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Protein

UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (udg)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:udg
Synonyms:pagA, pmrE
Ordered Locus Names:STM2080
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740471 – 388UDP-glucose 6-dehydrogenaseAdd BLAST388

Proteomic databases

PaxDbiQ04873.
PRIDEiQ04873.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2080.

Structurei

3D structure databases

ProteinModelPortaliQ04873.
SMRiQ04873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6Y. Bacteria.
COG1004. LUCA.
HOGENOMiHOG000280378.
KOiK00012.
OMAiANVCFIF.
PhylomeDBiQ04873.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.100. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR013328. 6PGD_dom2.
IPR021157. Cyt_c1_TM_anchor_C.
IPR036291. NAD(P)-bd_dom_sf.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR036220. UDP-Glc/GDP-Man_DH_C_sf.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
PfamiView protein in Pfam
PF00984. UDPG_MGDP_dh. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiView protein in SMART
SM00984. UDPG_MGDP_dh_C. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITISGTGY VGLSNGLLIA QHHDVVALDI VPSRVELLND RISPIVDKEI
60 70 80 90 100
QQFLKEDNIR FRATLDKFDA YQNADYVIIA TPTDYDPKTN YFNTSSVESV
110 120 130 140 150
MQDVISINPA AVMIIKSTVP VGFTAAMRQK FATENIIFSP EFLREGKALY
160 170 180 190 200
DNLYPSRIVI GEQSERAREF AALLQEGAIK QEIPTLFTDS TEAEAIKLFA
210 220 230 240 250
NTYLAMRVAY FNELDSYAET LGLNTRQIIE GVCLDPRIGN HYNNPSFGYG
260 270 280 290 300
GYCLPKDTKQ LLANYQSVPN NIISAIVEAN RTRKDFIADA ILARKPKVVG
310 320 330 340 350
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVME EDTFFNSRLE
360 370 380
RDLHCFKQQA DVIISNRMAA ELLDVAEKVY TRDLFGSD
Length:388
Mass (Da):43,634
Last modified:February 1, 1994 - v1
Checksum:i04184EEE5DAA80F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17278 Genomic DNA. Translation: CAA78945.1.
AE006468 Genomic DNA. Translation: AAL20984.1.
RefSeqiNP_461025.1. NC_003197.2.
WP_000704831.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL20984; AAL20984; STM2080.
GeneIDi1253601.
KEGGistm:STM2080.
PATRICifig|99287.12.peg.2202.

Similar proteinsi

Entry informationi

Entry nameiUDG_SALTY
AccessioniPrimary (citable) accession number: Q04873
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families