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Q04886

- SOX8_MOUSE

UniProt

Q04886 - SOX8_MOUSE

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Protein
Transcription factor SOX-8
Gene
Sox8, Sox-8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi99 – 16769HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  3. protein binding Source: MGI
  4. protein heterodimerization activity Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. Sertoli cell development Source: UniProtKB
  2. adipose tissue development Source: MGI
  3. astrocyte fate commitment Source: MGI
  4. cell fate commitment Source: MGI
  5. cell maturation Source: MGI
  6. enteric nervous system development Source: UniProtKB
  7. fat cell differentiation Source: MGI
  8. in utero embryonic development Source: MGI
  9. male gonad development Source: MGI
  10. metanephric nephron tubule formation Source: MGI
  11. morphogenesis of a branching epithelium Source: MGI
  12. negative regulation of apoptotic process Source: UniProtKB
  13. negative regulation of myoblast differentiation Source: MGI
  14. negative regulation of photoreceptor cell differentiation Source: MGI
  15. negative regulation of transcription, DNA-templated Source: UniProtKB
  16. neural crest cell migration Source: UniProtKB
  17. oligodendrocyte differentiation Source: MGI
  18. osteoblast differentiation Source: MGI
  19. peripheral nervous system development Source: MGI
  20. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  21. positive regulation of gene expression Source: MGI
  22. positive regulation of gliogenesis Source: UniProtKB
  23. positive regulation of kidney development Source: UniProtKB
  24. positive regulation of osteoblast proliferation Source: MGI
  25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  26. positive regulation of transcription, DNA-templated Source: UniProtKB
  27. regulation of hormone levels Source: MGI
  28. renal vesicle induction Source: UniProtKB
  29. retina development in camera-type eye Source: MGI
  30. retinal rod cell differentiation Source: MGI
  31. signal transduction Source: UniProtKB
  32. skeletal muscle cell differentiation Source: MGI
  33. spermatogenesis Source: MGI
  34. transcription from RNA polymerase II promoter Source: GOC
  35. ureter morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-8
Gene namesi
Name:Sox8
Synonyms:Sox-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:98370. Sox8.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear transcription factor complex Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Transcription factor SOX-8
PRO_0000048734Add
BLAST

Proteomic databases

MaxQBiQ04886.
PaxDbiQ04886.
PRIDEiQ04886.

PTM databases

PhosphoSiteiQ04886.

Expressioni

Tissue specificityi

Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.

Gene expression databases

BgeeiQ04886.
CleanExiMM_SOX8.
GenevestigatoriQ04886.

Interactioni

Protein-protein interaction databases

BioGridi203412. 15 interactions.
IntActiQ04886. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ04886.
SMRiQ04886. Positions 97-168.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG324597.
HOGENOMiHOG000108876.
HOVERGENiHBG002061.
InParanoidiQ04886.
KOiK09270.
OMAiDQSHGSP.
OrthoDBiEOG7Q2N5K.
PhylomeDBiQ04886.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04886-1 [UniParc]FASTAAdd to Basket

« Hide

MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR    50
GDTAEAADER FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK 100
RPMNAFMVWA QAARRKLADQ YPHLHNAELS KTLGKLWRLL SESEKRPFVE 150
EAERLRVQHK KDHPDYKYQP RRRKSVKTGR SDSDSGTELG HHPGGPMYKA 200
DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK QELRLEGRRL 250
VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP 300
SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI 350
KTEQLSPSHY NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD 400
YTDLQASNYY SPYPGYPPSL YQYPYFHSSR RPYASPLLNG LSMPPAHSPS 450
SNWDQPVYTT LTRP 464
Length:464
Mass (Da):49,879
Last modified:December 1, 2000 - v2
Checksum:i3C080629F58F5AB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191325 Genomic DNA. Translation: AAF35837.1.
BC085619 mRNA. Translation: AAH85619.1.
Z18957 mRNA. Translation: CAA79482.1.
CCDSiCCDS28521.1.
PIRiS30246.
RefSeqiNP_035577.1. NM_011447.3.
UniGeneiMm.258220.

Genome annotation databases

EnsembliENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
GeneIDi20681.
KEGGimmu:20681.
UCSCiuc008bay.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191325 Genomic DNA. Translation: AAF35837.1 .
BC085619 mRNA. Translation: AAH85619.1 .
Z18957 mRNA. Translation: CAA79482.1 .
CCDSi CCDS28521.1.
PIRi S30246.
RefSeqi NP_035577.1. NM_011447.3.
UniGenei Mm.258220.

3D structure databases

ProteinModelPortali Q04886.
SMRi Q04886. Positions 97-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203412. 15 interactions.
IntActi Q04886. 1 interaction.

PTM databases

PhosphoSitei Q04886.

Proteomic databases

MaxQBi Q04886.
PaxDbi Q04886.
PRIDEi Q04886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025003 ; ENSMUSP00000025003 ; ENSMUSG00000024176 .
GeneIDi 20681.
KEGGi mmu:20681.
UCSCi uc008bay.1. mouse.

Organism-specific databases

CTDi 30812.
MGIi MGI:98370. Sox8.

Phylogenomic databases

eggNOGi NOG324597.
HOGENOMi HOG000108876.
HOVERGENi HBG002061.
InParanoidi Q04886.
KOi K09270.
OMAi DQSHGSP.
OrthoDBi EOG7Q2N5K.
PhylomeDBi Q04886.
TreeFami TF351735.

Miscellaneous databases

ChiTaRSi SOX8. mouse.
NextBioi 299189.
PROi Q04886.
SOURCEi Search...

Gene expression databases

Bgeei Q04886.
CleanExi MM_SOX8.
Genevestigatori Q04886.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterisation of the Sry-related transcription factor gene Sox8."
    Schepers G.E., Bullejos M., Hosking B.M., Koopman P.
    Nucleic Acids Res. 28:1473-1480(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  3. "Seven new members of the Sox gene family expressed during mouse development."
    Wright E.M., Snopek B., Koopman P.
    Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.

Entry informationi

Entry nameiSOX8_MOUSE
AccessioniPrimary (citable) accession number: Q04886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi