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Protein

Elongator complex protein 6

Gene

ELP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP6 is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.6 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • protein urmylation Source: SGD
  • regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
  • tRNA wobble uridine modification Source: SGD

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32976-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 6
Alternative name(s):
Gamma-toxin target 6
HAT-associated protein 3
Gene namesi
Name:ELP6
Synonyms:HAP3, TOT6
Ordered Locus Names:YMR312W
ORF Names:YM9924.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR312W
SGDiS000004929 ELP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033551 – 273Elongator complex protein 6Add BLAST273

Proteomic databases

MaxQBiQ04868
PaxDbiQ04868
PRIDEiQ04868

PTM databases

CarbonylDBiQ04868

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex, which consists of IKI3, ELP2, ELP3, ELP4, IKI1 and ELP6. ELP4, IKI1 and ELP6 form a distinct subcomplex (HAP).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi35492, 449 interactors
DIPiDIP-1966N
IntActiQ04868, 9 interactors
MINTiQ04868
STRINGi4932.YMR312W

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 23Combined sources4
Beta strandi25 – 27Combined sources3
Beta strandi30 – 36Combined sources7
Helixi43 – 55Combined sources13
Helixi59 – 62Combined sources4
Beta strandi76 – 84Combined sources9
Helixi86 – 95Combined sources10
Helixi100 – 102Combined sources3
Beta strandi103 – 109Combined sources7
Helixi112 – 116Combined sources5
Turni117 – 119Combined sources3
Helixi122 – 138Combined sources17
Beta strandi143 – 149Combined sources7
Helixi151 – 153Combined sources3
Helixi154 – 157Combined sources4
Helixi163 – 169Combined sources7
Helixi171 – 176Combined sources6
Beta strandi179 – 186Combined sources8
Helixi188 – 190Combined sources3
Helixi197 – 200Combined sources4
Helixi202 – 214Combined sources13
Beta strandi216 – 222Combined sources7
Beta strandi234 – 240Combined sources7
Beta strandi257 – 264Combined sources8
Beta strandi267 – 271Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A8JX-ray2.10C/F1-273[»]
4EJSX-ray2.61C1-273[»]
ProteinModelPortaliQ04868
SMRiQ04868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP6 family.Curated

Phylogenomic databases

HOGENOMiHOG000248084
InParanoidiQ04868
KOiK11377
OMAiEYVYHIT
OrthoDBiEOG092C3TKX

Sequencei

Sequence statusi: Complete.

Q04868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVQRQDLV LFSDQSVLPA HFFQDSNSHN LFFITHQSCT QPLWMINALV
60 70 80 90 100
ETHVLGSPSS LNESSSSMLP SSTRSHAVLA SFIHEQNYFT NSLNKLKIPS
110 120 130 140 150
NNYNVLDFLS DFIVNNIHNK PRDKILSDVL AKFSAAIQNN PTDTIVIIEQ
160 170 180 190 200
PELLLSLVSG LTCSELNNKF ITPLLRQCKV LIIVSNSDIF NIDEYDASVH
210 220 230 240 250
SSNLQNFYKS SFIKSMINLN LNPLKTGFAK DVTGSLHVCR GGAPIATSNT
260 270
SLHVVENEYL YLNEKESTKL FYR
Length:273
Mass (Da):30,574
Last modified:November 1, 1997 - v1
Checksum:i1A5062465AF67F47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54141 Genomic DNA Translation: CAA90830.1
AY557983 Genomic DNA Translation: AAS56309.1
BK006946 Genomic DNA Translation: DAA10213.1
PIRiS59305
RefSeqiNP_014043.1, NM_001182823.1

Genome annotation databases

EnsemblFungiiYMR312W; YMR312W; YMR312W
GeneIDi855360
KEGGisce:YMR312W

Similar proteinsi

Entry informationi

Entry nameiELP6_YEAST
AccessioniPrimary (citable) accession number: Q04868
Secondary accession number(s): D6W0D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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