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Q04835

- YM87_YEAST

UniProt

Q04835 - YM87_YEAST

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Protein

Uncharacterized membrane protein YMR253C

Gene
YMR253C, YM9920.07C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-32930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YMR253C
Gene namesi
Ordered Locus Names:YMR253C
ORF Names:YM9920.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR253c.
SGDiS000004866. YMR253C.

Subcellular locationi

Membrane; Multi-pass membrane protein
Note: Localizes to cytoplasmic punctate structures.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666Lumenal Reviewed predictionAdd
BLAST
Transmembranei67 – 8721Helical; Reviewed predictionAdd
BLAST
Topological domaini88 – 10619Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei107 – 12721Helical; Reviewed predictionAdd
BLAST
Topological domaini128 – 14417Lumenal Reviewed predictionAdd
BLAST
Transmembranei145 – 16723Helical; Reviewed predictionAdd
BLAST
Topological domaini168 – 1714Cytoplasmic Reviewed prediction
Transmembranei172 – 19120Helical; Reviewed predictionAdd
BLAST
Topological domaini192 – 1998Lumenal Reviewed prediction
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Topological domaini221 – 24121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei242 – 26221Helical; Reviewed predictionAdd
BLAST
Topological domaini263 – 2697Lumenal Reviewed prediction
Transmembranei270 – 29021Helical; Reviewed predictionAdd
BLAST
Topological domaini291 – 30717Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei308 – 32821Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 35729Lumenal Reviewed predictionAdd
BLAST
Transmembranei358 – 37821Helical; Reviewed predictionAdd
BLAST
Topological domaini379 – 41436Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Uncharacterized membrane protein YMR253CPRO_0000203340Add
BLAST

Proteomic databases

MaxQBiQ04835.
PaxDbiQ04835.

Expressioni

Gene expression databases

GenevestigatoriQ04835.

Interactioni

Protein-protein interaction databases

BioGridi35432. 9 interactions.
DIPiDIP-5067N.
IntActiQ04835. 4 interactions.
MINTiMINT-563831.
STRINGi4932.YMR253C.

Structurei

3D structure databases

ProteinModelPortaliQ04835.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 215138EamA 1Add
BLAST
Domaini253 – 379127EamA 2Add
BLAST

Sequence similaritiesi

Contains 2 EamA domains.
To yeast YPL264c.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00730000111035.
HOGENOMiHOG000248677.
OMAiAFIAWVA.
OrthoDBiEOG744TKH.

Family and domain databases

InterProiIPR000620. DMT.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04835-1 [UniParc]FASTAAdd to Basket

« Hide

MNPSVPKVMK RENNTHLLVS KEMNDTSLQL PSTTRSLSPK ESNSNEDFNV    50
DGNETTLQRI SKDYLKPNIG LVLLTVSYFF NSAMVVSTKV LENDPDDIAN 100
DRQIKPLQIL LVRMVITYIG TLIYMYINKS TISDVPFGKP EVRKWLVLRG 150
CTGFFGVFGM YYSLMYLTIS DAVLITFLAP SLTIFLSWVI LRERFTKVEA 200
LGSLISLLGV VLIVRPSFLF GTPELTDSSS QIVESSDPKS RLIATLVGLW 250
GVLGMSCVYI IIRYIGKRAH AIMSVSYFSL ITAIVSFIGI NTIPSMKFQI 300
PHSKKQWILF GNLGVSGFIF QLLLTMGIQR ERAGRGSLMT YTQLLYAVFW 350
DVALYKHWPN IWSWIGMIII ISATLWVIRI RAANNETTAK DLTPIIDDEE 400
NSIPLTEFDL SDSK 414
Length:414
Mass (Da):46,659
Last modified:November 1, 1997 - v1
Checksum:iE0EBD0F3BE4CC8AB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781F → L in AAU09774. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48639 Genomic DNA. Translation: CAA88580.1.
AY723857 Genomic DNA. Translation: AAU09774.1.
BK006946 Genomic DNA. Translation: DAA10154.1.
PIRiS53075.
RefSeqiNP_013980.1. NM_001182760.1.

Genome annotation databases

EnsemblFungiiYMR253C; YMR253C; YMR253C.
GeneIDi855295.
KEGGisce:YMR253C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48639 Genomic DNA. Translation: CAA88580.1 .
AY723857 Genomic DNA. Translation: AAU09774.1 .
BK006946 Genomic DNA. Translation: DAA10154.1 .
PIRi S53075.
RefSeqi NP_013980.1. NM_001182760.1.

3D structure databases

ProteinModelPortali Q04835.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35432. 9 interactions.
DIPi DIP-5067N.
IntActi Q04835. 4 interactions.
MINTi MINT-563831.
STRINGi 4932.YMR253C.

Proteomic databases

MaxQBi Q04835.
PaxDbi Q04835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR253C ; YMR253C ; YMR253C .
GeneIDi 855295.
KEGGi sce:YMR253C.

Organism-specific databases

CYGDi YMR253c.
SGDi S000004866. YMR253C.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00730000111035.
HOGENOMi HOG000248677.
OMAi AFIAWVA.
OrthoDBi EOG744TKH.

Enzyme and pathway databases

BioCyci YEAST:G3O-32930-MONOMER.

Miscellaneous databases

NextBioi 978952.

Gene expression databases

Genevestigatori Q04835.

Family and domain databases

InterProi IPR000620. DMT.
[Graphical view ]
Pfami PF00892. EamA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYM87_YEAST
AccessioniPrimary (citable) accession number: Q04835
Secondary accession number(s): D6W080, Q66R30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi