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Q04895 (DAL4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Allantoin permease
Alternative name(s):
Allantoin transport protein
Gene names
Name:DAL4
Ordered Locus Names:YIR028W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transport of allantoin.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the purine-cytosine permease family.

Ontologies

Keywords
   Biological processPurine metabolism
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processallantoin catabolic process

Inferred from mutant phenotype. Source: SGD

purine base metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionallantoin uptake transmembrane transporter activity

Inferred from mutant phenotype. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Allantoin permease
PRO_0000197919

Regions

Topological domain1 – 144144Cytoplasmic Potential
Transmembrane145 – 16521Helical; Potential
Topological domain166 – 1749Extracellular Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 1983Cytoplasmic Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 24324Extracellular Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 2695Cytoplasmic Potential
Transmembrane270 – 29021Helical; Potential
Topological domain291 – 31121Extracellular Potential
Transmembrane312 – 33221Helical; Potential
Topological domain333 – 35119Cytoplasmic Potential
Transmembrane352 – 37221Helical; Potential
Topological domain373 – 40129Extracellular Potential
Transmembrane402 – 42221Helical; Potential
Topological domain423 – 44321Cytoplasmic Potential
Transmembrane444 – 46421Helical; Potential
Topological domain465 – 4662Extracellular Potential
Transmembrane467 – 48721Helical; Potential
Topological domain488 – 52235Cytoplasmic Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 56017Extracellular Potential
Transmembrane561 – 58121Helical; Potential
Topological domain582 – 63554Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q04895 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 4728BBC786DC6698

FASTA63571,756
        10         20         30         40         50         60 
MANDALSAIF SNPSRKGVQP STSIVSYTNN EDDIIDVENG KFNKNKNINT NVYVDNSSIE 

        70         80         90        100        110        120 
ESEVVPLPET KSIWSKIYYD FIVLDKTTLN VSLKESFLYN RDLKPVEEER RCWSWFNYLY 

       130        140        150        160        170        180 
FWLADCFNIN TWQIAGTGLQ LGLNWWQCWL TVWIGYTFAG IFVVLNSRFG SAYHLSFPIT 

       190        200        210        220        230        240 
VRASFGIFFS MWPIINRVVM AIVWYAVQAW LGATPVALML KSIFGKNLED RIPNHFGSPN 

       250        260        270        280        290        300 
STTFEFMCFF IFWVVSIPFV LVAPHKIRHL FTVKAALIPF AAFGFLIWAL KKSHGKIELG 

       310        320        330        340        350        360 
TLNDYSPHGS EFSWIFVRSL MACVANFAAL IINAPDFGRF AKNPQASLWP QLVAIPLFFA 

       370        380        390        400        410        420 
ITCLIGIIVT AAGYHLYGVN YWSPLDVLGQ FLETTYTRGT RAGVFLISFV FALAQLGTNI 

       430        440        450        460        470        480 
SANSLACGAD MTALFPRYIN IRRGSLFCVA MALCICPWNL MASSSKFTSA LGAYAIFLSS 

       490        500        510        520        530        540 
IAGVICADYF VVRRGYVKLT HLFLAQKGSF YMFGNKFGAN WRAFVAYICG IAPNLPGFIG 

       550        560        570        580        590        600 
DVGAPKITVS EGAMRLYYLG YPVGFFISAV IYLILCYFFP VPGTPVTNFL TEKGWFQRWA 

       610        620        630 
YVEDFEQDWK NELRRDDLCD DTVSIYDGTE EKIVY

« Hide

References

« Hide 'large scale' references
[1]"The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical."
Yoo H.S., Cunningham T.S., Cooper T.G.
Yeast 8:997-1006(1992) [PubMed: 1293888] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed: 9169870] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z15121 Genomic DNA. Translation: CAA78826.1.
Z38061 Genomic DNA. Translation: CAA86188.1.
BK006942 Genomic DNA. Translation: DAA08575.1.
PIRS30018.
RefSeqNP_012294.1. NM_001179550.1.

3D structure databases

ProteinModelPortalQ04895.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-7194N.
IntActQ04895. 1 interaction.
STRINGQ04895.

Protein family/group databases

TCDB2.A.39.3.1. nucleobase:cation symporter-1 (NCS1) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIR028W; YIR028W; YIR028W.
GeneID854846.
KEGGsce:YIR028W.
NMPDRfig|4932.3.peg.1837.

Organism-specific databases

CYGDYIR028w.
SGDS000001467. DAL4.

Phylogenomic databases

eggNOGfuNOG06698.
GeneTreeEFGT00050000000882.
HOGENOMHBG333533.
OMANLAPRRI.
OrthoDBEOG4XPTQ8.

Gene expression databases

ArrayExpressQ04895.
GenevestigatorQ04895.
GermOnlineYIR028W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
KOK03457.
PfamPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsTIGR00800. Ncs1. 1 hit.
ProtoNetSearch...

Other

NextBio977737.

Entry information

Entry nameDAL4_YEAST
AccessionPrimary (citable) accession number: Q04895
Secondary accession number(s): D6VVV9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

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