Q04886 (SOX8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-8

Gene names

Name:	Sox8
Synonyms:	Sox-8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
Subcellular location	Nucleus Potential.
Tissue specificity	Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Sertoli cell development Inferred from expression pattern PubMed 11875113. Source: UniProtKB adipose tissue development Inferred from mutant phenotype PubMed 11564878PubMed 19286648. Source: MGI astrocyte fate commitment Inferred from genetic interaction PubMed 19490914. Source: MGI cell maturation Inferred from mutant phenotype PubMed 15102707. Source: MGI enteric nervous system development Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB fat cell differentiation Inferred from mutant phenotype PubMed 19286648. Source: MGI in utero embryonic development Inferred from genetic interaction PubMed 16790476. Source: MGI metanephric nephron tubule formation Inferred from genetic interaction PubMed 21212101. Source: MGI morphogenesis of a branching epithelium Inferred from genetic interaction PubMed 21212101. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB negative regulation of myoblast differentiation Inferred from direct assay PubMed 12782625. Source: MGI negative regulation of photoreceptor cell differentiation Inferred from genetic interaction PubMed 19490914. Source: MGI negative regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB neural crest cell migration Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB oligodendrocyte differentiation Inferred from mutant phenotype PubMed 17084361. Source: MGI osteoblast differentiation Inferred from mutant phenotype PubMed 15753123. Source: MGI peripheral nervous system development Inferred from genetic interaction PubMed 16790476. Source: MGI positive regulation of branching involved in ureteric bud morphogenesis Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB positive regulation of gliogenesis Inferred from mutant phenotype PubMed 15572147. Source: UniProtKB positive regulation of osteoblast proliferation Inferred from mutant phenotype PubMed 15753123. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1PubMed 12732652PubMed 15102707PubMed 15590666. Source: MGI regulation of hormone levels Inferred from mutant phenotype PubMed 19286648. Source: MGI renal vesicle induction Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB retinal rod cell differentiation Inferred from genetic interaction PubMed 19490914. Source: MGI signal transduction Inferred from mutant phenotype PubMed 21212101. Source: UniProtKB skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 22147266. Source: MGI spermatogenesis Inferred from mutant phenotype PubMed 18342849. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ureter morphogenesis Inferred from genetic interaction PubMed 21212101. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay PubMed 15572147. Source: UniProtKB nucleus Inferred from direct assay PubMed 12782625PubMed 18342849. Source: MGI
Molecular_function	RNA polymerase II core promoter sequence-specific DNA binding Inferred from direct assay PubMed 11875113. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.1PubMed 12732652. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Transcription factor SOX-8		PRO_0000048734
Regions
	DNA binding	99 – 167	69	HMG box

Sequences

	Sequence		Length	Mass (Da)
	Q04886 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 3C080629F58F5AB5	FASTA	464	49,879
	10 20 30 40 50 60 MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR GDTAEAADER 70 80 90 100 110 120 FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK RPMNAFMVWA QAARRKLADQ 130 140 150 160 170 180 YPHLHNAELS KTLGKLWRLL SESEKRPFVE EAERLRVQHK KDHPDYKYQP RRRKSVKTGR 190 200 210 220 230 240 SDSDSGTELG HHPGGPMYKA DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK 250 260 270 280 290 300 QELRLEGRRL VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP 310 320 330 340 350 360 SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI KTEQLSPSHY 370 380 390 400 410 420 NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD YTDLQASNYY SPYPGYPPSL 430 440 450 460 YQYPYFHSSR RPYASPLLNG LSMPPAHSPS SNWDQPVYTT LTRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterisation of the Sry-related transcription factor gene Sox8." Schepers G.E., Bullejos M., Hosking B.M., Koopman P. Nucleic Acids Res. 28:1473-1480(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
[3]	"Seven new members of the Sox gene family expressed during mouse development." Wright E.M., Snopek B., Koopman P. Nucleic Acids Res. 21:744-744(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF191325 Genomic DNA. Translation: AAF35837.1. BC085619 mRNA. Translation: AAH85619.1. Z18957 mRNA. Translation: CAA79482.1.
IPI	IPI00111141.
PIR	S30246.
RefSeq	NP_035577.1. NM_011447.3.
UniGene	Mm.258220.
3D structure databases
ProteinModelPortal	Q04886.
SMR	Q04886. Positions 97-168.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q04886. 1 interaction.
PTM databases
PhosphoSite	Q04886.
Proteomic databases
PaxDb	Q04886.
PRIDE	Q04886.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
GeneID	20681.
KEGG	mmu:20681.
Organism-specific databases
CTD	30812.
MGI	MGI:98370. Sox8.
Phylogenomic databases
eggNOG	NOG324597.
HOGENOM	HOG000108876.
HOVERGEN	HBG002061.
InParanoid	Q04886.
KO	K09270.
OMA	DQSHGSP.
OrthoDB	EOG4ZKJMD.
Gene expression databases
ArrayExpress	Q04886.
Bgee	Q04886.
CleanEx	MM_SOX8.
Genevestigator	Q04886.
GermOnline	ENSMUSG00000024176. Mus musculus.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR022151. Sox_N. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. PF12444. Sox_N. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX8. mouse.
NextBio	299189.
SOURCE	Search...

Entry information

Entry name

SOX8_MOUSE

Accession

Primary (citable) accession number: Q04886

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program