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Q04837

- SSBP_HUMAN

UniProt

Q04837 - SSBP_HUMAN

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Protein
Single-stranded DNA-binding protein, mitochondrial
Gene
SSBP1, SSBP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.UniRule annotation

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. mitochondrion morphogenesis Source: Ensembl
  3. positive regulation of helicase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_200608. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Mt-SSB
Short name:
MtSSB
Alternative name(s):
PWP1-interacting protein 17
Gene namesi
Name:SSBP1
Synonyms:SSBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11317. SSBP1.

Subcellular locationi

Mitochondrion. Mitochondrion matrixmitochondrion nucleoid 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrial nucleoid Source: BHF-UCL
  3. mitochondrion Source: HPA
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion1 Publication
Add
BLAST
Chaini17 – 148132Single-stranded DNA-binding protein, mitochondrialUniRule annotation
PRO_0000033263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791Phosphoserine1 Publication
Modified residuei113 – 1131N6-acetyllysine1 Publication
Modified residuei122 – 1221N6-succinyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04837.
PaxDbiQ04837.
PeptideAtlasiQ04837.
PRIDEiQ04837.

2D gel databases

UCD-2DPAGEQ04837.

PTM databases

PhosphoSiteiQ04837.

Expressioni

Gene expression databases

ArrayExpressiQ04837.
BgeeiQ04837.
CleanExiHS_SSBP1.
GenevestigatoriQ04837.

Organism-specific databases

HPAiHPA002866.

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-353460,EBI-6164309From a different organism.

Protein-protein interaction databases

BioGridi112620. 80 interactions.
IntActiQ04837. 26 interactions.
MINTiMINT-3025472.
STRINGi9606.ENSP00000265304.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 3910
Beta strandi44 – 463
Beta strandi48 – 514
Beta strandi54 – 6512
Beta strandi79 – 8911
Helixi94 – 1018
Beta strandi107 – 1159
Beta strandi119 – 1268
Beta strandi130 – 1389

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S3OX-ray2.47A/B17-148[»]
2DUDX-ray2.70A/B16-148[»]
3ULLX-ray2.40A/B17-148[»]
ProteinModelPortaliQ04837.
SMRiQ04837. Positions 26-140.

Miscellaneous databases

EvolutionaryTraceiQ04837.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 141112SSB
Add
BLAST

Sequence similaritiesi

Contains 1 SSB domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0629.
HOVERGENiHBG001181.
InParanoidiQ04837.
KOiK03111.
OMAiRNPVTIF.
PhylomeDBiQ04837.
TreeFamiTF314629.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00984. SSB.
InterProiIPR012340. NA-bd_OB-fold.
IPR000424. Primosome_PriB/ssb.
IPR011344. ssDNA-bd.
[Graphical view]
PANTHERiPTHR10302. PTHR10302. 1 hit.
PfamiPF00436. SSB. 1 hit.
[Graphical view]
PIRSFiPIRSF002070. SSB. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00621. ssb. 1 hit.
PROSITEiPS50935. SSB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04837-1 [UniParc]FASTAAdd to Basket

« Hide

MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG    50
KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ 100
YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE 148
Length:148
Mass (Da):17,260
Last modified:October 1, 1993 - v1
Checksum:i98EE9E396D5636C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94556 mRNA. Translation: AAA36332.1.
AF277319 mRNA. Translation: AAK69112.1.
BC000895 mRNA. Translation: AAH00895.1.
CCDSiCCDS5866.1.
PIRiJN0568.
RefSeqiNP_001243439.1. NM_001256510.1.
NP_001243440.1. NM_001256511.1.
NP_001243441.1. NM_001256512.1.
NP_001243442.1. NM_001256513.1.
NP_003134.1. NM_003143.2.
UniGeneiHs.490394.

Genome annotation databases

EnsembliENST00000265304; ENSP00000265304; ENSG00000106028.
ENST00000465582; ENSP00000420485; ENSG00000106028.
ENST00000481508; ENSP00000419665; ENSG00000106028.
ENST00000484178; ENSP00000419388; ENSG00000106028.
ENST00000498107; ENSP00000419541; ENSG00000106028.
ENST00000570667; ENSP00000460028; ENSG00000262771.
ENST00000571430; ENSP00000459367; ENSG00000262771.
ENST00000574199; ENSP00000461884; ENSG00000262771.
ENST00000575059; ENSP00000458815; ENSG00000262771.
ENST00000576834; ENSP00000459208; ENSG00000262771.
GeneIDi6742.
KEGGihsa:6742.
UCSCiuc003vwo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94556 mRNA. Translation: AAA36332.1 .
AF277319 mRNA. Translation: AAK69112.1 .
BC000895 mRNA. Translation: AAH00895.1 .
CCDSi CCDS5866.1.
PIRi JN0568.
RefSeqi NP_001243439.1. NM_001256510.1.
NP_001243440.1. NM_001256511.1.
NP_001243441.1. NM_001256512.1.
NP_001243442.1. NM_001256513.1.
NP_003134.1. NM_003143.2.
UniGenei Hs.490394.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S3O X-ray 2.47 A/B 17-148 [» ]
2DUD X-ray 2.70 A/B 16-148 [» ]
3ULL X-ray 2.40 A/B 17-148 [» ]
ProteinModelPortali Q04837.
SMRi Q04837. Positions 26-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112620. 80 interactions.
IntActi Q04837. 26 interactions.
MINTi MINT-3025472.
STRINGi 9606.ENSP00000265304.

PTM databases

PhosphoSitei Q04837.

2D gel databases

UCD-2DPAGE Q04837.

Proteomic databases

MaxQBi Q04837.
PaxDbi Q04837.
PeptideAtlasi Q04837.
PRIDEi Q04837.

Protocols and materials databases

DNASUi 6742.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265304 ; ENSP00000265304 ; ENSG00000106028 .
ENST00000465582 ; ENSP00000420485 ; ENSG00000106028 .
ENST00000481508 ; ENSP00000419665 ; ENSG00000106028 .
ENST00000484178 ; ENSP00000419388 ; ENSG00000106028 .
ENST00000498107 ; ENSP00000419541 ; ENSG00000106028 .
ENST00000570667 ; ENSP00000460028 ; ENSG00000262771 .
ENST00000571430 ; ENSP00000459367 ; ENSG00000262771 .
ENST00000574199 ; ENSP00000461884 ; ENSG00000262771 .
ENST00000575059 ; ENSP00000458815 ; ENSG00000262771 .
ENST00000576834 ; ENSP00000459208 ; ENSG00000262771 .
GeneIDi 6742.
KEGGi hsa:6742.
UCSCi uc003vwo.2. human.

Organism-specific databases

CTDi 6742.
GeneCardsi GC07P141442.
HGNCi HGNC:11317. SSBP1.
HPAi HPA002866.
MIMi 600439. gene.
neXtProti NX_Q04837.
PharmGKBi PA36141.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0629.
HOVERGENi HBG001181.
InParanoidi Q04837.
KOi K03111.
OMAi RNPVTIF.
PhylomeDBi Q04837.
TreeFami TF314629.

Enzyme and pathway databases

Reactomei REACT_200608. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSi SSBP1. human.
EvolutionaryTracei Q04837.
GeneWikii SSBP1.
GenomeRNAii 6742.
NextBioi 26300.
PROi Q04837.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q04837.
Bgeei Q04837.
CleanExi HS_SSBP1.
Genevestigatori Q04837.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00984. SSB.
InterProi IPR012340. NA-bd_OB-fold.
IPR000424. Primosome_PriB/ssb.
IPR011344. ssDNA-bd.
[Graphical view ]
PANTHERi PTHR10302. PTHR10302. 1 hit.
Pfami PF00436. SSB. 1 hit.
[Graphical view ]
PIRSFi PIRSF002070. SSB. 1 hit.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00621. ssb. 1 hit.
PROSITEi PS50935. SSB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)."
    Tiranti V., Rocchi M., Didonato S., Zeviani M.
    Gene 126:219-225(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "hPWP1-interacting protein 17 (ssDNA BP)."
    Honore B.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  4. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 17-29.
    Tissue: Leukemic T-cell.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. "The layered structure of human mitochondrial DNA nucleoids."
    Bogenhagen D.F., Rousseau D., Burke S.
    J. Biol. Chem. 283:3665-3675(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH MITOCHONDRIAL DNA, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)."
    van Loon B., Samson L.D.
    DNA Repair 12:177-187(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH MPG.
  10. "Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4-A resolution."
    Yang C., Curth U., Urbanke C., Kang C.
    Nat. Struct. Biol. 4:153-157(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 26-141.
  11. "Crystal structure of human mitochondrial single-stranded DNA-binding protein (HMTSSB)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 16-148.

Entry informationi

Entry nameiSSBP_HUMAN
AccessioniPrimary (citable) accession number: Q04837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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