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Q04891 (SOX13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-13
Alternative name(s):
SRY (Sex determining region Y)-box 13
Short name=mSox13
Gene names
Name:Sox13
Synonyms:Sox-13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the sequence 5'-AACAAT-3'. Ref.2 Ref.3

Subcellular location

Nucleus Ref.3.

Tissue specificity

In the embryo, high levels of expression are found in the arterial walls at 13.5 dpc. Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc. Expressed in the tracheal epithelium below the vocal cord and in the hair follicles at 18 dpc. In adults, expressed in the ovary and kidney. Ref.2 Ref.3

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence AAH07130.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA25786.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA04278.1 differs from that shown. Reason: Several frameshifts.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 613613Transcription factor SOX-13
PRO_0000048757

Regions

DNA binding416 – 48469HMG box
Compositional bias177 – 21438Gln-rich
Compositional bias218 – 332115Pro-rich

Amino acid modifications

Modified residue3271Phosphoserine By similarity
Modified residue3741Phosphoserine By similarity
Modified residue3781Phosphoserine By similarity
Modified residue6041Phosphoserine By similarity

Experimental info

Sequence conflict31M → L in BAA25786. Ref.2
Sequence conflict531L → P in AAH07130. Ref.1
Sequence conflict59 – 602TN → AT in AAH07130. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04891 [UniParc].

Last modified February 9, 2010. Version 4.
Checksum: F62C88A052436E91

FASTA61368,168
        10         20         30         40         50         60 
MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD PALASQDATN 

        70         80         90        100        110        120 
AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN LQEVVPAIEK LLSSDWKERF 

       130        140        150        160        170        180 
LGRSNVEAKD VKGTQESLAE KELQLLVMIH QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ 

       190        200        210        220        230        240 
MELARQQQEQ IAKQQQQLIQ QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL 

       250        260        270        280        290        300 
ALPIQPIPCK PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS 

       310        320        330        340        350        360 
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR QLLHSHSGAL 

       370        380        390        400        410        420 
ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD MDGSRHFSES RNSSHIKRPM 

       430        440        450        460        470        480 
NAFMVWAKDE RRKILQAFPD MHNSSISKIL GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY 

       490        500        510        520        530        540 
PDYKYKPRPK RTCVVEGRRL RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA 

       550        560        570        580        590        600 
AGLPLARPLV EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG 

       610 
DEKSDEELVV LTD 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[2]"Cloning and characterization of mouse mSox13 cDNA."
Kido S., Hiraoka Y., Ogawa M., Sakai Y., Yoshimura Y., Aiso S.
Gene 208:201-206(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-613, FUNCTION, TISSUE SPECIFICITY.
Tissue: Embryo.
[3]"High expression of the HMG box factor sox-13 in arterial walls during embryonic development."
Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers W., Clevers H.
Nucleic Acids Res. 26:469-476(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-613, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Embryo.
[4]"Seven new members of the Sox gene family expressed during mouse development."
Wright E.M., Snopek B., Koopman P.
Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-479.
Strain: Swiss.
Tissue: Fetus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC007130 mRNA. Translation: AAH07130.1. Different initiation.
AB006329 mRNA. Translation: BAA25786.1. Different initiation.
AJ000740 mRNA. Translation: CAA04278.1. Sequence problems.
Z18962 mRNA. Translation: CAA79487.1.
CCDSCCDS48363.1.
PIRJC6550.
S30241.
RefSeqNP_035569.2. NM_011439.2.
XP_006529341.1. XM_006529278.1.
XP_006529342.1. XM_006529279.1.
UniGeneMm.8575.

3D structure databases

ProteinModelPortalQ04891.
SMRQ04891. Positions 415-483.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ04891.

Proteomic databases

PRIDEQ04891.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643.
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643.
GeneID20668.
KEGGmmu:20668.
UCSCuc007cqk.1. mouse.

Organism-specific databases

CTD9580.
MGIMGI:98361. Sox13.

Phylogenomic databases

eggNOGNOG275089.
GeneTreeENSGT00750000117281.
HOGENOMHOG000056455.
HOVERGENHBG003915.
InParanoidQ04891.
KOK09269.
OMACDVDGSR.
OrthoDBEOG7R56S9.
PhylomeDBQ04891.
TreeFamTF320471.

Gene expression databases

ArrayExpressQ04891.
BgeeQ04891.
CleanExMM_SOX13.
GenevestigatorQ04891.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299137.
PROQ04891.
SOURCESearch...

Entry information

Entry nameSOX13_MOUSE
AccessionPrimary (citable) accession number: Q04891
Secondary accession number(s): Q922L3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot