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Protein

Transcription factor SOX-9

Gene

Sox9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi105 – 17369HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • chromatin binding Source: UniProtKB
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • DNA binding Source: MGI
  • enhancer binding Source: UniProtKB
  • enhancer sequence-specific DNA binding Source: UniProtKB
  • pre-mRNA intronic binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein kinase A catalytic subunit binding Source: MGI
  • protein kinase activity Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  • sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  • sequence-specific DNA binding transcription factor activity Source: MGI
  • transcription regulatory region DNA binding Source: MGI
  • transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • astrocyte fate commitment Source: MGI
  • branching involved in ureteric bud morphogenesis Source: UniProtKB
  • bronchus cartilage development Source: MGI
  • cAMP-mediated signaling Source: UniProtKB
  • cartilage condensation Source: MGI
  • cartilage development Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cell fate specification Source: MGI
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to heparin Source: UniProtKB
  • cellular response to interleukin-1 Source: Ensembl
  • cellular response to mechanical stimulus Source: UniProtKB
  • cellular response to retinoic acid Source: MGI
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • chondrocyte development Source: MGI
  • chondrocyte differentiation Source: UniProtKB
  • chondrocyte differentiation involved in endochondral bone morphogenesis Source: UniProtKB
  • chondrocyte hypertrophy Source: UniProtKB
  • chromatin remodeling Source: UniProtKB
  • cochlea morphogenesis Source: MGI
  • cytoskeleton organization Source: MGI
  • endocardial cushion morphogenesis Source: MGI
  • endochondral bone morphogenesis Source: MGI
  • endocrine pancreas development Source: MGI
  • epidermal growth factor receptor signaling pathway Source: UniProtKB
  • epithelial cell proliferation involved in prostatic bud elongation Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • ERK1 and ERK2 cascade Source: UniProtKB
  • extracellular matrix organization Source: MGI
  • hair follicle development Source: MGI
  • Harderian gland development Source: MGI
  • heart development Source: MGI
  • heart valve development Source: UniProtKB
  • heart valve formation Source: MGI
  • heart valve morphogenesis Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • intestinal epithelial structure maintenance Source: MGI
  • intrahepatic bile duct development Source: MGI
  • lacrimal gland development Source: MGI
  • limb bud formation Source: UniProtKB
  • lung epithelial cell differentiation Source: MGI
  • lung smooth muscle development Source: MGI
  • male germ-line sex determination Source: MGI
  • male gonad development Source: UniProtKB
  • male sex determination Source: MGI
  • mammary gland development Source: UniProtKB
  • metanephric nephron tubule formation Source: MGI
  • metanephric tubule development Source: UniProtKB
  • morphogenesis of a branching epithelium Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of biomineral tissue development Source: UniProtKB
  • negative regulation of bone mineralization Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of chondrocyte differentiation Source: MGI
  • negative regulation of epithelial cell differentiation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of immune system process Source: UniProtKB
  • negative regulation of mesenchymal cell apoptotic process Source: MGI
  • negative regulation of myoblast differentiation Source: MGI
  • negative regulation of ossification Source: UniProtKB
  • negative regulation of photoreceptor cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neural crest cell development Source: MGI
  • Notch signaling pathway Source: MGI
  • notochord development Source: UniProtKB
  • nucleosome assembly Source: UniProtKB
  • oligodendrocyte differentiation Source: MGI
  • ossification Source: UniProtKB
  • otic vesicle development Source: UniProtKB
  • otic vesicle formation Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cell proliferation involved in heart morphogenesis Source: MGI
  • positive regulation of chondrocyte differentiation Source: UniProtKB
  • positive regulation of epithelial cell differentiation Source: MGI
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of extracellular matrix assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of kidney development Source: UniProtKB
  • positive regulation of male gonad development Source: UniProtKB
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of mesenchymal stem cell differentiation Source: UniProtKB
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein catabolic process Source: MGI
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • prostate gland development Source: UniProtKB
  • prostate gland morphogenesis Source: MGI
  • protein complex assembly Source: UniProtKB
  • protein kinase B signaling Source: UniProtKB
  • protein localization to nucleus Source: MGI
  • regulation of branching involved in lung morphogenesis Source: MGI
  • regulation of cell adhesion Source: MGI
  • regulation of cell cycle process Source: UniProtKB
  • regulation of cell differentiation Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of cell proliferation involved in tissue homeostasis Source: MGI
  • regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • renal vesicle induction Source: UniProtKB
  • retina development in camera-type eye Source: MGI
  • retinal rod cell differentiation Source: MGI
  • Sertoli cell development Source: MGI
  • Sertoli cell differentiation Source: MGI
  • signal transduction Source: UniProtKB
  • single organismal cell-cell adhesion Source: MGI
  • skeletal system development Source: UniProtKB
  • somatic stem cell maintenance Source: MGI
  • spermatogenesis Source: MGI
  • tissue homeostasis Source: UniProtKB
  • trachea cartilage development Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
  • ureter development Source: MGI
  • ureter morphogenesis Source: MGI
  • ureter smooth muscle cell differentiation Source: MGI
  • ureter urothelium development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_351655. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-9
Gene namesi
Name:Sox9
Synonyms:Sox-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98371. Sox9.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear transcription factor complex Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Transcription factor SOX-9PRO_0000048741Add
BLAST

Proteomic databases

MaxQBiQ04887.
PRIDEiQ04887.

