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Protein

Allantoin permease

Gene

DAL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of allantoin.

GO - Molecular functioni

  • allantoin:proton symporter activity Source: SGD

GO - Biological processi

  • allantoin catabolic process Source: SGD
  • allantoin transport Source: SGD
  • purine nucleobase metabolic process Source: UniProtKB-KW

Keywordsi

Biological processPurine metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31446-MONOMER

Protein family/group databases

TCDBi2.A.39.3.1 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoin permease
Alternative name(s):
Allantoin transport protein
Gene namesi
Name:DAL4
Ordered Locus Names:YIR028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR028W
SGDiS000001467 DAL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 144CytoplasmicSequence analysisAdd BLAST144
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 174ExtracellularSequence analysis9
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 198CytoplasmicSequence analysis3
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 243ExtracellularSequence analysisAdd BLAST24
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 269CytoplasmicSequence analysis5
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 311ExtracellularSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 351CytoplasmicSequence analysisAdd BLAST19
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 401ExtracellularSequence analysisAdd BLAST29
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 443CytoplasmicSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 466ExtracellularSequence analysis2
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 560ExtracellularSequence analysisAdd BLAST17
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Topological domaini582 – 635CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979191 – 635Allantoin permeaseAdd BLAST635

Proteomic databases

PaxDbiQ04895
PRIDEiQ04895

Interactioni

Protein-protein interaction databases

BioGridi35019, 30 interactors
DIPiDIP-7194N
IntActiQ04895, 1 interactor
STRINGi4932.YIR028W

Structurei

3D structure databases

ProteinModelPortaliQ04895
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049
HOGENOMiHOG000202588
InParanoidiQ04895
KOiK03457
OMAiVPFPVMS
OrthoDBiEOG092C1JZY

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

Q04895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDALSAIF SNPSRKGVQP STSIVSYTNN EDDIIDVENG KFNKNKNINT
60 70 80 90 100
NVYVDNSSIE ESEVVPLPET KSIWSKIYYD FIVLDKTTLN VSLKESFLYN
110 120 130 140 150
RDLKPVEEER RCWSWFNYLY FWLADCFNIN TWQIAGTGLQ LGLNWWQCWL
160 170 180 190 200
TVWIGYTFAG IFVVLNSRFG SAYHLSFPIT VRASFGIFFS MWPIINRVVM
210 220 230 240 250
AIVWYAVQAW LGATPVALML KSIFGKNLED RIPNHFGSPN STTFEFMCFF
260 270 280 290 300
IFWVVSIPFV LVAPHKIRHL FTVKAALIPF AAFGFLIWAL KKSHGKIELG
310 320 330 340 350
TLNDYSPHGS EFSWIFVRSL MACVANFAAL IINAPDFGRF AKNPQASLWP
360 370 380 390 400
QLVAIPLFFA ITCLIGIIVT AAGYHLYGVN YWSPLDVLGQ FLETTYTRGT
410 420 430 440 450
RAGVFLISFV FALAQLGTNI SANSLACGAD MTALFPRYIN IRRGSLFCVA
460 470 480 490 500
MALCICPWNL MASSSKFTSA LGAYAIFLSS IAGVICADYF VVRRGYVKLT
510 520 530 540 550
HLFLAQKGSF YMFGNKFGAN WRAFVAYICG IAPNLPGFIG DVGAPKITVS
560 570 580 590 600
EGAMRLYYLG YPVGFFISAV IYLILCYFFP VPGTPVTNFL TEKGWFQRWA
610 620 630
YVEDFEQDWK NELRRDDLCD DTVSIYDGTE EKIVY
Length:635
Mass (Da):71,756
Last modified:October 1, 1993 - v1
Checksum:i4728BBC786DC6698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15121 Genomic DNA Translation: CAA78826.1
Z38061 Genomic DNA Translation: CAA86188.1
BK006942 Genomic DNA Translation: DAA08575.1
PIRiS30018
RefSeqiNP_012294.3, NM_001179550.3

Genome annotation databases

EnsemblFungiiYIR028W; YIR028W; YIR028W
GeneIDi854846
KEGGisce:YIR028W

Similar proteinsi

Entry informationi

Entry nameiDAL4_YEAST
AccessioniPrimary (citable) accession number: Q04895
Secondary accession number(s): D6VVV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health