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Q04887

- SOX9_MOUSE

UniProt

Q04887 - SOX9_MOUSE

Protein

Transcription factor SOX-9

Gene

Sox9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi105 – 17369HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. beta-catenin binding Source: MGI
    2. chromatin binding Source: UniProtKB
    3. core promoter sequence-specific DNA binding Source: UniProtKB
    4. DNA binding Source: MGI
    5. enhancer binding Source: UniProtKB
    6. enhancer sequence-specific DNA binding Source: UniProtKB
    7. pre-mRNA intronic binding Source: MGI
    8. protein binding Source: UniProtKB
    9. protein heterodimerization activity Source: MGI
    10. protein kinase activity Source: UniProtKB
    11. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    12. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: UniProtKB
    13. sequence-specific DNA binding Source: MGI
    14. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    15. sequence-specific DNA binding transcription factor activity Source: MGI
    16. transcription regulatory region DNA binding Source: MGI
    17. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. astrocyte fate commitment Source: MGI
    2. branching involved in ureteric bud morphogenesis Source: UniProtKB
    3. cAMP-mediated signaling Source: UniProtKB
    4. cartilage condensation Source: MGI
    5. cartilage development Source: MGI
    6. cell differentiation Source: MGI
    7. cell fate commitment Source: MGI
    8. cell fate specification Source: MGI
    9. cellular response to epidermal growth factor stimulus Source: UniProtKB
    10. cellular response to heparin Source: UniProtKB
    11. cellular response to interleukin-1 Source: Ensembl
    12. cellular response to mechanical stimulus Source: UniProtKB
    13. cellular response to retinoic acid Source: MGI
    14. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    15. central nervous system development Source: UniProtKB
    16. chondrocyte development Source: MGI
    17. chondrocyte differentiation Source: UniProtKB
    18. chondrocyte differentiation involved in endochondral bone morphogenesis Source: UniProtKB
    19. chondrocyte hypertrophy Source: UniProtKB
    20. chromatin remodeling Source: UniProtKB
    21. cochlea morphogenesis Source: MGI
    22. cytoskeleton organization Source: MGI
    23. endocardial cushion morphogenesis Source: MGI
    24. endochondral bone morphogenesis Source: MGI
    25. endocrine pancreas development Source: MGI
    26. epidermal growth factor receptor signaling pathway Source: UniProtKB
    27. epithelial cell proliferation involved in prostatic bud elongation Source: MGI
    28. epithelial to mesenchymal transition Source: MGI
    29. epithelial tube branching involved in lung morphogenesis Source: MGI
    30. ERK1 and ERK2 cascade Source: UniProtKB
    31. extracellular matrix organization Source: MGI
    32. hair follicle development Source: MGI
    33. heart development Source: MGI
    34. heart valve development Source: UniProtKB
    35. heart valve formation Source: MGI
    36. heart valve morphogenesis Source: MGI
    37. intestinal epithelial structure maintenance Source: MGI
    38. intrahepatic bile duct development Source: MGI
    39. limb bud formation Source: UniProtKB
    40. lung epithelial cell differentiation Source: MGI
    41. male germ-line sex determination Source: MGI
    42. male gonad development Source: UniProtKB
    43. male sex determination Source: MGI
    44. mammary gland development Source: UniProtKB
    45. metanephric nephron tubule formation Source: MGI
    46. metanephric tubule development Source: UniProtKB
    47. morphogenesis of a branching epithelium Source: MGI
    48. negative regulation of apoptotic process Source: UniProtKB
    49. negative regulation of biomineral tissue development Source: UniProtKB
    50. negative regulation of bone mineralization Source: MGI
    51. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    52. negative regulation of cell proliferation Source: MGI
    53. negative regulation of chondrocyte differentiation Source: MGI
    54. negative regulation of epithelial cell differentiation Source: MGI
    55. negative regulation of epithelial cell proliferation Source: MGI
    56. negative regulation of immune system process Source: UniProtKB
    57. negative regulation of mesenchymal cell apoptotic process Source: MGI
    58. negative regulation of myoblast differentiation Source: MGI
    59. negative regulation of ossification Source: UniProtKB
    60. negative regulation of photoreceptor cell differentiation Source: MGI
    61. negative regulation of transcription, DNA-templated Source: UniProtKB
    62. neural crest cell development Source: MGI
    63. notochord development Source: UniProtKB
    64. nucleosome assembly Source: UniProtKB
    65. oligodendrocyte differentiation Source: MGI
    66. ossification Source: UniProtKB
    67. otic vesicle development Source: UniProtKB
    68. otic vesicle formation Source: MGI
    69. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    70. positive regulation of cartilage development Source: MGI
    71. positive regulation of cell proliferation Source: MGI
    72. positive regulation of cell proliferation involved in heart morphogenesis Source: MGI
    73. positive regulation of chondrocyte differentiation Source: UniProtKB
    74. positive regulation of epithelial cell differentiation Source: MGI
    75. positive regulation of epithelial cell migration Source: UniProtKB
    76. positive regulation of epithelial cell proliferation Source: UniProtKB
    77. positive regulation of extracellular matrix assembly Source: MGI
    78. positive regulation of gene expression Source: MGI
    79. positive regulation of kidney development Source: UniProtKB
    80. positive regulation of male gonad development Source: UniProtKB
    81. positive regulation of mesenchymal cell proliferation Source: MGI
    82. positive regulation of mesenchymal stem cell differentiation Source: UniProtKB
    83. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    84. positive regulation of protein catabolic process Source: MGI
    85. positive regulation of protein phosphorylation Source: UniProtKB
    86. positive regulation of transcription, DNA-templated Source: UniProtKB
    87. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    88. prostate gland development Source: UniProtKB
    89. prostate gland morphogenesis Source: MGI
    90. protein complex assembly Source: UniProtKB
    91. protein kinase B signaling Source: UniProtKB
    92. protein phosphorylation Source: GOC
    93. regulation of branching involved in lung morphogenesis Source: MGI
    94. regulation of cell adhesion Source: MGI
    95. regulation of cell cycle process Source: UniProtKB
    96. regulation of cell differentiation Source: MGI
    97. regulation of cell proliferation Source: MGI
    98. regulation of cell proliferation involved in tissue homeostasis Source: MGI
    99. regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
    100. regulation of transcription, DNA-templated Source: MGI
    101. regulation of transcription from RNA polymerase II promoter Source: MGI
    102. renal vesicle induction Source: UniProtKB
    103. retina development in camera-type eye Source: MGI
    104. retinal rod cell differentiation Source: MGI
    105. Sertoli cell development Source: MGI
    106. Sertoli cell differentiation Source: MGI
    107. signal transduction Source: UniProtKB
    108. single organismal cell-cell adhesion Source: MGI
    109. skeletal system development Source: UniProtKB
    110. somatic stem cell maintenance Source: MGI
    111. spermatogenesis Source: MGI
    112. tissue homeostasis Source: UniProtKB
    113. transcription from RNA polymerase II promoter Source: GOC
    114. ureter development Source: MGI
    115. ureter morphogenesis Source: MGI
    116. ureter smooth muscle cell differentiation Source: MGI
    117. ureter urothelium development Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-9
    Gene namesi
    Name:Sox9
    Synonyms:Sox-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98371. Sox9.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear transcription factor complex Source: MGI
    2. nucleus Source: UniProtKB
    3. protein complex Source: UniProtKB
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Transcription factor SOX-9PRO_0000048741Add
    BLAST

