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Q04890 (SOX12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-12
Gene names
Name:Sox12
Synonyms:Sox-12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the sequence 5'-AACAAT-3' By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in embryonic molar and incisor teeth. Ref.4

Developmental stage

Expressed in the embryo at 11.5 dpc. Ref.3

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Transcription factor SOX-12
PRO_0000048755

Regions

DNA binding40 – 10869HMG box
Compositional bias15 – 228Poly-Pro
Compositional bias128 – 15831Gly-rich
Compositional bias167 – 18014Glu-rich
Compositional bias224 – 24926Glu-rich

Experimental info

Sequence conflict901V → E in CAA79486. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q04890 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: CAB9DEF059F2C5A0

FASTA31434,083
        10         20         30         40         50         60 
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW SQHERRKIMD 

        70         80         90        100        110        120 
QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH MADYPDYKYR PRKKSKGAPA 

       130        140        150        160        170        180 
KARPRPPGGG GGGSRLKPGP QLPGRGGRRA SGGPLGGGAA APEDDDEDEE EELLEVRLLE 

       190        200        210        220        230        240 
TPGRELWRMV PAGRAARGPA ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE 

       250        260        270        280        290        300 
EETVVSGEEP LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG 

       310 
DWRSSSIADL VFTY 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Seven new members of the Sox gene family expressed during mouse development."
Wright E.M., Snopek B., Koopman P.
Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-103, DEVELOPMENTAL STAGE.
[4]"Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-103, TISSUE SPECIFICITY.
Strain: Swiss Webster.
Tissue: Embryonic tooth.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928568 Genomic DNA. Translation: CAM23207.1.
BC067019 mRNA. Translation: AAH67019.1.
Z18961 mRNA. Translation: CAA79486.1.
U70442 mRNA. Translation: AAC52860.1.
CCDSCCDS38274.1.
PIRS30240.
RefSeqNP_035568.1. NM_011438.2.
UniGeneMm.28424.

3D structure databases

ProteinModelPortalQ04890.
SMRQ04890. Positions 38-113.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ04890.

Proteomic databases

PRIDEQ04890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
GeneID20667.
KEGGmmu:20667.
UCSCuc008nfi.1. mouse.

Organism-specific databases

CTD6666.
MGIMGI:98360. Sox12.

Phylogenomic databases

eggNOGNOG290369.
GeneTreeENSGT00690000101940.
HOGENOMHOG000231874.
HOVERGENHBG094895.
InParanoidA2AS82.
KOK09268.
OMAMVQQRGA.
OrthoDBEOG7TMZVP.
PhylomeDBQ04890.

Gene expression databases

BgeeQ04890.
CleanExMM_SOX12.
GenevestigatorQ04890.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX12. mouse.
NextBio299133.
PROQ04890.
SOURCESearch...

Entry information

Entry nameSOX12_MOUSE
AccessionPrimary (citable) accession number: Q04890
Secondary accession number(s): A2AS82, P70417, Q6NXL2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot