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Protein

Single-stranded DNA-binding protein, mitochondrial

Gene

SSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Mt-SSB
Short name:
MtSSB
Alternative name(s):
PWP1-interacting protein 17
Gene namesi
Name:SSBP1
Synonyms:SSBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106028.10
HGNCiHGNC:11317 SSBP1
MIMi600439 gene
neXtProtiNX_Q04837

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

DisGeNETi6742
OpenTargetsiENSG00000106028
PharmGKBiPA36141

Polymorphism and mutation databases

BioMutaiSSBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionCombined sources1 PublicationAdd BLAST16
ChainiPRO_000003326317 – 148Single-stranded DNA-binding protein, mitochondrialAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei113N6-acetyllysineCombined sources1
Modified residuei122N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ04837
MaxQBiQ04837
PaxDbiQ04837
PeptideAtlasiQ04837
PRIDEiQ04837
TopDownProteomicsiQ04837

2D gel databases

UCD-2DPAGEiQ04837

PTM databases

iPTMnetiQ04837
PhosphoSitePlusiQ04837

Expressioni

Gene expression databases

BgeeiENSG00000106028
CleanExiHS_SSBP1
ExpressionAtlasiQ04837 baseline and differential
GenevisibleiQ04837 HS

Organism-specific databases

HPAiHPA002866

Interactioni

Subunit structurei

Homotetramer (By similarity). Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-353460,EBI-6164309From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi112620, 111 interactors
IntActiQ04837, 49 interactors
MINTiQ04837
STRINGi9606.ENSP00000265304

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 39Combined sources10
Beta strandi44 – 46Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi54 – 65Combined sources12
Beta strandi79 – 89Combined sources11
Helixi94 – 101Combined sources8
Beta strandi107 – 115Combined sources9
Beta strandi119 – 126Combined sources8
Beta strandi130 – 138Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S3OX-ray2.47A/B17-148[»]
2DUDX-ray2.70A/B16-148[»]
3ULLX-ray2.40A/B17-148[»]
ProteinModelPortaliQ04837
SMRiQ04837
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04837

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 141SSBAdd BLAST112

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1653 Eukaryota
COG0629 LUCA
GeneTreeiENSGT00390000002796
HOVERGENiHBG001181
InParanoidiQ04837
KOiK03111
OMAiSLATHTN
OrthoDBiEOG091G1330
PhylomeDBiQ04837
TreeFamiTF314629

Family and domain databases

CDDicd04496 SSB_OBF, 1 hit
HAMAPiMF_00984 SSB, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd
PANTHERiPTHR10302 PTHR10302, 1 hit
PTHR10302:SF0 PTHR10302:SF0, 1 hit
PfamiView protein in Pfam
PF00436 SSB, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00621 ssb, 1 hit
PROSITEiView protein in PROSITE
PS50935 SSB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG
60 70 80 90 100
KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ
110 120 130 140
YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE
Length:148
Mass (Da):17,260
Last modified:October 1, 1993 - v1
Checksum:i98EE9E396D5636C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94556 mRNA Translation: AAA36332.1
AF277319 mRNA Translation: AAK69112.1
BC000895 mRNA Translation: AAH00895.1
CCDSiCCDS5866.1
PIRiJN0568
RefSeqiNP_001243439.1, NM_001256510.1
NP_001243440.1, NM_001256511.1
NP_001243441.1, NM_001256512.1
NP_001243442.1, NM_001256513.1
NP_003134.1, NM_003143.2
UniGeneiHs.490394
Hs.740496

Genome annotation databases

EnsembliENST00000265304; ENSP00000265304; ENSG00000106028
ENST00000465582; ENSP00000420485; ENSG00000106028
ENST00000481508; ENSP00000419665; ENSG00000106028
ENST00000484178; ENSP00000419388; ENSG00000106028
ENST00000498107; ENSP00000419541; ENSG00000106028
ENST00000570667; ENSP00000460028; ENSG00000262771
ENST00000571430; ENSP00000459367; ENSG00000262771
ENST00000574199; ENSP00000461884; ENSG00000262771
ENST00000575059; ENSP00000458815; ENSG00000262771
ENST00000576834; ENSP00000459208; ENSG00000262771
ENST00000612337; ENSP00000480488; ENSG00000106028
GeneIDi6742
KEGGihsa:6742
UCSCiuc003vwo.3 human

Similar proteinsi

Entry informationi

Entry nameiSSBP_HUMAN
AccessioniPrimary (citable) accession number: Q04837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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