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Protein

Transcription factor SOX-12

Gene

Sox12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 108HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

  • cell fate commitment Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein-DNA complex assembly Source: UniProtKB
  • spinal cord development Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Gene namesi
Name:Sox12
Synonyms:Sox-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98360. Sox12.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • protein-DNA complex Source: UniProtKB

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487551 – 314Transcription factor SOX-12Add BLAST314

Proteomic databases

MaxQBiQ04890.
PaxDbiQ04890.
PRIDEiQ04890.

PTM databases

PhosphoSitePlusiQ04890.

Expressioni

Tissue specificityi

Expressed in embryonic molar and incisor teeth.1 Publication

Developmental stagei

Expressed in the embryo at 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000051817.
CleanExiMM_SOX12.
GenevisibleiQ04890. MM.

Structurei

3D structure databases

ProteinModelPortaliQ04890.
SMRiQ04890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Pro8
Compositional biasi128 – 158Gly-richAdd BLAST31
Compositional biasi167 – 180Glu-richAdd BLAST14
Compositional biasi224 – 249Glu-richAdd BLAST26

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG4111TGC. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiQ04890.
KOiK09268.
OMAiGDWLMSS.
OrthoDBiEOG091G0F15.
PhylomeDBiQ04890.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR017386. SOX-11/4.
IPR031267. SOX-12.
PANTHERiPTHR10270:SF269. PTHR10270:SF269. 1 hit.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA
210 220 230 240 250
ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP
260 270 280 290 300
LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG
310
DWRSSSIADL VFTY
Length:314
Mass (Da):34,083
Last modified:March 29, 2005 - v2
Checksum:iCAB9DEF059F2C5A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → E in CAA79486 (PubMed:8921394).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA. Translation: CAM23207.1.
BC067019 mRNA. Translation: AAH67019.1.
Z18961 mRNA. Translation: CAA79486.1.
U70442 mRNA. Translation: AAC52860.1.
CCDSiCCDS38274.1.
PIRiS30240.
RefSeqiNP_035568.1. NM_011438.2.
UniGeneiMm.28424.

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817.
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817.
GeneIDi20667.
KEGGimmu:20667.
UCSCiuc008nfi.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSOX12_MOUSE
AccessioniPrimary (citable) accession number: Q04890
Secondary accession number(s): A2AS82, P70417, Q6NXL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 29, 2005
Last modified: August 30, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot