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Protein

Envelope small membrane protein

Gene

E

Organism
Human coronavirus OC43 (HCoV-OC43)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis (By similarity).By similarity

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope small membrane protein
Short name:
E protein
Short name:
sM protein
Alternative name(s):
NS3 protein
Gene namesi
Name:E
Synonyms:sM
ORF Names:5b
OrganismiHuman coronavirus OC43 (HCoV-OC43)
Taxonomic identifieri31631 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000100580 Componenti: Genome
  • UP000007552 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17Virion surfaceSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 84IntravirionSequence analysisAdd BLAST46

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060871 – 84Envelope small membrane proteinAdd BLAST84

Interactioni

Subunit structurei

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses E protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001NY.

Family and domain databases

InterProiView protein in InterPro
IPR003873. NS3/E.
PfamiView protein in Pfam
PF02723. NS3_envE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMADAYLAD TVWYVGQIIF IVAICLLVTI VVVAFLATFK LCIQLCGMCN
60 70 80
TLVLSPSIYV FNRGRQFYEF YNDVKPPVLD VDDV
Length:84
Mass (Da):9,538
Last modified:February 1, 1994 - v1
Checksum:i6E6CB46265EE7E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99576 Genomic RNA. Translation: AAA02570.1.
AY585228 Genomic RNA. Translation: AAT84356.1.
AY585229 Genomic RNA. Translation: AAT84364.1.
AY391777 Genomic RNA. Translation: AAR01017.1.
PIRiB44275.

Similar proteinsi

Entry informationi

Entry nameiVEMP_CVHOC
AccessioniPrimary (citable) accession number: Q04854
Secondary accession number(s): Q696P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 5, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome