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Protein

Uncharacterized membrane protein YMR253C

Gene

YMR253C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-32930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YMR253C
Gene namesi
Ordered Locus Names:YMR253C
ORF Names:YM9920.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR253C.
SGDiS000004866. YMR253C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66LumenalSequence analysisAdd BLAST66
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 106CytoplasmicSequence analysisAdd BLAST19
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 144LumenalSequence analysisAdd BLAST17
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23
Topological domaini168 – 171CytoplasmicSequence analysis4
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Topological domaini192 – 199LumenalSequence analysis8
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 241CytoplasmicSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 269LumenalSequence analysis7
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 307CytoplasmicSequence analysisAdd BLAST17
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 357LumenalSequence analysisAdd BLAST29
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 414CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033401 – 414Uncharacterized membrane protein YMR253CAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ04835.
PRIDEiQ04835.

PTM databases

iPTMnetiQ04835.

Interactioni

Protein-protein interaction databases

BioGridi35432. 8 interactors.
DIPiDIP-5067N.
IntActiQ04835. 4 interactors.
MINTiMINT-563831.

Structurei

3D structure databases

ProteinModelPortaliQ04835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 215EamA 1Add BLAST138
Domaini253 – 379EamA 2Add BLAST127

Sequence similaritiesi

Contains 2 EamA domains.Curated
To yeast YPL264c.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111035.
HOGENOMiHOG000248677.
InParanoidiQ04835.
OMAiLGANCPY.
OrthoDBiEOG092C346T.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSVPKVMK RENNTHLLVS KEMNDTSLQL PSTTRSLSPK ESNSNEDFNV
60 70 80 90 100
DGNETTLQRI SKDYLKPNIG LVLLTVSYFF NSAMVVSTKV LENDPDDIAN
110 120 130 140 150
DRQIKPLQIL LVRMVITYIG TLIYMYINKS TISDVPFGKP EVRKWLVLRG
160 170 180 190 200
CTGFFGVFGM YYSLMYLTIS DAVLITFLAP SLTIFLSWVI LRERFTKVEA
210 220 230 240 250
LGSLISLLGV VLIVRPSFLF GTPELTDSSS QIVESSDPKS RLIATLVGLW
260 270 280 290 300
GVLGMSCVYI IIRYIGKRAH AIMSVSYFSL ITAIVSFIGI NTIPSMKFQI
310 320 330 340 350
PHSKKQWILF GNLGVSGFIF QLLLTMGIQR ERAGRGSLMT YTQLLYAVFW
360 370 380 390 400
DVALYKHWPN IWSWIGMIII ISATLWVIRI RAANNETTAK DLTPIIDDEE
410
NSIPLTEFDL SDSK
Length:414
Mass (Da):46,659
Last modified:November 1, 1997 - v1
Checksum:iE0EBD0F3BE4CC8AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278F → L in AAU09774 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48639 Genomic DNA. Translation: CAA88580.1.
AY723857 Genomic DNA. Translation: AAU09774.1.
BK006946 Genomic DNA. Translation: DAA10154.1.
PIRiS53075.
RefSeqiNP_013980.1. NM_001182760.1.

Genome annotation databases

EnsemblFungiiYMR253C; YMR253C; YMR253C.
GeneIDi855295.
KEGGisce:YMR253C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48639 Genomic DNA. Translation: CAA88580.1.
AY723857 Genomic DNA. Translation: AAU09774.1.
BK006946 Genomic DNA. Translation: DAA10154.1.
PIRiS53075.
RefSeqiNP_013980.1. NM_001182760.1.

3D structure databases

ProteinModelPortaliQ04835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35432. 8 interactors.
DIPiDIP-5067N.
IntActiQ04835. 4 interactors.
MINTiMINT-563831.

PTM databases

iPTMnetiQ04835.

Proteomic databases

MaxQBiQ04835.
PRIDEiQ04835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR253C; YMR253C; YMR253C.
GeneIDi855295.
KEGGisce:YMR253C.

Organism-specific databases

EuPathDBiFungiDB:YMR253C.
SGDiS000004866. YMR253C.

Phylogenomic databases

GeneTreeiENSGT00730000111035.
HOGENOMiHOG000248677.
InParanoidiQ04835.
OMAiLGANCPY.
OrthoDBiEOG092C346T.

Enzyme and pathway databases

BioCyciYEAST:G3O-32930-MONOMER.

Miscellaneous databases

PROiQ04835.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYM87_YEAST
AccessioniPrimary (citable) accession number: Q04835
Secondary accession number(s): D6W080, Q66R30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.