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Q04886 (SOX8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-8
Gene names
Name:Sox8
Synonyms:Sox-8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Subcellular location

Nucleus Potential.

Tissue specificity

Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSertoli cell development

Inferred from expression pattern PubMed 11875113. Source: UniProtKB

adipose tissue development

Inferred from mutant phenotype PubMed 11564878PubMed 19286648. Source: MGI

astrocyte fate commitment

Inferred from genetic interaction PubMed 19490914. Source: MGI

cell fate commitment

Inferred from genetic interaction PubMed 15893981. Source: MGI

cell maturation

Inferred from mutant phenotype PubMed 15102707. Source: MGI

enteric nervous system development

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

fat cell differentiation

Inferred from mutant phenotype PubMed 19286648. Source: MGI

in utero embryonic development

Inferred from genetic interaction PubMed 16790476. Source: MGI

male gonad development

Inferred from genetic interaction PubMed 15056615PubMed 19124014. Source: MGI

metanephric nephron tubule formation

Inferred from genetic interaction PubMed 21212101. Source: MGI

morphogenesis of a branching epithelium

Inferred from genetic interaction PubMed 21212101. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

negative regulation of myoblast differentiation

Inferred from direct assay PubMed 12782625. Source: MGI

negative regulation of photoreceptor cell differentiation

Inferred from genetic interaction PubMed 19490914. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB

neural crest cell migration

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 17084361. Source: MGI

osteoblast differentiation

Inferred from mutant phenotype PubMed 15753123. Source: MGI

peripheral nervous system development

Inferred from genetic interaction PubMed 16790476. Source: MGI

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB

positive regulation of gene expression

Inferred from genetic interaction PubMed 19124014. Source: MGI

positive regulation of gliogenesis

Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB

positive regulation of kidney development

Inferred from genetic interaction PubMed 21212101. Source: UniProtKB

positive regulation of osteoblast proliferation

Inferred from mutant phenotype PubMed 15753123. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.1PubMed 12732652PubMed 15102707PubMed 15590666. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 11875113PubMed 16582099. Source: UniProtKB

regulation of hormone levels

Inferred from mutant phenotype PubMed 19286648. Source: MGI

renal vesicle induction

Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB

retina development in camera-type eye

Inferred from genetic interaction PubMed 19490914. Source: MGI

retinal rod cell differentiation

Inferred from genetic interaction PubMed 19490914. Source: MGI

signal transduction

Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

spermatogenesis

Inferred from mutant phenotype PubMed 18342849. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 22344693. Source: GOC

ureter morphogenesis

Inferred from genetic interaction PubMed 21212101. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15572147. Source: UniProtKB

nuclear transcription factor complex

Inferred from direct assay PubMed 22344693. Source: MGI

nucleus

Inferred from direct assay PubMed 12782625PubMed 18342849. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12732652PubMed 15102707. Source: MGI

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 11875113. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12732652. Source: MGI

protein heterodimerization activity

Inferred from direct assay PubMed 22344693. Source: MGI

sequence-specific DNA binding

Inferred from direct assay Ref.1. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 22344693. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.1PubMed 12732652. Source: MGI

transcription factor binding

Inferred from physical interaction PubMed 16582099. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Transcription factor SOX-8
PRO_0000048734

Regions

DNA binding99 – 16769HMG box

Sequences

Sequence LengthMass (Da)Tools
Q04886 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 3C080629F58F5AB5

FASTA46449,879
        10         20         30         40         50         60 
MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR GDTAEAADER 

        70         80         90        100        110        120 
FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK RPMNAFMVWA QAARRKLADQ 

       130        140        150        160        170        180 
YPHLHNAELS KTLGKLWRLL SESEKRPFVE EAERLRVQHK KDHPDYKYQP RRRKSVKTGR 

       190        200        210        220        230        240 
SDSDSGTELG HHPGGPMYKA DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK 

       250        260        270        280        290        300 
QELRLEGRRL VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP 

       310        320        330        340        350        360 
SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI KTEQLSPSHY 

       370        380        390        400        410        420 
NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD YTDLQASNYY SPYPGYPPSL 

       430        440        450        460 
YQYPYFHSSR RPYASPLLNG LSMPPAHSPS SNWDQPVYTT LTRP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterisation of the Sry-related transcription factor gene Sox8."
Schepers G.E., Bullejos M., Hosking B.M., Koopman P.
Nucleic Acids Res. 28:1473-1480(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[3]"Seven new members of the Sox gene family expressed during mouse development."
Wright E.M., Snopek B., Koopman P.
Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF191325 Genomic DNA. Translation: AAF35837.1.
BC085619 mRNA. Translation: AAH85619.1.
Z18957 mRNA. Translation: CAA79482.1.
CCDSCCDS28521.1.
PIRS30246.
RefSeqNP_035577.1. NM_011447.3.
UniGeneMm.258220.

3D structure databases

ProteinModelPortalQ04886.
SMRQ04886. Positions 97-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203412. 15 interactions.
IntActQ04886. 1 interaction.

PTM databases

PhosphoSiteQ04886.

Proteomic databases

MaxQBQ04886.
PaxDbQ04886.
PRIDEQ04886.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
GeneID20681.
KEGGmmu:20681.
UCSCuc008bay.1. mouse.

Organism-specific databases

CTD30812.
MGIMGI:98370. Sox8.

Phylogenomic databases

eggNOGNOG324597.
HOGENOMHOG000108876.
HOVERGENHBG002061.
InParanoidQ04886.
KOK09270.
OMADQSHGSP.
OrthoDBEOG7Q2N5K.
PhylomeDBQ04886.
TreeFamTF351735.

Gene expression databases

BgeeQ04886.
CleanExMM_SOX8.
GenevestigatorQ04886.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX8. mouse.
NextBio299189.
PROQ04886.
SOURCESearch...

Entry information

Entry nameSOX8_MOUSE
AccessionPrimary (citable) accession number: Q04886
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot