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Protein

Bone morphogenetic protein 6

Gene

Bmp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 6
Short name:
BMP-6
Alternative name(s):
VG-1-related protein
Short name:
VGR-1
Gene namesi
Name:Bmp6
Synonyms:Bmp-6, Vgr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2214 Bmp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003387421 – 367Sequence analysisAdd BLAST347
ChainiPRO_0000033875368 – 506Bone morphogenetic protein 6Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi405 ↔ 471By similarity
Disulfide bondi434 ↔ 503By similarity
Disulfide bondi438 ↔ 505By similarity
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi470InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ04906
PRIDEiQ04906

PTM databases

iPTMnetiQ04906
PhosphoSitePlusiQ04906

Expressioni

Gene expression databases

BgeeiENSRNOG00000013717
GenevisibleiQ04906 RN

Interactioni

Subunit structurei

Interacts with SOSTDC1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018359

Structurei

3D structure databases

ProteinModelPortaliQ04906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOVERGENiHBG004860
InParanoidiQ04906
KOiK16620
OMAiIYKDCVV
OrthoDBiEOG091G0C2J
PhylomeDBiQ04906

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLGRRAQW LCWWWGLLCS CGPPPLRPPL PVAAAAAGGQ LLGAGGSPVR
60 70 80 90 100
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ
110 120 130 140 150
SPVLPQQQQS QQTAREEPPP GRLKSAPLFM LDLYNSLSKD DEEDGVSEGE
160 170 180 190 200
GLEPESHGRA SSSQLKQPSP GAAHSLNRKS LLAPGPGGSA SPLTSAQDSA
210 220 230 240 250
FLNDADMVMS FVNLVEYDKE FSPRQRHHKE FKFNLSQIPE GEAVTAAEFR
260 270 280 290 300
VYKDCVVGSF KNQTFLISIY QVLQEHQHRD SDLFLLDTRV VWASEEGWLE
310 320 330 340 350
FDITATSNLW VVTPQHNMGL QLSVVTRDGL HINPRAAGLV GRDGPYDKQP
360 370 380 390 400
FMVAFFKVSE VHVRTTRSAS SRRRQQSRNR STQSQDVSRG SSASDYNSSE
410 420 430 440 450
LKTACKKHEL YVSFQDLGWQ DWIIAPKGYA ANYCDGECSF PLNAHMNATN
460 470 480 490 500
HAIVQTLVHL MNPEYVPKPC CAPTKLNAIS VLYFDDNSNV ILKKYRNMVV

RACGCH
Length:506
Mass (Da):56,223
Last modified:December 20, 2005 - v2
Checksum:i703D077D7E94416C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184240 mRNA Translation: AAO25744.1
X58830 mRNA Translation: CAA41634.1
PIRiS37618
RefSeqiNP_037239.1, NM_013107.1
UniGeneiRn.40476

Genome annotation databases

EnsembliENSRNOT00000018359; ENSRNOP00000018359; ENSRNOG00000013717
GeneIDi25644
KEGGirno:25644
UCSCiRGD:2214 rat

Similar proteinsi

Entry informationi

Entry nameiBMP6_RAT
AccessioniPrimary (citable) accession number: Q04906
Secondary accession number(s): Q811S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health