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Q04857

- CO6A1_MOUSE

UniProt

Q04857 - CO6A1_MOUSE

Protein

Collagen alpha-1(VI) chain

Gene

Col6a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Collagen VI acts as a cell-binding protein.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cellular response to amino acid stimulus Source: MGI
    3. protein heterotrimerization Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(VI) chain
    Gene namesi
    Name:Col6a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:88459. Col6a1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular matrix Source: MGI
    3. extracellular region Source: MGI
    4. lysosomal membrane Source: Ensembl
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    6. protein complex Source: MGI
    7. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 10251006Collagen alpha-1(VI) chainPRO_0000005759Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

    Keywords - PTMi

    Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiQ04857.
    PaxDbiQ04857.
    PRIDEiQ04857.

    PTM databases

    PhosphoSiteiQ04857.

    Expressioni

    Gene expression databases

    ArrayExpressiQ04857.
    BgeeiQ04857.
    CleanExiMM_COL6A1.
    GenevestigatoriQ04857.

    Interactioni

    Subunit structurei

    Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

    Protein-protein interaction databases

    BioGridi198823. 1 interaction.
    IntActiQ04857. 1 interaction.
    MINTiMINT-4091372.
    STRINGi10090.ENSMUSP00000001147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04857.
    SMRiQ04857. Positions 34-220, 613-972.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 234199VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini614 – 802189VWFA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini826 – 1018193VWFA 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 255236N-terminal globular domainAdd
    BLAST
    Regioni256 – 591336Triple-helical regionAdd
    BLAST
    Regioni592 – 1025434C-terminal globular domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi261 – 2633Cell attachment site
    Motifi441 – 4433Cell attachment site
    Motifi477 – 4793Cell attachment site

    Sequence similaritiesi

    Belongs to the type VI collagen family.Curated
    Contains 3 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG256042.
    GeneTreeiENSGT00750000117694.
    HOGENOMiHOG000111863.
    HOVERGENiHBG095954.
    InParanoidiQ04857.
    KOiK06238.
    OMAiVKENYAE.
    OrthoDBiEOG71K628.
    PhylomeDBiQ04857.
    TreeFamiTF331207.

    Family and domain databases

    Gene3Di3.40.50.410. 3 hits.
    InterProiIPR008160. Collagen.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01391. Collagen. 6 hits.
    PF00092. VWA. 3 hits.
    [Graphical view]
    SMARTiSM00327. VWA. 3 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 3 hits.
    PROSITEiPS50234. VWFA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04857-1 [UniParc]FASTAAdd to Basket

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    MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR     50
    LKPYGALVDK VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR 100
    GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK 150
    YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS 200
    IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN NVEQVCCSFE 250
    CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK 300
    GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF 350
    DGIQGPPGPK GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG 400
    PPGEKGEAGD EGNAGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ 450
    GDQGREGPVG IPGDSGEAGP IGPKGYRGDE GPPGPEGLRG APGPVGPPGD 500
    PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG YPGLKGDEGE 550
    VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM 600
    KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV 650
    KFEPGQSHAG VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT 700
    FTGEALQYTR DRLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGADIQV 750
    VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR PGISLVKENY AELLDDGFLK 800
    NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH NFETTKVFAK 850
    RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS 900
    VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE 950
    AIEKAVQEAQ RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL 1000
    FRVPNYQALL RGVLYQTVSR KVALG 1025
    Length:1,025
    Mass (Da):108,489
    Last modified:June 1, 1994 - v1
    Checksum:i2A05DFED8771BBF7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti674 – 6752DM → TL in CAA79152. (PubMed:8489506)Curated
    Sequence conflicti709 – 7091T → A in CAA79152. (PubMed:8489506)Curated
    Sequence conflicti943 – 9431Missing in CAA79152. (PubMed:8489506)Curated
    Sequence conflicti960 – 9601Q → R in CAA79152. (PubMed:8489506)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66405 mRNA. Translation: CAA47032.1.
    X66406 Genomic DNA. Translation: CAA47033.1.
    Z18271 mRNA. Translation: CAA79152.1.
    CCDSiCCDS23952.1.
    PIRiS34839.
    RefSeqiNP_034063.1. NM_009933.4.
    UniGeneiMm.2509.

    Genome annotation databases

    EnsembliENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119.
    GeneIDi12833.
    KEGGimmu:12833.
    UCSCiuc007fux.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66405 mRNA. Translation: CAA47032.1 .
    X66406 Genomic DNA. Translation: CAA47033.1 .
    Z18271 mRNA. Translation: CAA79152.1 .
    CCDSi CCDS23952.1.
    PIRi S34839.
    RefSeqi NP_034063.1. NM_009933.4.
    UniGenei Mm.2509.

    3D structure databases

    ProteinModelPortali Q04857.
    SMRi Q04857. Positions 34-220, 613-972.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198823. 1 interaction.
    IntActi Q04857. 1 interaction.
    MINTi MINT-4091372.
    STRINGi 10090.ENSMUSP00000001147.

    PTM databases

    PhosphoSitei Q04857.

    Proteomic databases

    MaxQBi Q04857.
    PaxDbi Q04857.
    PRIDEi Q04857.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001147 ; ENSMUSP00000001147 ; ENSMUSG00000001119 .
    GeneIDi 12833.
    KEGGi mmu:12833.
    UCSCi uc007fux.1. mouse.

    Organism-specific databases

    CTDi 1291.
    MGIi MGI:88459. Col6a1.

    Phylogenomic databases

    eggNOGi NOG256042.
    GeneTreei ENSGT00750000117694.
    HOGENOMi HOG000111863.
    HOVERGENi HBG095954.
    InParanoidi Q04857.
    KOi K06238.
    OMAi VKENYAE.
    OrthoDBi EOG71K628.
    PhylomeDBi Q04857.
    TreeFami TF331207.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 282342.
    PROi Q04857.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04857.
    Bgeei Q04857.
    CleanExi MM_COL6A1.
    Genevestigatori Q04857.

    Family and domain databases

    Gene3Di 3.40.50.410. 3 hits.
    InterProi IPR008160. Collagen.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01391. Collagen. 6 hits.
    PF00092. VWA. 3 hits.
    [Graphical view ]
    SMARTi SM00327. VWA. 3 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 3 hits.
    PROSITEi PS50234. VWFA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine alpha 1(VI) collagen chain. Complete amino acid sequence and identification of the gene promoter region."
      Bonaldo P., Piccolo S., Marvulli D., Volpin D., Bressan G.M.
      Matrix 13:223-233(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI."
      Zhang R.Z., Pan T.C., Timpl R., Chu M.-L.
      Biochem. J. 291:787-792(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 442-1025.

    Entry informationi

    Entry nameiCO6A1_MOUSE
    AccessioniPrimary (citable) accession number: Q04857
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3