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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 172HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: UniProtKB
  • identical protein binding Source: MGI
  • promoter-specific chromatin binding Source: Ensembl
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II transcription factor binding Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  • cell differentiation Source: MGI
  • cell maturation Source: MGI
  • cellular response to drug Source: Ensembl
  • cellular response to progesterone stimulus Source: Ensembl
  • central nervous system myelination Source: UniProtKB
  • developmental growth Source: MGI
  • digestive tract morphogenesis Source: MGI
  • enteric nervous system development Source: UniProtKB
  • in utero embryonic development Source: MGI
  • lacrimal gland development Source: MGI
  • melanocyte differentiation Source: MGI
  • morphogenesis of a branching epithelium Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of Schwann cell proliferation Source: Ensembl
  • neural crest cell migration Source: UniProtKB
  • oligodendrocyte development Source: UniProtKB
  • oligodendrocyte differentiation Source: UniProtKB
  • peripheral nervous system development Source: MGI
  • positive regulation of gliogenesis Source: UniProtKB
  • positive regulation of myelination Source: Ensembl
  • positive regulation of neuroblast proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription elongation from RNA polymerase II promoter Source: Ensembl

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Alternative name(s):
Protein SOX-21
Transcription factor SOX-M
Gene namesi
Name:Sox10
Synonyms:Sox-10, Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98358. Sox10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487471 – 466Transcription factor SOX-10Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04888.
PaxDbiQ04888.
PeptideAtlasiQ04888.
PRIDEiQ04888.

PTM databases

iPTMnetiQ04888.
PhosphoSitePlusiQ04888.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033006.
CleanExiMM_SOX10.
MM_SOX21.
GenevisibleiQ04888. MM.

Interactioni

Subunit structurei

Monomer (PubMed:27532821). Interacts with Armcx3 at the mitochondrial outer membrane surface (PubMed:19304657). Interacts with PAX3 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: MGI
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi203397. 2 interactors.
STRINGi10090.ENSMUSP00000039466.

Structurei

3D structure databases

ProteinModelPortaliQ04888.
SMRiQ04888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Gly7

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04888.
KOiK09270.
OMAiRPLYTTI.
OrthoDBiEOG091G0EKD.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR022151. Sox_N.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):49,949
Last modified:July 15, 1999 - v2
Checksum:i84862547F039E71F
GO

Sequence cautioni

The sequence AAB49282 differs from that shown. Reason: Frameshift at positions 16 and 392.Curated
The sequence AAB99738 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41G → V in AAB49282 (PubMed:9027483).Curated1
Sequence conflicti119R → P in CAA79484 (PubMed:8441686).Curated1
Sequence conflicti357K → E in AAB49282 (PubMed:9027483).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11E → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017182 mRNA. Translation: AAB99738.1. Different initiation.
AF047043 mRNA. Translation: AAC24564.1.
U66141 mRNA. Translation: AAB49282.1. Frameshift.
BC018551 mRNA. Translation: AAH18551.1.
BC023356 mRNA. Translation: AAH23356.1.
BC025171 mRNA. Translation: AAH25171.1.
Z18959 mRNA. Translation: CAA79484.1.
U70441 mRNA. Translation: AAC52859.1.
CCDSiCCDS49668.1.
PIRiS30242.
RefSeqiNP_035567.1. NM_011437.1.
UniGeneiMm.276739.

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
GeneIDi20665.
KEGGimmu:20665.
UCSCiuc007wsu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSOX10_MOUSE
AccessioniPrimary (citable) accession number: Q04888
Secondary accession number(s): O08518
, O09141, O54856, P70416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: November 22, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot