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Q04900

- MUC24_HUMAN

UniProt

Q04900 - MUC24_HUMAN

Protein

Sialomucin core protein 24

Gene

CD164

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: MGI
    2. hemopoiesis Source: UniProtKB
    3. heterophilic cell-cell adhesion Source: MGI
    4. immune response Source: ProtInc
    5. multicellular organismal development Source: ProtInc
    6. muscle organ development Source: UniProtKB-KW
    7. negative regulation of cell adhesion Source: UniProtKB
    8. negative regulation of cell proliferation Source: UniProtKB
    9. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion, Myogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialomucin core protein 24
    Short name:
    MUC-24
    Alternative name(s):
    Endolyn
    Multi-glycosylated core protein 24
    Short name:
    MGC-24
    Short name:
    MGC-24v
    CD_antigen: CD164
    Gene namesi
    Name:CD164
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1632. CD164.

    Subcellular locationi

    Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. endosome Source: UniProtKB
    2. endosome membrane Source: UniProtKB-SubCell
    3. extracellular region Source: UniProtKB-SubCell
    4. integral component of plasma membrane Source: UniProtKB
    5. lysosomal membrane Source: UniProtKB-SubCell
    6. lysosome Source: UniProtKB
    7. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26191.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 197174Sialomucin core protein 24PRO_0000019292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Highly N- and O-glycosylated; contains sialic acid.1 Publication
    The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ04900.
    PRIDEiQ04900.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.5 Publications

    Inductioni

    Up-regulated by CXCL12 in prostate cancer cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ04900.
    BgeeiQ04900.
    CleanExiHS_CD164.
    GenevestigatoriQ04900.

    Organism-specific databases

    HPAiHPA010636.

    Interactioni

    Subunit structurei

    Homodimer (isoform 4). Interacts with CXCR4.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CXCR4P610732EBI-2115896,EBI-489411

    Protein-protein interaction databases

    BioGridi114297. 2 interactions.
    IntActiQ04900. 9 interactions.
    MINTiMINT-5225006.
    STRINGi9606.ENSP00000309376.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04900.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 162139ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 19714CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 1977Required for endosomal and lysosomal localizationBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi105 – 15248Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD164 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77756.
    HOVERGENiHBG052534.
    KOiK06546.
    OrthoDBiEOG7XDBJ6.
    PhylomeDBiQ04900.
    TreeFamiTF333380.

    Family and domain databases

    InterProiIPR007947. CD164_MGC24.
    [Graphical view]
    PANTHERiPTHR11337. PTHR11337. 1 hit.
    PfamiPF05283. MGC-24. 1 hit.
    [Graphical view]
    PRINTSiPR01701. CD164ANTIGEN.

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q04900-1) [UniParc]FASTAAdd to Basket

    Also known as: CD164(E1-6)

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL    50
    PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC 100
    QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT 150
    PTSQPVRKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL 197
    Length:197
    Mass (Da):20,917
    Last modified:September 1, 2009 - v2
    Checksum:i4855E02646F4CB35
    GO
    Isoform 2 (identifier: Q04900-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK

    Show »
    Length:189
    Mass (Da):20,011
    Checksum:iAC1E49F139D50B10
    GO
    Isoform 3 (identifier: Q04900-3) [UniParc]FASTAAdd to Basket

    Also known as: CD164(Delta 4)

    The sequence of this isoform differs from the canonical sequence as follows:
         111-123: Missing.

    Show »
    Length:184
    Mass (Da):19,689
    Checksum:iFB689B760D2EE1FC
    GO
    Isoform 4 (identifier: Q04900-4) [UniParc]FASTAAdd to Basket

    Also known as: CD164(Delta 5)

    The sequence of this isoform differs from the canonical sequence as follows:
         124-142: Missing.

    Show »
    Length:178
    Mass (Da):19,017
    Checksum:i06FC14ECF6372314
    GO
    Isoform 5 (identifier: Q04900-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-157: GTTNNTVTPTSQPVR → EIRCHTRNYIPDLKK
         158-197: Missing.

