SNO4

Functionⁱ

Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893).By similarity1 Publication

Catalytic activityⁱ

(R)-lactate = methylglyoxal + H₂O.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	138	By similarity	1
Active siteⁱ	139	By similarity	1
Active siteⁱ	170	By similarity	1

GO - Molecular functionⁱ

cysteine-type peptidase activity
Source: SGD
Inferred from sequence or structural similarityⁱ
- 14745011
lyase activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

cellular response to nutrient levels
Source: SGD
Inferred from mutant phenotypeⁱ
- 24706893

Complete GO annotation...

Keywordsⁱ

Molecular function	Lyase
Biological process	Stress response

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32985-MONOMER.

BioCycⁱ

YEAST:G3O-32985-MONOMER.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C56.A04.

MEROPSⁱ

C56.A04.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable glutathione-independent glyoxalase SNO4By similarity (EC:4.2.1.130By similarity) Alternative name(s): Glyoxalase 3 homolog 4By similarity Heat shock protein 341 Publication SNZ proximal open reading frame 41 Publication
Gene namesⁱ	Name:SNO41 Publication Synonyms:HSP341 Publication Ordered Locus Names:YMR322CImported ORF Names:YM9924.14C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIII

Organism-specific databases

EuPathDBⁱ	FungiDB:YMR322C.
Saccharomyces Genome Database More...SGDⁱ	S000004941. SNO4.

Subcellular locationⁱ

Cytoplasm › P-body
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q04432 (HSP31_YEAST)

Note:

Present in processing bodies (P-bodies) and stress granule (SG) foci upon glucose starvation and heat shock.By similarity

GO - Cellular componentⁱ

P-body Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Results in higher sensitivity to oxidative stress, reduced thermotolerance, accumulation of higher levels of reactive oxygen species, and reduced chronological life span.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000157853	1 – 237	Probable glutathione-independent glyoxalase SNO4Add BLAST		237

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04902.
PRIDEⁱ	Q04902.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

BioGridⁱ	35501. 87 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1968N.
IntActⁱ	Q04902. 8 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-386922.
STRINGⁱ	4932.YMR322C.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04902.
SMRⁱ	Q04902.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C56 family. HSP31-like subfamily.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013431.
HOGENOMⁱ	HOG000181653.
InParanoidⁱ	Q04902.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4O4J.

Family and domain databases

Gene3Dⁱ	3.40.50.880. 1 hit.
InterProⁱ	View protein in InterPro IPR029062. Class_I_gatase-like.
SUPFAMⁱ	SSF52317. SSF52317. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q04902-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPKRALISL TSYHGPFYKD GAKTGVFVVE ILRSFDTFEK HGFEVDFVSE 
        60         70         80         90        100
TGGFGWDEHY LPKSFIGGED KMNFETKNSA FNKALARIKT ANEVNASDYK 
       110        120        130        140        150
IFFASAGHGA LFDYPKAKNL QDIASKIYAN GGVIAAICHG PLLFDGLIDI 
       160        170        180        190        200
KTTRPLIEGK AITGFPLEGE IALGVDDILR SRKLTTVERV ANKNRAKYLA 
       210        220        230 
PIHPWDDYSI TDGKLVTGVN ANSSYSTTIR AINALYS

Length:237

Mass (Da):26,040

Last modified:November 1, 1997 - v1

Checksum:ⁱ004EA3E702332905

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z54141 Genomic DNA. Translation: CAA90840.1. BK006946 Genomic DNA. Translation: DAA10223.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_014055.1. NM_001182835.1.

Genome annotation databases

EnsemblFungiⁱ	YMR322C; YMR322C; YMR322C.
GeneIDⁱ	855372.
KEGGⁱ	sce:YMR322C.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z54141 Genomic DNA. Translation: CAA90840.1. BK006946 Genomic DNA. Translation: DAA10223.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_014055.1. NM_001182835.1.

3D structure databases

ProteinModelPortalⁱ	Q04902.
SMRⁱ	Q04902.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35501. 87 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1968N.
IntActⁱ	Q04902. 8 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-386922.
STRINGⁱ	4932.YMR322C.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C56.A04.

MEROPSⁱ

C56.A04.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04902.
PRIDEⁱ	Q04902.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YMR322C; YMR322C; YMR322C.
GeneIDⁱ	855372.
KEGGⁱ	sce:YMR322C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YMR322C.
Saccharomyces Genome Database More...SGDⁱ	S000004941. SNO4.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013431.
HOGENOMⁱ	HOG000181653.
InParanoidⁱ	Q04902.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4O4J.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32985-MONOMER.

BioCycⁱ

YEAST:G3O-32985-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q04902.

PROⁱ

PR:Q04902.

Family and domain databases

Gene3Dⁱ	3.40.50.880. 1 hit.
InterProⁱ	View protein in InterPro IPR029062. Class_I_gatase-like.
SUPFAMⁱ	SSF52317. SSF52317. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNO4_YEAST
Accessionⁱ	Q04902Primary (citable) accession number: Q04902 Secondary accession number(s): D6W0E9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	July 5, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q04902 (SNO4_YEAST)

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Probable glutathione-independent glyoxalase SNO4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