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Q04890

- SOX12_MOUSE

UniProt

Q04890 - SOX12_MOUSE

Protein

Transcription factor SOX-12

Gene

Sox12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Binds to the sequence 5'-AACAAT-3'.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi40 – 10869HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    2. RNA polymerase II transcription coactivator activity Source: UniProtKB
    3. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. protein-DNA complex assembly Source: UniProtKB
    4. spinal cord development Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-12
    Gene namesi
    Name:Sox12
    Synonyms:Sox-12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:98360. Sox12.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein-DNA complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Transcription factor SOX-12PRO_0000048755Add
    BLAST

    Proteomic databases

    PRIDEiQ04890.

    PTM databases

    PhosphoSiteiQ04890.

    Expressioni

    Tissue specificityi

    Expressed in embryonic molar and incisor teeth.1 Publication

    Developmental stagei

    Expressed in the embryo at 11.5 dpc.1 Publication

    Gene expression databases

    BgeeiQ04890.
    CleanExiMM_SOX12.
    GenevestigatoriQ04890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04890.
    SMRiQ04890. Positions 38-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 228Poly-Pro
    Compositional biasi128 – 15831Gly-richAdd
    BLAST
    Compositional biasi167 – 18014Glu-richAdd
    BLAST
    Compositional biasi224 – 24926Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290369.
    GeneTreeiENSGT00690000101940.
    HOGENOMiHOG000231874.
    HOVERGENiHBG094895.
    InParanoidiA2AS82.
    KOiK09268.
    OMAiMVQQRGA.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiQ04890.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04890-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW    50
    SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH 100
    MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA 150
    SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA 200
    ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP 250
    LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG 300
    DWRSSSIADL VFTY 314
    Length:314
    Mass (Da):34,083
    Last modified:March 29, 2005 - v2
    Checksum:iCAB9DEF059F2C5A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901V → E in CAA79486. (PubMed:8921394)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928568 Genomic DNA. Translation: CAM23207.1.
    BC067019 mRNA. Translation: AAH67019.1.
    Z18961 mRNA. Translation: CAA79486.1.
    U70442 mRNA. Translation: AAC52860.1.
    CCDSiCCDS38274.1.
    PIRiS30240.
    RefSeqiNP_035568.1. NM_011438.2.
    UniGeneiMm.28424.

    Genome annotation databases

    EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
    ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
    GeneIDi20667.
    KEGGimmu:20667.
    UCSCiuc008nfi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928568 Genomic DNA. Translation: CAM23207.1 .
    BC067019 mRNA. Translation: AAH67019.1 .
    Z18961 mRNA. Translation: CAA79486.1 .
    U70442 mRNA. Translation: AAC52860.1 .
    CCDSi CCDS38274.1.
    PIRi S30240.
    RefSeqi NP_035568.1. NM_011438.2.
    UniGenei Mm.28424.

    3D structure databases

    ProteinModelPortali Q04890.
    SMRi Q04890. Positions 38-113.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q04890.

    Proteomic databases

    PRIDEi Q04890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063332 ; ENSMUSP00000064250 ; ENSMUSG00000051817 .
    ENSMUST00000182625 ; ENSMUSP00000138293 ; ENSMUSG00000051817 .
    GeneIDi 20667.
    KEGGi mmu:20667.
    UCSCi uc008nfi.1. mouse.

    Organism-specific databases

    CTDi 6666.
    MGIi MGI:98360. Sox12.

    Phylogenomic databases

    eggNOGi NOG290369.
    GeneTreei ENSGT00690000101940.
    HOGENOMi HOG000231874.
    HOVERGENi HBG094895.
    InParanoidi A2AS82.
    KOi K09268.
    OMAi MVQQRGA.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi Q04890.

    Miscellaneous databases

    ChiTaRSi SOX12. mouse.
    NextBioi 299133.
    PROi Q04890.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04890.
    CleanExi MM_SOX12.
    Genevestigatori Q04890.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-103, DEVELOPMENTAL STAGE.
    4. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
      Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
      Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-103, TISSUE SPECIFICITY.
      Strain: Swiss Webster.
      Tissue: Embryonic tooth.

    Entry informationi

    Entry nameiSOX12_MOUSE
    AccessioniPrimary (citable) accession number: Q04890
    Secondary accession number(s): A2AS82, P70417, Q6NXL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3