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Protein

Sialomucin core protein 24

Gene

CD164

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).By similarity3 Publications

GO - Biological processi

  • cell adhesion Source: MGI
  • hemopoiesis Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • immune response Source: ProtInc
  • multicellular organism development Source: ProtInc
  • muscle organ development Source: UniProtKB-KW
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Myogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135535-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
Gene namesi
Name:CD164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1632. CD164.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 162ExtracellularSequence analysisAdd BLAST139
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 197CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8763.
OpenTargetsiENSG00000135535.
PharmGKBiPA26191.

Polymorphism and mutation databases

BioMutaiCD164.
DMDMi257051036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001929224 – 197Sialomucin core protein 24Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.1 Publication
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ04900.
PaxDbiQ04900.
PeptideAtlasiQ04900.
PRIDEiQ04900.

PTM databases

iPTMnetiQ04900.
PhosphoSitePlusiQ04900.

Expressioni

Tissue specificityi

Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.5 Publications

Inductioni

Up-regulated by CXCL12 in prostate cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000135535.
CleanExiHS_CD164.
ExpressionAtlasiQ04900. baseline and differential.
GenevisibleiQ04900. HS.

Organism-specific databases

HPAiHPA010636.

Interactioni

Subunit structurei

Homodimer (isoform 4). Interacts with CXCR4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR4P610732EBI-2115896,EBI-489411
NOTCH2NLQ7Z3S93EBI-2115896,EBI-945833

Protein-protein interaction databases

BioGridi114297. 4 interactors.
IntActiQ04900. 10 interactors.
MINTiMINT-5225006.
STRINGi9606.ENSP00000309376.

Structurei

3D structure databases

ProteinModelPortaliQ04900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 197Required for endosomal and lysosomal localizationBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 152Thr-richAdd BLAST48

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOVERGENiHBG052534.
InParanoidiQ04900.
KOiK06546.
OMAiVSCFNAS.
OrthoDBiEOG091G141K.
PhylomeDBiQ04900.
TreeFamiTF333380.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q04900-1) [UniParc]FASTAAdd to basket
Also known as: CD164(E1-6)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL
60 70 80 90 100
PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC
110 120 130 140 150
QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT
160 170 180 190
PTSQPVRKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL
Length:197
Mass (Da):20,917
Last modified:September 1, 2009 - v2
Checksum:i4855E02646F4CB35
GO
Isoform 2 (identifier: Q04900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK

Show »
Length:189
Mass (Da):20,011
Checksum:iAC1E49F139D50B10
GO
Isoform 3 (identifier: Q04900-3) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 4)

The sequence of this isoform differs from the canonical sequence as follows:
     111-123: Missing.

Show »
Length:184
Mass (Da):19,689
Checksum:iFB689B760D2EE1FC
GO
Isoform 4 (identifier: Q04900-4) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 5)

The sequence of this isoform differs from the canonical sequence as follows:
     124-142: Missing.

Show »
Length:178
Mass (Da):19,017
Checksum:i06FC14ECF6372314
GO
Isoform 5 (identifier: Q04900-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-157: GTTNNTVTPTSQPVR → EIRCHTRNYIPDLKK
     158-197: Missing.

Show »
Length:157
Mass (Da):16,736
Checksum:i9F0212BE11D4F958
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037972111 – 123Missing in isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037973124 – 142Missing in isoform 4. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_038018143 – 157GTTNN…SQPVR → EIRCHTRNYIPDLKK in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_038019158 – 197Missing in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_037974175 – 197GVQAV…NYHTL → EIRCHTRNYIPDLKK in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14043 mRNA. Translation: BAA03130.1.
AF106518 mRNA. Translation: AAC82473.1.
AF263279 mRNA. Translation: AAF85965.1.
AF299341 mRNA. Translation: AAG53906.1.
AF299342 mRNA. Translation: AAG53907.1.
AF299343 mRNA. Translation: AAG53908.1.
AF299340 Genomic DNA. Translation: AAG53903.1.
AF299340 Genomic DNA. Translation: AAG53904.1.
AF299340 Genomic DNA. Translation: AAG53905.1.
AK298684 mRNA. Translation: BAG60847.1.
AK303525 mRNA. Translation: BAG64553.1.
AK312357 mRNA. Translation: BAG35275.1.
AK315908 mRNA. Translation: BAH14279.1.
AL359711 Genomic DNA. Translation: CAI40700.1.
AL359711 Genomic DNA. Translation: CAI40702.1.
AL359711 Genomic DNA. Translation: CAI40704.1.
CH471051 Genomic DNA. Translation: EAW48348.1.
CH471051 Genomic DNA. Translation: EAW48352.1.
CH471051 Genomic DNA. Translation: EAW48349.1.
CH471051 Genomic DNA. Translation: EAW48353.1.
CH471051 Genomic DNA. Translation: EAW48354.1.
CH471051 Genomic DNA. Translation: EAW48355.1.
BC011522 mRNA. Translation: AAH11522.1.
CCDSiCCDS47462.1. [Q04900-5]
CCDS47463.1. [Q04900-2]
CCDS47464.1. [Q04900-3]
CCDS47465.1. [Q04900-4]
CCDS5073.1. [Q04900-1]
PIRiJX0235.
RefSeqiNP_001135873.1. NM_001142401.1. [Q04900-3]
NP_001135874.1. NM_001142402.1. [Q04900-4]
NP_001135875.1. NM_001142403.1. [Q04900-2]
NP_001135876.1. NM_001142404.1. [Q04900-5]
NP_006007.2. NM_006016.4. [Q04900-1]
UniGeneiHs.520313.

Genome annotation databases

EnsembliENST00000275080; ENSP00000275080; ENSG00000135535. [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535. [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535. [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535. [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535. [Q04900-5]
GeneIDi8763.
KEGGihsa:8763.
UCSCiuc003ptd.4. human. [Q04900-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14043 mRNA. Translation: BAA03130.1.
AF106518 mRNA. Translation: AAC82473.1.
AF263279 mRNA. Translation: AAF85965.1.
AF299341 mRNA. Translation: AAG53906.1.
AF299342 mRNA. Translation: AAG53907.1.
AF299343 mRNA. Translation: AAG53908.1.
AF299340 Genomic DNA. Translation: AAG53903.1.
AF299340 Genomic DNA. Translation: AAG53904.1.
AF299340 Genomic DNA. Translation: AAG53905.1.
AK298684 mRNA. Translation: BAG60847.1.
AK303525 mRNA. Translation: BAG64553.1.
AK312357 mRNA. Translation: BAG35275.1.
AK315908 mRNA. Translation: BAH14279.1.
AL359711 Genomic DNA. Translation: CAI40700.1.
AL359711 Genomic DNA. Translation: CAI40702.1.
AL359711 Genomic DNA. Translation: CAI40704.1.
CH471051 Genomic DNA. Translation: EAW48348.1.
CH471051 Genomic DNA. Translation: EAW48352.1.
CH471051 Genomic DNA. Translation: EAW48349.1.
CH471051 Genomic DNA. Translation: EAW48353.1.
CH471051 Genomic DNA. Translation: EAW48354.1.
CH471051 Genomic DNA. Translation: EAW48355.1.
BC011522 mRNA. Translation: AAH11522.1.
CCDSiCCDS47462.1. [Q04900-5]
CCDS47463.1. [Q04900-2]
CCDS47464.1. [Q04900-3]
CCDS47465.1. [Q04900-4]
CCDS5073.1. [Q04900-1]
PIRiJX0235.
RefSeqiNP_001135873.1. NM_001142401.1. [Q04900-3]
NP_001135874.1. NM_001142402.1. [Q04900-4]
NP_001135875.1. NM_001142403.1. [Q04900-2]
NP_001135876.1. NM_001142404.1. [Q04900-5]
NP_006007.2. NM_006016.4. [Q04900-1]
UniGeneiHs.520313.

3D structure databases

ProteinModelPortaliQ04900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114297. 4 interactors.
IntActiQ04900. 10 interactors.
MINTiMINT-5225006.
STRINGi9606.ENSP00000309376.

PTM databases

iPTMnetiQ04900.
PhosphoSitePlusiQ04900.

Polymorphism and mutation databases

BioMutaiCD164.
DMDMi257051036.

Proteomic databases

MaxQBiQ04900.
PaxDbiQ04900.
PeptideAtlasiQ04900.
PRIDEiQ04900.

Protocols and materials databases

DNASUi8763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275080; ENSP00000275080; ENSG00000135535. [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535. [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535. [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535. [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535. [Q04900-5]
GeneIDi8763.
KEGGihsa:8763.
UCSCiuc003ptd.4. human. [Q04900-1]

Organism-specific databases

CTDi8763.
DisGeNETi8763.
GeneCardsiCD164.
HGNCiHGNC:1632. CD164.
HPAiHPA010636.
MIMi603356. gene.
neXtProtiNX_Q04900.
OpenTargetsiENSG00000135535.
PharmGKBiPA26191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOVERGENiHBG052534.
InParanoidiQ04900.
KOiK06546.
OMAiVSCFNAS.
OrthoDBiEOG091G141K.
PhylomeDBiQ04900.
TreeFamiTF333380.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135535-MONOMER.

Miscellaneous databases

ChiTaRSiCD164. human.
GeneWikiiCD164.
GenomeRNAii8763.
PROiQ04900.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135535.
CleanExiHS_CD164.
ExpressionAtlasiQ04900. baseline and differential.
GenevisibleiQ04900. HS.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.
ProtoNetiSearch...

Entry informationi

Entry nameiMUC24_HUMAN
AccessioniPrimary (citable) accession number: Q04900
Secondary accession number(s): B4DQ85
, E1P5E7, E1P5E8, E1P5E9, O95413, Q5JSU6, Q9BPV0, Q9NR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 1, 2009
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.