    Show »
    Length:157
    Mass (Da):16,736
    Checksum:i9F0212BE11D4F958
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei111 – 12313Missing in isoform 3. 2 PublicationsVSP_037972Add
    BLAST
    Alternative sequencei124 – 14219Missing in isoform 4. 3 PublicationsVSP_037973Add
    BLAST
    Alternative sequencei143 – 15715GTTNN…SQPVR → EIRCHTRNYIPDLKK in isoform 5. 1 PublicationVSP_038018Add
    BLAST
    Alternative sequencei158 – 19740Missing in isoform 5. 1 PublicationVSP_038019Add
    BLAST
    Alternative sequencei175 – 19723GVQAV…NYHTL → EIRCHTRNYIPDLKK in isoform 2. 1 PublicationVSP_037974Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14043 mRNA. Translation: BAA03130.1.
    AF106518 mRNA. Translation: AAC82473.1.
    AF263279 mRNA. Translation: AAF85965.1.
    AF299341 mRNA. Translation: AAG53906.1.
    AF299342 mRNA. Translation: AAG53907.1.
    AF299343 mRNA. Translation: AAG53908.1.
    AF299340 Genomic DNA. Translation: AAG53903.1.
    AF299340 Genomic DNA. Translation: AAG53904.1.
    AF299340 Genomic DNA. Translation: AAG53905.1.
    AK298684 mRNA. Translation: BAG60847.1.
    AK303525 mRNA. Translation: BAG64553.1.
    AK312357 mRNA. Translation: BAG35275.1.
    AK315908 mRNA. Translation: BAH14279.1.
    AL359711 Genomic DNA. Translation: CAI40700.1.
    AL359711 Genomic DNA. Translation: CAI40702.1.
    AL359711 Genomic DNA. Translation: CAI40704.1.
    CH471051 Genomic DNA. Translation: EAW48348.1.
    CH471051 Genomic DNA. Translation: EAW48352.1.
    CH471051 Genomic DNA. Translation: EAW48349.1.
    CH471051 Genomic DNA. Translation: EAW48353.1.
    CH471051 Genomic DNA. Translation: EAW48354.1.
    CH471051 Genomic DNA. Translation: EAW48355.1.
    BC011522 mRNA. Translation: AAH11522.1.
    CCDSiCCDS47462.1. [Q04900-5]
    CCDS47463.1. [Q04900-2]
    CCDS47464.1. [Q04900-3]
    CCDS47465.1. [Q04900-4]
    CCDS5073.1. [Q04900-1]
    PIRiJX0235.
    RefSeqiNP_001135873.1. NM_001142401.1. [Q04900-3]
    NP_001135874.1. NM_001142402.1. [Q04900-4]
    NP_001135875.1. NM_001142403.1. [Q04900-2]
    NP_001135876.1. NM_001142404.1. [Q04900-5]
    NP_006007.2. NM_006016.4. [Q04900-1]
    UniGeneiHs.520313.

    Genome annotation databases

    EnsembliENST00000275080; ENSP00000275080; ENSG00000135535. [Q04900-3]
    ENST00000310786; ENSP00000309376; ENSG00000135535. [Q04900-1]
    ENST00000324953; ENSP00000314177; ENSG00000135535. [Q04900-4]
    ENST00000413644; ENSP00000402237; ENSG00000135535. [Q04900-2]
    ENST00000512821; ENSP00000427546; ENSG00000135535. [Q04900-5]
    GeneIDi8763.
    KEGGihsa:8763.
    UCSCiuc003ptd.3. human. [Q04900-2]
    uc003pte.3. human. [Q04900-1]
    uc003ptf.3. human. [Q04900-4]
    uc010kdn.3. human. [Q04900-3]
    uc011eap.2. human. [Q04900-5]

    Polymorphism databases

    DMDMi257051036.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14043 mRNA. Translation: BAA03130.1 .
    AF106518 mRNA. Translation: AAC82473.1 .
    AF263279 mRNA. Translation: AAF85965.1 .
    AF299341 mRNA. Translation: AAG53906.1 .
    AF299342 mRNA. Translation: AAG53907.1 .
    AF299343 mRNA. Translation: AAG53908.1 .
    AF299340 Genomic DNA. Translation: AAG53903.1 .
    AF299340 Genomic DNA. Translation: AAG53904.1 .
    AF299340 Genomic DNA. Translation: AAG53905.1 .
    AK298684 mRNA. Translation: BAG60847.1 .
    AK303525 mRNA. Translation: BAG64553.1 .
    AK312357 mRNA. Translation: BAG35275.1 .
    AK315908 mRNA. Translation: BAH14279.1 .
    AL359711 Genomic DNA. Translation: CAI40700.1 .
    AL359711 Genomic DNA. Translation: CAI40702.1 .
    AL359711 Genomic DNA. Translation: CAI40704.1 .
    CH471051 Genomic DNA. Translation: EAW48348.1 .
    CH471051 Genomic DNA. Translation: EAW48352.1 .
    CH471051 Genomic DNA. Translation: EAW48349.1 .
    CH471051 Genomic DNA. Translation: EAW48353.1 .
    CH471051 Genomic DNA. Translation: EAW48354.1 .
    CH471051 Genomic DNA. Translation: EAW48355.1 .
    BC011522 mRNA. Translation: AAH11522.1 .
    CCDSi CCDS47462.1. [Q04900-5 ]
    CCDS47463.1. [Q04900-2 ]
    CCDS47464.1. [Q04900-3 ]
    CCDS47465.1. [Q04900-4 ]
    CCDS5073.1. [Q04900-1 ]
    PIRi JX0235.
    RefSeqi NP_001135873.1. NM_001142401.1. [Q04900-3 ]
    NP_001135874.1. NM_001142402.1. [Q04900-4 ]
    NP_001135875.1. NM_001142403.1. [Q04900-2 ]
    NP_001135876.1. NM_001142404.1. [Q04900-5 ]
    NP_006007.2. NM_006016.4. [Q04900-1 ]
    UniGenei Hs.520313.

