Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q04894 (ADH6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-dependent alcohol dehydrogenase 6

EC=1.1.1.2
Alternative name(s):
NADP-dependent alcohol dehydrogenase VI
ScADHVI
Gene names
Name:ADH6
Ordered Locus Names:YMR318C
ORF Names:YM9924.10C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

NADP-dependent alcohol dehydrogenase with a broad substrate specificity.

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Miscellaneous

Present with 21700 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360NADP-dependent alcohol dehydrogenase 6
PRO_0000160734

Regions

Nucleotide binding187 – 1926NAD By similarity
Nucleotide binding275 – 2773NAD By similarity

Sites

Metal binding461Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1061Zinc 2 By similarity
Metal binding1141Zinc 2 By similarity
Metal binding1631Zinc 1; catalytic By similarity
Binding site2151NAD By similarity
Binding site3481NAD By similarity

Amino acid modifications

Modified residue1311Phosphoserine Ref.5
Modified residue3591Phosphoserine Ref.5 Ref.6

Secondary structure

.......................................................................... 360
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q04894 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 3F785BE0C5ED8CF1

FASTA36039,618
        10         20         30         40         50         60 
MSYPEKFEGI AIQSHEDWKN PKKTKYDPKP FYDHDIDIKI EACGVCGSDI HCAAGHWGNM 

        70         80         90        100        110        120 
KMPLVVGHEI VGKVVKLGPK SNSGLKVGQR VGVGAQVFSC LECDRCKNDN EPYCTKFVTT 

       130        140        150        160        170        180 
YSQPYEDGYV SQGGYANYVR VHEHFVVPIP ENIPSHLAAP LLCGGLTVYS PLVRNGCGPG 

       190        200        210        220        230        240 
KKVGIVGLGG IGSMGTLISK AMGAETYVIS RSSRKREDAM KMGADHYIAT LEEGDWGEKY 

       250        260        270        280        290        300 
FDTFDLIVVC ASSLTDIDFN IMPKAMKVGG RIVSISIPEQ HEMLSLKPYG LKAVSISYSA 

       310        320        330        340        350        360 
LGSIKELNQL LKLVSEKDIK IWVETLPVGE AGVHEAFERM EKGDVRYRFT LVGYDKEFSD 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi."
Valencia E., Rosell A., Larroy C., Farres J., Biosca J.A., Fita I., Pares X., Ochoa W.F.
Acta Crystallogr. D 59:334-337(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CRYSTALLIZATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z54141 Genomic DNA. Translation: CAA90836.1.
BK006946 Genomic DNA. Translation: DAA10220.1.
PIRS59311.
RefSeqNP_014051.3. NM_001182831.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PIWX-ray3.00A/B1-360[»]
1PS0X-ray3.01A1-360[»]
1Q1NX-ray3.15A1-360[»]
ProteinModelPortalQ04894.
SMRQ04894. Positions 1-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35498. 36 interactions.
DIPDIP-6308N.
IntActQ04894. 1 interaction.
MINTMINT-696048.
STRING4932.YMR318C.

Proteomic databases

PaxDbQ04894.
PeptideAtlasQ04894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR318C; YMR318C; YMR318C.
GeneID855368.
KEGGsce:YMR318C.

Organism-specific databases

CYGDYMR318c.
SGDS000004937. ADH6.

Phylogenomic databases

eggNOGCOG1064.
GeneTreeENSGT00750000118226.
HOGENOMHOG000294667.
KOK00002.
OMAHDIDIKI.
OrthoDBEOG757D7B.

Enzyme and pathway databases

BioCycYEAST:YMR318C-MONOMER.
SABIO-RKQ04894.

Gene expression databases

GenevestigatorQ04894.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ04894.
NextBio979148.

Entry information

Entry nameADH6_YEAST
AccessionPrimary (citable) accession number: Q04894
Secondary accession number(s): D6W0E6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references