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Q04899

- CDK18_MOUSE

UniProt

Q04899 - CDK18_MOUSE

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Protein
Cyclin-dependent kinase 18
Gene
Cdk18, Pctaire3, Pctk3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501ATP By similarity
Active sitei242 – 2421Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi127 – 1359ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 18 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 18
    PCTAIRE-motif protein kinase 3
    Serine/threonine-protein kinase PCTAIRE-3
    Gene namesi
    Name:Cdk18
    Synonyms:Pctaire3, Pctk3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:97518. Cdk18.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Cyclin-dependent kinase 18
    PRO_0000086491Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphoserine By similarity
    Modified residuei51 – 511Phosphoserine By similarity
    Modified residuei66 – 661Phosphoserine By similarity
    Modified residuei75 – 751Phosphoserine By similarity
    Modified residuei109 – 1091Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04899.
    PaxDbiQ04899.
    PRIDEiQ04899.

    PTM databases

    PhosphoSiteiQ04899.

    Expressioni

    Tissue specificityi

    In brain, kidney, intestine and at a much lower level, in fetal tissues.

    Gene expression databases

    ArrayExpressiQ04899.
    BgeeiQ04899.
    CleanExiMM_PCTK3.
    GenevestigatoriQ04899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04899.
    SMRiQ04899. Positions 68-428.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 402282Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ04899.
    KOiK15596.
    OMAiHDLIHTD.
    OrthoDBiEOG7966H8.
    PhylomeDBiQ04899.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKMKNFKRR LSLSVPRPET IEESLAEFTE QFNQLHTQTN EDGTDEPEQL    50
    SPGMQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP 100
    LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK 150
    EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD 200
    SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHHRKILH RDLKPQNLLI 250
    NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 300
    MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE 350
    FRAYNFPRYL PQPLLSHAPR LDTEGINLLS SLLLYESKSR MSAEAALNHP 400
    YFQSLGDRVH QLHDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI 450
    F 451
    Length:451
    Mass (Da):51,848
    Last modified:October 1, 1993 - v1
    Checksum:i3FC500519714F7E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69026 mRNA. Translation: CAA48788.1.
    AK004998 mRNA. Translation: BAB23732.1.
    CCDSiCCDS15281.1.
    PIRiS30436.
    RefSeqiNP_032821.1. NM_008795.2.
    UniGeneiMm.28130.

    Genome annotation databases

    EnsembliENSMUST00000027697; ENSMUSP00000027697; ENSMUSG00000026437.
    ENSMUST00000112362; ENSMUSP00000107981; ENSMUSG00000026437.
    GeneIDi18557.
    KEGGimmu:18557.
    UCSCiuc007coh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69026 mRNA. Translation: CAA48788.1 .
    AK004998 mRNA. Translation: BAB23732.1 .
    CCDSi CCDS15281.1.
    PIRi S30436.
    RefSeqi NP_032821.1. NM_008795.2.
    UniGenei Mm.28130.

    3D structure databases

    ProteinModelPortali Q04899.
    SMRi Q04899. Positions 68-428.
    ModBasei Search...

    PTM databases

    PhosphoSitei Q04899.

    Proteomic databases

    MaxQBi Q04899.
    PaxDbi Q04899.
    PRIDEi Q04899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027697 ; ENSMUSP00000027697 ; ENSMUSG00000026437 .
    ENSMUST00000112362 ; ENSMUSP00000107981 ; ENSMUSG00000026437 .
    GeneIDi 18557.
    KEGGi mmu:18557.
    UCSCi uc007coh.2. mouse.

    Organism-specific databases

    CTDi 5129.
    MGIi MGI:97518. Cdk18.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q04899.
    KOi K15596.
    OMAi HDLIHTD.
    OrthoDBi EOG7966H8.
    PhylomeDBi Q04899.
    TreeFami TF106508.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 3474.

    Miscellaneous databases

    NextBioi 294380.
    PROi Q04899.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04899.
    Bgeei Q04899.
    CleanExi MM_PCTK3.
    Genevestigatori Q04899.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family."
      Okuda T., Cleveland J.L., Downing J.R.
      Oncogene 7:2249-2258(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibroblast.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCDK18_MOUSE
    AccessioniPrimary (citable) accession number: Q04899
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: July 9, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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