    3D structure databases

    ProteinModelPortali Q04900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114297. 2 interactions.
    IntActi Q04900. 9 interactions.
    MINTi MINT-5225006.
    STRINGi 9606.ENSP00000309376.

    Polymorphism databases

    DMDMi 257051036.

    Proteomic databases

    PaxDbi Q04900.
    PRIDEi Q04900.

    Protocols and materials databases

    DNASUi 8763.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275080 ; ENSP00000275080 ; ENSG00000135535 . [Q04900-3 ]
    ENST00000310786 ; ENSP00000309376 ; ENSG00000135535 . [Q04900-1 ]
    ENST00000324953 ; ENSP00000314177 ; ENSG00000135535 . [Q04900-4 ]
    ENST00000413644 ; ENSP00000402237 ; ENSG00000135535 . [Q04900-2 ]
    ENST00000512821 ; ENSP00000427546 ; ENSG00000135535 . [Q04900-5 ]
    GeneIDi 8763.
    KEGGi hsa:8763.
    UCSCi uc003ptd.3. human. [Q04900-2 ]
    uc003pte.3. human. [Q04900-1 ]
    uc003ptf.3. human. [Q04900-4 ]
    uc010kdn.3. human. [Q04900-3 ]
    uc011eap.2. human. [Q04900-5 ]

    Organism-specific databases

    CTDi 8763.
    GeneCardsi GC06M109687.
    HGNCi HGNC:1632. CD164.
    HPAi HPA010636.
    MIMi 603356. gene.
    neXtProti NX_Q04900.
    PharmGKBi PA26191.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77756.
    HOVERGENi HBG052534.
    KOi K06546.
    OrthoDBi EOG7XDBJ6.
    PhylomeDBi Q04900.
    TreeFami TF333380.

    Miscellaneous databases

    ChiTaRSi CD164. human.
    GeneWikii CD164.
    GenomeRNAii 8763.
    NextBioi 32868.
    PROi Q04900.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04900.
    Bgeei Q04900.
    CleanExi HS_CD164.
    Genevestigatori Q04900.

    Family and domain databases

    InterProi IPR007947. CD164_MGC24.
    [Graphical view ]
    PANTHERi PTHR11337. PTHR11337. 1 hit.
    Pfami PF05283. MGC-24. 1 hit.
    [Graphical view ]
    PRINTSi PR01701. CD164ANTIGEN.
    ProtoNeti Search...

    Publicationsi

    1. "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression."
      Masuzawa Y., Miyauchi T., Hamanoue M., Ando S., Yoshida J., Takao S., Shimazu H., Adachi M., Muramatsu T.
      J. Biochem. 112:609-615(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, GLYCOSYLATION.
      Tissue: Gastric carcinoma.
    2. "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis."
      Zannettino A.C.W., Buehring H.-J., Niutta S., Watt S.M., Benton M.A., Simmons P.J.
      Blood 92:2613-2628(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    3. "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor."
      Doyonnas R., Chan J.Y.-H., Butler L.H., Rappold I., Lee-Prudhoe J.E., Zannettino A.C.W., Simmons P.J., Buehring H.-J., Levesque J.-P., Watt S.M.
      J. Immunol. 165:840-851(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    4. "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."
      Chan J.Y.-H., Lee-Prudhoe J.E., Jorgensen B., Ihrke G., Doyonnas R., Zannettino A.C.W., Buckle V.J., Ward C.J., Simmons P.J., Watt S.M.
      J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 3 AND 4), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Tissue: Amygdala, Astrocyte, Neutrophil and Thymus.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    9. "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis."
      Havens A.M., Jung Y., Sun Y.X., Wang J., Shah R.B., Buehring H.J., Pienta K.J., Taichman R.S.
      BMC Cancer 6:195-195(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    10. "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells."
      Forde S., Tye B.J., Newey S.E., Roubelakis M., Smythe J., McGuckin C.P., Pettengell R., Watt S.M.
      Blood 109:1825-1833(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CXCR4.

    Entry informationi

    Entry nameiMUC24_HUMAN
    AccessioniPrimary (citable) accession number: Q04900
    Secondary accession number(s): B4DQ85
    , E1P5E7, E1P5E8, E1P5E9, O95413, Q5JSU6, Q9BPV0, Q9NR26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3