SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q04894

- ADH6_YEAST

UniProt

Q04894 - ADH6_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NADP-dependent alcohol dehydrogenase 6
Gene
ADH6, YMR318C, YM9924.10C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

NADP-dependent alcohol dehydrogenase with a broad substrate specificity.

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Zinc 1; catalytic By similarity
Metal bindingi68 – 681Zinc 1; catalytic By similarity
Metal bindingi100 – 1001Zinc 2 By similarity
Metal bindingi103 – 1031Zinc 2 By similarity
Metal bindingi106 – 1061Zinc 2 By similarity
Metal bindingi114 – 1141Zinc 2 By similarity
Metal bindingi163 – 1631Zinc 1; catalytic By similarity
Binding sitei215 – 2151NAD By similarity
Binding sitei348 – 3481NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi187 – 1926NAD By similarity
Nucleotide bindingi275 – 2773NAD By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NADP+) activity Source: SGD
  2. hydroxymethylfurfural reductase (NADH) activity Source: SGD
  3. hydroxymethylfurfural reductase (NADPH) activity Source: SGD
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. alcohol metabolic process Source: SGD
  2. cellular aldehyde metabolic process Source: SGD
  3. furaldehyde metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciYEAST:YMR318C-MONOMER.
SABIO-RKQ04894.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent alcohol dehydrogenase 6 (EC:1.1.1.2)
Alternative name(s):
NADP-dependent alcohol dehydrogenase VI
ScADHVI
Gene namesi
Name:ADH6
Ordered Locus Names:YMR318C
ORF Names:YM9924.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR318c.
SGDiS000004937. ADH6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360NADP-dependent alcohol dehydrogenase 6
PRO_0000160734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311Phosphoserine1 Publication
Modified residuei359 – 3591Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04894.
PaxDbiQ04894.
PeptideAtlasiQ04894.

Expressioni

Gene expression databases

GenevestigatoriQ04894.

Interactioni

Protein-protein interaction databases

BioGridi35498. 36 interactions.
DIPiDIP-6308N.
IntActiQ04894. 1 interaction.
MINTiMINT-696048.
STRINGi4932.YMR318C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 53
Beta strandi7 – 126
Beta strandi15 – 173
Beta strandi22 – 265
Beta strandi35 – 4511
Helixi47 – 537
Turni54 – 574
Beta strandi62 – 643
Beta strandi70 – 778
Beta strandi90 – 934
Beta strandi95 – 984
Beta strandi101 – 1033
Helixi104 – 1074
Helixi111 – 1133
Beta strandi118 – 1225
Beta strandi134 – 1429
Helixi143 – 1453
Beta strandi146 – 1483
Helixi155 – 1584
Helixi159 – 1624
Helixi164 – 17411
Beta strandi182 – 1865
Helixi190 – 20213
Beta strandi205 – 2139
Helixi216 – 2216
Beta strandi225 – 2295
Helixi230 – 2323
Helixi236 – 2394
Beta strandi244 – 2496
Beta strandi254 – 2563
Turni259 – 2613
Helixi262 – 2654
Beta strandi266 – 2749
Beta strandi284 – 2863
Helixi288 – 2903
Beta strandi295 – 2984
Helixi304 – 31613
Beta strandi323 – 3297
Helixi330 – 34213
Beta strandi346 – 3527
Helixi355 – 3584

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PIWX-ray3.00A/B1-360[»]
1PS0X-ray3.01A1-360[»]
1Q1NX-ray3.15A1-360[»]
ProteinModelPortaliQ04894.
SMRiQ04894. Positions 1-360.

Miscellaneous databases

EvolutionaryTraceiQ04894.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1064.
GeneTreeiENSGT00750000118226.
HOGENOMiHOG000294667.
KOiK00002.
OMAiHDIDIKI.
OrthoDBiEOG757D7B.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04894-1 [UniParc]FASTAAdd to Basket

« Hide

MSYPEKFEGI AIQSHEDWKN PKKTKYDPKP FYDHDIDIKI EACGVCGSDI    50
HCAAGHWGNM KMPLVVGHEI VGKVVKLGPK SNSGLKVGQR VGVGAQVFSC 100
LECDRCKNDN EPYCTKFVTT YSQPYEDGYV SQGGYANYVR VHEHFVVPIP 150
ENIPSHLAAP LLCGGLTVYS PLVRNGCGPG KKVGIVGLGG IGSMGTLISK 200
AMGAETYVIS RSSRKREDAM KMGADHYIAT LEEGDWGEKY FDTFDLIVVC 250
ASSLTDIDFN IMPKAMKVGG RIVSISIPEQ HEMLSLKPYG LKAVSISYSA 300
LGSIKELNQL LKLVSEKDIK IWVETLPVGE AGVHEAFERM EKGDVRYRFT 350
LVGYDKEFSD 360
Length:360
Mass (Da):39,618
Last modified:November 1, 1997 - v1
Checksum:i3F785BE0C5ED8CF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54141 Genomic DNA. Translation: CAA90836.1.
BK006946 Genomic DNA. Translation: DAA10220.1.
PIRiS59311.
RefSeqiNP_014051.3. NM_001182831.3.

Genome annotation databases

EnsemblFungiiYMR318C; YMR318C; YMR318C.
GeneIDi855368.
KEGGisce:YMR318C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54141 Genomic DNA. Translation: CAA90836.1 .
BK006946 Genomic DNA. Translation: DAA10220.1 .
PIRi S59311.
RefSeqi NP_014051.3. NM_001182831.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PIW X-ray 3.00 A/B 1-360 [» ]
1PS0 X-ray 3.01 A 1-360 [» ]
1Q1N X-ray 3.15 A 1-360 [» ]
ProteinModelPortali Q04894.
SMRi Q04894. Positions 1-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35498. 36 interactions.
DIPi DIP-6308N.
IntActi Q04894. 1 interaction.
MINTi MINT-696048.
STRINGi 4932.YMR318C.

Proteomic databases

MaxQBi Q04894.
PaxDbi Q04894.
PeptideAtlasi Q04894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR318C ; YMR318C ; YMR318C .
GeneIDi 855368.
KEGGi sce:YMR318C.

Organism-specific databases

CYGDi YMR318c.
SGDi S000004937. ADH6.

Phylogenomic databases

eggNOGi COG1064.
GeneTreei ENSGT00750000118226.
HOGENOMi HOG000294667.
KOi K00002.
OMAi HDIDIKI.
OrthoDBi EOG757D7B.

Enzyme and pathway databases

BioCyci YEAST:YMR318C-MONOMER.
SABIO-RK Q04894.

Miscellaneous databases

EvolutionaryTracei Q04894.
NextBioi 979148.

Gene expression databases

Genevestigatori Q04894.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi."
    Valencia E., Rosell A., Larroy C., Farres J., Biosca J.A., Fita I., Pares X., Ochoa W.F.
    Acta Crystallogr. D 59:334-337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADH6_YEAST
AccessioniPrimary (citable) accession number: Q04894
Secondary accession number(s): D6W0E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 21700 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi