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Q04873

- UDG_SALTY

UniProt

Q04873 - UDG_SALTY

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Protein
UDP-glucose 6-dehydrogenase
Gene
udg, pagA, pmrE, STM2080
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei253 – 2531 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2 – 1918NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2092-MONOMER.
UniPathwayiUPA00030.
UPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:udg
Synonyms:pagA, pmrE
Ordered Locus Names:STM2080
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388UDP-glucose 6-dehydrogenase
PRO_0000074047Add
BLAST

Proteomic databases

PaxDbiQ04873.
PRIDEiQ04873.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2080.

Structurei

3D structure databases

ProteinModelPortaliQ04873.
SMRiQ04873. Positions 1-388.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000280378.
KOiK00012.
OMAiVIVANRY.
OrthoDBiEOG61CM1K.
PhylomeDBiQ04873.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04873-1 [UniParc]FASTAAdd to Basket

« Hide

MKITISGTGY VGLSNGLLIA QHHDVVALDI VPSRVELLND RISPIVDKEI    50
QQFLKEDNIR FRATLDKFDA YQNADYVIIA TPTDYDPKTN YFNTSSVESV 100
MQDVISINPA AVMIIKSTVP VGFTAAMRQK FATENIIFSP EFLREGKALY 150
DNLYPSRIVI GEQSERAREF AALLQEGAIK QEIPTLFTDS TEAEAIKLFA 200
NTYLAMRVAY FNELDSYAET LGLNTRQIIE GVCLDPRIGN HYNNPSFGYG 250
GYCLPKDTKQ LLANYQSVPN NIISAIVEAN RTRKDFIADA ILARKPKVVG 300
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVME EDTFFNSRLE 350
RDLHCFKQQA DVIISNRMAA ELLDVAEKVY TRDLFGSD 388
Length:388
Mass (Da):43,634
Last modified:February 1, 1994 - v1
Checksum:i04184EEE5DAA80F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17278 Genomic DNA. Translation: CAA78945.1.
AE006468 Genomic DNA. Translation: AAL20984.1.
RefSeqiNP_461025.1. NC_003197.1.
WP_000704831.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20984; AAL20984; STM2080.
GeneIDi1253601.
KEGGistm:STM2080.
PATRICi32382743. VBISalEnt20916_2202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17278 Genomic DNA. Translation: CAA78945.1 .
AE006468 Genomic DNA. Translation: AAL20984.1 .
RefSeqi NP_461025.1. NC_003197.1.
WP_000704831.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q04873.
SMRi Q04873. Positions 1-388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2080.

Proteomic databases

PaxDbi Q04873.
PRIDEi Q04873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20984 ; AAL20984 ; STM2080 .
GeneIDi 1253601.
KEGGi stm:STM2080.
PATRICi 32382743. VBISalEnt20916_2202.

Phylogenomic databases

eggNOGi COG1004.
HOGENOMi HOG000280378.
KOi K00012.
OMAi VIVANRY.
OrthoDBi EOG61CM1K.
PhylomeDBi Q04873.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00038 ; UER00491 .
BioCyci SENT99287:GCTI-2092-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Repeat unit polysaccharides of bacteria: a model for polymerization resembling that of ribosomes and fatty acid synthetase, with a novel mechanism for determining chain length."
    Bastin D.A., Stevenson G., Brown P.K., Haase A., Reeves P.R.
    Mol. Microbiol. 7:725-734(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiUDG_SALTY
AccessioniPrimary (citable) accession number: Q04873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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