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Protein

Single-stranded DNA-binding protein, mitochondrial

Gene

SSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Mt-SSB
Short name:
MtSSB
Alternative name(s):
PWP1-interacting protein 17
Gene namesi
Name:SSBP1
Synonyms:SSBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11317. SSBP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial matrix Source: Reactome
  • mitochondrial nucleoid Source: BHF-UCL
  • mitochondrion Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

DisGeNETi6742.
OpenTargetsiENSG00000106028.
PharmGKBiPA36141.

Polymorphism and mutation databases

BioMutaiSSBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionCombined sources1 PublicationAdd BLAST16
ChainiPRO_000003326317 – 148Single-stranded DNA-binding protein, mitochondrialAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei113N6-acetyllysineCombined sources1
Modified residuei122N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ04837.
MaxQBiQ04837.
PaxDbiQ04837.
PeptideAtlasiQ04837.
PRIDEiQ04837.
TopDownProteomicsiQ04837.

2D gel databases

UCD-2DPAGEQ04837.

PTM databases

iPTMnetiQ04837.
PhosphoSitePlusiQ04837.

Expressioni

Gene expression databases

BgeeiENSG00000106028.
CleanExiHS_SSBP1.
ExpressionAtlasiQ04837. baseline and differential.
GenevisibleiQ04837. HS.

Organism-specific databases

HPAiHPA002866.

Interactioni

Subunit structurei

Homotetramer (By similarity). Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-353460,EBI-6164309From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi112620. 99 interactors.
IntActiQ04837. 38 interactors.
MINTiMINT-3025472.
STRINGi9606.ENSP00000265304.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 39Combined sources10
Beta strandi44 – 46Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi54 – 65Combined sources12
Beta strandi79 – 89Combined sources11
Helixi94 – 101Combined sources8
Beta strandi107 – 115Combined sources9
Beta strandi119 – 126Combined sources8
Beta strandi130 – 138Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S3OX-ray2.47A/B17-148[»]
2DUDX-ray2.70A/B16-148[»]
3ULLX-ray2.40A/B17-148[»]
ProteinModelPortaliQ04837.
SMRiQ04837.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04837.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 141SSBAdd BLAST112

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1653. Eukaryota.
COG0629. LUCA.
GeneTreeiENSGT00390000002796.
HOVERGENiHBG001181.
InParanoidiQ04837.
KOiK03111.
OMAiRNPVTIF.
OrthoDBiEOG090A0E0S.
PhylomeDBiQ04837.
TreeFamiTF314629.

Family and domain databases

HAMAPiMF_00984. SSB. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR000424. Primosome_PriB/ssb.
IPR011344. ssDNA-bd.
PANTHERiPTHR10302:SF16. PTHR10302:SF16. 1 hit.
PfamiView protein in Pfam
PF00436. SSB. 1 hit.
PIRSFiPIRSF002070. SSB. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00621. ssb. 1 hit.
PROSITEiView protein in PROSITE
PS50935. SSB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG
60 70 80 90 100
KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ
110 120 130 140
YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE
Length:148
Mass (Da):17,260
Last modified:October 1, 1993 - v1
Checksum:i98EE9E396D5636C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94556 mRNA. Translation: AAA36332.1.
AF277319 mRNA. Translation: AAK69112.1.
BC000895 mRNA. Translation: AAH00895.1.
CCDSiCCDS5866.1.
PIRiJN0568.
RefSeqiNP_001243439.1. NM_001256510.1.
NP_001243440.1. NM_001256511.1.
NP_001243441.1. NM_001256512.1.
NP_001243442.1. NM_001256513.1.
NP_003134.1. NM_003143.2.
UniGeneiHs.490394.
Hs.740496.

Genome annotation databases

EnsembliENST00000265304; ENSP00000265304; ENSG00000106028.
ENST00000465582; ENSP00000420485; ENSG00000106028.
ENST00000481508; ENSP00000419665; ENSG00000106028.
ENST00000484178; ENSP00000419388; ENSG00000106028.
ENST00000498107; ENSP00000419541; ENSG00000106028.
ENST00000570667; ENSP00000460028; ENSG00000262771.
ENST00000571430; ENSP00000459367; ENSG00000262771.
ENST00000574199; ENSP00000461884; ENSG00000262771.
ENST00000575059; ENSP00000458815; ENSG00000262771.
ENST00000576834; ENSP00000459208; ENSG00000262771.
ENST00000612337; ENSP00000480488; ENSG00000106028.
GeneIDi6742.
KEGGihsa:6742.
UCSCiuc003vwo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94556 mRNA. Translation: AAA36332.1.
AF277319 mRNA. Translation: AAK69112.1.
BC000895 mRNA. Translation: AAH00895.1.
CCDSiCCDS5866.1.
PIRiJN0568.
RefSeqiNP_001243439.1. NM_001256510.1.
NP_001243440.1. NM_001256511.1.
NP_001243441.1. NM_001256512.1.
NP_001243442.1. NM_001256513.1.
NP_003134.1. NM_003143.2.
UniGeneiHs.490394.
Hs.740496.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S3OX-ray2.47A/B17-148[»]
2DUDX-ray2.70A/B16-148[»]
3ULLX-ray2.40A/B17-148[»]
ProteinModelPortaliQ04837.
SMRiQ04837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112620. 99 interactors.
IntActiQ04837. 38 interactors.
MINTiMINT-3025472.
STRINGi9606.ENSP00000265304.

PTM databases

iPTMnetiQ04837.
PhosphoSitePlusiQ04837.

Polymorphism and mutation databases

BioMutaiSSBP1.

2D gel databases

UCD-2DPAGEQ04837.

Proteomic databases

EPDiQ04837.
MaxQBiQ04837.
PaxDbiQ04837.
PeptideAtlasiQ04837.
PRIDEiQ04837.
TopDownProteomicsiQ04837.

Protocols and materials databases

DNASUi6742.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265304; ENSP00000265304; ENSG00000106028.
ENST00000465582; ENSP00000420485; ENSG00000106028.
ENST00000481508; ENSP00000419665; ENSG00000106028.
ENST00000484178; ENSP00000419388; ENSG00000106028.
ENST00000498107; ENSP00000419541; ENSG00000106028.
ENST00000570667; ENSP00000460028; ENSG00000262771.
ENST00000571430; ENSP00000459367; ENSG00000262771.
ENST00000574199; ENSP00000461884; ENSG00000262771.
ENST00000575059; ENSP00000458815; ENSG00000262771.
ENST00000576834; ENSP00000459208; ENSG00000262771.
ENST00000612337; ENSP00000480488; ENSG00000106028.
GeneIDi6742.
KEGGihsa:6742.
UCSCiuc003vwo.3. human.

Organism-specific databases

CTDi6742.
DisGeNETi6742.
GeneCardsiSSBP1.
HGNCiHGNC:11317. SSBP1.
HPAiHPA002866.
MIMi600439. gene.
neXtProtiNX_Q04837.
OpenTargetsiENSG00000106028.
PharmGKBiPA36141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1653. Eukaryota.
COG0629. LUCA.
GeneTreeiENSGT00390000002796.
HOVERGENiHBG001181.
InParanoidiQ04837.
KOiK03111.
OMAiRNPVTIF.
OrthoDBiEOG090A0E0S.
PhylomeDBiQ04837.
TreeFamiTF314629.

Enzyme and pathway databases

ReactomeiR-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSiSSBP1. human.
EvolutionaryTraceiQ04837.
GeneWikiiSSBP1.
GenomeRNAii6742.
PROiQ04837.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106028.
CleanExiHS_SSBP1.
ExpressionAtlasiQ04837. baseline and differential.
GenevisibleiQ04837. HS.

Family and domain databases

HAMAPiMF_00984. SSB. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR000424. Primosome_PriB/ssb.
IPR011344. ssDNA-bd.
PANTHERiPTHR10302:SF16. PTHR10302:SF16. 1 hit.
PfamiView protein in Pfam
PF00436. SSB. 1 hit.
PIRSFiPIRSF002070. SSB. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00621. ssb. 1 hit.
PROSITEiView protein in PROSITE
PS50935. SSB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSBP_HUMAN
AccessioniPrimary (citable) accession number: Q04837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 15, 2017
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.