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Protein

Transcription factor SOX-14

Gene

Sox14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

GO - Biological processi

  • entrainment of circadian clock Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of neuron migration Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Gene namesi
Name:Sox14
Synonyms:Sox-14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98362. Sox14.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcription factor SOX-14PRO_0000048760Add
BLAST

Proteomic databases

PRIDEiQ04892.

PTM databases

PhosphoSiteiQ04892.

Expressioni

Tissue specificityi

Highly expressed in developing brain and spinal cord.1 Publication

Gene expression databases

BgeeiQ04892.
CleanExiMM_SOX14.
ExpressionAtlasiQ04892. baseline.
GenevisibleiQ04892. MM.

Interactioni

Protein-protein interaction databases

BioGridi203401. 1 interaction.
STRINGi10090.ENSMUSP00000091310.

Structurei

3D structure databases

ProteinModelPortaliQ04892.
SMRiQ04892. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
HOVERGENiHBG105618.
InParanoidiQ04892.
KOiK09267.
OMAiYSSAHAA.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ04892.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029549. SOX-14.
[Graphical view]
PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TSALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,515
Last modified:August 14, 2001 - v2
Checksum:i158D8AE76571C856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193437 Genomic DNA. Translation: AAF62397.1.
AF193435 mRNA. Translation: AAF62396.1.
AF182357 Genomic DNA. Translation: AAF19353.1.
Z18963 mRNA. Translation: CAA79488.1.
CCDSiCCDS57695.1.
PIRiS30244.
RefSeqiNP_035570.1. NM_011440.1.
UniGeneiMm.261595.
Mm.484077.

Genome annotation databases

EnsembliENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747.
GeneIDi20669.
KEGGimmu:20669.
UCSCiuc012gzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193437 Genomic DNA. Translation: AAF62397.1.
AF193435 mRNA. Translation: AAF62396.1.
AF182357 Genomic DNA. Translation: AAF19353.1.
Z18963 mRNA. Translation: CAA79488.1.
CCDSiCCDS57695.1.
PIRiS30244.
RefSeqiNP_035570.1. NM_011440.1.
UniGeneiMm.261595.
Mm.484077.

3D structure databases

ProteinModelPortaliQ04892.
SMRiQ04892. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203401. 1 interaction.
STRINGi10090.ENSMUSP00000091310.

PTM databases

PhosphoSiteiQ04892.

Proteomic databases

PRIDEiQ04892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747.
GeneIDi20669.
KEGGimmu:20669.
UCSCiuc012gzb.1. mouse.

Organism-specific databases

CTDi8403.
MGIiMGI:98362. Sox14.

Phylogenomic databases

eggNOGiNOG302715.
HOVERGENiHBG105618.
InParanoidiQ04892.
KOiK09267.
OMAiYSSAHAA.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ04892.
TreeFamiTF351735.

Miscellaneous databases

NextBioi299141.
PROiQ04892.
SOURCEiSearch...

Gene expression databases

BgeeiQ04892.
CleanExiMM_SOX14.
ExpressionAtlasiQ04892. baseline.
GenevisibleiQ04892. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029549. SOX-14.
[Graphical view]
PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog."
    Hargrave M., Karunaratne A., Cox L., Wood S., Koopman P., Yamada T.
    Dev. Biol. 219:142-153(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
  2. "SOX14 is a candidate gene for limb defects associated with BPES and Mobius syndrome."
    Wilmore H.P., Smith M.J., Wilcox S.A., Bell K.M., Sinclair A.H.
    Hum. Genet. 106:269-276(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-229.
  3. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-71.

Entry informationi

Entry nameiSOX14_MOUSE
AccessioniPrimary (citable) accession number: Q04892
Secondary accession number(s): Q9JLC9, Q9JLD0, Q9QXU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.