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Protein

Allantoin permease

Gene

DAL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transport of allantoin.

GO - Molecular functioni

  • allantoin uptake transmembrane transporter activity Source: SGD

GO - Biological processi

  • allantoin catabolic process Source: SGD
  • allantoin transport Source: SGD
  • purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Purine metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31446-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.1. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoin permease
Alternative name(s):
Allantoin transport protein
Gene namesi
Name:DAL4
Ordered Locus Names:YIR028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR028W.
SGDiS000001467. DAL4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 144144CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 1749ExtracellularSequence analysis
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 1983CytoplasmicSequence analysis
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 24324ExtracellularSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 2695CytoplasmicSequence analysis
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Topological domaini291 – 31121ExtracellularSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Topological domaini333 – 35119CytoplasmicSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Topological domaini373 – 40129ExtracellularSequence analysisAdd
BLAST
Transmembranei402 – 42221HelicalSequence analysisAdd
BLAST
Topological domaini423 – 44321CytoplasmicSequence analysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence analysisAdd
BLAST
Topological domaini465 – 4662ExtracellularSequence analysis
Transmembranei467 – 48721HelicalSequence analysisAdd
BLAST
Topological domaini488 – 52235CytoplasmicSequence analysisAdd
BLAST
Transmembranei523 – 54321HelicalSequence analysisAdd
BLAST
Topological domaini544 – 56017ExtracellularSequence analysisAdd
BLAST
Transmembranei561 – 58121HelicalSequence analysisAdd
BLAST
Topological domaini582 – 63554CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Allantoin permeasePRO_0000197919Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi35019. 16 interactions.
DIPiDIP-7194N.
IntActiQ04895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ04895.
SMRiQ04895. Positions 98-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiQ04895.
KOiK03457.
OMAiINAHVED.
OrthoDBiEOG75B8F6.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDALSAIF SNPSRKGVQP STSIVSYTNN EDDIIDVENG KFNKNKNINT
60 70 80 90 100
NVYVDNSSIE ESEVVPLPET KSIWSKIYYD FIVLDKTTLN VSLKESFLYN
110 120 130 140 150
RDLKPVEEER RCWSWFNYLY FWLADCFNIN TWQIAGTGLQ LGLNWWQCWL
160 170 180 190 200
TVWIGYTFAG IFVVLNSRFG SAYHLSFPIT VRASFGIFFS MWPIINRVVM
210 220 230 240 250
AIVWYAVQAW LGATPVALML KSIFGKNLED RIPNHFGSPN STTFEFMCFF
260 270 280 290 300
IFWVVSIPFV LVAPHKIRHL FTVKAALIPF AAFGFLIWAL KKSHGKIELG
310 320 330 340 350
TLNDYSPHGS EFSWIFVRSL MACVANFAAL IINAPDFGRF AKNPQASLWP
360 370 380 390 400
QLVAIPLFFA ITCLIGIIVT AAGYHLYGVN YWSPLDVLGQ FLETTYTRGT
410 420 430 440 450
RAGVFLISFV FALAQLGTNI SANSLACGAD MTALFPRYIN IRRGSLFCVA
460 470 480 490 500
MALCICPWNL MASSSKFTSA LGAYAIFLSS IAGVICADYF VVRRGYVKLT
510 520 530 540 550
HLFLAQKGSF YMFGNKFGAN WRAFVAYICG IAPNLPGFIG DVGAPKITVS
560 570 580 590 600
EGAMRLYYLG YPVGFFISAV IYLILCYFFP VPGTPVTNFL TEKGWFQRWA
610 620 630
YVEDFEQDWK NELRRDDLCD DTVSIYDGTE EKIVY
Length:635
Mass (Da):71,756
Last modified:October 1, 1993 - v1
Checksum:i4728BBC786DC6698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15121 Genomic DNA. Translation: CAA78826.1.
Z38061 Genomic DNA. Translation: CAA86188.1.
BK006942 Genomic DNA. Translation: DAA08575.1.
PIRiS30018.
RefSeqiNP_012294.3. NM_001179550.3.

Genome annotation databases

EnsemblFungiiYIR028W; YIR028W; YIR028W.
GeneIDi854846.
KEGGisce:YIR028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15121 Genomic DNA. Translation: CAA78826.1.
Z38061 Genomic DNA. Translation: CAA86188.1.
BK006942 Genomic DNA. Translation: DAA08575.1.
PIRiS30018.
RefSeqiNP_012294.3. NM_001179550.3.

3D structure databases

ProteinModelPortaliQ04895.
SMRiQ04895. Positions 98-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35019. 16 interactions.
DIPiDIP-7194N.
IntActiQ04895. 1 interaction.

Protein family/group databases

TCDBi2.A.39.3.1. the nucleobase:cation symporter-1 (ncs1) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR028W; YIR028W; YIR028W.
GeneIDi854846.
KEGGisce:YIR028W.

Organism-specific databases

EuPathDBiFungiDB:YIR028W.
SGDiS000001467. DAL4.

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiQ04895.
KOiK03457.
OMAiINAHVED.
OrthoDBiEOG75B8F6.

Enzyme and pathway databases

BioCyciYEAST:G3O-31446-MONOMER.

Miscellaneous databases

NextBioi977737.
PROiQ04895.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical."
    Yoo H.S., Cunningham T.S., Cooper T.G.
    Yeast 8:997-1006(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiDAL4_YEAST
AccessioniPrimary (citable) accession number: Q04895
Secondary accession number(s): D6VVV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.