PTM databases

PhosphoSiteiQ04887.

Expressioni

Gene expression databases

BgeeiQ04887.
CleanExiMM_SOX9.
ExpressionAtlasiQ04887. baseline and differential.
GenevisibleiQ04887. MM.

Interactioni

Protein-protein interaction databases

BioGridi203413. 7 interactions.
IntActiQ04887. 1 interaction.
STRINGi10090.ENSMUSP00000000579.

Structurei

3D structure databases

ProteinModelPortaliQ04887.
SMRiQ04887. Positions 103-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi339 – 41577Gln/Pro-richAdd
BLAST
Compositional biasi342 – 3465Poly-Pro

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295709.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04887.
KOiK18435.
OMAiTITRSQY.
OrthoDBiEOG7Q2N5K.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029548. SOX-9.
IPR022151. Sox_N.
[Graphical view]
PANTHERiPTHR10270:SF212. PTHR10270:SF212. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE
60 70 80 90 100
NTFPKGEPDL KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK
110 120 130 140 150
NKPHVKRPMN AFMVWAQAAR RKLADQYPHL HNAELSKTLG KLWRLLNESE
160 170 180 190 200
KRPFVEEAER LRVQHKKDHP DYKYQPRRRK SVKNGQAEAE EATEQTHISP
210 220 230 240 250
NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT PKTDVQAGKV
260 270 280 290 300
DLKREGRPLA EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP
310 320 330 340 350
NGHPGVPATH GQVTYTGSYG ISSTAPTPAT AGHVWMSKQQ APPPPPQQPP
360 370 380 390 400
QAPQAPQAPP QQQAPPQQPQ APQQQQAHTL TTLSSEPGQS QRTHIKTEQL
410 420 430 440 450
SPSHYSEQQQ HSPQQISYSP FNLPHYSPSY PPITRSQYDY ADHQNSGSYY
460 470 480 490 500
SHAAGQGSGL YSTFTYMNPA QRPMYTPIAD TSGVPSIPQT HSPQHWEQPV

YTQLTRP
Length:507
Mass (Da):56,077
Last modified:May 10, 2004 - v2
Checksum:i01FC3B54FF329BDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621K → R in BAC34018 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421878 mRNA. Translation: AAL16093.1.
AK030187 mRNA. Translation: BAC26830.1.
AK049986 mRNA. Translation: BAC34018.1.
BC004064 mRNA. Translation: AAH04064.1.
BC023796 mRNA. Translation: AAH23796.1.
BC023808 mRNA. Translation: AAH23808.1.
BC023953 mRNA. Translation: AAH23953.1.
BC024958 mRNA. Translation: AAH24958.1.
BC034264 mRNA. Translation: AAH34264.1.
Z18958 mRNA. Translation: CAA79483.1.
CCDSiCCDS25595.1.
PIRiS30243.
S52469.
RefSeqiNP_035578.3. NM_011448.4.
UniGeneiMm.286407.

Genome annotation databases

EnsembliENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567.
GeneIDi20682.
KEGGimmu:20682.
UCSCiuc007med.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421878 mRNA. Translation: AAL16093.1.
AK030187 mRNA. Translation: BAC26830.1.
AK049986 mRNA. Translation: BAC34018.1.
BC004064 mRNA. Translation: AAH04064.1.
BC023796 mRNA. Translation: AAH23796.1.
BC023808 mRNA. Translation: AAH23808.1.
BC023953 mRNA. Translation: AAH23953.1.
BC024958 mRNA. Translation: AAH24958.1.
BC034264 mRNA. Translation: AAH34264.1.
Z18958 mRNA. Translation: CAA79483.1.
CCDSiCCDS25595.1.
PIRiS30243.
S52469.
RefSeqiNP_035578.3. NM_011448.4.
UniGeneiMm.286407.

3D structure databases

ProteinModelPortaliQ04887.
SMRiQ04887. Positions 103-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203413. 7 interactions.
IntActiQ04887. 1 interaction.
STRINGi10090.ENSMUSP00000000579.

PTM databases

PhosphoSiteiQ04887.

Proteomic databases

MaxQBiQ04887.
PRIDEiQ04887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567.
GeneIDi20682.
KEGGimmu:20682.
UCSCiuc007med.2. mouse.

Organism-specific databases

CTDi6662.
MGIiMGI:98371. Sox9.

Phylogenomic databases

eggNOGiNOG295709.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG002061.
InParanoidiQ04887.
KOiK18435.
OMAiTITRSQY.
OrthoDBiEOG7Q2N5K.
TreeFamiTF351735.

Enzyme and pathway databases

ReactomeiREACT_351655. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

NextBioi299193.
PROiQ04887.
SOURCEiSearch...

Gene expression databases

BgeeiQ04887.
CleanExiMM_SOX9.
ExpressionAtlasiQ04887. baseline and differential.
GenevisibleiQ04887. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029548. SOX-9.
IPR022151. Sox_N.
[Graphical view]
PANTHERiPTHR10270:SF212. PTHR10270:SF212. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene expression of Sox9 in mouse genital ridges."
    Lee H.-H.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-168.

Entry informationi

Entry nameiSOX9_MOUSE
AccessioniPrimary (citable) accession number: Q04887
Secondary accession number(s): Q8C7L2, Q91ZK2, Q99KQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 10, 2004
Last modified: July 22, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.