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Q04857 (CO6A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(VI) chain
Gene names
Name:Col6a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1025 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Collagen VI acts as a cell-binding protein.

Subunit structure

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sequence similarities

Belongs to the type VI collagen family.

Contains 3 VWFA domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 10251006Collagen alpha-1(VI) chain
PRO_0000005759

Regions

Domain36 – 234199VWFA 1
Domain614 – 802189VWFA 2
Domain826 – 1018193VWFA 3
Region20 – 255236N-terminal globular domain
Region256 – 591336Triple-helical region
Region592 – 1025434C-terminal globular domain
Motif261 – 2633Cell attachment site
Motif441 – 4433Cell attachment site
Motif477 – 4793Cell attachment site

Amino acid modifications

Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation5361N-linked (GlcNAc...) Potential
Glycosylation8011N-linked (GlcNAc...) Potential
Glycosylation8931N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict674 – 6752DM → TL in CAA79152. Ref.2
Sequence conflict7091T → A in CAA79152. Ref.2
Sequence conflict9431Missing in CAA79152. Ref.2
Sequence conflict9601Q → R in CAA79152. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q04857 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 2A05DFED8771BBF7

FASTA1,025108,489
        10         20         30         40         50         60 
MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR LKPYGALVDK 

        70         80         90        100        110        120 
VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR GLTRMPSGRD ELKASVDAVK 

       130        140        150        160        170        180 
YFGKGTYTDC AIKKGLEELL IGGSHLKENK YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH 

       190        200        210        220        230        240 
LGIKVFSVAI TPDHLEPRLS IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN 

       250        260        270        280        290        300 
NVEQVCCSFE CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK 

       310        320        330        340        350        360 
GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF DGIQGPPGPK 

       370        380        390        400        410        420 
GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG PPGEKGEAGD EGNAGPDGAP 

       430        440        450        460        470        480 
GERGGPGERG PRGTPGVRGP RGDPGEAGPQ GDQGREGPVG IPGDSGEAGP IGPKGYRGDE 

       490        500        510        520        530        540 
GPPGPEGLRG APGPVGPPGD PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG 

       550        560        570        580        590        600 
YPGLKGDEGE VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM 

       610        620        630        640        650        660 
KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV KFEPGQSHAG 

       670        680        690        700        710        720 
VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT FTGEALQYTR DRLLPPTQNN 

       730        740        750        760        770        780 
RIALVITDGR SDTQRDTTPL SVLCGADIQV VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR 

       790        800        810        820        830        840 
PGISLVKENY AELLDDGFLK NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH 

       850        860        870        880        890        900 
NFETTKVFAK RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS 

       910        920        930        940        950        960 
VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE AIEKAVQEAQ 

       970        980        990       1000       1010       1020 
RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL FRVPNYQALL RGVLYQTVSR 


KVALG 

« Hide

References

[1]"Murine alpha 1(VI) collagen chain. Complete amino acid sequence and identification of the gene promoter region."
Bonaldo P., Piccolo S., Marvulli D., Volpin D., Bressan G.M.
Matrix 13:223-233(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI."
Zhang R.Z., Pan T.C., Timpl R., Chu M.-L.
Biochem. J. 291:787-792(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 442-1025.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66405 mRNA. Translation: CAA47032.1.
X66406 Genomic DNA. Translation: CAA47033.1.
Z18271 mRNA. Translation: CAA79152.1.
CCDSCCDS23952.1.
PIRS34839.
RefSeqNP_034063.1. NM_009933.4.
UniGeneMm.2509.

3D structure databases

ProteinModelPortalQ04857.
SMRQ04857. Positions 34-220, 613-972.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198823. 1 interaction.
IntActQ04857. 1 interaction.
MINTMINT-4091372.
STRING10090.ENSMUSP00000001147.

PTM databases

PhosphoSiteQ04857.

Proteomic databases

MaxQBQ04857.
PaxDbQ04857.
PRIDEQ04857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119.
GeneID12833.
KEGGmmu:12833.
UCSCuc007fux.1. mouse.

Organism-specific databases

CTD1291.
MGIMGI:88459. Col6a1.

Phylogenomic databases

eggNOGNOG256042.
GeneTreeENSGT00750000117694.
HOGENOMHOG000111863.
HOVERGENHBG095954.
InParanoidQ04857.
KOK06238.
OMAVKENYAE.
OrthoDBEOG71K628.
PhylomeDBQ04857.
TreeFamTF331207.

Gene expression databases

ArrayExpressQ04857.
BgeeQ04857.
CleanExMM_COL6A1.
GenevestigatorQ04857.

Family and domain databases

Gene3D3.40.50.410. 3 hits.
InterProIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamPF01391. Collagen. 6 hits.
PF00092. VWA. 3 hits.
[Graphical view]
SMARTSM00327. VWA. 3 hits.
[Graphical view]
SUPFAMSSF53300. SSF53300. 3 hits.
PROSITEPS50234. VWFA. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio282342.
PROQ04857.
SOURCESearch...

Entry information

Entry nameCO6A1_MOUSE
AccessionPrimary (citable) accession number: Q04857
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot