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Q04892 (SOX14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-14
Gene names
Name:Sox14
Synonyms:Sox-14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a negative regulator of transcription By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in developing brain and spinal cord. Ref.1

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Transcription factor SOX-14
PRO_0000048760

Regions

DNA binding8 – 7669HMG box

Sequences

Sequence LengthMass (Da)Tools
Q04892 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 158D8AE76571C856

FASTA24026,515
        10         20         30         40         50         60 
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE 

        70         80         90        100        110        120 
AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS 

       130        140        150        160        170        180 
APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TSALPYASTL GYQNGAFGSL 

       190        200        210        220        230        240 
SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM 

« Hide

References

[1]"The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog."
Hargrave M., Karunaratne A., Cox L., Wood S., Koopman P., Yamada T.
Dev. Biol. 219:142-153(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Strain: 129/Sv.
[2]"SOX14 is a candidate gene for limb defects associated with BPES and Mobius syndrome."
Wilmore H.P., Smith M.J., Wilcox S.A., Bell K.M., Sinclair A.H.
Hum. Genet. 106:269-276(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-229.
[3]"Seven new members of the Sox gene family expressed during mouse development."
Wright E.M., Snopek B., Koopman P.
Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-71.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193437 Genomic DNA. Translation: AAF62397.1.
AF193435 mRNA. Translation: AAF62396.1.
AF182357 Genomic DNA. Translation: AAF19353.1.
Z18963 mRNA. Translation: CAA79488.1.
CCDSCCDS57695.1.
PIRS30244.
RefSeqNP_035570.1. NM_011440.1.
UniGeneMm.261595.
Mm.484077.

3D structure databases

ProteinModelPortalQ04892.
SMRQ04892. Positions 6-82.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ04892.

Proteomic databases

PRIDEQ04892.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747.
GeneID20669.
KEGGmmu:20669.
UCSCuc012gzb.1. mouse.

Organism-specific databases

CTD8403.
MGIMGI:98362. Sox14.

Phylogenomic databases

eggNOGNOG302715.
HOVERGENHBG105618.
InParanoidQ04892.
KOK09267.
OMATLGCPSQ.
OrthoDBEOG7TMZVP.
PhylomeDBQ04892.
TreeFamTF351735.

Gene expression databases

BgeeQ04892.
CleanExMM_SOX14.
GenevestigatorQ04892.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299141.
PROQ04892.
SOURCESearch...

Entry information

Entry nameSOX14_MOUSE
AccessionPrimary (citable) accession number: Q04892
Secondary accession number(s): Q9JLC9, Q9JLD0, Q9QXU4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 14, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot