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Protein

NADP-dependent alcohol dehydrogenase 6

Gene

ADH6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADP-dependent alcohol dehydrogenase with a broad substrate specificity.

Miscellaneous

Present with 21700 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi163Zinc 1; catalyticBy similarity1
Binding sitei215NADBy similarity1
Binding sitei348NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 192NADBy similarity6
Nucleotide bindingi275 – 277NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: SGD
  • hydroxymethylfurfural reductase (NADH) activity Source: SGD
  • hydroxymethylfurfural reductase (NADPH) activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: SGD
  • cellular aldehyde metabolic process Source: SGD
  • furaldehyde metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciYEAST:YMR318C-MONOMER
SABIO-RKiQ04894

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent alcohol dehydrogenase 6 (EC:1.1.1.2)
Alternative name(s):
NADP-dependent alcohol dehydrogenase VI
ScADHVI
Gene namesi
Name:ADH6
Ordered Locus Names:YMR318C
ORF Names:YM9924.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR318C
SGDiS000004937 ADH6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607341 – 360NADP-dependent alcohol dehydrogenase 6Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131PhosphoserineCombined sources1
Modified residuei315PhosphoserineBy similarity1
Modified residuei359PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04894
PaxDbiQ04894
PRIDEiQ04894

PTM databases

iPTMnetiQ04894

Interactioni

Protein-protein interaction databases

BioGridi35498, 75 interactors
DIPiDIP-6308N
IntActiQ04894, 3 interactors
STRINGi4932.YMR318C

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 5Combined sources3
Beta strandi7 – 12Combined sources6
Beta strandi15 – 17Combined sources3
Beta strandi22 – 26Combined sources5
Beta strandi35 – 45Combined sources11
Helixi47 – 53Combined sources7
Turni54 – 57Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi70 – 77Combined sources8
Beta strandi90 – 93Combined sources4
Beta strandi95 – 98Combined sources4
Beta strandi101 – 103Combined sources3
Helixi104 – 107Combined sources4
Helixi111 – 113Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi134 – 142Combined sources9
Helixi143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Helixi155 – 158Combined sources4
Helixi159 – 162Combined sources4
Helixi164 – 174Combined sources11
Beta strandi182 – 186Combined sources5
Helixi190 – 202Combined sources13
Beta strandi205 – 213Combined sources9
Helixi216 – 221Combined sources6
Beta strandi225 – 229Combined sources5
Helixi230 – 232Combined sources3
Helixi236 – 239Combined sources4
Beta strandi244 – 249Combined sources6
Beta strandi254 – 256Combined sources3
Turni259 – 261Combined sources3
Helixi262 – 265Combined sources4
Beta strandi266 – 274Combined sources9
Beta strandi284 – 286Combined sources3
Helixi288 – 290Combined sources3
Beta strandi295 – 298Combined sources4
Helixi304 – 316Combined sources13
Beta strandi323 – 329Combined sources7
Helixi330 – 342Combined sources13
Beta strandi346 – 352Combined sources7
Helixi355 – 358Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PIWX-ray3.00A/B1-360[»]
1PS0X-ray3.01A1-360[»]
1Q1NX-ray3.15A1-360[»]
ProteinModelPortaliQ04894
SMRiQ04894
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04894

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00840000131639
HOGENOMiHOG000294667
InParanoidiQ04894
KOiK00002
OMAiDRHTISG
OrthoDBiEOG092C34I7

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q04894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPEKFEGI AIQSHEDWKN PKKTKYDPKP FYDHDIDIKI EACGVCGSDI
60 70 80 90 100
HCAAGHWGNM KMPLVVGHEI VGKVVKLGPK SNSGLKVGQR VGVGAQVFSC
110 120 130 140 150
LECDRCKNDN EPYCTKFVTT YSQPYEDGYV SQGGYANYVR VHEHFVVPIP
160 170 180 190 200
ENIPSHLAAP LLCGGLTVYS PLVRNGCGPG KKVGIVGLGG IGSMGTLISK
210 220 230 240 250
AMGAETYVIS RSSRKREDAM KMGADHYIAT LEEGDWGEKY FDTFDLIVVC
260 270 280 290 300
ASSLTDIDFN IMPKAMKVGG RIVSISIPEQ HEMLSLKPYG LKAVSISYSA
310 320 330 340 350
LGSIKELNQL LKLVSEKDIK IWVETLPVGE AGVHEAFERM EKGDVRYRFT
360
LVGYDKEFSD
Length:360
Mass (Da):39,618
Last modified:November 1, 1997 - v1
Checksum:i3F785BE0C5ED8CF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54141 Genomic DNA Translation: CAA90836.1
BK006946 Genomic DNA Translation: DAA10220.1
PIRiS59311
RefSeqiNP_014051.3, NM_001182831.3

Genome annotation databases

EnsemblFungiiYMR318C; YMR318C; YMR318C
GeneIDi855368
KEGGisce:YMR318C

Similar proteinsi

Entry informationi

Entry nameiADH6_YEAST
AccessioniPrimary (citable) accession number: Q04894
Secondary accession number(s): D6W0E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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