Q04887 (SOX9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-9

Gene names

Name:	Sox9
Synonyms:	Sox-9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from direct assay PubMed 21512138. Source: UniProtKB Sertoli cell development Inferred from genetic interaction PubMed 19124014. Source: MGI astrocyte fate commitment Inferred from genetic interaction PubMed 19490914. Source: MGI branching involved in ureteric bud morphogenesis Inferred from expression pattern PubMed 8787755. Source: UniProtKB cAMP-mediated signaling Inferred from sequence or structural similarity. Source: UniProtKB cartilage condensation Inferred from mutant phenotype PubMed 10319868PubMed 12414734. Source: MGI cell fate specification Inferred from mutant phenotype PubMed 12842915. Source: MGI cellular response to epidermal growth factor stimulus Inferred from direct assay PubMed 21512138. Source: UniProtKB cellular response to heparin Inferred from direct assay PubMed 21512138. Source: UniProtKB cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from direct assay PubMed 21512138. Source: UniProtKB cellular response to retinoic acid Inferred from direct assay PubMed 19389355. Source: MGI cellular response to transforming growth factor beta stimulus Inferred from expression pattern PubMed 17525254. Source: UniProtKB chondrocyte differentiation involved in endochondral bone morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB chondrocyte hypertrophy Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB chromatin remodeling Inferred from sequence or structural similarity. Source: UniProtKB cochlea morphogenesis Inferred from mutant phenotype PubMed 20346939. Source: MGI endocardial cushion morphogenesis Inferred from mutant phenotype PubMed 11951052. Source: MGI endocrine pancreas development Inferred from mutant phenotype PubMed 18723011. Source: MGI epidermal growth factor receptor signaling pathway Inferred from direct assay PubMed 21512138. Source: UniProtKB epithelial cell proliferation involved in prostatic bud elongation Inferred from mutant phenotype PubMed 18325490. Source: MGI epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 15096597. Source: MGI extracellular matrix organization Inferred from mutant phenotype PubMed 17350610. Source: MGI hair follicle development Inferred from mutant phenotype PubMed 16085486. Source: MGI heart valve formation Inferred from mutant phenotype PubMed 17350610. Source: MGI intestinal epithelial structure maintenance Inferred from mutant phenotype PubMed 17681175. Source: MGI intrahepatic bile duct development Inferred from mutant phenotype PubMed 19403103. Source: MGI limb bud formation Inferred from expression pattern PubMed 20940257. Source: UniProtKB male germ-line sex determination Inferred from mutant phenotype PubMed 11431689PubMed 16207837. Source: MGI mammary gland development Inferred from expression pattern PubMed 12420222. Source: UniProtKB metanephric nephron tubule formation Inferred from genetic interaction PubMed 21212101. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB negative regulation of bone mineralization Inferred from mutant phenotype PubMed 11371614. Source: MGI negative regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 17875931. Source: UniProtKB negative regulation of chondrocyte differentiation Inferred from mutant phenotype PubMed 11371614. Source: MGI negative regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 17681175. Source: MGI negative regulation of immune system process Inferred from mutant phenotype PubMed 20056916. Source: UniProtKB negative regulation of myoblast differentiation Inferred from direct assay PubMed 12782625. Source: MGI negative regulation of photoreceptor cell differentiation Inferred from genetic interaction PubMed 19490914. Source: MGI negative regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB neural crest cell development Inferred from mutant phenotype PubMed 15691760. Source: MGI notochord development Inferred from expression pattern PubMed 9119111. Source: UniProtKB nucleosome assembly Inferred from sequence or structural similarity. Source: UniProtKB oligodendrocyte differentiation Inferred from mutant phenotype PubMed 17084361. Source: MGI ossification Inferred from expression pattern PubMed 9119111. Source: UniProtKB otic vesicle formation Inferred from mutant phenotype PubMed 18377888. Source: MGI positive regulation of branching involved in ureteric bud morphogenesis Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB positive regulation of cartilage development Inferred from direct assay PubMed 19047045. Source: MGI positive regulation of cell proliferation involved in heart morphogenesis Inferred from mutant phenotype PubMed 17350610. Source: MGI positive regulation of chondrocyte differentiation Inferred from direct assay PubMed 20940257. Source: UniProtKB positive regulation of epithelial cell differentiation Inferred from mutant phenotype PubMed 17681175. Source: MGI positive regulation of epithelial cell migration Inferred from sequence or structural similarity PubMed 21512138. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 20103652. Source: UniProtKB positive regulation of male gonad development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of mesenchymal cell proliferation Inferred from mutant phenotype PubMed 17350610PubMed 20346939. Source: MGI positive regulation of mesenchymal stem cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of phosphatidylinositol 3-kinase cascade Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB positive regulation of protein catabolic process Inferred from direct assay PubMed 19047045. Source: MGI positive regulation of protein phosphorylation Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB protein complex assembly Inferred from sequence or structural similarity. Source: UniProtKB protein kinase B signaling cascade Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB regulation of cell adhesion Inferred from mutant phenotype PubMed 18377888. Source: MGI regulation of cell cycle process Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell proliferation involved in tissue homeostasis Inferred from mutant phenotype PubMed 17698607. Source: MGI renal vesicle induction Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB retinal rod cell differentiation Inferred from genetic interaction PubMed 19490914. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 20871603. Source: MGI spermatogenesis Inferred from genetic interaction PubMed 19124014. Source: MGI ureter morphogenesis Inferred from genetic interaction PubMed 21212101. Source: MGI ureter urothelium development Inferred from expression pattern PubMed 21512138. Source: UniProtKB
Cellular_component	transcription factor complex Inferred from physical interaction PubMed 21346191. Source: MGI
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 21367821. Source: UniProtKB RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 17525254. Source: UniProtKB chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB core promoter sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB enhancer sequence-specific DNA binding Inferred from direct assay PubMed 17525254. Source: UniProtKB protein kinase activity Inferred from mutant phenotype PubMed 21367821. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Transcription factor SOX-9		PRO_0000048741
Regions
	DNA binding	105 – 173	69	HMG box
	Compositional bias	339 – 415	77	Gln/Pro-rich
	Compositional bias	342 – 346	5	Poly-Pro
Experimental info
	Sequence conflict	62	1	K → R in BAC34018. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q04887 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 01FC3B54FF329BDA	FASTA	507	56,077
	10 20 30 40 50 60 MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE NTFPKGEPDL 70 80 90 100 110 120 KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR 130 140 150 160 170 180 RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK 190 200 210 220 230 240 SVKNGQAEAE EATEQTHISP NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT 250 260 270 280 290 300 PKTDVQAGKV DLKREGRPLA EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP 310 320 330 340 350 360 NGHPGVPATH GQVTYTGSYG ISSTAPTPAT AGHVWMSKQQ APPPPPQQPP QAPQAPQAPP 370 380 390 400 410 420 QQQAPPQQPQ APQQQQAHTL TTLSSEPGQS QRTHIKTEQL SPSHYSEQQQ HSPQQISYSP 430 440 450 460 470 480 FNLPHYSPSY PPITRSQYDY ADHQNSGSYY SHAAGQGSGL YSTFTYMNPA QRPMYTPIAD 490 500 TSGVPSIPQT HSPQHWEQPV YTQLTRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene expression of Sox9 in mouse genital ridges." Lee H.-H. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
[4]	"Seven new members of the Sox gene family expressed during mouse development." Wright E.M., Snopek B., Koopman P. Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-168.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF421878 mRNA. Translation: AAL16093.1. AK030187 mRNA. Translation: BAC26830.1. AK049986 mRNA. Translation: BAC34018.1. BC004064 mRNA. Translation: AAH04064.1. BC023796 mRNA. Translation: AAH23796.1. BC023808 mRNA. Translation: AAH23808.1. BC023953 mRNA. Translation: AAH23953.1. BC024958 mRNA. Translation: AAH24958.1. BC034264 mRNA. Translation: AAH34264.1. Z18958 mRNA. Translation: CAA79483.1.
IPI	IPI00131219.
PIR	S30243. S52469.
RefSeq	NP_035578.3. NM_011448.4.
UniGene	Mm.286407.
3D structure databases
ProteinModelPortal	Q04887.
SMR	Q04887. Positions 103-174.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q04887. 1 interaction.
PTM databases
PhosphoSite	Q04887.
Proteomic databases
PRIDE	Q04887.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567.
GeneID	20682.
KEGG	mmu:20682.
Organism-specific databases
CTD	6662.
MGI	MGI:98371. Sox9.
Phylogenomic databases
eggNOG	NOG295709.
GeneTree	ENSGT00670000097649.
HOVERGEN	HBG002061.
InParanoid	Q04887.
KO	K09270.
OMA	GAGHVWM.
OrthoDB	EOG4TXBRZ.
Gene expression databases
ArrayExpress	Q04887.
Bgee	Q04887.
CleanEx	MM_SOX9.
Genevestigator	Q04887.
GermOnline	ENSMUSG00000000567. Mus musculus.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR022151. Sox_N. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. PF12444. Sox_N. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	299193.
SOURCE	Search...

Entry information

Entry name

SOX9_MOUSE

Accession

Primary (citable) accession number: Q04887
Secondary accession number(s): Q8C7L2, Q91ZK2, Q99KQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program