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Protein

Transcription factor SOX-8

Gene

Sox8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi99 – 167HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • adipose tissue development Source: MGI
  • astrocyte fate commitment Source: MGI
  • cell fate commitment Source: MGI
  • cell maturation Source: MGI
  • enteric nervous system development Source: UniProtKB
  • fat cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • male gonad development Source: MGI
  • metanephric nephron tubule formation Source: MGI
  • morphogenesis of a branching epithelium Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of myoblast differentiation Source: MGI
  • negative regulation of photoreceptor cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • neural crest cell migration Source: UniProtKB
  • oligodendrocyte differentiation Source: MGI
  • osteoblast differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of gene expression Source: MGI
  • positive regulation of gliogenesis Source: UniProtKB
  • positive regulation of kidney development Source: UniProtKB
  • positive regulation of osteoblast proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of hormone levels Source: MGI
  • renal vesicle induction Source: UniProtKB
  • retina development in camera-type eye Source: MGI
  • retinal rod cell differentiation Source: MGI
  • Sertoli cell development Source: MGI
  • signal transduction Source: UniProtKB
  • skeletal muscle cell differentiation Source: MGI
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • ureter morphogenesis Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-8
Gene namesi
Name:Sox8
Synonyms:Sox-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98370 Sox8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487341 – 464Transcription factor SOX-8Add BLAST464

Proteomic databases

PaxDbiQ04886
PRIDEiQ04886

PTM databases

iPTMnetiQ04886
PhosphoSitePlusiQ04886

Expressioni

Tissue specificityi

Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.

Gene expression databases

BgeeiENSMUSG00000024176
CleanExiMM_SOX8
ExpressionAtlasiQ04886 baseline and differential
GenevisibleiQ04886 MM

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi203412, 15 interactors
IntActiQ04886, 1 interactor
STRINGi10090.ENSMUSP00000025003

Structurei

3D structure databases

ProteinModelPortaliQ04886
SMRiQ04886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZ6 Eukaryota
ENOG4111U1K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000108876
HOVERGENiHBG002061
InParanoidiQ04886
KOiK09270
OMAiNWDQPVY
OrthoDBiEOG091G0EKD
PhylomeDBiQ04886
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR031265 SOX-8
IPR022151 Sox_N
PANTHERiPTHR10270:SF20 PTHR10270:SF20, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR
60 70 80 90 100
GDTAEAADER FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK
110 120 130 140 150
RPMNAFMVWA QAARRKLADQ YPHLHNAELS KTLGKLWRLL SESEKRPFVE
160 170 180 190 200
EAERLRVQHK KDHPDYKYQP RRRKSVKTGR SDSDSGTELG HHPGGPMYKA
210 220 230 240 250
DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK QELRLEGRRL
260 270 280 290 300
VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP
310 320 330 340 350
SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI
360 370 380 390 400
KTEQLSPSHY NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD
410 420 430 440 450
YTDLQASNYY SPYPGYPPSL YQYPYFHSSR RPYASPLLNG LSMPPAHSPS
460
SNWDQPVYTT LTRP
Length:464
Mass (Da):49,879
Last modified:December 1, 2000 - v2
Checksum:i3C080629F58F5AB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191325 Genomic DNA Translation: AAF35837.1
BC085619 mRNA Translation: AAH85619.1
Z18957 mRNA Translation: CAA79482.1
CCDSiCCDS28521.1
PIRiS30246
RefSeqiNP_035577.1, NM_011447.3
UniGeneiMm.258220

Genome annotation databases

EnsembliENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176
GeneIDi20681
KEGGimmu:20681
UCSCiuc008bay.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSOX8_MOUSE
AccessioniPrimary (citable) accession number: Q04886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health