Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04888

- SOX10_MOUSE

UniProt

Q04888 - SOX10_MOUSE

Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi104 – 17269HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: UniProtKB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
    5. RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
    6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    7. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: MGI
    8. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    9. sequence-specific DNA binding transcription factor activity Source: MGI
    10. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. cell maturation Source: MGI
    3. developmental growth Source: MGI
    4. digestive tract morphogenesis Source: MGI
    5. enteric nervous system development Source: UniProtKB
    6. in utero embryonic development Source: MGI
    7. melanocyte differentiation Source: MGI
    8. negative regulation of apoptotic process Source: UniProtKB
    9. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: Ensembl
    11. neural crest cell migration Source: UniProtKB
    12. oligodendrocyte differentiation Source: MGI
    13. peripheral nervous system development Source: MGI
    14. positive regulation of gliogenesis Source: UniProtKB
    15. positive regulation of neuroblast proliferation Source: MGI
    16. positive regulation of transcription, DNA-templated Source: UniProtKB
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-10
    Alternative name(s):
    Protein SOX-21
    Transcription factor SOX-M
    Gene namesi
    Name:Sox10
    Synonyms:Sox-10, Sox21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:98358. Sox10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extrinsic component of mitochondrial outer membrane Source: MGI
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Transcription factor SOX-10PRO_0000048747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04888.
    PaxDbiQ04888.
    PRIDEiQ04888.

    PTM databases

    PhosphoSiteiQ04888.

    Expressioni

    Gene expression databases

    ArrayExpressiQ04888.
    BgeeiQ04888.
    CleanExiMM_SOX10.
    MM_SOX21.
    GenevestigatoriQ04888.

    Interactioni

    Protein-protein interaction databases

    BioGridi203397. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04888.
    SMRiQ04888. Positions 102-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 417Poly-Gly

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG295709.
    GeneTreeiENSGT00740000115373.
    HOVERGENiHBG002061.
    InParanoidiQ04888.
    KOiK09270.
    OMAiPYYGHSS.
    OrthoDBiEOG7Q2N5K.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR022151. Sox_N.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE    50
    LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS 100
    KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK 150
    RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA 200
    AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ 250
    SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 300
    LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV 350
    DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF 400
    DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH 450
    SPTHWEQPVY TTLSRP 466
    Length:466
    Mass (Da):49,949
    Last modified:July 15, 1999 - v2
    Checksum:i84862547F039E71F
    GO

    Sequence cautioni

    The sequence AAB49282.1 differs from that shown. Reason: Frameshift at positions 16 and 392.
    The sequence AAB99738.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411G → V in AAB49282. (PubMed:9027483)Curated
    Sequence conflicti119 – 1191R → P in CAA79484. (PubMed:8441686)Curated
    Sequence conflicti357 – 3571K → E in AAB49282. (PubMed:9027483)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111E → V.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017182 mRNA. Translation: AAB99738.1. Different initiation.
    AF047043 mRNA. Translation: AAC24564.1.
    U66141 mRNA. Translation: AAB49282.1. Frameshift.
    BC018551 mRNA. Translation: AAH18551.1.
    BC023356 mRNA. Translation: AAH23356.1.
    BC025171 mRNA. Translation: AAH25171.1.
    Z18959 mRNA. Translation: CAA79484.1.
    U70441 mRNA. Translation: AAC52859.1.
    CCDSiCCDS49668.1.
    PIRiS30242.
    RefSeqiNP_035567.1. NM_011437.1.
    UniGeneiMm.276739.

    Genome annotation databases

    EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
    GeneIDi20665.
    KEGGimmu:20665.
    UCSCiuc007wsu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017182 mRNA. Translation: AAB99738.1 . Different initiation.
    AF047043 mRNA. Translation: AAC24564.1 .
    U66141 mRNA. Translation: AAB49282.1 . Frameshift.
    BC018551 mRNA. Translation: AAH18551.1 .
    BC023356 mRNA. Translation: AAH23356.1 .
    BC025171 mRNA. Translation: AAH25171.1 .
    Z18959 mRNA. Translation: CAA79484.1 .
    U70441 mRNA. Translation: AAC52859.1 .
    CCDSi CCDS49668.1.
    PIRi S30242.
    RefSeqi NP_035567.1. NM_011437.1.
    UniGenei Mm.276739.

    3D structure databases

    ProteinModelPortali Q04888.
    SMRi Q04888. Positions 102-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203397. 2 interactions.

    PTM databases

    PhosphoSitei Q04888.

    Proteomic databases

    MaxQBi Q04888.
    PaxDbi Q04888.
    PRIDEi Q04888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040019 ; ENSMUSP00000039466 ; ENSMUSG00000033006 .
    GeneIDi 20665.
    KEGGi mmu:20665.
    UCSCi uc007wsu.2. mouse.

    Organism-specific databases

    CTDi 6663.
    MGIi MGI:98358. Sox10.

    Phylogenomic databases

    eggNOGi NOG295709.
    GeneTreei ENSGT00740000115373.
    HOVERGENi HBG002061.
    InParanoidi Q04888.
    KOi K09270.
    OMAi PYYGHSS.
    OrthoDBi EOG7Q2N5K.

    Miscellaneous databases

    ChiTaRSi SOX10. mouse.
    NextBioi 299123.
    PROi Q04888.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04888.
    Bgeei Q04888.
    CleanExi MM_SOX10.
    MM_SOX21.
    Genevestigatori Q04888.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR022151. Sox_N.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model."
      Southard-Smith E.M., Kos L., Pavan W.J.
      Nat. Genet. 18:60-64(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease."
      Herbarth B., Pingault V., Bondurand N., Kuhlbrodt K., Hermans-Borgmeyer I., Puliti A., Lemort N., Goossens M., Wegner M.
      Proc. Natl. Acad. Sci. U.S.A. 95:5161-5165(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor."
      Pusch C., Hustert E., Pfeifer D., Sudbeck P., Kist R., Roe B., Wang Z., Balling R., Blin N., Scherer G.
      Hum. Genet. 103:115-123(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells."
      Tani M., Shindo-Okada N., Hashimoto Y., Shiroishi T., Takenoshita S., Nagamachi Y., Yokota J.
      Genomics 39:30-37(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H/HeN.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary gland and Salivary gland.
    6. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-167.
    7. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
      Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
      Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-167.
      Strain: Swiss Webster.
      Tissue: Embryonic tooth.

    Entry informationi

    Entry nameiSOX10_MOUSE
    AccessioniPrimary (citable) accession number: Q04888
    Secondary accession number(s): O08518
    , O09141, O54856, P70416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3