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Protein

Transcription factor SOX-13

Gene

Sox13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi416 – 48469HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  2. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. regulation of gamma-delta T cell differentiation Source: MGI
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-13
Alternative name(s):
SRY (Sex determining region Y)-box 13
Short name:
mSox13
Gene namesi
Name:Sox13
Synonyms:Sox-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98361. Sox13.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Transcription factor SOX-13PRO_0000048757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271PhosphoserineBy similarity
Modified residuei374 – 3741PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei604 – 6041PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ04891.

PTM databases

PhosphoSiteiQ04891.

Expressioni

Tissue specificityi

In the embryo, high levels of expression are found in the arterial walls at 13.5 dpc. Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc. Expressed in the tracheal epithelium below the vocal cord and in the hair follicles at 18 dpc. In adults, expressed in the ovary and kidney.2 Publications

Gene expression databases

BgeeiQ04891.
CleanExiMM_SOX13.
ExpressionAtlasiQ04891. baseline and differential.
GenevestigatoriQ04891.

Structurei

3D structure databases

ProteinModelPortaliQ04891.
SMRiQ04891. Positions 415-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi177 – 21438Gln-richAdd
BLAST
Compositional biasi218 – 332115Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275089.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000056455.
HOVERGENiHBG003915.
InParanoidiQ04891.
KOiK09269.
OMAiCDVDGSR.
OrthoDBiEOG7R56S9.
PhylomeDBiQ04891.
TreeFamiTF320471.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029547. SOX-13.
[Graphical view]
PANTHERiPTHR10270:SF109. PTHR10270:SF109. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04891-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD
60 70 80 90 100
PALASQDATN AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN
110 120 130 140 150
LQEVVPAIEK LLSSDWKERF LGRSNVEAKD VKGTQESLAE KELQLLVMIH
160 170 180 190 200
QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ MELARQQQEQ IAKQQQQLIQ
210 220 230 240 250
QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL ALPIQPIPCK
260 270 280 290 300
PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS
310 320 330 340 350
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR
360 370 380 390 400
QLLHSHSGAL ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD
410 420 430 440 450
MDGSRHFSES RNSSHIKRPM NAFMVWAKDE RRKILQAFPD MHNSSISKIL
460 470 480 490 500
GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY PDYKYKPRPK RTCVVEGRRL
510 520 530 540 550
RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA AGLPLARPLV
560 570 580 590 600
EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG
610
DEKSDEELVV LTD
Length:613
Mass (Da):68,168
Last modified:February 9, 2010 - v4
Checksum:iF62C88A052436E91
GO

Sequence cautioni

The sequence AAH07130.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA25786.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA04278.1 differs from that shown.Several frameshifts.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31M → L in BAA25786. (PubMed:9524265)Curated
Sequence conflicti53 – 531L → P in AAH07130. (PubMed:15489334)Curated
Sequence conflicti59 – 602TN → AT in AAH07130. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007130 mRNA. Translation: AAH07130.1. Different initiation.
AB006329 mRNA. Translation: BAA25786.1. Different initiation.
AJ000740 mRNA. Translation: CAA04278.1. Sequence problems.
Z18962 mRNA. Translation: CAA79487.1.
CCDSiCCDS48363.1.
PIRiJC6550.
S30241.
RefSeqiNP_035569.2. NM_011439.2.
XP_006529341.1. XM_006529278.1.
XP_006529342.1. XM_006529279.1.
UniGeneiMm.8575.

Genome annotation databases

EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643.
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643.
GeneIDi20668.
KEGGimmu:20668.
UCSCiuc007cqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007130 mRNA. Translation: AAH07130.1. Different initiation.
AB006329 mRNA. Translation: BAA25786.1. Different initiation.
AJ000740 mRNA. Translation: CAA04278.1. Sequence problems.
Z18962 mRNA. Translation: CAA79487.1.
CCDSiCCDS48363.1.
PIRiJC6550.
S30241.
RefSeqiNP_035569.2. NM_011439.2.
XP_006529341.1. XM_006529278.1.
XP_006529342.1. XM_006529279.1.
UniGeneiMm.8575.

3D structure databases

ProteinModelPortaliQ04891.
SMRiQ04891. Positions 415-483.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ04891.

Proteomic databases

PRIDEiQ04891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643.
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643.
GeneIDi20668.
KEGGimmu:20668.
UCSCiuc007cqk.1. mouse.

Organism-specific databases

CTDi9580.
MGIiMGI:98361. Sox13.

Phylogenomic databases

eggNOGiNOG275089.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000056455.
HOVERGENiHBG003915.
InParanoidiQ04891.
KOiK09269.
OMAiCDVDGSR.
OrthoDBiEOG7R56S9.
PhylomeDBiQ04891.
TreeFamiTF320471.

Miscellaneous databases

NextBioi299137.
PROiQ04891.
SOURCEiSearch...

Gene expression databases

BgeeiQ04891.
CleanExiMM_SOX13.
ExpressionAtlasiQ04891. baseline and differential.
GenevestigatoriQ04891.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029547. SOX-13.
[Graphical view]
PANTHERiPTHR10270:SF109. PTHR10270:SF109. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  2. "Cloning and characterization of mouse mSox13 cDNA."
    Kido S., Hiraoka Y., Ogawa M., Sakai Y., Yoshimura Y., Aiso S.
    Gene 208:201-206(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-613, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "High expression of the HMG box factor sox-13 in arterial walls during embryonic development."
    Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers W., Clevers H.
    Nucleic Acids Res. 26:469-476(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-613, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  4. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 424-479.
    Strain: Swiss.
    Tissue: Fetus.

Entry informationi

Entry nameiSOX13_MOUSE
AccessioniPrimary (citable) accession number: Q04891
Secondary accession number(s): Q922L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 9, 2010
Last modified: February 4, 2015
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.