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Q04888

- SOX10_MOUSE

UniProt

Q04888 - SOX10_MOUSE

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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 17269HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  6. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cell maturation Source: MGI
  3. developmental growth Source: MGI
  4. digestive tract morphogenesis Source: MGI
  5. enteric nervous system development Source: UniProtKB
  6. in utero embryonic development Source: MGI
  7. melanocyte differentiation Source: MGI
  8. negative regulation of apoptotic process Source: UniProtKB
  9. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  10. negative regulation of transcription, DNA-templated Source: Ensembl
  11. neural crest cell migration Source: UniProtKB
  12. oligodendrocyte differentiation Source: MGI
  13. peripheral nervous system development Source: MGI
  14. positive regulation of gliogenesis Source: UniProtKB
  15. positive regulation of neuroblast proliferation Source: MGI
  16. positive regulation of transcription, DNA-templated Source: UniProtKB
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Alternative name(s):
Protein SOX-21
Transcription factor SOX-M
Gene namesi
Name:Sox10
Synonyms:Sox-10, Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:98358. Sox10.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extrinsic component of mitochondrial outer membrane Source: MGI
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Transcription factor SOX-10PRO_0000048747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04888.
PaxDbiQ04888.
PRIDEiQ04888.

PTM databases

PhosphoSiteiQ04888.

Expressioni

Gene expression databases

BgeeiQ04888.
CleanExiMM_SOX10.
MM_SOX21.
ExpressionAtlasiQ04888. baseline and differential.
GenevestigatoriQ04888.

Interactioni

Protein-protein interaction databases

BioGridi203397. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ04888.
SMRiQ04888. Positions 102-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Gly

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295709.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04888.
KOiK09270.
OMAiPYYGHSS.
OrthoDBiEOG7Q2N5K.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04888-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):49,949
Last modified:July 15, 1999 - v2
Checksum:i84862547F039E71F
GO

Sequence cautioni

The sequence AAB49282.1 differs from that shown. Reason: Frameshift at positions 16 and 392.
The sequence AAB99738.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411G → V in AAB49282. (PubMed:9027483)Curated
Sequence conflicti119 – 1191R → P in CAA79484. (PubMed:8441686)Curated
Sequence conflicti357 – 3571K → E in AAB49282. (PubMed:9027483)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111E → V.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017182 mRNA. Translation: AAB99738.1. Different initiation.
AF047043 mRNA. Translation: AAC24564.1.
U66141 mRNA. Translation: AAB49282.1. Frameshift.
BC018551 mRNA. Translation: AAH18551.1.
BC023356 mRNA. Translation: AAH23356.1.
BC025171 mRNA. Translation: AAH25171.1.
Z18959 mRNA. Translation: CAA79484.1.
U70441 mRNA. Translation: AAC52859.1.
CCDSiCCDS49668.1.
PIRiS30242.
RefSeqiNP_035567.1. NM_011437.1.
UniGeneiMm.276739.

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006.
GeneIDi20665.
KEGGimmu:20665.
UCSCiuc007wsu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017182 mRNA. Translation: AAB99738.1 . Different initiation.
AF047043 mRNA. Translation: AAC24564.1 .
U66141 mRNA. Translation: AAB49282.1 . Frameshift.
BC018551 mRNA. Translation: AAH18551.1 .
BC023356 mRNA. Translation: AAH23356.1 .
BC025171 mRNA. Translation: AAH25171.1 .
Z18959 mRNA. Translation: CAA79484.1 .
U70441 mRNA. Translation: AAC52859.1 .
CCDSi CCDS49668.1.
PIRi S30242.
RefSeqi NP_035567.1. NM_011437.1.
UniGenei Mm.276739.

3D structure databases

ProteinModelPortali Q04888.
SMRi Q04888. Positions 102-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203397. 2 interactions.

PTM databases

PhosphoSitei Q04888.

Proteomic databases

MaxQBi Q04888.
PaxDbi Q04888.
PRIDEi Q04888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040019 ; ENSMUSP00000039466 ; ENSMUSG00000033006 .
GeneIDi 20665.
KEGGi mmu:20665.
UCSCi uc007wsu.2. mouse.

Organism-specific databases

CTDi 6663.
MGIi MGI:98358. Sox10.

Phylogenomic databases

eggNOGi NOG295709.
GeneTreei ENSGT00760000118988.
HOVERGENi HBG002061.
InParanoidi Q04888.
KOi K09270.
OMAi PYYGHSS.
OrthoDBi EOG7Q2N5K.

Miscellaneous databases

ChiTaRSi SOX10. mouse.
NextBioi 299123.
PROi Q04888.
SOURCEi Search...

Gene expression databases

Bgeei Q04888.
CleanExi MM_SOX10.
MM_SOX21.
ExpressionAtlasi Q04888. baseline and differential.
Genevestigatori Q04888.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model."
    Southard-Smith E.M., Kos L., Pavan W.J.
    Nat. Genet. 18:60-64(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease."
    Herbarth B., Pingault V., Bondurand N., Kuhlbrodt K., Hermans-Borgmeyer I., Puliti A., Lemort N., Goossens M., Wegner M.
    Proc. Natl. Acad. Sci. U.S.A. 95:5161-5165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor."
    Pusch C., Hustert E., Pfeifer D., Sudbeck P., Kist R., Roe B., Wang Z., Balling R., Blin N., Scherer G.
    Hum. Genet. 103:115-123(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of a novel Sry-related gene that is expressed in high-metastatic K-1735 murine melanoma cells."
    Tani M., Shindo-Okada N., Hashimoto Y., Shiroishi T., Takenoshita S., Nagamachi Y., Yokota J.
    Genomics 39:30-37(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeN.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary gland and Salivary gland.
  6. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-167.
  7. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-167.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.

Entry informationi

Entry nameiSOX10_MOUSE
AccessioniPrimary (citable) accession number: Q04888
Secondary accession number(s): O08518
, O09141, O54856, P70416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3