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Protein

Collagen alpha-1(VI) chain

Gene

Col6a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(VI) chain
Gene namesi
Name:Col6a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88459 Col6a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000575920 – 1025Collagen alpha-1(VI) chainAdd BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi893N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ04857
PaxDbiQ04857
PeptideAtlasiQ04857
PRIDEiQ04857

PTM databases

iPTMnetiQ04857
PhosphoSitePlusiQ04857

Expressioni

Gene expression databases

BgeeiENSMUSG00000001119
CleanExiMM_COL6A1
GenevisibleiQ04857 MM

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198823, 1 interactor
IntActiQ04857, 1 interactor
MINTiQ04857
STRINGi10090.ENSMUSP00000001147

Structurei

3D structure databases

ProteinModelPortaliQ04857
SMRiQ04857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 234VWFA 1PROSITE-ProRule annotationAdd BLAST199
Domaini614 – 802VWFA 2PROSITE-ProRule annotationAdd BLAST189
Domaini826 – 1018VWFA 3PROSITE-ProRule annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 255N-terminal globular domainAdd BLAST236
Regioni256 – 591Triple-helical regionAdd BLAST336
Regioni592 – 1025C-terminal globular domainAdd BLAST434

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi261 – 263Cell attachment site3
Motifi441 – 443Cell attachment site3
Motifi477 – 479Cell attachment site3

Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410ZQTS LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000111863
HOVERGENiHBG095954
InParanoidiQ04857
KOiK06238
OMAiVKENYAE
OrthoDBiEOG091G01WB
PhylomeDBiQ04857
TreeFamiTF331207

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF00092 VWA, 3 hits
SMARTiView protein in SMART
SM00327 VWA, 3 hits
SUPFAMiSSF53300 SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR
60 70 80 90 100
LKPYGALVDK VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR
110 120 130 140 150
GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK
160 170 180 190 200
YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS
210 220 230 240 250
IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN NVEQVCCSFE
260 270 280 290 300
CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK
310 320 330 340 350
GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF
360 370 380 390 400
DGIQGPPGPK GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG
410 420 430 440 450
PPGEKGEAGD EGNAGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ
460 470 480 490 500
GDQGREGPVG IPGDSGEAGP IGPKGYRGDE GPPGPEGLRG APGPVGPPGD
510 520 530 540 550
PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG YPGLKGDEGE
560 570 580 590 600
VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM
610 620 630 640 650
KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV
660 670 680 690 700
KFEPGQSHAG VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT
710 720 730 740 750
FTGEALQYTR DRLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGADIQV
760 770 780 790 800
VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR PGISLVKENY AELLDDGFLK
810 820 830 840 850
NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH NFETTKVFAK
860 870 880 890 900
RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS
910 920 930 940 950
VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE
960 970 980 990 1000
AIEKAVQEAQ RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL
1010 1020
FRVPNYQALL RGVLYQTVSR KVALG
Length:1,025
Mass (Da):108,489
Last modified:June 1, 1994 - v1
Checksum:i2A05DFED8771BBF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti674 – 675DM → TL in CAA79152 (PubMed:8489506).Curated2
Sequence conflicti709T → A in CAA79152 (PubMed:8489506).Curated1
Sequence conflicti943Missing in CAA79152 (PubMed:8489506).Curated1
Sequence conflicti960Q → R in CAA79152 (PubMed:8489506).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66405 mRNA Translation: CAA47032.1
X66406 Genomic DNA Translation: CAA47033.1
Z18271 mRNA Translation: CAA79152.1
CCDSiCCDS23952.1
PIRiS34839
RefSeqiNP_034063.1, NM_009933.4
UniGeneiMm.2509

Genome annotation databases

EnsembliENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119
GeneIDi12833
KEGGimmu:12833
UCSCiuc007fux.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCO6A1_MOUSE
AccessioniPrimary (citable) accession number: Q04857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health