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Protein

Cyclin-dependent kinase 18

Gene

Cdk18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei150ATPPROSITE-ProRule annotation1
Active sitei242Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi127 – 135ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97518. Cdk18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864911 – 451Cyclin-dependent kinase 18Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei109PhosphoserineCombined sources1
Modified residuei417PhosphoserineBy similarity1
Modified residuei420PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04899.
PeptideAtlasiQ04899.
PRIDEiQ04899.

PTM databases

iPTMnetiQ04899.
PhosphoSitePlusiQ04899.

Expressioni

Tissue specificityi

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Gene expression databases

BgeeiENSMUSG00000026437.
CleanExiMM_PCTK3.
ExpressionAtlasiQ04899. baseline and differential.
GenevisibleiQ04899. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027697.

Structurei

3D structure databases

ProteinModelPortaliQ04899.
SMRiQ04899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 402Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
GeneTreeiENSGT00790000122986.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ04899.
KOiK15596.
OMAiHDLIHTD.
OrthoDBiEOG091G0CH0.
PhylomeDBiQ04899.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKMKNFKRR LSLSVPRPET IEESLAEFTE QFNQLHTQTN EDGTDEPEQL
60 70 80 90 100
SPGMQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP
110 120 130 140 150
LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK
160 170 180 190 200
EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD
210 220 230 240 250
SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHHRKILH RDLKPQNLLI
260 270 280 290 300
NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID
310 320 330 340 350
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE
360 370 380 390 400
FRAYNFPRYL PQPLLSHAPR LDTEGINLLS SLLLYESKSR MSAEAALNHP
410 420 430 440 450
YFQSLGDRVH QLHDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI

F
Length:451
Mass (Da):51,848
Last modified:October 1, 1993 - v1
Checksum:i3FC500519714F7E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69026 mRNA. Translation: CAA48788.1.
AK004998 mRNA. Translation: BAB23732.1.
CCDSiCCDS15281.1.
PIRiS30436.
RefSeqiNP_032821.1. NM_008795.2.
UniGeneiMm.28130.

Genome annotation databases

EnsembliENSMUST00000027697; ENSMUSP00000027697; ENSMUSG00000026437.
ENSMUST00000112362; ENSMUSP00000107981; ENSMUSG00000026437.
GeneIDi18557.
KEGGimmu:18557.
UCSCiuc007coh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69026 mRNA. Translation: CAA48788.1.
AK004998 mRNA. Translation: BAB23732.1.
CCDSiCCDS15281.1.
PIRiS30436.
RefSeqiNP_032821.1. NM_008795.2.
UniGeneiMm.28130.

3D structure databases

ProteinModelPortaliQ04899.
SMRiQ04899.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027697.

PTM databases

iPTMnetiQ04899.
PhosphoSitePlusiQ04899.

Proteomic databases

PaxDbiQ04899.
PeptideAtlasiQ04899.
PRIDEiQ04899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027697; ENSMUSP00000027697; ENSMUSG00000026437.
ENSMUST00000112362; ENSMUSP00000107981; ENSMUSG00000026437.
GeneIDi18557.
KEGGimmu:18557.
UCSCiuc007coh.2. mouse.

Organism-specific databases

CTDi5129.
MGIiMGI:97518. Cdk18.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
GeneTreeiENSGT00790000122986.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ04899.
KOiK15596.
OMAiHDLIHTD.
OrthoDBiEOG091G0CH0.
PhylomeDBiQ04899.
TreeFamiTF106508.

Enzyme and pathway databases

BRENDAi2.7.11.22. 3474.

Miscellaneous databases

PROiQ04899.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026437.
CleanExiMM_PCTK3.
ExpressionAtlasiQ04899. baseline and differential.
GenevisibleiQ04899. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK18_MOUSE
AccessioniPrimary (citable) accession number: Q04899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.