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Q04830

- ENAN_BPK1F

UniProt

Q04830 - ENAN_BPK1F

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Protein

Endo-N-acetylneuraminidase

Gene
N/A
Organism
Enterobacteria phage K1F (Bacteriophage K1F)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for initial absorption of the phage to the host bacterium. Degradation of the alpha-2,8-linked polysialic acid K1 capsule.

Catalytic activityi

Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids.

GO - Molecular functioni

  1. endo-alpha-(2,8)-sialidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.129. 716.

Protein family/group databases

CAZyiGH58. Glycoside Hydrolase Family 58.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-N-acetylneuraminidase (EC:3.2.1.129)
Short name:
Endo-N
Alternative name(s):
Endosialidase
G102
OrganismiEnterobacteria phage K1F (Bacteriophage K1F)
Taxonomic identifieri344021 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7likevirus
Virus hostiEscherichia coli [TaxID: 562]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by host1 Publication
Chaini2 – 920919Endo-N-acetylneuraminidasePRO_0000057709Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1
920
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi249 – 2535
Helixi255 – 26410
Beta strandi277 – 2793
Helixi286 – 2883
Beta strandi289 – 2913
Beta strandi293 – 2964
Beta strandi304 – 3074
Beta strandi311 – 3188
Beta strandi323 – 3275
Beta strandi334 – 3363
Beta strandi339 – 35214
Beta strandi356 – 3649
Beta strandi373 – 3764
Turni380 – 3845
Beta strandi385 – 3884
Beta strandi392 – 3954
Beta strandi398 – 40710
Turni408 – 4103
Beta strandi413 – 42210
Beta strandi426 – 4316
Beta strandi433 – 4353
Beta strandi441 – 4455
Beta strandi456 – 4616
Beta strandi469 – 4724
Beta strandi475 – 4784
Beta strandi481 – 4855
Beta strandi500 – 5056
Beta strandi513 – 5164
Beta strandi524 – 5318
Beta strandi533 – 5353
Beta strandi537 – 5437
Beta strandi545 – 5484
Beta strandi550 – 5567
Turni557 – 5615
Beta strandi567 – 5704
Helixi573 – 5753
Beta strandi579 – 5879
Beta strandi590 – 5989
Beta strandi606 – 6127
Beta strandi618 – 6214
Beta strandi633 – 6364
Beta strandi639 – 6457
Beta strandi667 – 6748
Turni675 – 6773
Beta strandi686 – 6905
Beta strandi696 – 6983
Beta strandi702 – 7109
Beta strandi713 – 7219
Turni728 – 7347
Beta strandi746 – 7538
Beta strandi772 – 7743
Beta strandi784 – 7863
Beta strandi790 – 7923
Beta strandi796 – 8038
Turni808 – 8114
Beta strandi812 – 8176
Beta strandi819 – 8268
Helixi833 – 8353
Beta strandi837 – 84711
Helixi848 – 8503
Beta strandi853 – 8575
Beta strandi861 – 8633
Beta strandi867 – 8704
Beta strandi872 – 8798
Beta strandi884 – 8896
Beta strandi891 – 8933
Beta strandi901 – 9055

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V0EX-ray1.90A/B/C/D/E/F246-910[»]
1V0FX-ray2.55A/B/C/D/E/F246-910[»]
3GVJX-ray1.48A246-910[»]
3GVKX-ray1.84A/B/C246-910[»]
3GVLX-ray1.41A246-910[»]
3GW6X-ray2.60A/B/C/D/E/F790-913[»]
3JU4X-ray0.98A246-910[»]
ProteinModelPortaliQ04830.
SMRiQ04830. Positions 246-910.

Miscellaneous databases

EvolutionaryTraceiQ04830.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati360 – 37112BNR 1Add
BLAST
Repeati496 – 5038BNR 2
Repeati608 – 61912BNR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 21619Gly-rich (hinge)Add
BLAST

Sequence similaritiesi

Contains 3 BNR repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.40.30.20. 1 hit.
3.30.750.60. 1 hit.
4.10.1090.10. 1 hit.
InterProiIPR023366. ATPase_asu-like.
IPR024427. Endosialidase_beta_barrel.
IPR024428. Endosialidase_beta_prop.
IPR024430. Endosialidase_C_dom.
IPR024429. Endosialidase_N-extension.
IPR001724. Glycl_Hydrolase_58.
IPR005604. Phage_T7_tail_fibre.
IPR011040. Sialidases.
[Graphical view]
PfamiPF12195. End_beta_barrel. 1 hit.
PF12217. End_beta_propel. 1 hit.
PF12218. End_N_terminal. 1 hit.
PF12219. End_tail_spike. 1 hit.
PF03906. Phage_T7_tail. 1 hit.
[Graphical view]
PRINTSiPR00849. GLHYDRLASE58.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04830-1 [UniParc]FASTAAdd to Basket

« Hide

MSTITQFPSG NTQYRIEFDY LARTFVVVTL VNSSNPTLNR VLEVGRDYRF    50
LNPTMIEMLV DQSGFDIVRI HRQTGTDLVV DFRNGSVLTA SDLTTAELQA 100
IHIAEEGRDQ TVDLAKEYAD AAGSSAGNAK DSEDEARRIA ESIRAAGLIG 150
YMTRRSFEKG YNVTTWSEVL LWEEDGDYYR WDGTLPKNVP AGSTPETSGG 200
IGLGAWVSVG DAALRSQISN PEGAILYPEL HRARWLDEKD ARGWGAKGDG 250
VTDDTAALTS ALNDTPVGQK INGNGKTYKV TSLPDISRFI NTRFVYERIP 300
GQPLYYASEE FVQGELFKIT DTPYYNAWPQ DKAFVYENVI YAPYMGSDRH 350
GVSRLHVSWV KSGDDGQTWS TPEWLTDLHP DYPTVNYHCM SMGVCRNRLF 400
AMIETRTLAK NALTNCALWD RPMSRSLHLT GGITKAANQR YATIHVPDHG 450
LFVGDFVNFS NSAVTGVSGD MTVATVIDKD NFTVLTPNQQ TSDLNNAGKN 500
WHMGTSFHKS PWRKTDLGLI PSVTEVHSFA TIDNNGFAMG YHQGDVAPRE 550
VGLFYFPDAF NSPSNYVRRQ IPSEYEPDAS EPCIKYYDGV LYLITRGTRG 600
DRLGSSLHRS RDIGQTWESL RFPHNVHRTT LPFAKVGDDL IMFGSERAEN 650
EWEAGAPDDR YKASYPRTFY ARLNVNNWNA DDIEWVNITD QIYQGGIVNS 700
GVGVGSVVVK DNYIYYMFGG EDHFNPWTYG DNSAKDPFKS DGHPSDLYCY 750
KMKIGPDNRV SRDFRYGAVP NRAVPVFFDT NGVRTVPAPM EFTGDLGLGH 800
VTIRASTSSN IRSEVLMEGE YGFIGKSIPT DNPAGQRIIF CGGEGTSSTT 850
GAQITLYGAN NTDSRRIVYN GDEHLFQSAD VKPYNDNVTA LGGPSNRFTT 900
AYLGSNPIVT SNGGGGKQSR 920
Length:920
Mass (Da):102,013
Last modified:January 23, 2007 - v3
Checksum:i62B77613F55884B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63657 Unassigned DNA. Translation: AAC37340.1.
PIRiA36887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63657 Unassigned DNA. Translation: AAC37340.1 .
PIRi A36887.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1V0E X-ray 1.90 A/B/C/D/E/F 246-910 [» ]
1V0F X-ray 2.55 A/B/C/D/E/F 246-910 [» ]
3GVJ X-ray 1.48 A 246-910 [» ]
3GVK X-ray 1.84 A/B/C 246-910 [» ]
3GVL X-ray 1.41 A 246-910 [» ]
3GW6 X-ray 2.60 A/B/C/D/E/F 790-913 [» ]
3JU4 X-ray 0.98 A 246-910 [» ]
ProteinModelPortali Q04830.
SMRi Q04830. Positions 246-910.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH58. Glycoside Hydrolase Family 58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 3.2.1.129. 716.

Miscellaneous databases

EvolutionaryTracei Q04830.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.40.30.20. 1 hit.
3.30.750.60. 1 hit.
4.10.1090.10. 1 hit.
InterProi IPR023366. ATPase_asu-like.
IPR024427. Endosialidase_beta_barrel.
IPR024428. Endosialidase_beta_prop.
IPR024430. Endosialidase_C_dom.
IPR024429. Endosialidase_N-extension.
IPR001724. Glycl_Hydrolase_58.
IPR005604. Phage_T7_tail_fibre.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF12195. End_beta_barrel. 1 hit.
PF12217. End_beta_propel. 1 hit.
PF12218. End_N_terminal. 1 hit.
PF12219. End_tail_spike. 1 hit.
PF03906. Phage_T7_tail. 1 hit.
[Graphical view ]
PRINTSi PR00849. GLHYDRLASE58.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase (endo-N) and comparison to an endo-N homolog in bacteriophage PK1E."
    Petter J.G., Vimr E.R.
    J. Bacteriol. 175:4354-4363(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 2-31 AND 917-920.

Entry informationi

Entry nameiENAN_BPK1F
AccessioniPrimary (citable) accession number: Q04830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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