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Protein

G1/S-specific cyclin-D2

Gene

Ccnd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).By similarity

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to insulin stimulus Source: RGD
  • G1/S transition of mitotic cell cycle Source: RGD
  • liver development Source: RGD
  • ovarian follicle development Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of epithelial cell proliferation Source: RGD
  • regulation of neuron differentiation Source: RGD
  • response to cAMP Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to testosterone Source: RGD
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D2
Alternative name(s):
Vin-1 proto-oncogene
Gene namesi
Name:Ccnd2
Synonyms:Vin-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621083 Ccnd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804391 – 288G1/S-specific cyclin-D2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1
Modified residuei279PhosphothreonineBy similarity1

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ04827

Interactioni

Subunit structurei

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (By similarity).By similarity

Protein-protein interaction databases

BioGridi248951, 3 interactors
STRINGi10116.ENSRNOP00000027084

Structurei

3D structure databases

ProteinModelPortaliQ04827
SMRiQ04827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 151Cyclin N-terminalAdd BLAST126

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
HOGENOMiHOG000008182
HOVERGENiHBG050837
InParanoidiQ04827
KOiK10151
PhylomeDBiQ04827

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF66 PTHR10177:SF66, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q04827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEVDP VRRAVPDRNL LEDRVLQNLL TIEERYLPQC SYFKCVQKDI
60 70 80 90 100
QPYMRRMVAT WMLEVCEEQK CEEEVFPLAM NYLDRFLAGV PTPKTHLQLL
110 120 130 140 150
GAVCMFLASK LKETIPLTAE KLCIYTDNSV KPQELLEWEL VVLGKLKWNL
160 170 180 190 200
AAVTPHDFIE HILRKLPQQK EKLSLIRKHA QTFIALCATD FKFAMYPPSM
210 220 230 240 250
IATGSVGAAI CGLQQDEEVN ALTCDALTEL LTKITHTDVD CLKACQEQIE
260 270 280
AVLLNSLQQF RQEQHNGSKS VEDPDQATTP TDVRDVDL
Length:288
Mass (Da):32,826
Last modified:October 1, 1993 - v1
Checksum:i4B522BF4E9835FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68E → G in BAA03815 (PubMed:7926809).Curated1
Sequence conflicti104C → V in BAA03815 (PubMed:7926809).Curated1
Sequence conflicti232T → A in BAA03815 (PubMed:7926809).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09752 mRNA Translation: AAA41010.1
D16308 mRNA Translation: BAA03815.1
PIRiI58372
JC4011
RefSeqiNP_071603.1, NM_022267.1
UniGeneiRn.96083

Genome annotation databases

GeneIDi64033
KEGGirno:64033
UCSCiRGD:621083 rat

Similar proteinsi

Entry informationi

Entry nameiCCND2_RAT
AccessioniPrimary (citable) accession number: Q04827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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