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Q04873

- UDG_SALTY

UniProt

Q04873 - UDG_SALTY

Protein

UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei253 – 2531By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2092-MONOMER.
    UniPathwayiUPA00030.
    UPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Gene namesi
    Name:udg
    Synonyms:pagA, pmrE
    Ordered Locus Names:STM2080
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388UDP-glucose 6-dehydrogenasePRO_0000074047Add
    BLAST

    Proteomic databases

    PaxDbiQ04873.
    PRIDEiQ04873.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM2080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04873.
    SMRiQ04873. Positions 1-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    HOGENOMiHOG000280378.
    KOiK00012.
    OMAiVIVANRY.
    OrthoDBiEOG61CM1K.
    PhylomeDBiQ04873.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04873-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKITISGTGY VGLSNGLLIA QHHDVVALDI VPSRVELLND RISPIVDKEI    50
    QQFLKEDNIR FRATLDKFDA YQNADYVIIA TPTDYDPKTN YFNTSSVESV 100
    MQDVISINPA AVMIIKSTVP VGFTAAMRQK FATENIIFSP EFLREGKALY 150
    DNLYPSRIVI GEQSERAREF AALLQEGAIK QEIPTLFTDS TEAEAIKLFA 200
    NTYLAMRVAY FNELDSYAET LGLNTRQIIE GVCLDPRIGN HYNNPSFGYG 250
    GYCLPKDTKQ LLANYQSVPN NIISAIVEAN RTRKDFIADA ILARKPKVVG 300
    IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVME EDTFFNSRLE 350
    RDLHCFKQQA DVIISNRMAA ELLDVAEKVY TRDLFGSD 388
    Length:388
    Mass (Da):43,634
    Last modified:February 1, 1994 - v1
    Checksum:i04184EEE5DAA80F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17278 Genomic DNA. Translation: CAA78945.1.
    AE006468 Genomic DNA. Translation: AAL20984.1.
    RefSeqiNP_461025.1. NC_003197.1.
    WP_000704831.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20984; AAL20984; STM2080.
    GeneIDi1253601.
    KEGGistm:STM2080.
    PATRICi32382743. VBISalEnt20916_2202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17278 Genomic DNA. Translation: CAA78945.1 .
    AE006468 Genomic DNA. Translation: AAL20984.1 .
    RefSeqi NP_461025.1. NC_003197.1.
    WP_000704831.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q04873.
    SMRi Q04873. Positions 1-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2080.

    Proteomic databases

    PaxDbi Q04873.
    PRIDEi Q04873.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20984 ; AAL20984 ; STM2080 .
    GeneIDi 1253601.
    KEGGi stm:STM2080.
    PATRICi 32382743. VBISalEnt20916_2202.

    Phylogenomic databases

    eggNOGi COG1004.
    HOGENOMi HOG000280378.
    KOi K00012.
    OMAi VIVANRY.
    OrthoDBi EOG61CM1K.
    PhylomeDBi Q04873.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00038 ; UER00491 .
    BioCyci SENT99287:GCTI-2092-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Repeat unit polysaccharides of bacteria: a model for polymerization resembling that of ribosomes and fatty acid synthetase, with a novel mechanism for determining chain length."
      Bastin D.A., Stevenson G., Brown P.K., Haase A., Reeves P.R.
      Mol. Microbiol. 7:725-734(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiUDG_SALTY
    AccessioniPrimary (citable) accession number: Q04873
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3