Reviewed, UniProtKB/Swiss-Prot Q04903 (FNTB_PEA)

Names and origin

Protein names

Recommended name:
    Protein farnesyltransferase subunit beta
      Short name=FTase-beta
    EC=2.5.1.58
Alternative name(s):
    CAAX farnesyltransferase subunit beta
    Ras proteins prenyltransferase subunit beta

Gene names

Name:

FTB

Organism

Pisum sativum (Garden pea)

Taxonomic identifier

3888 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding By similarity.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Gene Ontology (GO)
Molecular function	protein farnesyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Protein farnesyltransferase subunit beta		PRO_0000119765
Regions
	Repeat	68 – 109	42	PFTB 1
	Repeat	119 – 160	42	PFTB 2
	Repeat	167 – 208	42	PFTB 3
	Repeat	215 – 256	42	PFTB 4
	Repeat	329 – 371	43	PFTB 5
Sites
	Metal binding	241	1	Zinc By similarity
	Metal binding	243	1	Zinc By similarity
	Metal binding	359	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04903-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 4F040E0094277D7C	FASTA	419	46,794
	10 20 30 40 50 60 MEASTAAETP TPTVSQRDQW IVESQVFHIY QLFANIPPNA QSIIRPWLCY WIIHSIALLG 70 80 90 100 110 120 ESIDDDLEDN TVDFLNRCQD PNGGYAGGPG QMPHLATTYA AVNTLITLGG EKSLASINRN 130 140 150 160 170 180 KLYGFMRRMK QPNGGFRMHD EGEIDVRACY TAISVASVLN ILDDELIKNV GDFILSCQTY 190 200 210 220 230 240 EGGLAGEPGS EAHGGYTFCG LAAMILIGEV NRLDLPRLLD WVVFRQGKEC GFQGRTNKLV 250 260 270 280 290 300 DGCYSFWQGG AVALLQRLHS IIDEQMAEAS QFVTVSDAPE EKECLDGTSS HATSHIRHEG 310 320 330 340 350 360 MNESCSSDVK NIGYNFISEW RQSEPLFHSI ALQQYILLCS QEQDGGLRDK PGKRRDHYHS 370 380 390 400 410 CYCLSGLSLC QYSWSKRPDS PPLPKVVMGP YSNLLEPIHP LFNVVLDRYR EAHEFFSQL

References

[1]

"Protein farnesyltransferase in plants. Molecular cloning and expression of a homolog of the beta subunit from the garden pea." Yang Z., Cramer C.L., Watson J.C. Plant Physiol. 101:667-674(1993) [PubMed: 8278509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Alaska. Tissue: Seedling.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L08664 mRNA. Translation: AAA33649.1.
PIR	JQ2254.
3D structure databases
HSSP	HSSP built from PDB template 1LD8 based on UniProtKB P49356.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.58. 287.
Family and domain databases
InterPro	IPR001330. Prenyltrans. [Graphical view]
Pfam	PF00432. Prenyltrans. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FNTB_PEA

Accession

Primary (citable) accession number: Q04903

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 5, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)