Reviewed, UniProtKB/Swiss-Prot Q04873 (UDG_SALTY)

Names and origin

Protein names

Recommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22

Gene names

Name:	udg
Synonyms:	pagA, pmrE
Ordered Locus Names:	STM2080

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1. Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	UDP-glucose 6-dehydrogenase		PRO_0000074047
Regions
	Nucleotide binding	2 – 19	18	NAD Potential
Sites
	Active site	253	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04873-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 04184EEE5DAA80F7	FASTA	388	43,634
	10 20 30 40 50 60 MKITISGTGY VGLSNGLLIA QHHDVVALDI VPSRVELLND RISPIVDKEI QQFLKEDNIR 70 80 90 100 110 120 FRATLDKFDA YQNADYVIIA TPTDYDPKTN YFNTSSVESV MQDVISINPA AVMIIKSTVP 130 140 150 160 170 180 VGFTAAMRQK FATENIIFSP EFLREGKALY DNLYPSRIVI GEQSERAREF AALLQEGAIK 190 200 210 220 230 240 QEIPTLFTDS TEAEAIKLFA NTYLAMRVAY FNELDSYAET LGLNTRQIIE GVCLDPRIGN 250 260 270 280 290 300 HYNNPSFGYG GYCLPKDTKQ LLANYQSVPN NIISAIVEAN RTRKDFIADA ILARKPKVVG 310 320 330 340 350 360 IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVME EDTFFNSRLE RDLHCFKQQA 370 380 DVIISNRMAA ELLDVAEKVY TRDLFGSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Repeat unit polysaccharides of bacteria: a model for polymerization resembling that of ribosomes and fatty acid synthetase, with a novel mechanism for determining chain length." Bastin D.A., Stevenson G., Brown P.K., Haase A., Reeves P.R. Mol. Microbiol. 7:725-734(1993) [PubMed: 7682279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z17278 Genomic DNA. Translation: CAA78945.1. AE008792 Genomic DNA. Translation: AAL20984.1.
RefSeq	NP_461025.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLJ based on UniProtKB Q07172.
ModBase	Search...
Genome annotation databases
GeneID	1253601.
GenomeReviews	Gene locus STM2080 in contig AE006468_GR.
KEGG	stm:STM2080.
NMPDR	fig|99287.1.peg.2005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q04873.
OMA	Q04873. ILFTDST.
Enzyme and pathway databases
BioCyc	STYP99287:STM2080-MON.
BRENDA	1.1.1.22. 2.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.
PANTHER	PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR03026. NDP-sugDHase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UDG_SALTY

Accession

Primary (citable) accession number: Q04873

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)