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Q04890

- SOX12_MOUSE

UniProt

Q04890 - SOX12_MOUSE

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Protein

Transcription factor SOX-12

Gene

Sox12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 10869HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  2. RNA polymerase II transcription coactivator activity Source: UniProtKB
  3. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. protein-DNA complex assembly Source: UniProtKB
  4. spinal cord development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Gene namesi
Name:Sox12
Synonyms:Sox-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:98360. Sox12.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. protein-DNA complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Transcription factor SOX-12PRO_0000048755Add
BLAST

Proteomic databases

PRIDEiQ04890.

PTM databases

PhosphoSiteiQ04890.

Expressioni

Tissue specificityi

Expressed in embryonic molar and incisor teeth.1 Publication

Developmental stagei

Expressed in the embryo at 11.5 dpc.1 Publication

Gene expression databases

BgeeiQ04890.
CleanExiMM_SOX12.
GenevestigatoriQ04890.

Structurei

3D structure databases

ProteinModelPortaliQ04890.
SMRiQ04890. Positions 38-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 228Poly-Pro
Compositional biasi128 – 15831Gly-richAdd
BLAST
Compositional biasi167 – 18014Glu-richAdd
BLAST
Compositional biasi224 – 24926Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG290369.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiQ04890.
KOiK09268.
OMAiMVQQRGA.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ04890.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04890-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA
210 220 230 240 250
ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP
260 270 280 290 300
LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG
310
DWRSSSIADL VFTY
Length:314
Mass (Da):34,083
Last modified:March 29, 2005 - v2
Checksum:iCAB9DEF059F2C5A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901V → E in CAA79486. (PubMed:8921394)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA. Translation: CAM23207.1.
BC067019 mRNA. Translation: AAH67019.1.
Z18961 mRNA. Translation: CAA79486.1.
U70442 mRNA. Translation: AAC52860.1.
CCDSiCCDS38274.1.
PIRiS30240.
RefSeqiNP_035568.1. NM_011438.2.
UniGeneiMm.28424.

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
GeneIDi20667.
KEGGimmu:20667.
UCSCiuc008nfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA. Translation: CAM23207.1 .
BC067019 mRNA. Translation: AAH67019.1 .
Z18961 mRNA. Translation: CAA79486.1 .
U70442 mRNA. Translation: AAC52860.1 .
CCDSi CCDS38274.1.
PIRi S30240.
RefSeqi NP_035568.1. NM_011438.2.
UniGenei Mm.28424.

3D structure databases

ProteinModelPortali Q04890.
SMRi Q04890. Positions 38-113.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q04890.

Proteomic databases

PRIDEi Q04890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063332 ; ENSMUSP00000064250 ; ENSMUSG00000051817 .
ENSMUST00000182625 ; ENSMUSP00000138293 ; ENSMUSG00000051817 .
GeneIDi 20667.
KEGGi mmu:20667.
UCSCi uc008nfi.1. mouse.

Organism-specific databases

CTDi 6666.
MGIi MGI:98360. Sox12.

Phylogenomic databases

eggNOGi NOG290369.
GeneTreei ENSGT00760000118988.
HOGENOMi HOG000231874.
HOVERGENi HBG094895.
InParanoidi Q04890.
KOi K09268.
OMAi MVQQRGA.
OrthoDBi EOG7TMZVP.
PhylomeDBi Q04890.

Miscellaneous databases

ChiTaRSi Sox12. mouse.
NextBioi 299133.
PROi Q04890.
SOURCEi Search...

Gene expression databases

Bgeei Q04890.
CleanExi MM_SOX12.
Genevestigatori Q04890.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-103, DEVELOPMENTAL STAGE.
  4. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-103, TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.

Entry informationi

Entry nameiSOX12_MOUSE
AccessioniPrimary (citable) accession number: Q04890
Secondary accession number(s): A2AS82, P70417, Q6NXL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 29, 2005
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3