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Q04888 (SOX10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-10
Alternative name(s):
Protein SOX-21
Transcription factor SOX-M
Gene names
Name:Sox10
Synonyms:Sox-10, Sox21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia By similarity.

Subcellular location

Nucleus.

Involvement in disease

Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence AAB49282.1 differs from that shown. Reason: Frameshift at positions 16 and 392.

The sequence AAB99738.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from mutant phenotype PubMed 11799060. Source: MGI

cell maturation

Inferred from mutant phenotype PubMed 15102707. Source: MGI

developmental growth

Inferred from mutant phenotype PubMed 16790476. Source: MGI

digestive tract morphogenesis

Inferred from mutant phenotype PubMed 15843399PubMed 6512238. Source: MGI

enteric nervous system development

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

in utero embryonic development

Inferred from genetic interaction PubMed 16790476. Source: MGI

melanocyte differentiation

Inferred from mutant phenotype PubMed 16790476. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 17875931. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 16790476PubMed 17084361. Source: MGI

peripheral nervous system development

Inferred from genetic interaction PubMed 16790476. Source: MGI

positive regulation of gliogenesis

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

positive regulation of neuroblast proliferation

Inferred from mutant phenotype PubMed 16857183. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19304657. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 21610032. Source: UniProtKB

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15729346PubMed 21610032. Source: GOC

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 19304657. Source: MGI

extrinsic component of mitochondrial outer membrane

Inferred from direct assay PubMed 19304657. Source: MGI

nucleus

Inferred from direct assay PubMed 15572147PubMed 15713637. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15102707. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from direct assay PubMed 21610032. Source: UniProtKB

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 21610032. Source: UniProtKB

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15729346. Source: MGI

RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription

Inferred from genetic interaction PubMed 23575864. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15729346. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 21610032. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype PubMed 17084361. Source: MGI

transcription regulatory region DNA binding

Inferred from direct assay PubMed 17084361. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Transcription factor SOX-10
PRO_0000048747

Regions

DNA binding104 – 17269HMG box
Compositional bias35 – 417Poly-Gly

Amino acid modifications

Modified residue241Phosphoserine By similarity

Natural variations

Natural variant111E → V.

Experimental info

Sequence conflict411G → V in AAB49282. Ref.4
Sequence conflict1191R → P in CAA79484. Ref.6
Sequence conflict3571K → E in AAB49282. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q04888 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 84862547F039E71F

FASTA46649,949
        10         20         30         40         50         60 
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD 

        70         80         90        100        110        120 
GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR 

       130        140        150        160        170        180 
KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN 

       190        200        210        220        230        240 
GKAAQGEAEC PGGEAEQGGA AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT 

       250        260        270        280        290        300 
PPTTPKTELQ SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 

       310        320        330        340        350        360 
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV DAKAQVKTET 

       370        380        390        400        410        420 
TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF DYSDHQPSGP YYGHAGQASG 

       430        440        450        460 
LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH SPTHWEQPVY TTLSRP 

« Hide

References

« Hide 'large scale' references
[1]"Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model."
Southard-Smith E.M., Kos L., Pavan W.J.
Nat. Genet. 18:60-64(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease."
Herbarth B., Pingault V., Bondurand N., Kuhlbrodt K., Hermans-Borgmeyer I., Puliti A., Lemort N., Goossens M., Wegner M.
Proc. Natl. Acad. Sci. U.S.A. 95:5161-5165(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[3]"The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor."
Pusch C., Hustert E., Pfeifer D., Sudbeck P., Kist R., Roe B., Wang Z., Balling R., Blin N., Scherer G.
Hum. Genet. 103:115-123(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells."
Tani M., Shindo-Okada N., Hashimoto Y., Shiroishi T., Takenoshita S., Nagamachi Y., Yokota J.
Genomics 39:30-37(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H/HeN.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and FVB/N.
Tissue: Mammary gland and Salivary gland.
[6]"Seven new members of the Sox gene family expressed during mouse development."
Wright E.M., Snopek B., Koopman P.
Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-167.
[7]"Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-167.
Strain: Swiss Webster.
Tissue: Embryonic tooth.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017182 mRNA. Translation: AAB99738.1. Different initiation.
AF047043 mRNA. Translation: AAC24564.1.
U66141 mRNA. Translation: AAB49282.1. Frameshift.
BC018551 mRNA. Translation: AAH18551.1.
BC023356 mRNA. Translation: AAH23356.1.
BC025171 mRNA. Translation: AAH25171.1.
Z18959 mRNA. Translation: CAA79484.1.
U70441 mRNA. Translation: AAC52859.1.
PIRS30242.
RefSeqNP_035567.1. NM_011437.1.
UniGeneMm.276739.

3D structure databases

ProteinModelPortalQ04888.
SMRQ04888. Positions 102-173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203397. 2 interactions.

PTM databases

PhosphoSiteQ04888.

Proteomic databases

PaxDbQ04888.
PRIDEQ04888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
GeneID20665.
KEGGmmu:20665.
UCSCuc007wsu.2. mouse.

Organism-specific databases

CTD6663.
MGIMGI:98358. Sox10.

Phylogenomic databases

eggNOGNOG295709.
GeneTreeENSGT00740000115373.
HOVERGENHBG002061.
InParanoidQ04888.
KOK09270.
OMAPYYGHSS.
OrthoDBEOG7Q2N5K.

Gene expression databases

ArrayExpressQ04888.
BgeeQ04888.
CleanExMM_SOX10.
MM_SOX21.
GenevestigatorQ04888.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX10. mouse.
NextBio299123.
PROQ04888.
SOURCESearch...

Entry information

Entry nameSOX10_MOUSE
AccessionPrimary (citable) accession number: Q04888
Secondary accession number(s): O08518 expand/collapse secondary AC list , O09141, O54856, P70416
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot