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Q04891

- SOX13_MOUSE

UniProt

Q04891 - SOX13_MOUSE

Protein

Transcription factor SOX-13

Gene

Sox13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Binds to the sequence 5'-AACAAT-3'.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi416 – 48469HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. regulation of gamma-delta T cell differentiation Source: MGI
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-13
    Alternative name(s):
    SRY (Sex determining region Y)-box 13
    Short name:
    mSox13
    Gene namesi
    Name:Sox13
    Synonyms:Sox-13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98361. Sox13.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Transcription factor SOX-13PRO_0000048757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei327 – 3271PhosphoserineBy similarity
    Modified residuei374 – 3741PhosphoserineBy similarity
    Modified residuei378 – 3781PhosphoserineBy similarity
    Modified residuei604 – 6041PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ04891.

    PTM databases

    PhosphoSiteiQ04891.

    Expressioni

    Tissue specificityi

    In the embryo, high levels of expression are found in the arterial walls at 13.5 dpc. Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc. Expressed in the tracheal epithelium below the vocal cord and in the hair follicles at 18 dpc. In adults, expressed in the ovary and kidney.2 Publications

    Gene expression databases

    ArrayExpressiQ04891.
    BgeeiQ04891.
    CleanExiMM_SOX13.
    GenevestigatoriQ04891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04891.
    SMRiQ04891. Positions 415-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi177 – 21438Gln-richAdd
    BLAST
    Compositional biasi218 – 332115Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275089.
    GeneTreeiENSGT00750000117281.
    HOGENOMiHOG000056455.
    HOVERGENiHBG003915.
    InParanoidiQ04891.
    KOiK09269.
    OMAiCDVDGSR.
    OrthoDBiEOG7R56S9.
    PhylomeDBiQ04891.
    TreeFamiTF320471.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029547. SOX-13.
    [Graphical view]
    PANTHERiPTHR10270:SF109. PTHR10270:SF109. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04891-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD    50
    PALASQDATN AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN 100
    LQEVVPAIEK LLSSDWKERF LGRSNVEAKD VKGTQESLAE KELQLLVMIH 150
    QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ MELARQQQEQ IAKQQQQLIQ 200
    QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL ALPIQPIPCK 250
    PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS 300
    SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR 350
    QLLHSHSGAL ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD 400
    MDGSRHFSES RNSSHIKRPM NAFMVWAKDE RRKILQAFPD MHNSSISKIL 450
    GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY PDYKYKPRPK RTCVVEGRRL 500
    RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA AGLPLARPLV 550
    EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG 600
    DEKSDEELVV LTD 613
    Length:613
    Mass (Da):68,168
    Last modified:February 9, 2010 - v4
    Checksum:iF62C88A052436E91
    GO

    Sequence cautioni

    The sequence CAA04278.1 differs from that shown. Reason: Several frameshifts.
    The sequence AAH07130.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA25786.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31M → L in BAA25786. (PubMed:9524265)Curated
    Sequence conflicti53 – 531L → P in AAH07130. (PubMed:15489334)Curated
    Sequence conflicti59 – 602TN → AT in AAH07130. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC007130 mRNA. Translation: AAH07130.1. Different initiation.
    AB006329 mRNA. Translation: BAA25786.1. Different initiation.
    AJ000740 mRNA. Translation: CAA04278.1. Sequence problems.
    Z18962 mRNA. Translation: CAA79487.1.
    CCDSiCCDS48363.1.
    PIRiJC6550.
    S30241.
    RefSeqiNP_035569.2. NM_011439.2.
    XP_006529341.1. XM_006529278.1.
    XP_006529342.1. XM_006529279.1.
    UniGeneiMm.8575.

    Genome annotation databases

    EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643.
    ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643.
    GeneIDi20668.
    KEGGimmu:20668.
    UCSCiuc007cqk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC007130 mRNA. Translation: AAH07130.1 . Different initiation.
    AB006329 mRNA. Translation: BAA25786.1 . Different initiation.
    AJ000740 mRNA. Translation: CAA04278.1 . Sequence problems.
    Z18962 mRNA. Translation: CAA79487.1 .
    CCDSi CCDS48363.1.
    PIRi JC6550.
    S30241.
    RefSeqi NP_035569.2. NM_011439.2.
    XP_006529341.1. XM_006529278.1.
    XP_006529342.1. XM_006529279.1.
    UniGenei Mm.8575.

    3D structure databases

    ProteinModelPortali Q04891.
    SMRi Q04891. Positions 415-483.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q04891.

    Proteomic databases

    PRIDEi Q04891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094551 ; ENSMUSP00000092130 ; ENSMUSG00000070643 .
    ENSMUST00000153799 ; ENSMUSP00000119729 ; ENSMUSG00000070643 .
    GeneIDi 20668.
    KEGGi mmu:20668.
    UCSCi uc007cqk.1. mouse.

    Organism-specific databases

    CTDi 9580.
    MGIi MGI:98361. Sox13.

    Phylogenomic databases

    eggNOGi NOG275089.
    GeneTreei ENSGT00750000117281.
    HOGENOMi HOG000056455.
    HOVERGENi HBG003915.
    InParanoidi Q04891.
    KOi K09269.
    OMAi CDVDGSR.
    OrthoDBi EOG7R56S9.
    PhylomeDBi Q04891.
    TreeFami TF320471.

    Miscellaneous databases

    NextBioi 299137.
    PROi Q04891.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04891.
    Bgeei Q04891.
    CleanExi MM_SOX13.
    Genevestigatori Q04891.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029547. SOX-13.
    [Graphical view ]
    PANTHERi PTHR10270:SF109. PTHR10270:SF109. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    2. "Cloning and characterization of mouse mSox13 cDNA."
      Kido S., Hiraoka Y., Ogawa M., Sakai Y., Yoshimura Y., Aiso S.
      Gene 208:201-206(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-613, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. "High expression of the HMG box factor sox-13 in arterial walls during embryonic development."
      Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers W., Clevers H.
      Nucleic Acids Res. 26:469-476(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-613, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    4. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-479.
      Strain: Swiss.
      Tissue: Fetus.

    Entry informationi

    Entry nameiSOX13_MOUSE
    AccessioniPrimary (citable) accession number: Q04891
    Secondary accession number(s): Q922L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3