    Proteomic databases

    MaxQBiQ04887.
    PRIDEiQ04887.

    PTM databases

    PhosphoSiteiQ04887.

    Expressioni

    Gene expression databases

    ArrayExpressiQ04887.
    BgeeiQ04887.
    CleanExiMM_SOX9.
    GenevestigatoriQ04887.

    Interactioni

    Protein-protein interaction databases

    BioGridi203413. 6 interactions.
    IntActiQ04887. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04887.
    SMRiQ04887. Positions 103-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi339 – 41577Gln/Pro-richAdd
    BLAST
    Compositional biasi342 – 3465Poly-Pro

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG295709.
    GeneTreeiENSGT00740000115373.
    HOVERGENiHBG002061.
    InParanoidiQ04887.
    KOiK09270.
    OMAiIAYSPFS.
    OrthoDBiEOG7Q2N5K.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029548. SOX-9.
    IPR022151. Sox_N.
    [Graphical view]
    PANTHERiPTHR10270:SF212. PTHR10270:SF212. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE    50
    NTFPKGEPDL KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK 100
    NKPHVKRPMN AFMVWAQAAR RKLADQYPHL HNAELSKTLG KLWRLLNESE 150
    KRPFVEEAER LRVQHKKDHP DYKYQPRRRK SVKNGQAEAE EATEQTHISP 200
    NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT PKTDVQAGKV 250
    DLKREGRPLA EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP 300
    NGHPGVPATH GQVTYTGSYG ISSTAPTPAT AGHVWMSKQQ APPPPPQQPP 350
    QAPQAPQAPP QQQAPPQQPQ APQQQQAHTL TTLSSEPGQS QRTHIKTEQL 400
    SPSHYSEQQQ HSPQQISYSP FNLPHYSPSY PPITRSQYDY ADHQNSGSYY 450
    SHAAGQGSGL YSTFTYMNPA QRPMYTPIAD TSGVPSIPQT HSPQHWEQPV 500
    YTQLTRP 507
    Length:507
    Mass (Da):56,077
    Last modified:May 10, 2004 - v2
    Checksum:i01FC3B54FF329BDA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621K → R in BAC34018. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421878 mRNA. Translation: AAL16093.1.
    AK030187 mRNA. Translation: BAC26830.1.
    AK049986 mRNA. Translation: BAC34018.1.
    BC004064 mRNA. Translation: AAH04064.1.
    BC023796 mRNA. Translation: AAH23796.1.
    BC023808 mRNA. Translation: AAH23808.1.
    BC023953 mRNA. Translation: AAH23953.1.
    BC024958 mRNA. Translation: AAH24958.1.
    BC034264 mRNA. Translation: AAH34264.1.
    Z18958 mRNA. Translation: CAA79483.1.
    CCDSiCCDS25595.1.
    PIRiS30243.
    S52469.
    RefSeqiNP_035578.3. NM_011448.4.
    UniGeneiMm.286407.

    Genome annotation databases

    EnsembliENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567.
    GeneIDi20682.
    KEGGimmu:20682.
    UCSCiuc007med.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421878 mRNA. Translation: AAL16093.1 .
    AK030187 mRNA. Translation: BAC26830.1 .
    AK049986 mRNA. Translation: BAC34018.1 .
    BC004064 mRNA. Translation: AAH04064.1 .
    BC023796 mRNA. Translation: AAH23796.1 .
    BC023808 mRNA. Translation: AAH23808.1 .
    BC023953 mRNA. Translation: AAH23953.1 .
    BC024958 mRNA. Translation: AAH24958.1 .
    BC034264 mRNA. Translation: AAH34264.1 .
    Z18958 mRNA. Translation: CAA79483.1 .
    CCDSi CCDS25595.1.
    PIRi S30243.
    S52469.
    RefSeqi NP_035578.3. NM_011448.4.
    UniGenei Mm.286407.

    3D structure databases

    ProteinModelPortali Q04887.
    SMRi Q04887. Positions 103-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203413. 6 interactions.
    IntActi Q04887. 1 interaction.

    PTM databases

    PhosphoSitei Q04887.

    Proteomic databases

    MaxQBi Q04887.
    PRIDEi Q04887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000579 ; ENSMUSP00000000579 ; ENSMUSG00000000567 .
    GeneIDi 20682.
    KEGGi mmu:20682.
    UCSCi uc007med.2. mouse.

    Organism-specific databases

    CTDi 6662.
    MGIi MGI:98371. Sox9.

    Phylogenomic databases

    eggNOGi NOG295709.
    GeneTreei ENSGT00740000115373.
    HOVERGENi HBG002061.
    InParanoidi Q04887.
    KOi K09270.
    OMAi IAYSPFS.
    OrthoDBi EOG7Q2N5K.
    TreeFami TF351735.

    Miscellaneous databases

    NextBioi 299193.
    PROi Q04887.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04887.
    Bgeei Q04887.
    CleanExi MM_SOX9.
    Genevestigatori Q04887.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029548. SOX-9.
    IPR022151. Sox_N.
    [Graphical view ]
    PANTHERi PTHR10270:SF212. PTHR10270:SF212. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene expression of Sox9 in mouse genital ridges."
      Lee H.-H.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-168.

    Entry informationi

    Entry nameiSOX9_MOUSE
    AccessioniPrimary (citable) accession number: Q04887
    Secondary accession number(s): Q8C7L2, Q91ZK2, Q99KQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3