Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q04896 (HME1A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein engrailed-1a
Short name=Homeobox protein en-1a
Gene names
Name:eng1a
Synonyms:eng-1, eng1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus.

Sequence similarities

Belongs to the engrailed homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Homeobox protein engrailed-1a
PRO_0000196072

Regions

DNA binding143 – 20260Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q04896 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 91BA2674ED886455

FASTA23126,200
        10         20         30         40         50         60 
MEDQRRGQGE EEDDSGSLPS PPLLPAHRNT DFFIDNILRP DFGCKRERER VTRDSGVRPT 

        70         80         90        100        110        120 
ALPDSRSDGV SSSASSTVSS PVSSRQSNKV EQGSSKSSSP SKDSQKQILW PAWVYCTRYS 

       130        140        150        160        170        180 
DRPSSGPRTR KLKKKNNNTE SDDKRPRTAF TAEQLQRLKA EFQTSRYITE QRRQALAREL 

       190        200        210        220        230 
GLNESQIKIW FQNKRAKIKK SSGFKNALAM QLMAQGLYNH STTTIQEEED N

« Hide

References

[1]"Coordinate embryonic expression of three zebrafish engrailed genes."
Ekker M., Wegner J., Akimenko M.-A., Westerfield M.
Development 116:1001-1010(1992) [PubMed: 1363539] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X68445 mRNA. Translation: CAA48490.1.
IPIIPI00500053.
PIRS30438.
RefSeqNP_571120.1. NM_131045.1.
UniGeneDr.75072.

3D structure databases

ProteinModelPortalQ04896.
SMRQ04896. Positions 142-201.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ04896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID30244.
KEGGdre:30244.

Organism-specific databases

CTD30244.
ZFINZDB-GENE-980526-216. eng1a.

Phylogenomic databases

eggNOGfiNOG13158.
HOGENOMHBG716207.
HOVERGENHBG005975.
InParanoidQ04896.
OrthoDBEOG461458.

Gene expression databases

ArrayExpressQ04896.
BgeeQ04896.

Family and domain databases

InterProIPR001356. Homeobox.
IPR000747. Homeobox-engrailed.
IPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHME1A_DANRE
AccessionPrimary (citable) accession number: Q04896
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents