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Q04892

- SOX14_MOUSE

UniProt

Q04892 - SOX14_MOUSE

Protein

Transcription factor SOX-14

Gene

Sox14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator of transcription.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein heterodimerization activity Source: MGI
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

    GO - Biological processi

    1. entrainment of circadian clock Source: MGI
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. regulation of neuron migration Source: MGI
    5. transcription from RNA polymerase II promoter Source: GOC
    6. visual perception Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-14
    Gene namesi
    Name:Sox14
    Synonyms:Sox-14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:98362. Sox14.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Transcription factor SOX-14PRO_0000048760Add
    BLAST

    Proteomic databases

    PRIDEiQ04892.

    PTM databases

    PhosphoSiteiQ04892.

    Expressioni

    Tissue specificityi

    Highly expressed in developing brain and spinal cord.1 Publication

    Gene expression databases

    BgeeiQ04892.
    CleanExiMM_SOX14.
    GenevestigatoriQ04892.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04892.
    SMRiQ04892. Positions 6-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG302715.
    HOVERGENiHBG105618.
    InParanoidiQ04892.
    KOiK09267.
    OMAiTLGCPSQ.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiQ04892.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029549. SOX-14.
    [Graphical view]
    PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04892-1 [UniParc]FASTAAdd to Basket

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    MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS    50
    EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG 100
    DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ 150
    KMGEVPHTLA TSALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV 200
    PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM 240
    Length:240
    Mass (Da):26,515
    Last modified:August 14, 2001 - v2
    Checksum:i158D8AE76571C856
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193437 Genomic DNA. Translation: AAF62397.1.
    AF193435 mRNA. Translation: AAF62396.1.
    AF182357 Genomic DNA. Translation: AAF19353.1.
    Z18963 mRNA. Translation: CAA79488.1.
    CCDSiCCDS57695.1.
    PIRiS30244.
    RefSeqiNP_035570.1. NM_011440.1.
    UniGeneiMm.261595.
    Mm.484077.

    Genome annotation databases

    EnsembliENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747.
    GeneIDi20669.
    KEGGimmu:20669.
    UCSCiuc012gzb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193437 Genomic DNA. Translation: AAF62397.1 .
    AF193435 mRNA. Translation: AAF62396.1 .
    AF182357 Genomic DNA. Translation: AAF19353.1 .
    Z18963 mRNA. Translation: CAA79488.1 .
    CCDSi CCDS57695.1.
    PIRi S30244.
    RefSeqi NP_035570.1. NM_011440.1.
    UniGenei Mm.261595.
    Mm.484077.

    3D structure databases

    ProteinModelPortali Q04892.
    SMRi Q04892. Positions 6-82.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q04892.

    Proteomic databases

    PRIDEi Q04892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054819 ; ENSMUSP00000091310 ; ENSMUSG00000053747 .
    GeneIDi 20669.
    KEGGi mmu:20669.
    UCSCi uc012gzb.1. mouse.

    Organism-specific databases

    CTDi 8403.
    MGIi MGI:98362. Sox14.

    Phylogenomic databases

    eggNOGi NOG302715.
    HOVERGENi HBG105618.
    InParanoidi Q04892.
    KOi K09267.
    OMAi TLGCPSQ.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi Q04892.
    TreeFami TF351735.

    Miscellaneous databases

    NextBioi 299141.
    PROi Q04892.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04892.
    CleanExi MM_SOX14.
    Genevestigatori Q04892.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029549. SOX-14.
    [Graphical view ]
    PANTHERi PTHR10270:SF107. PTHR10270:SF107. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog."
      Hargrave M., Karunaratne A., Cox L., Wood S., Koopman P., Yamada T.
      Dev. Biol. 219:142-153(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
    2. "SOX14 is a candidate gene for limb defects associated with BPES and Mobius syndrome."
      Wilmore H.P., Smith M.J., Wilcox S.A., Bell K.M., Sinclair A.H.
      Hum. Genet. 106:269-276(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-229.
    3. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-71.

    Entry informationi

    Entry nameiSOX14_MOUSE
    AccessioniPrimary (citable) accession number: Q04892
    Secondary accession number(s): Q9JLC9, Q9JLD0, Q9QXU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3