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Q04886

- SOX8_MOUSE

UniProt

Q04886 - SOX8_MOUSE

Protein

Transcription factor SOX-8

Gene

Sox8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi99 – 16769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI
    4. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    7. sequence-specific DNA binding transcription factor activity Source: MGI
    8. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. adipose tissue development Source: MGI
    2. astrocyte fate commitment Source: MGI
    3. cell fate commitment Source: MGI
    4. cell maturation Source: MGI
    5. enteric nervous system development Source: UniProtKB
    6. fat cell differentiation Source: MGI
    7. in utero embryonic development Source: MGI
    8. male gonad development Source: MGI
    9. metanephric nephron tubule formation Source: MGI
    10. morphogenesis of a branching epithelium Source: MGI
    11. negative regulation of apoptotic process Source: UniProtKB
    12. negative regulation of myoblast differentiation Source: MGI
    13. negative regulation of photoreceptor cell differentiation Source: MGI
    14. negative regulation of transcription, DNA-templated Source: UniProtKB
    15. neural crest cell migration Source: UniProtKB
    16. oligodendrocyte differentiation Source: MGI
    17. osteoblast differentiation Source: MGI
    18. peripheral nervous system development Source: MGI
    19. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    20. positive regulation of gene expression Source: MGI
    21. positive regulation of gliogenesis Source: UniProtKB
    22. positive regulation of kidney development Source: UniProtKB
    23. positive regulation of osteoblast proliferation Source: MGI
    24. positive regulation of transcription, DNA-templated Source: UniProtKB
    25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    26. regulation of hormone levels Source: MGI
    27. renal vesicle induction Source: UniProtKB
    28. retina development in camera-type eye Source: MGI
    29. retinal rod cell differentiation Source: MGI
    30. Sertoli cell development Source: UniProtKB
    31. signal transduction Source: UniProtKB
    32. skeletal muscle cell differentiation Source: MGI
    33. spermatogenesis Source: MGI
    34. transcription from RNA polymerase II promoter Source: GOC
    35. ureter morphogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-8
    Gene namesi
    Name:Sox8
    Synonyms:Sox-8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:98370. Sox8.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nuclear transcription factor complex Source: MGI
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 464464Transcription factor SOX-8PRO_0000048734Add
    BLAST

    Proteomic databases

    MaxQBiQ04886.
    PaxDbiQ04886.
    PRIDEiQ04886.

    PTM databases

    PhosphoSiteiQ04886.

    Expressioni

    Tissue specificityi

    Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.

    Gene expression databases

    BgeeiQ04886.
    CleanExiMM_SOX8.
    GenevestigatoriQ04886.

    Interactioni

    Protein-protein interaction databases

    BioGridi203412. 15 interactions.
    IntActiQ04886. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04886.
    SMRiQ04886. Positions 97-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG324597.
    HOGENOMiHOG000108876.
    HOVERGENiHBG002061.
    InParanoidiQ04886.
    KOiK09270.
    OMAiDQSHGSP.
    OrthoDBiEOG7Q2N5K.
    PhylomeDBiQ04886.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR022151. Sox_N.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04886-1 [UniParc]FASTAAdd to Basket

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    MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR    50
    GDTAEAADER FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK 100
    RPMNAFMVWA QAARRKLADQ YPHLHNAELS KTLGKLWRLL SESEKRPFVE 150
    EAERLRVQHK KDHPDYKYQP RRRKSVKTGR SDSDSGTELG HHPGGPMYKA 200
    DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK QELRLEGRRL 250
    VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP 300
    SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI 350
    KTEQLSPSHY NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD 400
    YTDLQASNYY SPYPGYPPSL YQYPYFHSSR RPYASPLLNG LSMPPAHSPS 450
    SNWDQPVYTT LTRP 464
    Length:464
    Mass (Da):49,879
    Last modified:December 1, 2000 - v2
    Checksum:i3C080629F58F5AB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191325 Genomic DNA. Translation: AAF35837.1.
    BC085619 mRNA. Translation: AAH85619.1.
    Z18957 mRNA. Translation: CAA79482.1.
    CCDSiCCDS28521.1.
    PIRiS30246.
    RefSeqiNP_035577.1. NM_011447.3.
    UniGeneiMm.258220.

    Genome annotation databases

    EnsembliENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
    GeneIDi20681.
    KEGGimmu:20681.
    UCSCiuc008bay.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191325 Genomic DNA. Translation: AAF35837.1 .
    BC085619 mRNA. Translation: AAH85619.1 .
    Z18957 mRNA. Translation: CAA79482.1 .
    CCDSi CCDS28521.1.
    PIRi S30246.
    RefSeqi NP_035577.1. NM_011447.3.
    UniGenei Mm.258220.

    3D structure databases

    ProteinModelPortali Q04886.
    SMRi Q04886. Positions 97-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203412. 15 interactions.
    IntActi Q04886. 1 interaction.

    PTM databases

    PhosphoSitei Q04886.

    Proteomic databases

    MaxQBi Q04886.
    PaxDbi Q04886.
    PRIDEi Q04886.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025003 ; ENSMUSP00000025003 ; ENSMUSG00000024176 .
    GeneIDi 20681.
    KEGGi mmu:20681.
    UCSCi uc008bay.1. mouse.

    Organism-specific databases

    CTDi 30812.
    MGIi MGI:98370. Sox8.

    Phylogenomic databases

    eggNOGi NOG324597.
    HOGENOMi HOG000108876.
    HOVERGENi HBG002061.
    InParanoidi Q04886.
    KOi K09270.
    OMAi DQSHGSP.
    OrthoDBi EOG7Q2N5K.
    PhylomeDBi Q04886.
    TreeFami TF351735.

    Miscellaneous databases

    ChiTaRSi SOX8. mouse.
    NextBioi 299189.
    PROi Q04886.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q04886.
    CleanExi MM_SOX8.
    Genevestigatori Q04886.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR022151. Sox_N.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12444. Sox_N. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterisation of the Sry-related transcription factor gene Sox8."
      Schepers G.E., Bullejos M., Hosking B.M., Koopman P.
      Nucleic Acids Res. 28:1473-1480(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    3. "Seven new members of the Sox gene family expressed during mouse development."
      Wright E.M., Snopek B., Koopman P.
      Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.

    Entry informationi

    Entry nameiSOX8_MOUSE
    AccessioniPrimary (citable) accession number: Q04886
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3