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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 17269HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • identical protein binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  • RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: MGI
  • sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: MGI
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  • cell differentiation Source: MGI
  • cell maturation Source: MGI
  • developmental growth Source: MGI
  • digestive tract morphogenesis Source: MGI
  • enteric nervous system development Source: UniProtKB
  • in utero embryonic development Source: MGI
  • lacrimal gland development Source: MGI
  • melanocyte differentiation Source: MGI
  • morphogenesis of a branching epithelium Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • neural crest cell migration Source: UniProtKB
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of gliogenesis Source: UniProtKB
  • positive regulation of neuroblast proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Alternative name(s):
Protein SOX-21
Transcription factor SOX-M
Gene namesi
Name:Sox10
Synonyms:Sox-10, Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98358. Sox10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extrinsic component of mitochondrial outer membrane Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Transcription factor SOX-10PRO_0000048747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04888.
PaxDbiQ04888.
PRIDEiQ04888.

PTM databases

PhosphoSiteiQ04888.

Expressioni

Gene expression databases

BgeeiQ04888.
CleanExiMM_SOX10.
MM_SOX21.
ExpressionAtlasiQ04888. baseline and differential.
GenevisibleiQ04888. MM.

Interactioni

Protein-protein interaction databases

BioGridi203397. 2 interactions.
STRINGi10090.ENSMUSP00000039466.

Structurei

3D structure databases

ProteinModelPortaliQ04888.
SMRiQ04888. Positions 102-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Gly

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295709.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04888.
KOiK09270.
OMAiYADQPST.
OrthoDBiEOG7Q2N5K.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):49,949
Last modified:July 15, 1999 - v2
Checksum:i84862547F039E71F
GO

Sequence cautioni

The sequence AAB49282.1 differs from that shown. Reason: Frameshift at positions 16 and 392. Curated
The sequence AAB99738.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411G → V in AAB49282 (PubMed:9027483).Curated
Sequence conflicti119 – 1191R → P in CAA79484 (PubMed:8441686).Curated
Sequence conflicti357 – 3571K → E in AAB49282 (PubMed:9027483).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111E → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017182 mRNA. Translation: AAB99738.1. Different initiation.
AF047043 mRNA. Translation: AAC24564.1.
U66141 mRNA. Translation: AAB49282.1. Frameshift.
BC018551 mRNA. Translation: AAH18551.1.
BC023356 mRNA. Translation: AAH23356.1.
BC025171 mRNA. Translation: AAH25171.1.
Z18959 mRNA. Translation: CAA79484.1.
U70441 mRNA. Translation: AAC52859.1.
CCDSiCCDS49668.1.
PIRiS30242.
RefSeqiNP_035567.1. NM_011437.1.
UniGeneiMm.276739.

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
GeneIDi20665.
KEGGimmu:20665.
UCSCiuc007wsu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017182 mRNA. Translation: AAB99738.1. Different initiation.
AF047043 mRNA. Translation: AAC24564.1.
U66141 mRNA. Translation: AAB49282.1. Frameshift.
BC018551 mRNA. Translation: AAH18551.1.
BC023356 mRNA. Translation: AAH23356.1.
BC025171 mRNA. Translation: AAH25171.1.
Z18959 mRNA. Translation: CAA79484.1.
U70441 mRNA. Translation: AAC52859.1.
CCDSiCCDS49668.1.
PIRiS30242.
RefSeqiNP_035567.1. NM_011437.1.
UniGeneiMm.276739.

3D structure databases

ProteinModelPortaliQ04888.
SMRiQ04888. Positions 102-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203397. 2 interactions.
STRINGi10090.ENSMUSP00000039466.

PTM databases

PhosphoSiteiQ04888.

Proteomic databases

MaxQBiQ04888.
PaxDbiQ04888.
PRIDEiQ04888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
GeneIDi20665.
KEGGimmu:20665.
UCSCiuc007wsu.2. mouse.

Organism-specific databases

CTDi6663.
MGIiMGI:98358. Sox10.

Phylogenomic databases

eggNOGiNOG295709.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04888.
KOiK09270.
OMAiYADQPST.
OrthoDBiEOG7Q2N5K.

Miscellaneous databases

NextBioi299123.
PROiQ04888.
SOURCEiSearch...

Gene expression databases

BgeeiQ04888.
CleanExiMM_SOX10.
MM_SOX21.
ExpressionAtlasiQ04888. baseline and differential.
GenevisibleiQ04888. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model."
    Southard-Smith E.M., Kos L., Pavan W.J.
    Nat. Genet. 18:60-64(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease."
    Herbarth B., Pingault V., Bondurand N., Kuhlbrodt K., Hermans-Borgmeyer I., Puliti A., Lemort N., Goossens M., Wegner M.
    Proc. Natl. Acad. Sci. U.S.A. 95:5161-5165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor."
    Pusch C., Hustert E., Pfeifer D., Sudbeck P., Kist R., Roe B., Wang Z., Balling R., Blin N., Scherer G.
    Hum. Genet. 103:115-123(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells."
    Tani M., Shindo-Okada N., Hashimoto Y., Shiroishi T., Takenoshita S., Nagamachi Y., Yokota J.
    Genomics 39:30-37(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeN.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary gland and Salivary gland.
  6. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-167.
  7. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-167.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.

Entry informationi

Entry nameiSOX10_MOUSE
AccessioniPrimary (citable) accession number: Q04888
Secondary accession number(s): O08518
, O09141, O54856, P70416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: July 22, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.