UniProtKB - Q04902 (SNO4_YEAST)
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Protein
Probable glutathione-independent glyoxalase SNO4
Gene
SNO4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).By similarity1 Publication
Catalytic activityi
(R)-lactate = methylglyoxal + H2O.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 138 | By similarity | 1 | |
Active sitei | 139 | By similarity | 1 | |
Active sitei | 170 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: SGD
- lyase activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to nutrient levels Source: SGD
Keywordsi
Molecular function | Lyase |
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32985-MONOMER. |
Protein family/group databases
MEROPSi | C56.A04. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable glutathione-independent glyoxalase SNO4By similarity (EC:4.2.1.130By similarity)Alternative name(s): Glyoxalase 3 homolog 4By similarity Heat shock protein 341 Publication SNZ proximal open reading frame 41 Publication |
Gene namesi | Ordered Locus Names:YMR322CImported ORF Names:YM9924.14C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YMR322C. |
SGDi | S000004941. SNO4. |
Pathology & Biotechi
Disruption phenotypei
Results in higher sensitivity to oxidative stress, reduced thermotolerance, accumulation of higher levels of reactive oxygen species, and reduced chronological life span.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157853 | 1 – 237 | Probable glutathione-independent glyoxalase SNO4Add BLAST | 237 |
Proteomic databases
MaxQBi | Q04902. |
PaxDbi | Q04902. |
PRIDEi | Q04902. |
Interactioni
Subunit structurei
Homodimer.By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
HSP31 | Q04432 | 3 | EBI-27696,EBI-35591 |
Protein-protein interaction databases
BioGridi | 35501. 87 interactors. |
DIPi | DIP-1968N. |
IntActi | Q04902. 13 interactors. |
MINTi | Q04902. |
STRINGi | 4932.YMR322C. |
Structurei
3D structure databases
ProteinModelPortali | Q04902. |
SMRi | Q04902. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000013431. |
HOGENOMi | HOG000181653. |
InParanoidi | Q04902. |
KOi | K22211. |
OrthoDBi | EOG092C4O4J. |
Family and domain databases
Gene3Di | 3.40.50.880. 1 hit. |
InterProi | View protein in InterPro IPR029062. Class_I_gatase-like. |
SUPFAMi | SSF52317. SSF52317. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q04902-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPKRALISL TSYHGPFYKD GAKTGVFVVE ILRSFDTFEK HGFEVDFVSE
60 70 80 90 100
TGGFGWDEHY LPKSFIGGED KMNFETKNSA FNKALARIKT ANEVNASDYK
110 120 130 140 150
IFFASAGHGA LFDYPKAKNL QDIASKIYAN GGVIAAICHG PLLFDGLIDI
160 170 180 190 200
KTTRPLIEGK AITGFPLEGE IALGVDDILR SRKLTTVERV ANKNRAKYLA
210 220 230
PIHPWDDYSI TDGKLVTGVN ANSSYSTTIR AINALYS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54141 Genomic DNA. Translation: CAA90840.1. BK006946 Genomic DNA. Translation: DAA10223.1. |
RefSeqi | NP_014055.1. NM_001182835.1. |
Genome annotation databases
EnsemblFungii | YMR322C; YMR322C; YMR322C. |
GeneIDi | 855372. |
KEGGi | sce:YMR322C. |
Similar proteinsi
Entry informationi
Entry namei | SNO4_YEAST | |
Accessioni | Q04902Primary (citable) accession number: Q04902 Secondary accession number(s): D6W0E9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |