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Q04857

- CO6A1_MOUSE

UniProt

Q04857 - CO6A1_MOUSE

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Protein
Collagen alpha-1(VI) chain
Gene
Col6a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Collagen VI acts as a cell-binding protein.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cellular response to amino acid stimulus Source: MGI
  3. protein heterotrimerization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(VI) chain
Gene namesi
Name:Col6a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:88459. Col6a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular matrix Source: MGI
  3. extracellular region Source: MGI
  4. lysosomal membrane Source: Ensembl
  5. protein complex Source: MGI
  6. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  7. sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 10251006Collagen alpha-1(VI) chain
PRO_0000005759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi536 – 5361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi801 – 8011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi893 – 8931N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ04857.
PaxDbiQ04857.
PRIDEiQ04857.

PTM databases

PhosphoSiteiQ04857.

Expressioni

Gene expression databases

ArrayExpressiQ04857.
BgeeiQ04857.
CleanExiMM_COL6A1.
GenevestigatoriQ04857.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

Protein-protein interaction databases

BioGridi198823. 1 interaction.
IntActiQ04857. 1 interaction.
MINTiMINT-4091372.
STRINGi10090.ENSMUSP00000001147.

Structurei

3D structure databases

ProteinModelPortaliQ04857.
SMRiQ04857. Positions 34-220, 613-972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 234199VWFA 1
Add
BLAST
Domaini614 – 802189VWFA 2
Add
BLAST
Domaini826 – 1018193VWFA 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 255236N-terminal globular domain
Add
BLAST
Regioni256 – 591336Triple-helical region
Add
BLAST
Regioni592 – 1025434C-terminal globular domain
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 2633Cell attachment site
Motifi441 – 4433Cell attachment site
Motifi477 – 4793Cell attachment site

Sequence similaritiesi

Belongs to the type VI collagen family.
Contains 3 VWFA domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG256042.
GeneTreeiENSGT00750000117694.
HOGENOMiHOG000111863.
HOVERGENiHBG095954.
InParanoidiQ04857.
KOiK06238.
OMAiVKENYAE.
OrthoDBiEOG71K628.
PhylomeDBiQ04857.
TreeFamiTF331207.

Family and domain databases

Gene3Di3.40.50.410. 3 hits.
InterProiIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 6 hits.
PF00092. VWA. 3 hits.
[Graphical view]
SMARTiSM00327. VWA. 3 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
PROSITEiPS50234. VWFA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04857-1 [UniParc]FASTAAdd to Basket

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MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR     50
LKPYGALVDK VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR 100
GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK 150
YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS 200
IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN NVEQVCCSFE 250
CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK 300
GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF 350
DGIQGPPGPK GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG 400
PPGEKGEAGD EGNAGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ 450
GDQGREGPVG IPGDSGEAGP IGPKGYRGDE GPPGPEGLRG APGPVGPPGD 500
PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG YPGLKGDEGE 550
VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM 600
KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV 650
KFEPGQSHAG VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT 700
FTGEALQYTR DRLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGADIQV 750
VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR PGISLVKENY AELLDDGFLK 800
NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH NFETTKVFAK 850
RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS 900
VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE 950
AIEKAVQEAQ RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL 1000
FRVPNYQALL RGVLYQTVSR KVALG 1025
Length:1,025
Mass (Da):108,489
Last modified:June 1, 1994 - v1
Checksum:i2A05DFED8771BBF7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti674 – 6752DM → TL in CAA79152. 1 Publication
Sequence conflicti709 – 7091T → A in CAA79152. 1 Publication
Sequence conflicti943 – 9431Missing in CAA79152. 1 Publication
Sequence conflicti960 – 9601Q → R in CAA79152. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66405 mRNA. Translation: CAA47032.1.
X66406 Genomic DNA. Translation: CAA47033.1.
Z18271 mRNA. Translation: CAA79152.1.
CCDSiCCDS23952.1.
PIRiS34839.
RefSeqiNP_034063.1. NM_009933.4.
UniGeneiMm.2509.

Genome annotation databases

EnsembliENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119.
GeneIDi12833.
KEGGimmu:12833.
UCSCiuc007fux.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66405 mRNA. Translation: CAA47032.1 .
X66406 Genomic DNA. Translation: CAA47033.1 .
Z18271 mRNA. Translation: CAA79152.1 .
CCDSi CCDS23952.1.
PIRi S34839.
RefSeqi NP_034063.1. NM_009933.4.
UniGenei Mm.2509.

3D structure databases

ProteinModelPortali Q04857.
SMRi Q04857. Positions 34-220, 613-972.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198823. 1 interaction.
IntActi Q04857. 1 interaction.
MINTi MINT-4091372.
STRINGi 10090.ENSMUSP00000001147.

PTM databases

PhosphoSitei Q04857.

Proteomic databases

MaxQBi Q04857.
PaxDbi Q04857.
PRIDEi Q04857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001147 ; ENSMUSP00000001147 ; ENSMUSG00000001119 .
GeneIDi 12833.
KEGGi mmu:12833.
UCSCi uc007fux.1. mouse.

Organism-specific databases

CTDi 1291.
MGIi MGI:88459. Col6a1.

Phylogenomic databases

eggNOGi NOG256042.
GeneTreei ENSGT00750000117694.
HOGENOMi HOG000111863.
HOVERGENi HBG095954.
InParanoidi Q04857.
KOi K06238.
OMAi VKENYAE.
OrthoDBi EOG71K628.
PhylomeDBi Q04857.
TreeFami TF331207.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 282342.
PROi Q04857.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q04857.
Bgeei Q04857.
CleanExi MM_COL6A1.
Genevestigatori Q04857.

Family and domain databases

Gene3Di 3.40.50.410. 3 hits.
InterProi IPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 6 hits.
PF00092. VWA. 3 hits.
[Graphical view ]
SMARTi SM00327. VWA. 3 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 3 hits.
PROSITEi PS50234. VWFA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine alpha 1(VI) collagen chain. Complete amino acid sequence and identification of the gene promoter region."
    Bonaldo P., Piccolo S., Marvulli D., Volpin D., Bressan G.M.
    Matrix 13:223-233(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI."
    Zhang R.Z., Pan T.C., Timpl R., Chu M.-L.
    Biochem. J. 291:787-792(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 442-1025.

Entry informationi

Entry nameiCO6A1_MOUSE
AccessioniPrimary (citable) accession number: Q04857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi