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Protein

Probable glutathione-independent glyoxalase SNO4

Gene

SNO4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).By similarity1 Publication

Catalytic activityi

(R)-lactate = methylglyoxal + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138By similarity1
Active sitei139By similarity1
Active sitei170By similarity1

GO - Molecular functioni

  • cysteine-type peptidase activity Source: SGD
  • lyase activity Source: UniProtKB-KW

GO - Biological processi

  • cellular response to nutrient levels Source: SGD

Keywordsi

Molecular functionLyase
Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-32985-MONOMER

Protein family/group databases

MEROPSiC56.A04

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione-independent glyoxalase SNO4By similarity (EC:4.2.1.130By similarity)
Alternative name(s):
Glyoxalase 3 homolog 4By similarity
Heat shock protein 341 Publication
SNZ proximal open reading frame 41 Publication
Gene namesi
Name:SNO41 Publication
Synonyms:HSP341 Publication
Ordered Locus Names:YMR322CImported
ORF Names:YM9924.14C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR322C
SGDiS000004941 SNO4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Results in higher sensitivity to oxidative stress, reduced thermotolerance, accumulation of higher levels of reactive oxygen species, and reduced chronological life span.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001578531 – 237Probable glutathione-independent glyoxalase SNO4Add BLAST237

Proteomic databases

MaxQBiQ04902
PaxDbiQ04902
PRIDEiQ04902

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi35501, 87 interactors
DIPiDIP-1968N
IntActiQ04902, 8 interactors
MINTiQ04902
STRINGi4932.YMR322C

Structurei

3D structure databases

ProteinModelPortaliQ04902
SMRiQ04902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000013431
HOGENOMiHOG000181653
InParanoidiQ04902
KOiK22211
OrthoDBiEOG092C4O4J

Family and domain databases

Gene3Di3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
SUPFAMiSSF52317 SSF52317, 1 hit

Sequencei

Sequence statusi: Complete.

Q04902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPKRALISL TSYHGPFYKD GAKTGVFVVE ILRSFDTFEK HGFEVDFVSE
60 70 80 90 100
TGGFGWDEHY LPKSFIGGED KMNFETKNSA FNKALARIKT ANEVNASDYK
110 120 130 140 150
IFFASAGHGA LFDYPKAKNL QDIASKIYAN GGVIAAICHG PLLFDGLIDI
160 170 180 190 200
KTTRPLIEGK AITGFPLEGE IALGVDDILR SRKLTTVERV ANKNRAKYLA
210 220 230
PIHPWDDYSI TDGKLVTGVN ANSSYSTTIR AINALYS
Length:237
Mass (Da):26,040
Last modified:November 1, 1997 - v1
Checksum:i004EA3E702332905
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54141 Genomic DNA Translation: CAA90840.1
BK006946 Genomic DNA Translation: DAA10223.1
RefSeqiNP_014055.1, NM_001182835.1

Genome annotation databases

EnsemblFungiiYMR322C; YMR322C; YMR322C
GeneIDi855372
KEGGisce:YMR322C

Similar proteinsi

Entry informationi

Entry nameiSNO4_YEAST
AccessioniPrimary (citable) accession number: Q04902
Secondary accession number(s): D6W0E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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