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Protein

Transcription factor SOX-12

Gene

Sox12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 108HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

  • cell fate commitment Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein-DNA complex assembly Source: UniProtKB
  • spinal cord development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Gene namesi
Name:Sox12
Synonyms:Sox-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98360. Sox12.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • protein-DNA complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487551 – 314Transcription factor SOX-12Add BLAST314

Proteomic databases

MaxQBiQ04890.
PaxDbiQ04890.
PRIDEiQ04890.

PTM databases

PhosphoSitePlusiQ04890.

Expressioni

Tissue specificityi

Expressed in embryonic molar and incisor teeth.1 Publication

Developmental stagei

Expressed in the embryo at 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000051817.
CleanExiMM_SOX12.
GenevisibleiQ04890. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064250.

Structurei

3D structure databases

ProteinModelPortaliQ04890.
SMRiQ04890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Pro8
Compositional biasi128 – 158Gly-richAdd BLAST31
Compositional biasi167 – 180Glu-richAdd BLAST14
Compositional biasi224 – 249Glu-richAdd BLAST26

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG4111TGC. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiQ04890.
KOiK09268.
OMAiEPAWCKT.
OrthoDBiEOG091G0F15.
PhylomeDBiQ04890.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR031267. SOX-12.
[Graphical view]
PANTHERiPTHR10270:SF221. PTHR10270:SF221. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA
210 220 230 240 250
ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP
260 270 280 290 300
LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG
310
DWRSSSIADL VFTY
Length:314
Mass (Da):34,083
Last modified:March 29, 2005 - v2
Checksum:iCAB9DEF059F2C5A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → E in CAA79486 (PubMed:8921394).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA. Translation: CAM23207.1.
BC067019 mRNA. Translation: AAH67019.1.
Z18961 mRNA. Translation: CAA79486.1.
U70442 mRNA. Translation: AAC52860.1.
CCDSiCCDS38274.1.
PIRiS30240.
RefSeqiNP_035568.1. NM_011438.2.
UniGeneiMm.28424.

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
GeneIDi20667.
KEGGimmu:20667.
UCSCiuc008nfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA. Translation: CAM23207.1.
BC067019 mRNA. Translation: AAH67019.1.
Z18961 mRNA. Translation: CAA79486.1.
U70442 mRNA. Translation: AAC52860.1.
CCDSiCCDS38274.1.
PIRiS30240.
RefSeqiNP_035568.1. NM_011438.2.
UniGeneiMm.28424.

3D structure databases

ProteinModelPortaliQ04890.
SMRiQ04890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064250.

PTM databases

PhosphoSitePlusiQ04890.

Proteomic databases

MaxQBiQ04890.
PaxDbiQ04890.
PRIDEiQ04890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
GeneIDi20667.
KEGGimmu:20667.
UCSCiuc008nfi.1. mouse.

Organism-specific databases

CTDi6666.
MGIiMGI:98360. Sox12.

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG4111TGC. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiQ04890.
KOiK09268.
OMAiEPAWCKT.
OrthoDBiEOG091G0F15.
PhylomeDBiQ04890.

Miscellaneous databases

ChiTaRSiSox12. mouse.
PROiQ04890.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051817.
CleanExiMM_SOX12.
GenevisibleiQ04890. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR031267. SOX-12.
[Graphical view]
PANTHERiPTHR10270:SF221. PTHR10270:SF221. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX12_MOUSE
AccessioniPrimary (citable) accession number: Q04890
Secondary accession number(s): A2AS82, P70417, Q6NXL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.