell development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15589212. Source: RGD

extracellular space

Inferred from direct assay PubMed 11245809PubMed 18758911. Source: RGD

membrane-bounded vesicle

Inferred from direct assay PubMed 18758911. Source: RGD

   Molecular_functiongrowth factor activity

Inferred from direct assay PubMed 9168801. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 367347 Potential
PRO_0000033874
Chain368 – 506139Bone morphogenetic protein 6
PRO_0000033875

Amino acid modifications

Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation4471N-linked (GlcNAc...) Potential
Disulfide bond405 ↔ 471 By similarity
Disulfide bond434 ↔ 503 By similarity
Disulfide bond438 ↔ 505 By similarity
Disulfide bond470Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04906 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 703D077D7E94416C

FASTA50656,223
        10         20         30         40         50         60 
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR AEQPPPQSSS 

        70         80         90        100        110        120 
SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ SPVLPQQQQS QQTAREEPPP 

       130        140        150        160        170        180 
GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE GLEPESHGRA SSSQLKQPSP GAAHSLNRKS 

       190        200        210        220        230        240 
LLAPGPGGSA SPLTSAQDSA FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE 

       250        260        270        280        290        300 
GEAVTAAEFR VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE 

       310        320        330        340        350        360 
FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP FMVAFFKVSE 

       370        380        390        400        410        420 
VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE LKTACKKHEL YVSFQDLGWQ 

       430        440        450        460        470        480 
DWIIAPKGYA ANYCDGECSF PLNAHMNATN HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS 

       490        500 
VLYFDDNSNV ILKKYRNMVV RACGCH 

« Hide

References

[1]"An immunological study of BMP6 adenoviral gene therapy."
Li H., Li J., Pittman D.D., Amalfitano A., Hankins G.R., Helm G.A.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines."
Sauermann U., Meyermann R., Schluesener H.J.
J. Neurosci. Res. 33:142-147(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 300-506.
Strain: Lewis.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY184240 mRNA. Translation: AAO25744.1.
X58830 mRNA. Translation: CAA41634.1.
PIRS37618.
RefSeqNP_037239.1. NM_013107.1.
UniGeneRn.40476.

3D structure databases

ProteinModelPortalQ04906.
SMRQ04906. Positions 402-506.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018359.

PTM databases

PhosphoSiteQ04906.

Proteomic databases

PRIDEQ04906.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717.
GeneID25644.
KEGGrno:25644.
UCSCRGD:2214. rat.

Organism-specific databases

CTD654.
RGD2214. Bmp6.

Phylogenomic databases

eggNOGNOG272883.
GeneTreeENSGT00730000110505.
HOVERGENHBG004860.
KOK16620.
OMAWWGLLCS.
OrthoDBEOG7J9VPQ.
PhylomeDBQ04906.

Gene expression databases

ArrayExpressQ04906.
GenevestigatorQ04906.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607495.
PROQ04906.

Entry information

Entry nameBMP6_RAT
AccessionPrimary (citable) accession number: Q04906
Secondary accession number(s): Q811S4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families